GREMLIN Database
PUR7 - Putative phosphoribosylaminoimidazole-succinocarboxamide synthase
UniProt: Q9HNU7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (271)
Sequences: 2054 (948)
Seq/√Len: 57.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_F201_A4.1621.00
128_V170_S3.4781.00
191_D195_A3.2791.00
182_R198_D2.9191.00
61_A207_T2.9171.00
122_L236_A2.8711.00
266_S304_I2.8141.00
254_V257_E2.7951.00
123_V233_V2.7811.00
43_G309_A2.7791.00
184_M187_E2.6831.00
32_F272_G2.5741.00
302_P306_Q2.5471.00
161_E213_A2.3761.00
193_D228_Y2.3711.00
157_Q160_V2.3211.00
160_V255_S2.3151.00
317_N323_E2.3011.00
167_V185_A2.2621.00
219_H247_F2.2411.00
65_P232_E2.2361.00
213_A250_D2.1851.00
57_E60_A2.1821.00
52_G56_F2.1671.00
39_D299_P2.1441.00
37_M267_D2.1311.00
252_R260_R2.1161.00
20_R69_Q2.1021.00
125_L185_A2.0731.00
123_V193_D2.0241.00
140_R144_A2.0211.00
200_L233_V1.9901.00
309_A313_A1.9891.00
120_N229_V1.9621.00
196_E232_E1.9531.00
39_D305_L1.9131.00
196_E199_A1.8951.00
170_S179_Y1.8781.00
123_V197_L1.8701.00
29_Y267_D1.8571.00
140_R146_A1.8401.00
217_F247_F1.8340.99
64_V200_L1.8150.99
306_Q310_D1.8010.99
25_F49_C1.7720.99
164_E206_E1.7590.99
43_G46_A1.7540.99
307_A310_D1.7430.99
46_A50_T1.7380.99
58_Q211_C1.7320.99
3_S6_D1.7310.99
182_R194_I1.7210.99
11_S26_S1.7170.99
313_A324_W1.7160.99
129_F202_R1.7010.99
156_P162_L1.6840.99
53_A71_V1.6760.99
54_Y211_C1.6700.99
270_W287_A1.6620.99
125_L180_L1.6430.99
313_A317_N1.5830.98
158_G258_A1.5760.98
235_V239_A1.5750.98
204_V224_L1.5320.98
107_S111_D1.5260.98
38_P299_P1.5010.98
148_V179_Y1.5000.98
136_G179_Y1.4830.98
193_D233_V1.4680.97
58_Q207_T1.4680.97
203_R207_T1.4620.97
186_D191_D1.4490.97
31_V271_V1.4300.97
204_V239_A1.4000.97
180_L184_M1.3860.96
145_P154_E1.3680.96
193_D196_E1.3450.96
184_M188_I1.3410.96
199_A203_R1.3400.96
127_V197_L1.3190.95
133_V147_D1.3120.95
146_A151_D1.3050.95
54_Y58_Q1.2960.95
34_W297_P1.2840.95
139_L272_G1.2800.94
210_D214_D1.2670.94
206_E210_D1.2660.94
229_V232_E1.2590.94
163_P209_T1.2590.94
195_A199_A1.2570.94
292_L295_P1.2430.94
161_E209_T1.2380.93
157_Q255_S1.2310.93
131_N205_N1.2220.93
138_S142_R1.2150.93
211_C214_D1.2150.93
134_P158_G1.2150.93
152_A162_L1.2140.93
120_N236_A1.2130.93
123_V228_Y1.2090.93
249_F260_R1.1970.92
181_S184_M1.1780.92
182_R195_A1.1730.91
205_N209_T1.1660.91
209_T213_A1.1650.91
159_P258_A1.1640.91
314_A318_R1.1530.91
43_G313_A1.1460.90
265_R269_E1.1440.90
124_P174_E1.1360.90
53_A112_R1.1340.90
272_G293_C1.1320.90
182_R186_D1.1310.90
53_A68_Y1.1310.90
270_W300_L1.1240.90
56_F67_H1.1110.89
266_S307_A1.1000.88
59_L63_G1.0880.88
196_E200_L1.0820.88
46_A109_D1.0810.88
249_F252_R1.0810.88
16_T19_G1.0800.88
289_W298_D1.0780.87
70_G75_D1.0700.87
132_A161_E1.0700.87
180_L188_I1.0650.87
15_D119_S1.0590.86
50_T53_A1.0560.86
53_A57_E1.0560.86
59_L204_V1.0430.86
127_V201_A1.0390.85
173_Y178_R1.0380.85
55_T248_R1.0380.85
304_I308_A1.0350.85
17_D20_R1.0280.85
183_S186_D1.0260.85
228_Y233_V1.0190.84
6_D11_S1.0150.84
50_T316_A1.0020.83
196_E233_V0.9990.83
307_A311_L0.9900.83
189_A193_D0.9840.82
159_P259_V0.9830.82
262_F315_G0.9810.82
171_T188_I0.9790.82
297_P300_L0.9610.81
127_V167_V0.9580.80
71_V74_P0.9550.80
186_D195_A0.9500.80
63_G203_R0.9470.80
195_A198_D0.9460.80
317_N324_W0.9420.79
262_F318_R0.9410.79
5_K12_P0.9340.79
121_Y231_G0.9210.78
57_E322_R0.9200.78
178_R184_M0.9100.77
38_P297_P0.9080.77
134_P159_P0.9080.77
74_P108_Y0.9050.76
34_W294_E0.8880.75
22_V107_S0.8840.75
206_E209_T0.8830.75
15_D18_L0.8800.74
72_R75_D0.8750.74
5_K23_F0.8740.74
137_S152_A0.8740.74
316_A320_T0.8710.74
59_L207_T0.8690.74
34_W295_P0.8680.73
229_V234_R0.8670.73
151_D154_E0.8660.73
63_G66_T0.8620.73
70_G113_Y0.8530.72
310_D317_N0.8500.72
47_S309_A0.8370.71
299_P302_P0.8370.71
170_S180_L0.8360.71
138_S157_Q0.8350.70
189_A197_L0.8340.70
134_P258_A0.8340.70
207_T211_C0.8260.70
194_I198_D0.8250.70
142_R157_Q0.8210.69
58_Q61_A0.8180.69
211_C319_Y0.8160.69
115_D234_R0.8110.68
287_A294_E0.8100.68
3_S13_A0.8060.68
16_T20_R0.8060.68
139_L142_R0.8050.68
134_P162_L0.8010.67
59_L66_T0.7970.67
140_R145_P0.7930.67
152_A166_I0.7910.66
47_S242_F0.7890.66
123_V171_T0.7830.66
132_A218_V0.7830.66
150_I166_I0.7820.65
222_G245_N0.7780.65
137_S140_R0.7760.65
258_A269_E0.7750.65
16_T113_Y0.7740.65
63_G200_L0.7740.65
267_D308_A0.7720.64
211_C215_A0.7710.64
165_T206_E0.7640.64
43_G324_W0.7630.64
120_N234_R0.7630.64
210_D213_A0.7600.63
203_R206_E0.7560.63
68_Y113_Y0.7560.63
251_G318_R0.7540.63
46_A108_Y0.7540.63
180_L185_A0.7530.62
70_G74_P0.7530.62
134_P163_P0.7530.62
204_V240_G0.7520.62
286_V303_E0.7510.62
59_L239_A0.7400.61
9_V28_R0.7360.61
185_A188_I0.7340.61
185_A194_I0.7340.61
123_V189_A0.7310.60
17_D119_S0.7280.60
190_G193_D0.7270.60
272_G287_A0.7220.59
38_P298_D0.7210.59
39_D297_P0.7190.59
138_S236_A0.7170.59
224_L239_A0.7160.59
47_S324_W0.7140.58
150_I182_R0.7130.58
133_V138_S0.7090.58
137_S162_L0.7070.58
161_E211_C0.7070.58
138_S160_V0.7040.57
60_A310_D0.7030.57
69_Q72_R0.7020.57
125_L188_I0.7020.57
49_C56_F0.7010.57
29_Y266_S0.7010.57
121_Y230_D0.6960.56
207_T210_D0.6930.56
15_D19_G0.6930.56
249_F262_F0.6910.56
139_L265_R0.6890.56
201_A204_V0.6860.55
137_S148_V0.6850.55
289_W292_L0.6830.55
128_V197_L0.6810.55
34_W296_S0.6800.55
316_A321_A0.6770.54
310_D314_A0.6740.54
271_V300_L0.6680.53
160_V253_E0.6660.53
133_V160_V0.6630.53
222_G244_E0.6620.53
112_R115_D0.6620.53
159_P253_E0.6610.53
208_I219_H0.6600.53
57_E68_Y0.6600.53
132_A205_N0.6580.52
213_A218_V0.6580.52
170_S181_S0.6570.52
260_R269_E0.6560.52
153_D156_P0.6550.52
199_A214_D0.6540.52
301_P304_I0.6520.52
289_W297_P0.6520.52
267_D300_L0.6510.52
133_V156_P0.6490.51
253_E256_K0.6470.51
25_F56_F0.6450.51
21_G114_H0.6420.51
12_P21_G0.6380.50
61_A65_P0.6360.50
140_R143_C0.6320.49
186_D198_D0.6270.49
12_P25_F0.6270.49
26_S184_M0.6260.49
32_F300_L0.6250.49
286_V294_E0.6240.49
23_F236_A0.6230.48
286_V293_C0.6220.48
263_Y267_D0.6220.48
137_S147_D0.6210.48
182_R191_D0.6190.48
124_P188_I0.6180.48
146_A150_I0.6180.48
70_G73_T0.6160.48
192_A196_E0.6130.47
313_A323_E0.6110.47
138_S158_G0.6100.47
5_K112_R0.6070.47
60_A192_A0.6070.47
128_V179_Y0.6060.47
156_P160_V0.6060.47
54_Y214_D0.6030.46
272_G288_D0.6030.46
38_P267_D0.6020.46
255_S259_V0.6010.46
41_V305_L0.6010.46
138_S319_Y0.5990.46
200_L226_C0.5960.45
65_P234_R0.5960.45
34_W300_L0.5920.45
34_W38_P0.5910.45
179_Y224_L0.5870.45
121_Y206_E0.5860.44
293_C297_P0.5860.44
266_S311_L0.5840.44
170_S184_M0.5830.44
168_E245_N0.5820.44
10_E245_N0.5800.44
34_W170_S0.5780.44
171_T259_V0.5770.43
39_D267_D0.5760.43
128_V136_G0.5740.43
137_S150_I0.5730.43
107_S120_N0.5720.43
238_V244_E0.5720.43
61_A66_T0.5700.43
208_I240_G0.5690.43
54_Y253_E0.5680.42
191_D206_E0.5670.42
202_R206_E0.5650.42
139_L292_L0.5630.42
10_E238_V0.5620.42
12_P23_F0.5620.42
10_E141_T0.5610.42
130_R221_D0.5600.42
38_P296_S0.5600.42
148_V152_A0.5590.41
49_C53_A0.5590.41
42_P305_L0.5580.41
304_I315_G0.5540.41
179_Y271_V0.5530.41
138_S258_A0.5520.41
168_E222_G0.5510.41
149_G165_T0.5510.41
161_E255_S0.5500.41
23_F59_L0.5490.40
151_D196_E0.5480.40
11_S28_R0.5470.40
54_Y57_E0.5460.40
192_A231_G0.5460.40
158_G259_V0.5460.40
238_V245_N0.5460.40
56_F234_R0.5440.40
251_G254_V0.5410.40
134_P140_R0.5410.40
257_E302_P0.5400.39
140_R148_V0.5380.39
160_V163_P0.5350.39
168_E238_V0.5350.39
115_D229_V0.5330.39
249_F266_S0.5330.39
231_G234_R0.5320.39
294_E297_P0.5310.39
123_V236_A0.5310.39
27_D40_H0.5310.39
47_S51_M0.5290.38
164_E183_S0.5280.38
23_F63_G0.5270.38
134_P272_G0.5270.38
161_E206_E0.5260.38
287_A295_P0.5250.38
316_A324_W0.5240.38
6_D26_S0.5240.38
238_V241_T0.5240.38
71_V113_Y0.5220.38
248_R263_Y0.5210.37
196_E228_Y0.5190.37
200_L203_R0.5190.37
148_V170_S0.5180.37
153_D163_P0.5180.37
306_Q309_A0.5180.37
152_A201_A0.5170.37
286_V302_P0.5170.37
198_D202_R0.5170.37
293_C296_S0.5160.37
130_R246_R0.5160.37
29_Y242_F0.5140.37
304_I307_A0.5110.36
168_E244_E0.5110.36
260_R319_Y0.5100.36
269_E272_G0.5100.36
182_R199_A0.5090.36
10_E244_E0.5090.36
10_E168_E0.5080.36
170_S178_R0.5070.36
22_V113_Y0.5060.36
52_G239_A0.5060.36
249_F318_R0.5050.36
187_E206_E0.5050.36
289_W300_L0.5050.36
270_W288_D0.5050.36
259_V316_A0.5040.36
301_P308_A0.5040.36
134_P257_E0.5030.36
5_K174_E0.5020.36
106_G109_D0.5020.36
39_D302_P0.5010.35
18_L119_S0.5010.35
40_H305_L0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cnqA 1 0.855 100 0.247 Contact Map
3r9rA 1 0.8373 100 0.253 Contact Map
2ywvA 2 0.6775 100 0.414 Contact Map
3nuaA 2 0.6746 100 0.415 Contact Map
4fe2A 2 0.6775 100 0.416 Contact Map
2z02A 2 0.6746 100 0.42 Contact Map
1kutA 2 0.6509 100 0.423 Contact Map
2gqrA 2 0.6834 100 0.426 Contact Map
3kreA 2 0.6805 100 0.429 Contact Map
2h31A 6 0.6538 100 0.432 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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