GREMLIN Database
Q9HNU5 - Uncharacterized protein
UniProt: Q9HNU5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 359 (273)
Sequences: 2007 (1422)
Seq/√Len: 86.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_T209_A3.4921.00
217_L236_S3.4511.00
136_R167_T3.2611.00
159_R205_E3.2181.00
195_D198_D3.1691.00
207_R247_H3.0461.00
197_E201_A2.9621.00
200_E239_R2.8681.00
288_D329_P2.8621.00
323_F326_R2.8371.00
199_F215_A2.8291.00
75_T265_L2.7621.00
183_D197_E2.6981.00
136_R140_E2.5251.00
239_R242_A2.4891.00
323_F327_Q2.4691.00
183_D188_D2.4091.00
182_T232_D2.3761.00
174_V206_A2.3411.00
207_R245_G2.2561.00
162_I209_A2.1921.00
229_A232_D2.1621.00
201_A205_E2.0941.00
159_R208_A2.0891.00
297_P301_G2.0481.00
178_L199_F2.0431.00
176_V206_A2.0301.00
230_I285_S2.0211.00
219_M233_M2.0201.00
296_D299_G2.0001.00
330_S333_S2.0001.00
75_T262_V1.9911.00
297_P300_H1.9891.00
275_W278_S1.9811.00
235_S239_R1.9571.00
95_L141_T1.9351.00
235_S238_R1.9251.00
158_D161_K1.8961.00
274_P282_V1.8721.00
183_D196_F1.8671.00
184_R232_D1.8551.00
132_A164_D1.8311.00
215_A246_C1.7851.00
184_R188_D1.7851.00
264_Q268_R1.7341.00
292_I295_S1.7261.00
182_T235_S1.6941.00
296_D301_G1.6851.00
93_D96_A1.6641.00
219_M286_T1.6251.00
312_C315_R1.6131.00
191_N261_M1.6051.00
296_D300_H1.5781.00
292_I297_P1.5771.00
198_D201_A1.5751.00
285_S288_D1.5501.00
295_S301_G1.5281.00
230_I281_E1.4910.99
234_Q238_R1.4850.99
329_P333_S1.4840.99
290_D293_V1.4750.99
140_E168_V1.4740.99
289_V297_P1.4660.99
295_S300_H1.4360.99
162_I206_A1.4270.99
285_S327_Q1.4110.99
304_R307_H1.4000.99
292_I300_H1.3910.99
159_R163_T1.3880.99
217_L237_I1.3800.99
53_V56_S1.3800.99
200_E204_A1.3700.99
196_F239_R1.3630.99
237_I286_T1.3570.99
166_T209_A1.3460.99
292_I296_D1.3440.99
114_G146_E1.3400.99
134_T138_I1.3290.99
289_V292_I1.3290.99
199_F246_C1.3290.99
180_T186_R1.3200.99
181_A239_R1.3170.99
284_E323_F1.3120.99
217_L240_C1.2990.99
295_S299_G1.2970.99
289_V295_S1.2950.99
204_A208_A1.2880.98
305_G308_N1.2780.98
265_L270_G1.2520.98
57_L115_L1.2500.98
190_V221_P1.2470.98
263_D305_G1.2050.98
289_V296_D1.2000.98
295_S298_V1.1980.98
99_D103_A1.1930.97
322_D326_R1.1910.97
291_A297_P1.1830.97
163_T167_T1.1710.97
205_E209_A1.1600.97
196_F200_E1.1600.97
54_Y114_G1.1570.97
201_A204_A1.1540.97
203_C213_I1.1350.97
289_V300_H1.1320.97
256_V263_D1.1240.96
136_R168_V1.1220.96
284_E327_Q1.1200.96
298_V301_G1.1180.96
205_E208_A1.1180.96
96_A137_A1.1170.96
92_E134_T1.1110.96
128_R150_V1.1070.96
95_L99_D1.0960.96
294_V297_P1.0940.96
54_Y113_A1.0910.96
289_V299_G1.0900.96
292_I299_G1.0830.96
323_F329_P1.0730.95
189_C223_F1.0710.95
212_G247_H1.0620.95
284_E329_P1.0600.95
304_R308_N1.0540.95
164_D168_V1.0500.95
92_E96_A1.0460.95
289_V301_G1.0440.95
162_I211_A1.0320.94
49_T52_G1.0270.94
179_E192_K1.0240.94
212_G248_T1.0230.94
158_D205_E1.0220.94
218_L254_T1.0210.94
203_C246_C1.0160.94
280_A283_L1.0160.94
140_E144_D1.0110.94
230_I234_Q1.0100.93
154_P194_F1.0060.93
291_A296_D1.0060.93
248_T296_D1.0020.93
93_D141_T1.0020.93
185_V228_E0.9900.93
157_V176_V0.9820.93
292_I301_G0.9800.92
293_V299_G0.9750.92
236_S240_C0.9720.92
117_K142_F0.9720.92
189_C265_L0.9710.92
173_D214_K0.9680.92
56_S114_G0.9670.92
319_A322_D0.9620.92
232_D235_S0.9610.92
306_A309_C0.9550.91
289_V298_V0.9530.91
154_P192_K0.9520.91
102_L145_R0.9510.91
203_C243_V0.9430.91
178_L215_A0.9340.91
52_G171_E0.9290.90
99_D145_R0.9270.90
96_A99_D0.9240.90
328_D331_V0.9230.90
143_A168_V0.9190.90
123_S126_D0.9170.90
139_A143_A0.9160.90
328_D333_S0.9160.90
149_V173_D0.9120.89
231_A234_Q0.9110.89
237_I249_V0.9060.89
281_E284_E0.8960.89
90_A93_D0.8910.88
280_A319_A0.8900.88
288_D333_S0.8870.88
291_A298_V0.8840.88
135_R164_D0.8810.88
324_D328_D0.8760.87
147_R171_E0.8720.87
130_V134_T0.8710.87
200_E243_V0.8670.87
307_H310_G0.8660.87
70_R193_Y0.8660.87
100_E104_H0.8640.87
132_A136_R0.8610.87
329_P332_F0.8540.86
186_R194_F0.8520.86
98_I101_C0.8500.86
303_D306_A0.8500.86
203_C215_A0.8390.85
100_E103_A0.8390.85
157_V206_A0.8360.85
55_N58_T0.8330.85
62_N90_A0.8280.84
263_D267_F0.8280.84
241_A289_V0.8270.84
213_I246_C0.8250.84
306_A314_D0.8240.84
74_C77_C0.8210.84
136_R164_D0.8140.83
69_A80_V0.8120.83
288_D327_Q0.8100.83
165_F170_L0.8090.83
320_I323_F0.8090.83
199_F203_C0.8070.83
261_M265_L0.8050.83
327_Q332_F0.7980.82
313_D317_Q0.7970.82
103_A141_T0.7920.82
272_R278_S0.7920.82
181_A236_S0.7920.82
303_D307_H0.7910.82
238_R241_A0.7910.82
98_I145_R0.7900.81
261_M264_Q0.7890.81
78_G257_Q0.7880.81
216_Y250_S0.7850.81
53_V58_T0.7850.81
206_A213_I0.7820.81
94_L142_F0.7810.81
317_Q321_K0.7780.80
121_S124_F0.7770.80
307_H313_D0.7700.80
254_T262_V0.7690.80
96_A100_E0.7690.80
311_E314_D0.7680.80
130_V135_R0.7680.80
281_E285_S0.7670.80
50_P53_V0.7660.79
139_A168_V0.7630.79
293_V297_P0.7620.79
206_A211_A0.7600.79
311_E315_R0.7600.79
256_V271_Y0.7600.79
185_V221_P0.7600.79
70_R191_N0.7590.79
185_V232_D0.7590.79
258_R267_F0.7590.79
48_N51_D0.7560.79
139_A148_I0.7510.78
287_A329_P0.7490.78
288_D323_F0.7460.78
304_R309_C0.7450.78
157_V161_K0.7450.78
197_E200_E0.7420.77
132_A135_R0.7390.77
137_A141_T0.7360.77
61_L142_F0.7300.76
59_I101_C0.7250.76
202_A205_E0.7200.75
132_A160_E0.7130.74
134_T137_A0.7070.74
293_V300_H0.7060.74
75_T190_V0.7030.73
141_T144_D0.7020.73
173_D212_G0.7010.73
66_C74_C0.6980.73
51_D56_S0.6980.73
282_V286_T0.6970.73
274_P279_V0.6950.72
94_L99_D0.6930.72
61_L117_K0.6930.72
310_G317_Q0.6910.72
234_Q285_S0.6890.72
138_I142_F0.6890.72
310_G313_D0.6840.71
178_L181_A0.6820.71
150_V165_F0.6810.71
302_S305_G0.6800.71
285_S323_F0.6800.71
131_P134_T0.6780.71
253_P310_G0.6740.70
266_H271_Y0.6720.70
240_C246_C0.6700.70
50_P56_S0.6690.70
99_D137_A0.6690.70
157_V202_A0.6670.69
105_E112_Q0.6650.69
302_S306_A0.6630.69
291_A301_G0.6620.69
159_R209_A0.6550.68
65_G129_E0.6530.68
290_D301_G0.6500.67
137_A140_E0.6500.67
230_I282_V0.6490.67
240_C245_G0.6480.67
153_L221_P0.6480.67
315_R319_A0.6460.67
203_C210_D0.6440.67
186_R196_F0.6430.67
76_M296_D0.6420.66
192_K216_Y0.6380.66
292_I298_V0.6370.66
243_V246_C0.6370.66
265_L271_Y0.6370.66
184_R189_C0.6370.66
119_Y142_F0.6340.66
204_A242_A0.6310.65
194_F252_N0.6280.65
207_R246_C0.6280.65
305_G309_C0.6270.65
279_V287_A0.6250.64
315_R322_D0.6250.64
110_D113_A0.6230.64
314_D321_K0.6230.64
78_G82_E0.6210.64
87_G90_A0.6200.64
280_A287_A0.6130.63
56_S116_I0.6120.63
143_A148_I0.6090.62
318_K322_D0.6080.62
116_I146_E0.6070.62
140_E164_D0.6060.62
306_A310_G0.6060.62
284_E324_D0.6030.62
293_V296_D0.6020.62
148_I165_F0.5980.61
190_V262_V0.5980.61
84_V255_N0.5970.61
309_C312_C0.5960.61
162_I174_V0.5950.61
214_K248_T0.5930.60
66_C77_C0.5930.60
328_D332_F0.5930.60
326_R329_P0.5920.60
75_T260_T0.5870.60
173_D248_T0.5850.59
269_G272_R0.5840.59
125_L128_R0.5830.59
181_A199_F0.5800.59
178_L196_F0.5790.59
194_F198_D0.5770.58
204_A272_R0.5760.58
80_V83_S0.5760.58
162_I205_E0.5760.58
196_F240_C0.5750.58
154_P202_A0.5750.58
319_A323_F0.5740.58
78_G301_G0.5730.58
257_Q260_T0.5730.58
141_T145_R0.5700.57
318_K321_K0.5700.57
291_A294_V0.5700.57
69_A156_F0.5690.57
103_A107_A0.5690.57
200_E203_C0.5670.57
283_L287_A0.5660.57
273_P306_A0.5650.57
307_H317_Q0.5650.57
177_G250_S0.5630.56
125_L255_N0.5630.56
105_E110_D0.5610.56
302_S307_H0.5610.56
171_E212_G0.5600.56
306_A316_V0.5590.56
76_M190_V0.5590.56
70_R261_M0.5590.56
75_T189_C0.5530.55
261_M270_G0.5530.55
214_K296_D0.5530.55
175_A216_Y0.5470.54
265_L268_R0.5470.54
56_S146_E0.5460.54
88_S180_T0.5440.54
78_G151_E0.5420.54
54_Y57_L0.5390.53
54_Y58_T0.5380.53
64_G130_V0.5360.53
94_L101_C0.5350.53
310_G314_D0.5340.53
192_K252_N0.5310.52
63_T130_V0.5310.52
207_R210_D0.5310.52
253_P260_T0.5290.52
57_L113_A0.5290.52
291_A295_S0.5280.52
246_C292_I0.5270.52
99_D141_T0.5270.52
264_Q272_R0.5250.51
255_N299_G0.5250.51
217_L249_V0.5240.51
308_N312_C0.5230.51
201_A267_F0.5230.51
181_A235_S0.5220.51
238_R242_A0.5220.51
122_G151_E0.5210.51
240_C289_V0.5200.51
67_R155_D0.5200.51
198_D202_A0.5200.51
220_K228_E0.5190.51
314_D318_K0.5190.51
80_V84_V0.5180.50
269_G273_P0.5180.50
48_N52_G0.5170.50
251_M286_T0.5170.50
112_Q115_L0.5150.50
210_D247_H0.5140.50
199_F240_C0.5140.50
79_Y84_V0.5130.50
175_A250_S0.5110.49
182_T185_V0.5110.49
314_D317_Q0.5100.49
305_G316_V0.5100.49
57_L105_E0.5080.49
279_V283_L0.5080.49
230_I278_S0.5070.49
153_L252_N0.5050.49
67_R297_P0.5050.49
76_M173_D0.5040.49
57_L110_D0.5040.49
128_R142_F0.5030.48
190_V222_P0.5030.48
266_H305_G0.5010.48
109_G112_Q0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oltA 1 0.8886 100 0.581 Contact Map
2qgqA 1 0.6797 99.9 0.699 Contact Map
4jc0A 1 0.8552 99.9 0.7 Contact Map
1r30A 2 0.8189 99.9 0.717 Contact Map
3iixA 1 0.8942 99.9 0.723 Contact Map
4u0oB 1 0.7131 99.9 0.734 Contact Map
4r33A 2 0.9025 99.9 0.736 Contact Map
3t7vA 1 0.8858 99.9 0.738 Contact Map
4wcxA 1 0.9136 99.9 0.744 Contact Map
4rtbA 2 0.8914 99.8 0.758 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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