GREMLIN Database
Q9HNU1 - Uncharacterized protein
UniProt: Q9HNU1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 84 (76)
Sequences: 1239 (659)
Seq/√Len: 75.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_D65_H3.6301.00
62_E66_R2.7891.00
53_E57_A2.2981.00
50_A56_A2.2471.00
24_T40_S2.1571.00
33_F63_M2.0071.00
16_V73_I1.9981.00
40_S44_F1.9881.00
6_A80_V1.9021.00
9_T43_R1.8911.00
22_E25_Q1.8461.00
7_T45_E1.8391.00
57_A61_D1.8141.00
36_D49_D1.7531.00
7_T79_A1.7111.00
55_A58_E1.6591.00
64_A76_Y1.6231.00
50_A55_A1.6041.00
25_Q37_A1.5150.99
12_L73_I1.4300.99
11_R77_D1.4280.99
28_L63_M1.4140.99
59_R62_E1.4030.99
5_T47_D1.3820.99
9_T77_D1.3740.98
21_A38_L1.3080.98
41_A74_H1.2300.97
7_T43_R1.2270.97
11_R75_D1.2070.96
5_T45_E1.1850.96
28_L38_L1.1610.96
9_T79_A1.1300.95
12_L72_T1.1280.95
6_A48_L1.1230.95
54_Q57_A1.1020.94
20_E74_H1.0870.94
20_E40_S1.0520.93
10_V44_F1.0500.93
21_A41_A1.0490.92
38_L46_I1.0420.92
15_G40_S1.0150.91
11_R43_R1.0090.91
20_E24_T0.9930.90
55_A59_R0.9790.90
61_D76_Y0.9680.89
48_L56_A0.9570.89
4_Y50_A0.9560.88
8_V46_I0.9460.88
60_A64_A0.9400.88
17_L22_E0.9390.88
21_A42_D0.9260.87
37_A47_D0.9240.87
57_A78_V0.9240.87
51_D55_A0.8950.85
24_T44_F0.8580.82
17_L23_T0.8220.80
60_A78_V0.7970.78
22_E37_A0.7880.77
34_E49_D0.7690.75
64_A78_V0.7670.75
65_H71_P0.7490.73
15_G22_E0.7480.73
20_E41_A0.7450.73
25_Q29_E0.7440.73
51_D56_A0.7400.72
36_D47_D0.7280.71
23_T72_T0.6960.67
21_A39_R0.6910.67
4_Y13_Q0.6850.66
58_E61_D0.6680.64
22_E26_Q0.6660.64
36_D54_Q0.6560.63
63_M67_L0.6480.62
33_F59_R0.6410.61
12_L39_R0.6410.61
42_D74_H0.6370.61
4_Y47_D0.6170.58
59_R63_M0.6150.58
35_L38_L0.6110.57
24_T42_D0.6080.57
6_A56_A0.5950.55
25_Q36_D0.5950.55
53_E80_V0.5890.55
69_A72_T0.5870.54
62_E65_H0.5860.54
61_D78_V0.5830.54
23_T40_S0.5800.54
4_Y17_L0.5760.53
64_A80_V0.5710.52
65_H76_Y0.5620.51
18_D39_R0.5590.51
34_E53_E0.5580.51
22_E30_R0.5540.50
26_Q78_V0.5530.50
13_Q75_D0.5530.50
22_E75_D0.5500.50
54_Q58_E0.5440.49
18_D41_A0.5410.49
44_F72_T0.5400.49
27_A69_A0.5400.49
28_L46_I0.5390.48
14_H37_A0.5270.47
15_G23_T0.5250.47
48_L63_M0.5250.47
22_E63_M0.5160.46
33_F62_E0.5160.46
56_A80_V0.5110.45
14_H80_V0.5110.45
15_G63_M0.5110.45
20_E30_R0.5110.45
50_A53_E0.5040.44
58_E62_E0.5020.44
53_E64_A0.5020.44
12_L15_G0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dgbA 2 0.9762 100 0.194 Contact Map
1vq3A 4 0.9643 100 0.213 Contact Map
2yx5A 4 0.9643 100 0.215 Contact Map
1gtdA 3 0.9762 100 0.217 Contact Map
1t4aA 3 0.9405 100 0.222 Contact Map
2zw2A 2 0.9881 100 0.223 Contact Map
4lgyA 1 0.9405 93 0.839 Contact Map
2pc6A 2 0.8929 57.1 0.89 Contact Map
2f1fA 4 0.881 53.5 0.892 Contact Map
2fgcA 2 0.8929 49.1 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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