GREMLIN Database
COFH - FO synthase subunit 2
UniProt: Q9HNU8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 453 (354)
Sequences: 2263 (1217)
Seq/√Len: 64.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_E295_R7.3621.00
345_H367_D5.1841.00
238_E281_H4.6861.00
410_S414_T4.4771.00
213_D262_D3.8121.00
153_H218_T3.6391.00
287_D339_F3.4891.00
32_L338_L3.0541.00
63_D67_A3.0111.00
65_R338_L3.0071.00
187_S225_D2.8901.00
61_A338_L2.8731.00
183_I196_I2.7371.00
278_N281_H2.7191.00
76_F396_A2.6981.00
31_R294_D2.5481.00
37_G339_F2.5171.00
135_S408_E2.5101.00
258_E292_L2.2831.00
198_P257_M2.2161.00
25_N36_D2.1681.00
249_T252_E2.1601.00
41_I335_V2.1401.00
23_L61_A2.1381.00
273_Y329_D2.1321.00
129_A134_V2.1171.00
236_V281_H2.1131.00
20_E57_L2.0981.00
254_V292_L2.0971.00
282_R332_M2.0271.00
254_V288_V2.0191.00
333_I361_L1.9771.00
31_R341_D1.9761.00
99_D113_G1.9671.00
34_V284_H1.9121.00
269_A289_I1.9071.00
118_T121_E1.9021.00
42_T280_A1.8451.00
287_D291_A1.8421.00
213_D217_E1.8221.00
213_D259_A1.8181.00
121_E124_A1.8041.00
34_V287_D1.7931.00
124_A127_A1.7891.00
202_H252_E1.7881.00
251_D255_A1.7821.00
369_F395_Y1.7521.00
91_G100_T1.7501.00
328_E332_M1.7421.00
59_L364_C1.7361.00
37_G287_D1.7300.99
255_A259_A1.7190.99
345_H366_A1.7080.99
399_I406_P1.7060.99
330_E361_L1.6980.99
294_D341_D1.6980.99
69_V344_D1.6920.99
251_D288_V1.6710.99
67_A72_D1.6610.99
27_R64_R1.6510.99
117_K125_T1.6440.99
101_A146_A1.6430.99
64_R68_D1.6280.99
123_K185_A1.6210.99
150_N154_R1.5990.99
75_T407_V1.5920.99
220_A265_L1.5800.99
237_D251_D1.5470.99
37_G283_I1.5450.99
23_L26_A1.5330.99
34_V38_I1.5320.99
38_I283_I1.5310.99
396_A400_S1.5300.99
212_Y256_A1.5180.99
218_T221_D1.5030.99
400_S406_P1.5010.99
407_V415_T1.4860.98
150_N153_H1.4810.98
34_V283_I1.4810.98
24_A28_D1.4760.98
19_F39_E1.4750.98
194_H349_S1.4680.98
127_A131_Q1.4610.98
41_I332_M1.4450.98
116_T147_F1.4410.98
210_W218_T1.4080.98
87_A116_T1.4000.98
122_S182_Q1.3980.98
289_I343_I1.3970.98
123_K127_A1.3850.98
252_E255_A1.3760.97
226_T266_G1.3740.97
236_V284_H1.3720.97
25_N30_R1.3690.97
33_T36_D1.3660.97
238_E278_N1.3600.97
325_S328_E1.3420.97
144_H203_H1.3420.97
43_T58_V1.3370.97
69_V341_D1.3340.97
312_T315_Y1.3330.97
212_Y259_A1.3260.97
66_R404_R1.3250.97
397_E401_A1.3150.97
211_G214_E1.3040.96
330_E360_A1.2930.96
137_V186_M1.2900.96
84_V141_S1.2850.96
148_G151_E1.2840.96
73_D407_V1.2810.96
282_R328_E1.2790.96
361_L366_A1.2690.96
356_A359_L1.2540.95
65_R68_D1.2530.95
149_L153_H1.2460.95
63_D404_R1.2450.95
202_H206_R1.2410.95
261_A298_N1.2320.95
34_V339_F1.2200.95
196_I204_A1.2160.95
90_T143_L1.2140.95
375_S378_I1.2040.94
394_D397_E1.2020.94
236_V239_V1.1990.94
217_E220_A1.1960.94
38_I280_A1.1940.94
135_S411_T1.1910.94
73_D415_T1.1810.94
234_I271_I1.1740.94
258_E262_D1.1710.94
126_V186_M1.1580.93
21_N39_E1.1500.93
74_V362_L1.1480.93
363_N402_I1.1420.93
312_T316_E1.1410.93
254_V258_E1.1360.92
187_S193_V1.1230.92
204_A215_V1.1110.92
151_E154_R1.1060.91
124_A128_D1.1020.91
201_A224_L1.1010.91
63_D66_R1.1010.91
392_V396_A1.0950.91
348_S358_G1.0910.91
64_R67_A1.0890.91
44_G331_L1.0860.91
128_D131_Q1.0800.90
347_Q370_M1.0790.90
373_I378_I1.0790.90
373_I377_E1.0720.90
237_D250_T1.0680.90
185_A188_E1.0650.90
374_L378_I1.0650.90
212_Y255_A1.0640.90
81_N370_M1.0580.89
216_Y227_V1.0540.89
140_V197_T1.0490.89
217_E263_A1.0460.89
292_L296_T1.0390.89
35_A280_A1.0390.89
86_T99_D1.0380.89
227_V267_T1.0360.88
149_L208_V1.0210.88
392_V408_E1.0160.87
214_E217_E1.0130.87
76_F416_R1.0100.87
216_Y263_A1.0040.87
82_N137_V0.9950.86
125_T375_S0.9920.86
311_Q314_L0.9910.86
83_N376_E0.9890.86
283_I339_F0.9880.86
79_N136_E0.9850.86
326_D356_A0.9800.86
291_A295_R0.9720.85
242_V276_V0.9640.85
60_E64_R0.9630.85
138_T370_M0.9620.84
72_D404_R0.9590.84
63_D363_N0.9570.84
149_L218_T0.9550.84
238_E242_V0.9480.84
139_S182_Q0.9420.83
26_A61_A0.9420.83
43_T331_L0.9340.83
96_N312_T0.9310.82
235_L284_H0.9300.82
24_A27_R0.9220.82
119_P123_K0.9190.82
80_L134_V0.9180.82
93_L242_V0.9170.81
271_I332_M0.9170.81
116_T144_H0.9160.81
149_L152_A0.9140.81
66_R70_V0.9100.81
268_T370_M0.9050.81
126_V134_V0.9040.81
77_V135_S0.9040.81
239_V276_V0.9030.80
127_A130_I0.8990.80
37_G335_V0.8970.80
77_V300_T0.8960.80
260_A267_T0.8930.80
41_I279_A0.8910.80
76_F407_V0.8900.80
130_I191_A0.8850.79
203_H207_G0.8840.79
186_M193_V0.8830.79
236_V276_V0.8820.79
270_T305_L0.8790.79
137_V193_V0.8780.79
258_E296_T0.8770.79
84_V196_I0.8760.78
78_A408_E0.8760.78
82_N126_V0.8740.78
273_Y282_R0.8680.78
359_L398_M0.8680.78
279_A332_M0.8680.78
150_N218_T0.8670.78
260_A263_A0.8620.77
119_P185_A0.8610.77
194_H347_Q0.8600.77
149_L204_A0.8600.77
80_L375_S0.8590.77
391_S394_D0.8590.77
76_F415_T0.8570.77
250_T288_V0.8560.77
271_I285_H0.8510.76
257_M269_A0.8480.76
72_D405_T0.8480.76
235_L288_V0.8450.76
100_T111_A0.8450.76
269_A343_I0.8440.76
70_V367_D0.8440.76
286_L336_S0.8440.76
283_I287_D0.8430.76
147_F151_E0.8390.75
305_L378_I0.8360.75
83_N140_V0.8360.75
259_A262_D0.8330.75
184_A221_D0.8320.75
326_D357_K0.8300.75
75_T347_Q0.8280.74
74_V399_I0.8280.74
149_L215_V0.8260.74
82_N122_S0.8250.74
217_E221_D0.8230.74
119_P154_R0.8190.74
42_T279_A0.8180.74
90_T199_E0.8180.74
58_V331_L0.8180.74
32_L37_G0.8140.73
310_E385_Q0.8130.73
238_E280_A0.8090.73
213_D263_A0.8050.72
97_F115_F0.8040.72
140_V305_L0.8020.72
262_D295_R0.8000.72
140_V370_M0.8000.72
266_G344_D0.8000.72
69_V343_I0.7960.71
269_A299_I0.7950.71
400_S405_T0.7870.71
280_A284_H0.7870.71
90_T246_G0.7870.71
80_L129_A0.7840.70
85_T234_I0.7820.70
91_G98_K0.7810.70
308_I379_T0.7790.70
192_H226_T0.7760.70
45_T57_L0.7760.70
149_L210_W0.7760.70
349_S370_M0.7760.70
348_S366_A0.7730.69
372_T399_I0.7720.69
184_A188_E0.7710.69
261_A296_T0.7680.69
18_S21_N0.7670.69
192_H228_P0.7660.69
258_E291_A0.7640.68
197_T200_E0.7640.68
27_R61_A0.7640.68
324_A329_D0.7630.68
138_T349_S0.7570.68
136_E411_T0.7570.68
309_H314_L0.7570.68
260_A265_L0.7570.68
311_Q316_E0.7570.68
259_A263_A0.7550.67
32_L287_D0.7540.67
148_G152_A0.7530.67
21_N24_A0.7530.67
220_A263_A0.7500.67
308_I323_G0.7460.66
41_I283_I0.7460.66
141_S152_A0.7450.66
206_R252_E0.7420.66
144_H147_F0.7390.66
371_G376_E0.7370.66
303_V340_L0.7370.66
279_A282_R0.7350.65
20_E28_D0.7320.65
309_H323_G0.7320.65
143_L199_E0.7290.65
81_N140_V0.7290.65
140_V194_H0.7290.65
45_T58_V0.7270.64
286_L289_I0.7260.64
17_Q20_E0.7260.64
76_F392_V0.7250.64
38_I42_T0.7220.64
22_A39_E0.7220.64
81_N352_K0.7170.63
286_L340_L0.7160.63
194_H272_M0.7120.63
183_I193_V0.7100.63
268_T347_Q0.7090.63
141_S147_F0.7090.63
327_A364_C0.7080.62
352_K379_T0.7050.62
313_P316_E0.7040.62
257_M289_I0.7010.62
44_G58_V0.7000.62
55_K327_A0.6990.61
59_L330_E0.6990.61
73_D405_T0.6980.61
273_Y324_A0.6960.61
138_T347_Q0.6960.61
30_R36_D0.6950.61
314_L317_R0.6950.61
239_V281_H0.6900.60
84_V122_S0.6900.60
306_S324_A0.6900.60
81_N349_S0.6900.60
184_A187_S0.6860.60
77_V194_H0.6850.60
81_N373_I0.6820.60
272_M275_H0.6810.59
268_T411_T0.6800.59
148_G154_R0.6760.59
310_E315_Y0.6760.59
194_H197_T0.6760.59
226_T411_T0.6750.59
126_V129_A0.6750.59
301_E352_K0.6750.59
34_V37_G0.6720.58
290_R294_D0.6720.58
351_V370_M0.6720.58
138_T194_H0.6700.58
81_N347_Q0.6670.58
126_V191_A0.6670.58
57_L401_A0.6670.58
76_F417_H0.6660.58
253_W269_A0.6660.58
194_H370_M0.6650.58
201_A227_V0.6650.58
201_A205_Q0.6620.57
27_R57_L0.6620.57
187_S190_G0.6610.57
122_S186_M0.6600.57
214_E218_T0.6590.57
81_N268_T0.6580.57
101_A114_G0.6580.57
183_I204_A0.6570.57
98_K114_G0.6570.57
305_L379_T0.6560.57
250_T254_V0.6550.56
22_A26_A0.6540.56
192_H225_D0.6510.56
371_G377_E0.6500.56
399_I405_T0.6480.56
371_G375_S0.6470.56
83_N143_L0.6430.55
34_V290_R0.6420.55
227_V260_A0.6420.55
227_V265_L0.6420.55
100_T110_A0.6410.55
226_T412_D0.6410.55
243_I276_V0.6380.55
268_T349_S0.6380.55
371_G378_I0.6340.54
55_K331_L0.6340.54
84_V152_A0.6330.54
210_W214_E0.6330.54
36_D338_L0.6330.54
294_D342_N0.6330.54
261_A267_T0.6290.53
352_K370_M0.6280.53
26_A65_R0.6260.53
58_V335_V0.6260.53
154_R185_A0.6250.53
140_V228_P0.6220.53
75_T370_M0.6220.53
138_T230_T0.6220.53
126_V182_Q0.6200.52
355_D394_D0.6200.52
277_E282_R0.6200.52
188_E201_A0.6190.52
19_F23_L0.6190.52
239_V242_V0.6160.52
75_T349_S0.6150.52
99_D114_G0.6150.52
330_E364_C0.6150.52
359_L402_I0.6100.51
86_T189_A0.6080.51
302_F340_L0.6080.51
148_G196_I0.6070.51
374_L377_E0.6060.51
81_N194_H0.6060.51
80_L374_L0.6030.50
23_L57_L0.6020.50
74_V367_D0.6000.50
79_N244_C0.5990.50
370_M379_T0.5970.50
136_E305_L0.5970.50
98_K246_G0.5950.50
65_R341_D0.5950.50
75_T81_N0.5930.49
84_V98_K0.5930.49
70_V345_H0.5930.49
110_A114_G0.5920.49
244_C268_T0.5920.49
77_V81_N0.5920.49
357_K360_A0.5910.49
326_D360_A0.5900.49
55_K58_V0.5890.49
272_M349_S0.5880.49
61_A65_R0.5870.49
238_E279_A0.5870.49
194_H226_T0.5870.49
24_A401_A0.5860.48
28_D213_D0.5860.48
289_I340_L0.5860.48
329_D353_F0.5850.48
235_L250_T0.5850.48
354_G362_L0.5800.48
91_G246_G0.5770.47
327_A331_L0.5740.47
341_D344_D0.5730.47
283_I332_M0.5710.47
110_A113_G0.5700.47
28_D154_R0.5690.46
70_V404_R0.5680.46
132_R374_L0.5680.46
39_E43_T0.5670.46
20_E24_A0.5670.46
368_D409_R0.5670.46
237_D241_D0.5660.46
217_E325_S0.5660.46
129_A137_V0.5650.46
398_M401_A0.5650.46
293_Q296_T0.5650.46
44_G335_V0.5650.46
311_Q315_Y0.5650.46
183_I224_L0.5630.46
255_A258_E0.5600.45
33_T287_D0.5600.45
187_S194_H0.5590.45
358_G369_F0.5570.45
331_L335_V0.5570.45
137_V191_A0.5540.45
154_R218_T0.5530.45
268_T300_T0.5520.45
75_T268_T0.5520.45
202_H256_A0.5520.45
27_R68_D0.5520.45
79_N329_D0.5510.44
361_L364_C0.5500.44
138_T197_T0.5490.44
27_R217_E0.5470.44
123_K188_E0.5460.44
56_E364_C0.5450.44
404_R411_T0.5440.44
215_V218_T0.5430.43
32_L36_D0.5430.43
138_T305_L0.5430.43
62_A243_I0.5420.43
306_S353_F0.5390.43
345_H351_V0.5380.43
122_S151_E0.5370.43
188_E216_Y0.5360.43
42_T283_I0.5360.43
21_N36_D0.5350.43
138_T352_K0.5320.42
123_K126_V0.5300.42
301_E347_Q0.5300.42
192_H412_D0.5300.42
184_A262_D0.5300.42
144_H328_E0.5300.42
85_T116_T0.5290.42
323_G326_D0.5280.42
27_R30_R0.5280.42
292_L295_R0.5260.42
140_V272_M0.5260.42
286_L355_D0.5260.42
279_A328_E0.5250.41
70_V74_V0.5240.41
212_Y252_E0.5230.41
355_D398_M0.5230.41
153_H221_D0.5220.41
117_K122_S0.5220.41
114_G307_F0.5220.41
345_H413_Y0.5210.41
98_K313_P0.5200.41
326_D359_L0.5190.41
219_L260_A0.5190.41
206_R209_S0.5180.41
399_I402_I0.5150.40
31_R338_L0.5140.40
86_T114_G0.5140.40
128_D132_R0.5120.40
272_M305_L0.5120.40
140_V253_W0.5120.40
93_L314_L0.5120.40
33_T37_G0.5120.40
28_D221_D0.5120.40
410_S416_R0.5120.40
94_F243_I0.5110.40
83_N388_E0.5110.40
66_R301_E0.5110.40
315_Y322_G0.5100.40
197_T370_M0.5100.40
98_K387_G0.5090.40
359_L401_A0.5080.40
82_N125_T0.5080.40
284_H288_V0.5070.39
348_S402_I0.5060.39
80_L128_D0.5060.39
209_S288_V0.5050.39
283_I289_I0.5040.39
58_V131_Q0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t7vA 1 0.7241 100 0.608 Contact Map
4r33A 2 0.7682 100 0.613 Contact Map
4wcxA 1 0.8742 100 0.636 Contact Map
3iixA 1 0.7417 100 0.638 Contact Map
4rtbA 2 0.83 100 0.653 Contact Map
1r30A 2 0.6755 100 0.658 Contact Map
4u0oB 1 0.5784 100 0.803 Contact Map
2qgqA 1 0.5475 99.6 0.878 Contact Map
4jc0A 1 0.7241 99.6 0.884 Contact Map
1tv8A 2 0.6711 99.5 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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