GREMLIN Database
COFG - FO synthase subunit 1
UniProt: Q9HNU9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (313)
Sequences: 3639 (2231)
Seq/√Len: 126.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_D225_R5.3651.00
108_H146_R4.9881.00
269_G288_D3.8801.00
328_L332_E3.7381.00
27_D31_A3.5411.00
56_T65_V3.5171.00
74_P109_E3.2711.00
141_P192_D3.2671.00
29_R262_A3.1361.00
168_D181_E2.9991.00
167_A211_D2.8521.00
31_A37_S2.5551.00
73_T76_E2.5191.00
77_I110_Q2.3541.00
141_P145_T2.3471.00
217_L263_V2.2531.00
25_A262_A2.2061.00
79_E82_R2.1431.00
199_T219_I2.1121.00
185_H189_V2.1051.00
181_E185_H2.0151.00
141_P189_V2.0141.00
113_E117_D2.0121.00
82_R115_G1.9911.00
208_D211_D1.9721.00
170_Q174_G1.9631.00
84_G89_C1.9631.00
310_L314_S1.9401.00
212_R256_V1.8661.00
179_S182_Q1.8601.00
28_V32_D1.8511.00
184_L218_A1.8421.00
82_R86_D1.8281.00
90_T326_E1.8241.00
113_E156_N1.8001.00
148_Q193_L1.7821.00
297_T300_H1.7761.00
145_T152_V1.7461.00
10_E263_V1.7351.00
52_A71_L1.7301.00
294_S297_T1.7171.00
78_R82_R1.7101.00
9_D13_V1.7101.00
212_R252_T1.6901.00
27_D30_P1.6871.00
109_E112_G1.6601.00
76_E79_E1.6601.00
104_Y108_H1.6511.00
23_E285_C1.6431.00
18_S21_A1.6401.00
318_D324_L1.6021.00
296_V299_D1.6011.00
249_G252_T1.5651.00
254_R282_L1.5611.00
10_E13_V1.5601.00
188_D222_L1.5581.00
27_D284_D1.5541.00
314_S318_D1.5491.00
301_I304_D1.5491.00
296_V301_I1.5291.00
167_A214_E1.5251.00
71_L99_Q1.5191.00
83_V86_D1.5181.00
309_A312_E1.5171.00
146_R152_V1.5131.00
113_E116_Y1.5101.00
294_S301_I1.4921.00
24_R28_V1.4661.00
203_V253_M1.4661.00
99_Q102_D1.4641.00
217_L221_A1.4621.00
317_A324_L1.4621.00
105_T109_E1.4581.00
182_Q185_H1.4391.00
294_S299_D1.4381.00
315_A319_H1.4371.00
114_W117_D1.4331.00
105_T108_H1.4251.00
70_S76_E1.4171.00
148_Q195_V1.4161.00
130_A182_Q1.4071.00
148_Q152_V1.3941.00
294_S298_K1.3881.00
284_D320_A1.3831.00
167_A206_G1.3721.00
296_V300_H1.3631.00
111_L155_V1.3631.00
172_H175_P1.3391.00
9_D14_S1.3171.00
11_Y14_S1.3121.00
294_S300_H1.2991.00
224_E265_P1.2881.00
29_R32_D1.2831.00
37_S322_V1.2831.00
299_D302_N1.2681.00
107_I147_A1.2621.00
139_A142_G1.2491.00
38_S323_P1.2451.00
145_T148_Q1.2341.00
74_P78_R1.2341.00
157_A196_P1.2320.99
104_Y143_D1.2280.99
146_R153_A1.2120.99
45_V84_G1.2110.99
105_T146_R1.2060.99
213_A217_L1.1990.99
188_D192_D1.1940.99
108_H153_A1.1920.99
112_G153_A1.1830.99
241_A245_G1.1790.99
300_H305_Y1.1790.99
108_H112_G1.1640.99
19_E23_E1.1620.99
27_D322_V1.1530.99
28_V31_A1.1490.99
169_V206_G1.1460.99
257_V282_L1.1420.99
302_N305_Y1.1330.99
168_D171_A1.1290.99
189_V192_D1.1240.99
185_H188_D1.1210.99
170_Q175_P1.1210.99
19_E255_R1.1190.99
78_R116_Y1.1130.99
300_H303_P1.1040.99
15_V210_R1.1020.99
241_A244_Q1.1010.99
184_L222_L1.1000.99
295_P299_D1.1000.99
56_T63_Y1.0990.99
11_Y15_V1.0990.99
30_P322_V1.0990.99
213_A263_V1.0980.99
10_E14_S1.0960.99
181_E218_A1.0890.99
180_P184_L1.0850.99
312_E315_A1.0830.99
66_P101_D1.0800.99
311_D315_A1.0790.99
269_G287_V1.0730.99
113_E121_E1.0710.99
318_D323_P1.0700.99
290_L313_L1.0660.99
104_Y146_R1.0630.99
301_I305_Y1.0610.98
130_A134_G1.0600.98
72_L80_Q1.0580.98
216_L260_A1.0580.98
201_I215_S1.0580.98
295_P300_H1.0570.98
280_R316_I1.0570.98
161_V186_T1.0440.98
219_I267_E1.0340.98
37_S323_P1.0310.98
310_L326_E1.0310.98
10_E213_A1.0300.98
58_T172_H1.0290.98
283_V317_A1.0280.98
168_D180_P1.0270.98
317_A320_A1.0200.98
47_V92_A1.0140.98
297_T301_I1.0130.98
78_R114_W1.0050.98
23_E258_A1.0020.98
50_T96_F1.0010.98
219_I264_L0.9890.98
279_V290_L0.9850.98
12_D16_S0.9840.98
158_S190_A0.9830.98
33_V265_P0.9810.97
297_T302_N0.9800.97
118_S121_E0.9780.97
22_V255_R0.9780.97
9_D12_D0.9720.97
295_P298_K0.9710.97
296_V302_N0.9700.97
298_K301_I0.9690.97
272_V275_N0.9680.97
242_R245_G0.9660.97
272_V287_V0.9650.97
38_S325_R0.9650.97
30_P34_A0.9640.97
299_D305_Y0.9620.97
51_T62_Y0.9550.97
55_Y98_D0.9510.97
11_Y213_A0.9510.97
237_V241_A0.9420.97
252_T256_V0.9410.97
49_L77_I0.9380.97
282_L287_V0.9370.97
300_H304_D0.9370.97
227_D264_L0.9370.97
79_E83_V0.9310.97
271_Q274_P0.9300.97
10_E217_L0.9290.96
16_S251_E0.9260.96
240_N244_Q0.9240.96
12_D15_V0.9220.96
78_R115_G0.9190.96
298_K305_Y0.9180.96
254_R281_G0.9170.96
74_P110_Q0.9170.96
214_E217_L0.9160.96
33_V268_V0.9160.96
144_Q158_S0.9160.96
63_Y242_R0.9140.96
43_R326_E0.9140.96
142_G145_T0.9120.96
271_Q276_L0.9060.96
25_A29_R0.9040.96
144_Q193_L0.8960.96
254_R285_C0.8960.96
107_I111_L0.8940.96
297_T303_P0.8880.95
140_N186_T0.8830.95
145_T193_L0.8810.95
296_V303_P0.8740.95
78_R81_C0.8670.95
71_L102_D0.8600.95
180_P218_A0.8600.95
122_Y273_P0.8570.94
191_G197_F0.8540.94
99_Q131_L0.8530.94
45_V89_C0.8520.94
23_E254_R0.8480.94
44_N162_M0.8450.94
47_V81_C0.8440.94
40_T325_R0.8410.94
272_V282_L0.8340.94
92_A119_I0.8330.94
238_R241_A0.8300.94
273_P291_G0.8300.94
31_A322_V0.8280.93
58_T175_P0.8260.93
189_V193_L0.8220.93
279_V292_G0.8210.93
171_A178_K0.8190.93
14_S256_V0.8160.93
49_L96_F0.8140.93
169_V172_H0.8120.93
82_R116_Y0.8120.93
104_Y136_L0.8080.93
49_L110_Q0.8070.93
15_V18_S0.8040.92
113_E118_S0.8040.92
222_L226_H0.8000.92
140_N192_D0.7990.92
172_H206_G0.7970.92
9_D15_V0.7930.92
295_P301_I0.7920.92
139_A147_A0.7910.92
299_D303_P0.7900.92
270_V287_V0.7900.92
90_T329_P0.7890.92
216_L219_I0.7870.92
271_Q291_G0.7860.92
132_E143_D0.7860.92
39_L283_V0.7860.92
184_L188_D0.7800.91
165_T211_D0.7790.91
269_G275_N0.7700.91
93_L273_P0.7700.91
163_L166_T0.7690.91
17_V255_R0.7690.91
273_P276_L0.7640.90
187_I199_T0.7640.90
46_F291_G0.7620.90
169_V205_I0.7610.90
131_L135_L0.7560.90
11_Y210_R0.7540.90
218_A221_A0.7500.90
297_T305_Y0.7460.89
190_A197_F0.7430.89
255_R259_M0.7420.89
93_L291_G0.7350.89
13_V259_M0.7330.88
209_W252_T0.7280.88
75_E79_E0.7270.88
188_D221_A0.7270.88
271_Q275_N0.7260.88
289_D292_G0.7260.88
10_E15_V0.7260.88
251_E255_R0.7240.88
107_I110_Q0.7230.88
311_D314_S0.7220.88
203_V248_P0.7200.88
272_V276_L0.7160.87
157_A329_P0.7160.87
166_T218_A0.7140.87
132_E135_L0.7140.87
16_S22_V0.7090.87
202_L205_I0.7050.86
155_V195_V0.7040.86
221_A225_R0.7030.86
20_A23_E0.7020.86
44_N91_E0.7000.86
120_H157_A0.6960.86
165_T201_I0.6940.86
105_T112_G0.6920.85
114_W119_I0.6920.85
220_R224_E0.6900.85
198_T291_G0.6860.85
65_V68_E0.6840.85
21_A24_R0.6830.85
139_A182_Q0.6830.85
257_V270_V0.6820.85
14_S259_M0.6810.85
43_R310_L0.6780.84
49_L63_Y0.6760.84
257_V287_V0.6720.84
55_Y176_R0.6720.84
43_R324_L0.6710.84
315_A318_D0.6660.83
312_E316_I0.6660.83
280_R319_H0.6650.83
200_G235_Q0.6620.83
48_P95_T0.6600.83
138_H146_R0.6590.83
140_N189_V0.6570.82
279_V291_G0.6570.82
267_E274_P0.6560.82
51_T64_D0.6560.82
296_V304_D0.6520.82
46_F95_T0.6520.82
213_A220_R0.6510.82
282_L285_C0.6500.82
203_V212_R0.6500.82
140_N143_D0.6490.82
100_P103_R0.6480.81
49_L136_L0.6470.81
116_Y119_I0.6450.81
103_R106_A0.6420.81
82_R85_A0.6420.81
120_H156_N0.6420.81
293_V310_L0.6370.80
167_A218_A0.6360.80
294_S304_D0.6330.80
271_Q289_D0.6320.80
191_G228_H0.6320.80
95_T291_G0.6290.80
144_Q186_T0.6270.79
72_L77_I0.6260.79
39_L317_A0.6240.79
313_L316_I0.6240.79
175_P178_K0.6210.79
280_R320_A0.6190.78
141_P193_L0.6180.78
209_W256_V0.6170.78
166_T214_E0.6150.78
102_D106_A0.6130.78
170_Q173_G0.6120.78
223_H264_L0.6120.78
106_A110_Q0.6100.77
143_D146_R0.6090.77
316_I319_H0.6080.77
51_T61_T0.6080.77
132_E136_L0.6070.77
308_P312_E0.6070.77
210_R214_E0.6060.77
269_G272_V0.6050.77
117_D121_E0.6050.77
295_P305_Y0.6050.77
217_L220_R0.6040.77
169_V211_D0.6020.77
66_P69_A0.6020.77
269_G274_P0.5990.76
224_E267_E0.5990.76
85_A90_T0.5950.76
19_E251_E0.5930.75
308_P313_L0.5920.75
134_G137_P0.5870.75
284_D287_V0.5860.75
298_K303_P0.5860.75
250_A281_G0.5860.75
12_D17_V0.5850.74
39_L288_D0.5840.74
159_M162_M0.5820.74
51_T69_A0.5820.74
34_A288_D0.5820.74
198_T329_P0.5810.74
11_Y209_W0.5800.74
140_N145_T0.5780.74
20_A24_R0.5780.74
298_K302_N0.5780.74
75_E78_R0.5780.74
119_I123_L0.5770.73
64_D69_A0.5770.73
192_D225_R0.5740.73
14_S209_W0.5710.73
104_Y107_I0.5700.73
17_V22_V0.5690.72
92_A121_E0.5680.72
95_T235_Q0.5650.72
22_V258_A0.5630.72
298_K304_D0.5620.72
295_P302_N0.5600.71
40_T198_T0.5590.71
314_S324_L0.5590.71
309_A316_I0.5590.71
172_H211_D0.5580.71
15_V209_W0.5550.71
227_D230_Q0.5550.71
107_I136_L0.5540.70
30_P39_L0.5530.70
104_Y138_H0.5530.70
269_G273_P0.5530.70
99_Q103_R0.5520.70
310_L316_I0.5500.70
81_C116_Y0.5480.70
198_T230_Q0.5450.69
111_L132_E0.5440.69
173_G205_I0.5430.69
117_D120_H0.5430.69
46_F202_L0.5430.69
272_V279_V0.5420.69
40_T271_Q0.5410.69
197_F229_V0.5390.68
29_R265_P0.5370.68
313_L317_A0.5350.68
106_A109_E0.5350.68
117_D122_Y0.5350.68
196_P230_Q0.5340.68
166_T180_P0.5340.68
213_A252_T0.5340.68
114_W118_S0.5330.68
220_R264_L0.5330.68
131_L236_P0.5320.67
55_Y178_K0.5320.67
102_D105_T0.5320.67
322_V329_P0.5310.67
135_L138_H0.5310.67
299_D304_D0.5290.67
274_P278_D0.5290.67
17_V21_A0.5290.67
50_T97_G0.5290.67
95_T202_L0.5280.67
104_Y147_A0.5270.67
114_W156_N0.5270.67
59_Y183_R0.5260.67
314_S326_E0.5250.66
290_L317_A0.5230.66
87_A293_V0.5220.66
93_L271_Q0.5210.66
272_V277_T0.5200.66
34_A269_G0.5190.66
129_I158_S0.5180.65
211_D214_E0.5170.65
93_L122_Y0.5160.65
16_S252_T0.5160.65
190_A195_V0.5140.65
171_A175_P0.5140.65
103_R109_E0.5140.65
158_S197_F0.5130.65
46_F93_L0.5120.64
61_T241_A0.5120.64
209_W212_R0.5120.64
190_A193_L0.5110.64
171_A174_G0.5090.64
236_P248_P0.5090.64
144_Q190_A0.5080.64
25_A28_V0.5080.64
257_V286_G0.5060.64
168_D184_L0.5060.64
199_T257_V0.5050.63
285_C291_G0.5040.63
56_T176_R0.5030.63
108_H152_V0.5020.63
75_E315_A0.5020.63
80_Q83_V0.5020.63
213_A256_V0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t7vA 1 0.8474 100 0.526 Contact Map
1r30A 2 0.8147 100 0.542 Contact Map
4r33A 2 0.8474 100 0.547 Contact Map
3iixA 1 0.8529 100 0.553 Contact Map
4wcxA 1 0.9564 100 0.581 Contact Map
4rtbA 2 0.9183 100 0.593 Contact Map
4u0oB 1 0.7003 100 0.722 Contact Map
1oltA 1 0.891 99.7 0.827 Contact Map
2qgqA 1 0.6975 99.7 0.832 Contact Map
4jc0A 1 0.8556 99.7 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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