Q9HNU5 - HALSA - GREMLIN Contacts

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Q9HNU5 - Uncharacterized protein

UniProt:	Q9HNU5	Sequences: MSEPSADVYEQGRGMDAHNKVMRELRDEKGAKDYDPREPTRVWLDEDNTPDGVYNSLTIILNTGGCRWARAGGCTMCGYVAESVEGGSVAHEDLLAQIDECLAHERAEGDEQAGLIKIYTSGSFLDEREVPAETRRAIAETFADRERIVVESLPDFVDREKITDFTTVGLETDVAVGLETATDRVRHDCVNKYFDFEDFEAACAEARAADAGIKAYLLMKPPFLAESEAIADMQSSIRRCAAVDGCHTVSMNPTNVQRYTMVDQLHFRGGYRPPWLWSVAEVLESTADVDAIVVSDPVGHGSDRGAHNCGECDDRVQKAIKDFDLRQDPSVFSEVACECEATHEAVVERETAYNLPLAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	359 (273)
Sequences:	2007 (1422)
Seq/√Len:	86.1

ECOLI - YHCC HEMN
BACSU - HEMZ YTQA YQER
HALSA - Q9HNU5 Q9HPR3
SULSO - Q97ZU7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
163_T	209_A	3.492	1.00
217_L	236_S	3.451	1.00
136_R	167_T	3.261	1.00
159_R	205_E	3.218	1.00
195_D	198_D	3.169	1.00
207_R	247_H	3.046	1.00
197_E	201_A	2.962	1.00
200_E	239_R	2.868	1.00
288_D	329_P	2.862	1.00
323_F	326_R	2.837	1.00
199_F	215_A	2.829	1.00
75_T	265_L	2.762	1.00
183_D	197_E	2.698	1.00
136_R	140_E	2.525	1.00
239_R	242_A	2.489	1.00
323_F	327_Q	2.469	1.00
183_D	188_D	2.409	1.00
182_T	232_D	2.376	1.00
174_V	206_A	2.341	1.00
207_R	245_G	2.256	1.00
162_I	209_A	2.192	1.00
229_A	232_D	2.162	1.00
201_A	205_E	2.094	1.00
159_R	208_A	2.089	1.00
297_P	301_G	2.048	1.00
178_L	199_F	2.043	1.00
176_V	206_A	2.030	1.00
230_I	285_S	2.021	1.00
219_M	233_M	2.020	1.00
296_D	299_G	2.000	1.00
330_S	333_S	2.000	1.00
75_T	262_V	1.991	1.00
297_P	300_H	1.989	1.00
275_W	278_S	1.981	1.00
235_S	239_R	1.957	1.00
95_L	141_T	1.935	1.00
235_S	238_R	1.925	1.00
158_D	161_K	1.896	1.00
274_P	282_V	1.872	1.00
183_D	196_F	1.867	1.00
184_R	232_D	1.855	1.00
132_A	164_D	1.831	1.00
215_A	246_C	1.785	1.00
184_R	188_D	1.785	1.00
264_Q	268_R	1.734	1.00
292_I	295_S	1.726	1.00
182_T	235_S	1.694	1.00
296_D	301_G	1.685	1.00
93_D	96_A	1.664	1.00
219_M	286_T	1.625	1.00
312_C	315_R	1.613	1.00
191_N	261_M	1.605	1.00
296_D	300_H	1.578	1.00
292_I	297_P	1.577	1.00
198_D	201_A	1.575	1.00
285_S	288_D	1.550	1.00
295_S	301_G	1.528	1.00
230_I	281_E	1.491	0.99
234_Q	238_R	1.485	0.99
329_P	333_S	1.484	0.99
290_D	293_V	1.475	0.99
140_E	168_V	1.474	0.99
289_V	297_P	1.466	0.99
295_S	300_H	1.436	0.99
162_I	206_A	1.427	0.99
285_S	327_Q	1.411	0.99
304_R	307_H	1.400	0.99
292_I	300_H	1.391	0.99
159_R	163_T	1.388	0.99
217_L	237_I	1.380	0.99
53_V	56_S	1.380	0.99
200_E	204_A	1.370	0.99
196_F	239_R	1.363	0.99
237_I	286_T	1.357	0.99
166_T	209_A	1.346	0.99
292_I	296_D	1.344	0.99
114_G	146_E	1.340	0.99
134_T	138_I	1.329	0.99
289_V	292_I	1.329	0.99
199_F	246_C	1.329	0.99
180_T	186_R	1.320	0.99
181_A	239_R	1.317	0.99
284_E	323_F	1.312	0.99
217_L	240_C	1.299	0.99
295_S	299_G	1.297	0.99
289_V	295_S	1.295	0.99
204_A	208_A	1.288	0.98
305_G	308_N	1.278	0.98
265_L	270_G	1.252	0.98
57_L	115_L	1.250	0.98
190_V	221_P	1.247	0.98
263_D	305_G	1.205	0.98
289_V	296_D	1.200	0.98
295_S	298_V	1.198	0.98
99_D	103_A	1.193	0.97
322_D	326_R	1.191	0.97
291_A	297_P	1.183	0.97
163_T	167_T	1.171	0.97
205_E	209_A	1.160	0.97
196_F	200_E	1.160	0.97
54_Y	114_G	1.157	0.97
201_A	204_A	1.154	0.97
203_C	213_I	1.135	0.97
289_V	300_H	1.132	0.97
256_V	263_D	1.124	0.96
136_R	168_V	1.122	0.96
284_E	327_Q	1.120	0.96
298_V	301_G	1.118	0.96
205_E	208_A	1.118	0.96
96_A	137_A	1.117	0.96
92_E	134_T	1.111	0.96
128_R	150_V	1.107	0.96
95_L	99_D	1.096	0.96
294_V	297_P	1.094	0.96
54_Y	113_A	1.091	0.96
289_V	299_G	1.090	0.96
292_I	299_G	1.083	0.96
323_F	329_P	1.073	0.95
189_C	223_F	1.071	0.95
212_G	247_H	1.062	0.95
284_E	329_P	1.060	0.95
304_R	308_N	1.054	0.95
164_D	168_V	1.050	0.95
92_E	96_A	1.046	0.95
289_V	301_G	1.044	0.95
162_I	211_A	1.032	0.94
49_T	52_G	1.027	0.94
179_E	192_K	1.024	0.94
212_G	248_T	1.023	0.94
158_D	205_E	1.022	0.94
218_L	254_T	1.021	0.94
203_C	246_C	1.016	0.94
280_A	283_L	1.016	0.94
140_E	144_D	1.011	0.94
230_I	234_Q	1.010	0.93
154_P	194_F	1.006	0.93
291_A	296_D	1.006	0.93
248_T	296_D	1.002	0.93
93_D	141_T	1.002	0.93
185_V	228_E	0.990	0.93
157_V	176_V	0.982	0.93
292_I	301_G	0.980	0.92
293_V	299_G	0.975	0.92
236_S	240_C	0.972	0.92
117_K	142_F	0.972	0.92
189_C	265_L	0.971	0.92
173_D	214_K	0.968	0.92
56_S	114_G	0.967	0.92
319_A	322_D	0.962	0.92
232_D	235_S	0.961	0.92
306_A	309_C	0.955	0.91
289_V	298_V	0.953	0.91
154_P	192_K	0.952	0.91
102_L	145_R	0.951	0.91
203_C	243_V	0.943	0.91
178_L	215_A	0.934	0.91
52_G	171_E	0.929	0.90
99_D	145_R	0.927	0.90
96_A	99_D	0.924	0.90
328_D	331_V	0.923	0.90
143_A	168_V	0.919	0.90
123_S	126_D	0.917	0.90
139_A	143_A	0.916	0.90
328_D	333_S	0.916	0.90
149_V	173_D	0.912	0.89
231_A	234_Q	0.911	0.89
237_I	249_V	0.906	0.89
281_E	284_E	0.896	0.89
90_A	93_D	0.891	0.88
280_A	319_A	0.890	0.88
288_D	333_S	0.887	0.88
291_A	298_V	0.884	0.88
135_R	164_D	0.881	0.88
324_D	328_D	0.876	0.87
147_R	171_E	0.872	0.87
130_V	134_T	0.871	0.87
200_E	243_V	0.867	0.87
307_H	310_G	0.866	0.87
70_R	193_Y	0.866	0.87
100_E	104_H	0.864	0.87
132_A	136_R	0.861	0.87
329_P	332_F	0.854	0.86
186_R	194_F	0.852	0.86
98_I	101_C	0.850	0.86
303_D	306_A	0.850	0.86
203_C	215_A	0.839	0.85
100_E	103_A	0.839	0.85
157_V	206_A	0.836	0.85
55_N	58_T	0.833	0.85
62_N	90_A	0.828	0.84
263_D	267_F	0.828	0.84
241_A	289_V	0.827	0.84
213_I	246_C	0.825	0.84
306_A	314_D	0.824	0.84
74_C	77_C	0.821	0.84
136_R	164_D	0.814	0.83
69_A	80_V	0.812	0.83
288_D	327_Q	0.810	0.83
165_F	170_L	0.809	0.83
320_I	323_F	0.809	0.83
199_F	203_C	0.807	0.83
261_M	265_L	0.805	0.83
327_Q	332_F	0.798	0.82
313_D	317_Q	0.797	0.82
103_A	141_T	0.792	0.82
272_R	278_S	0.792	0.82
181_A	236_S	0.792	0.82
303_D	307_H	0.791	0.82
238_R	241_A	0.791	0.82
98_I	145_R	0.790	0.81
261_M	264_Q	0.789	0.81
78_G	257_Q	0.788	0.81
216_Y	250_S	0.785	0.81
53_V	58_T	0.785	0.81
206_A	213_I	0.782	0.81
94_L	142_F	0.781	0.81
317_Q	321_K	0.778	0.80
121_S	124_F	0.777	0.80
307_H	313_D	0.770	0.80
254_T	262_V	0.769	0.80
96_A	100_E	0.769	0.80
311_E	314_D	0.768	0.80
130_V	135_R	0.768	0.80
281_E	285_S	0.767	0.80
50_P	53_V	0.766	0.79
139_A	168_V	0.763	0.79
293_V	297_P	0.762	0.79
206_A	211_A	0.760	0.79
311_E	315_R	0.760	0.79
256_V	271_Y	0.760	0.79
185_V	221_P	0.760	0.79
70_R	191_N	0.759	0.79
185_V	232_D	0.759	0.79
258_R	267_F	0.759	0.79
48_N	51_D	0.756	0.79
139_A	148_I	0.751	0.78
287_A	329_P	0.749	0.78
288_D	323_F	0.746	0.78
304_R	309_C	0.745	0.78
157_V	161_K	0.745	0.78
197_E	200_E	0.742	0.77
132_A	135_R	0.739	0.77
137_A	141_T	0.736	0.77
61_L	142_F	0.730	0.76
59_I	101_C	0.725	0.76
202_A	205_E	0.720	0.75
132_A	160_E	0.713	0.74
134_T	137_A	0.707	0.74
293_V	300_H	0.706	0.74
75_T	190_V	0.703	0.73
141_T	144_D	0.702	0.73
173_D	212_G	0.701	0.73
66_C	74_C	0.698	0.73
51_D	56_S	0.698	0.73
282_V	286_T	0.697	0.73
274_P	279_V	0.695	0.72
94_L	99_D	0.693	0.72
61_L	117_K	0.693	0.72
310_G	317_Q	0.691	0.72
234_Q	285_S	0.689	0.72
138_I	142_F	0.689	0.72
310_G	313_D	0.684	0.71
178_L	181_A	0.682	0.71
150_V	165_F	0.681	0.71
302_S	305_G	0.680	0.71
285_S	323_F	0.680	0.71
131_P	134_T	0.678	0.71
253_P	310_G	0.674	0.70
266_H	271_Y	0.672	0.70
240_C	246_C	0.670	0.70
50_P	56_S	0.669	0.70
99_D	137_A	0.669	0.70
157_V	202_A	0.667	0.69
105_E	112_Q	0.665	0.69
302_S	306_A	0.663	0.69
291_A	301_G	0.662	0.69
159_R	209_A	0.655	0.68
65_G	129_E	0.653	0.68
290_D	301_G	0.650	0.67
137_A	140_E	0.650	0.67
230_I	282_V	0.649	0.67
240_C	245_G	0.648	0.67
153_L	221_P	0.648	0.67
315_R	319_A	0.646	0.67
203_C	210_D	0.644	0.67
186_R	196_F	0.643	0.67
76_M	296_D	0.642	0.66
192_K	216_Y	0.638	0.66
292_I	298_V	0.637	0.66
243_V	246_C	0.637	0.66
265_L	271_Y	0.637	0.66
184_R	189_C	0.637	0.66
119_Y	142_F	0.634	0.66
204_A	242_A	0.631	0.65
194_F	252_N	0.628	0.65
207_R	246_C	0.628	0.65
305_G	309_C	0.627	0.65
279_V	287_A	0.625	0.64
315_R	322_D	0.625	0.64
110_D	113_A	0.623	0.64
314_D	321_K	0.623	0.64
78_G	82_E	0.621	0.64
87_G	90_A	0.620	0.64
280_A	287_A	0.613	0.63
56_S	116_I	0.612	0.63
143_A	148_I	0.609	0.62
318_K	322_D	0.608	0.62
116_I	146_E	0.607	0.62
140_E	164_D	0.606	0.62
306_A	310_G	0.606	0.62
284_E	324_D	0.603	0.62
293_V	296_D	0.602	0.62
148_I	165_F	0.598	0.61
190_V	262_V	0.598	0.61
84_V	255_N	0.597	0.61
309_C	312_C	0.596	0.61
162_I	174_V	0.595	0.61
214_K	248_T	0.593	0.60
66_C	77_C	0.593	0.60
328_D	332_F	0.593	0.60
326_R	329_P	0.592	0.60
75_T	260_T	0.587	0.60
173_D	248_T	0.585	0.59
269_G	272_R	0.584	0.59
125_L	128_R	0.583	0.59
181_A	199_F	0.580	0.59
178_L	196_F	0.579	0.59
194_F	198_D	0.577	0.58
204_A	272_R	0.576	0.58
80_V	83_S	0.576	0.58
162_I	205_E	0.576	0.58
196_F	240_C	0.575	0.58
154_P	202_A	0.575	0.58
319_A	323_F	0.574	0.58
78_G	301_G	0.573	0.58
257_Q	260_T	0.573	0.58
141_T	145_R	0.570	0.57
318_K	321_K	0.570	0.57
291_A	294_V	0.570	0.57
69_A	156_F	0.569	0.57
103_A	107_A	0.569	0.57
200_E	203_C	0.567	0.57
283_L	287_A	0.566	0.57
273_P	306_A	0.565	0.57
307_H	317_Q	0.565	0.57
177_G	250_S	0.563	0.56
125_L	255_N	0.563	0.56
105_E	110_D	0.561	0.56
302_S	307_H	0.561	0.56
171_E	212_G	0.560	0.56
306_A	316_V	0.559	0.56
76_M	190_V	0.559	0.56
70_R	261_M	0.559	0.56
75_T	189_C	0.553	0.55
261_M	270_G	0.553	0.55
214_K	296_D	0.553	0.55
175_A	216_Y	0.547	0.54
265_L	268_R	0.547	0.54
56_S	146_E	0.546	0.54
88_S	180_T	0.544	0.54
78_G	151_E	0.542	0.54
54_Y	57_L	0.539	0.53
54_Y	58_T	0.538	0.53
64_G	130_V	0.536	0.53
94_L	101_C	0.535	0.53
310_G	314_D	0.534	0.53
192_K	252_N	0.531	0.52
63_T	130_V	0.531	0.52
207_R	210_D	0.531	0.52
253_P	260_T	0.529	0.52
57_L	113_A	0.529	0.52
291_A	295_S	0.528	0.52
246_C	292_I	0.527	0.52
99_D	141_T	0.527	0.52
264_Q	272_R	0.525	0.51
255_N	299_G	0.525	0.51
217_L	249_V	0.524	0.51
308_N	312_C	0.523	0.51
201_A	267_F	0.523	0.51
181_A	235_S	0.522	0.51
238_R	242_A	0.522	0.51
122_G	151_E	0.521	0.51
240_C	289_V	0.520	0.51
67_R	155_D	0.520	0.51
198_D	202_A	0.520	0.51
220_K	228_E	0.519	0.51
314_D	318_K	0.519	0.51
80_V	84_V	0.518	0.50
269_G	273_P	0.518	0.50
48_N	52_G	0.517	0.50
251_M	286_T	0.517	0.50
112_Q	115_L	0.515	0.50
210_D	247_H	0.514	0.50
199_F	240_C	0.514	0.50
79_Y	84_V	0.513	0.50
175_A	250_S	0.511	0.49
182_T	185_V	0.511	0.49
314_D	317_Q	0.510	0.49
305_G	316_V	0.510	0.49
57_L	105_E	0.508	0.49
279_V	283_L	0.508	0.49
230_I	278_S	0.507	0.49
153_L	252_N	0.505	0.49
67_R	297_P	0.505	0.49
76_M	173_D	0.504	0.49
57_L	110_D	0.504	0.49
128_R	142_F	0.503	0.48
190_V	222_P	0.503	0.48
266_H	305_G	0.501	0.48
109_G	112_Q	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1oltA	1	0.8886	100	0.581	Contact Map
2qgqA	1	0.6797	99.9	0.699	Contact Map
4jc0A	1	0.8552	99.9	0.7	Contact Map
1r30A	2	0.8189	99.9	0.717	Contact Map
3iixA	1	0.8942	99.9	0.723	Contact Map
4u0oB	1	0.7131	99.9	0.734	Contact Map
4r33A	2	0.9025	99.9	0.736	Contact Map
3t7vA	1	0.8858	99.9	0.738	Contact Map
4wcxA	1	0.9136	99.9	0.744	Contact Map
4rtbA	2	0.8914	99.8	0.758	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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