GREMLIN Database
PURQ - Phosphoribosylformylglycinamidine synthase subunit PurQ
UniProt: Q9HNU2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (208)
Sequences: 3314 (1624)
Seq/√Len: 112.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_V184_G3.8491.00
17_A84_V3.3011.00
105_A145_R2.9771.00
191_G195_H2.7951.00
133_D218_G2.7271.00
149_D152_A2.7141.00
148_I152_A2.6081.00
155_D192_D2.5981.00
43_G80_P2.5761.00
154_A158_A2.4501.00
119_E165_R2.4001.00
17_A45_V2.3871.00
157_V165_R2.3211.00
81_V196_V2.2451.00
92_C101_F2.2391.00
117_R134_V2.1761.00
21_L45_V2.1481.00
154_A184_G1.9861.00
22_A27_D1.9801.00
6_V46_V1.9761.00
4_A31_A1.9631.00
157_V162_V1.9271.00
20_A207_T1.9141.00
163_L190_T1.8881.00
36_G67_V1.8791.00
29_A41_T1.8391.00
13_C205_R1.8241.00
73_A76_A1.8151.00
80_P124_P1.8121.00
74_L79_V1.8001.00
60_A93_E1.7941.00
115_H134_V1.7351.00
116_L135_L1.7321.00
3_V21_L1.7191.00
70_E73_A1.6941.00
146_F189_V1.6511.00
164_F188_G1.6311.00
155_D158_A1.6211.00
113_R136_E1.6081.00
129_Y135_L1.5721.00
3_V43_G1.5651.00
7_R30_V1.5421.00
123_T163_L1.5391.00
18_V30_V1.5361.00
118_V164_F1.5311.00
110_Q139_I1.5141.00
156_L189_V1.4961.00
21_L43_G1.4751.00
11_S47_P1.4371.00
3_V26_V1.4371.00
72_R76_A1.4241.00
134_V167_C1.4151.00
73_A77_D1.4141.00
166_Y187_A1.3961.00
139_I179_P1.3911.00
120_N131_E1.3871.00
156_L162_V1.3541.00
18_V22_A1.3531.00
2_T27_D1.3471.00
162_V186_V1.3431.00
117_R167_C1.3411.00
150_D154_A1.3371.00
13_C140_A1.3091.00
115_H167_C1.2990.99
45_V82_L1.2960.99
102_T147_E1.2920.99
159_D192_D1.2910.99
140_A205_R1.2840.99
39_A73_A1.2790.99
88_A198_V1.2780.99
161_R190_T1.2700.99
117_R165_R1.2520.99
178_N185_A1.2450.99
163_L197_A1.2340.99
2_T40_D1.2290.99
179_P185_A1.2220.99
148_I153_Y1.2130.99
207_T211_L1.2130.99
188_G199_M1.2060.99
191_G196_V1.2010.99
21_L26_V1.2010.99
106_S110_Q1.1990.99
109_F140_A1.1990.99
161_R192_D1.1960.99
190_T194_D1.1820.99
153_Y157_V1.1720.99
115_H136_E1.1640.99
123_T190_T1.1580.99
19_R23_H1.1550.99
138_P206_A1.1500.99
22_A28_A1.1360.99
103_T107_A1.1320.99
151_D154_A1.1230.98
168_N177_A1.1140.98
155_D159_D1.1010.98
156_L161_R1.0990.98
75_A96_L1.0920.98
93_E100_A1.0840.98
151_D155_D1.0810.98
50_F85_C1.0710.98
92_C97_A1.0700.98
120_N160_D1.0700.98
65_S69_A1.0690.98
44_V81_V1.0680.98
39_A70_E1.0650.98
38_P44_V1.0460.98
126_T164_F1.0420.98
114_V139_I1.0410.97
102_T145_R1.0380.97
88_A97_A1.0290.97
23_H207_T1.0180.97
42_D78_G1.0130.97
4_A41_T1.0050.97
58_A143_E0.9980.97
164_F197_A0.9950.97
13_C137_I0.9940.97
33_H65_S0.9860.97
14_D30_V0.9790.96
177_A185_A0.9690.96
6_V71_V0.9570.96
19_R207_T0.9530.96
81_V91_G0.9530.96
153_Y183_T0.9520.96
44_V79_V0.9500.96
150_D183_T0.9480.96
162_V165_R0.9480.96
74_L77_D0.9470.96
120_N123_T0.9460.96
190_T197_A0.9410.95
209_P214_T0.9310.95
120_N194_D0.9270.95
153_Y184_G0.9230.95
5_V21_L0.9130.95
34_D65_S0.9050.94
150_D184_G0.8930.94
59_G63_A0.8870.94
151_D158_A0.8840.94
116_L203_P0.8830.94
58_A101_F0.8710.93
12_N85_C0.8660.93
113_R213_A0.8640.93
114_V179_P0.8590.93
11_S14_D0.8570.93
44_V74_L0.8570.93
97_A198_V0.8480.92
165_R184_G0.8440.92
118_V129_Y0.8420.92
5_V47_P0.8390.92
147_E183_T0.8350.92
113_R212_G0.8330.92
58_A103_T0.8250.91
91_G196_V0.8140.91
97_A196_V0.8140.91
126_T163_L0.8090.90
88_A101_F0.8060.90
112_E139_I0.8060.90
103_T108_R0.8060.90
23_H208_L0.8010.90
7_R18_V0.8000.90
140_A204_E0.7990.90
186_V189_V0.7960.90
129_Y133_D0.7900.89
148_I189_V0.7820.89
18_V28_A0.7770.88
121_A131_E0.7750.88
188_G198_V0.7710.88
156_L160_D0.7700.88
103_T142_G0.7680.88
128_A131_E0.7650.88
152_A155_D0.7580.87
2_T29_A0.7550.87
154_A157_V0.7490.87
74_L80_P0.7460.86
71_V75_A0.7440.86
5_V18_V0.7410.86
189_V198_V0.7410.86
45_V84_V0.7350.86
68_V94_A0.7350.86
122_T160_D0.7330.85
29_A40_D0.7330.85
123_T126_T0.7270.85
13_C211_L0.7260.85
68_V72_R0.7220.84
8_F62_A0.7210.84
85_C180_N0.7210.84
101_F146_F0.7100.83
123_T194_D0.7070.83
167_C185_A0.7070.83
69_A72_R0.7060.83
209_P215_D0.7060.83
47_P111_C0.7050.83
60_A100_A0.7030.83
68_V71_V0.6970.82
85_C89_Q0.6900.82
69_A73_A0.6880.82
24_L217_Q0.6840.81
160_D194_D0.6780.81
162_V184_G0.6780.81
101_F198_V0.6730.80
86_N89_Q0.6710.80
59_G90_I0.6690.80
76_A193_R0.6670.80
141_H180_N0.6630.79
50_F180_N0.6620.79
168_N179_P0.6610.79
163_L194_D0.6610.79
12_N140_A0.6600.79
20_A25_G0.6590.79
75_A81_V0.6550.78
178_N182_S0.6540.78
8_F33_H0.6530.78
67_V70_E0.6520.78
212_G215_D0.6500.78
19_R22_A0.6490.78
37_L67_V0.6450.77
161_R191_G0.6430.77
40_D70_E0.6430.77
21_L28_A0.6420.77
50_F141_H0.6380.76
208_L211_L0.6370.76
154_A183_T0.6340.76
153_Y186_V0.6330.76
85_C143_E0.6330.76
119_E132_G0.6310.76
78_G195_H0.6290.75
15_R30_V0.6240.75
12_N141_H0.6230.75
116_L187_A0.6220.75
157_V160_D0.6200.74
50_F202_H0.6190.74
36_G70_E0.6140.74
43_G125_W0.6120.73
57_R93_E0.6120.73
111_C140_A0.6090.73
153_Y162_V0.6090.73
8_F11_S0.6050.73
63_A72_R0.6020.72
7_R35_D0.5990.72
206_A212_G0.5970.72
33_H52_Y0.5970.72
200_M204_E0.5960.71
3_V45_V0.5950.71
109_F204_E0.5940.71
29_A35_D0.5930.71
213_A216_G0.5880.70
135_L138_P0.5880.70
85_C141_H0.5870.70
91_G198_V0.5850.70
54_D85_C0.5800.69
137_I205_R0.5770.69
5_V28_A0.5740.69
118_V132_G0.5730.69
124_P127_A0.5720.68
43_G82_L0.5700.68
194_D197_A0.5670.68
96_L196_V0.5620.67
59_G196_V0.5610.67
64_Q67_V0.5600.67
12_N50_F0.5600.67
67_V71_V0.5560.66
164_F199_M0.5560.66
148_I184_G0.5560.66
114_V168_N0.5560.66
12_N205_R0.5540.66
146_F183_T0.5540.66
85_C202_H0.5530.66
62_A90_I0.5500.65
118_V135_L0.5500.65
148_I183_T0.5500.65
80_P195_H0.5490.65
115_H177_A0.5480.65
3_V28_A0.5450.65
206_A213_A0.5450.65
48_G89_Q0.5440.65
110_Q179_P0.5440.65
46_V142_G0.5430.64
155_D161_R0.5420.64
3_V80_P0.5420.64
118_V133_D0.5420.64
19_R208_L0.5410.64
51_S180_N0.5400.64
141_H202_H0.5380.64
8_F68_V0.5380.64
14_D111_C0.5360.63
13_C17_A0.5340.63
126_T197_A0.5320.63
113_R137_I0.5310.63
113_R211_L0.5300.63
4_A29_A0.5300.63
4_A30_V0.5290.62
125_W197_A0.5290.62
93_E96_L0.5270.62
26_V80_P0.5260.62
82_L197_A0.5250.62
141_H200_M0.5250.62
55_Y216_G0.5220.61
141_H204_E0.5220.61
25_G28_A0.5170.61
180_N202_H0.5150.60
24_L28_A0.5130.60
121_A132_G0.5130.60
50_F54_D0.5120.60
50_F200_M0.5110.60
46_V71_V0.5080.59
46_V91_G0.5070.59
57_R62_A0.5070.59
86_N200_M0.5060.59
76_A79_V0.5060.59
114_V136_E0.5030.59
180_N200_M0.5030.59
121_A124_P0.5010.58
85_C200_M0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lgyA 1 0.9955 100 0.428 Contact Map
3d54D 1 0.9196 100 0.627 Contact Map
1l9xA 1 0.9196 99.9 0.754 Contact Map
2vxoA 2 0.7812 99.8 0.765 Contact Map
2w7tA 1 0.875 99.8 0.766 Contact Map
2vpiA 1 0.7545 99.8 0.769 Contact Map
1qdlB 2 0.817 99.8 0.773 Contact Map
1wl8A 1 0.7946 99.8 0.773 Contact Map
2ywbA 4 0.7768 99.8 0.774 Contact Map
3fijA 4 0.8304 99.8 0.775 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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