GREMLIN Database
Q9HNU0 - Formyltetrahydrofolate deformylase
UniProt: Q9HNU0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (274)
Sequences: 2280 (1214)
Seq/√Len: 73.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_E143_D5.4621.00
231_Y277_H5.4271.00
163_R166_E5.0571.00
136_D139_E4.6991.00
131_V142_A4.2271.00
243_T248_T3.9301.00
152_I160_D3.9061.00
212_Q215_R3.5691.00
36_L41_A3.3791.00
105_I126_A3.3651.00
35_L82_L3.2421.00
103_D280_G2.8901.00
187_P234_T2.7721.00
126_A278_L2.7631.00
106_A130_V2.7431.00
104_G127_P2.5831.00
109_V133_G2.5451.00
75_R79_Q2.5441.00
245_R269_A2.5381.00
165_L192_R2.5121.00
253_A261_R2.3831.00
166_E170_A2.3561.00
169_A192_R2.3181.00
129_N173_T2.2831.00
193_Y197_I2.1341.00
102_D127_P2.1331.00
235_D238_Q2.1021.00
104_G172_D2.0921.00
108_L164_L2.0911.00
24_D42_N2.0881.00
119_L274_V2.0721.00
161_E186_S1.9071.00
96_R280_G1.9071.00
106_A173_T1.8921.00
130_V171_Y1.8711.00
113_D138_L1.8651.00
156_T159_P1.8621.00
39_H81_A1.8351.00
24_D50_V1.8141.00
132_I164_L1.7961.00
229_A273_A1.7741.00
35_L81_A1.7541.00
136_D151_D1.7271.00
194_A197_I1.6981.00
175_L274_V1.6621.00
265_L269_A1.6491.00
168_L176_V1.6260.99
178_L232_V1.6160.99
111_K137_T1.5980.99
105_I175_L1.5520.99
165_L193_Y1.5400.99
45_D62_D1.5180.99
150_H171_Y1.5120.99
157_G186_S1.5100.99
32_V59_L1.5020.99
30_A34_G1.4980.99
83_D87_D1.4910.99
15_Y62_D1.4830.99
31_A88_E1.4820.99
195_G284_V1.4800.99
247_F265_L1.4650.99
285_R290_A1.4630.99
28_I89_L1.4620.99
255_V259_K1.4490.99
188_D191_F1.4370.99
255_V258_V1.4290.99
140_A143_D1.4250.99
250_P253_A1.4160.99
31_A89_L1.4080.99
130_V173_T1.3920.98
86_G93_V1.3880.98
34_G38_E1.3790.98
74_D77_A1.3620.98
17_E280_G1.3550.98
21_V92_D1.3200.98
104_G129_N1.3190.98
106_A168_L1.2990.98
158_T162_E1.2940.97
158_T188_D1.2900.97
118_A264_P1.2800.97
215_R259_K1.2600.97
77_A80_A1.2350.97
75_R97_F1.2280.96
275_R279_A1.2250.96
136_D143_D1.1960.96
187_P191_F1.1890.96
82_L86_G1.1870.96
33_T46_V1.1800.96
162_E166_E1.1730.95
25_R88_E1.1640.95
152_I167_L1.1600.95
209_P238_Q1.1600.95
157_G183_R1.1570.95
30_A37_F1.1550.95
152_I163_R1.1540.95
41_A65_F1.1450.95
102_D125_G1.1450.95
150_H167_L1.1390.95
126_A129_N1.1390.95
118_A271_V1.1380.95
216_Q238_Q1.1370.95
141_V145_H1.1350.95
123_D263_Q1.1310.94
277_H282_T1.1270.94
48_Q61_A1.1060.94
35_L39_H1.0950.93
17_E98_P1.0930.93
106_A132_I1.0900.93
108_L176_V1.0880.93
191_F194_A1.0770.93
32_V91_V1.0730.93
165_L188_D1.0700.93
103_D174_D1.0600.92
82_L95_V1.0570.92
140_A146_D1.0550.92
162_E188_D1.0520.92
159_P163_R1.0510.92
254_S257_A1.0510.92
215_R219_E1.0470.92
113_D117_R1.0420.92
84_D88_E1.0390.92
18_V63_C1.0230.91
133_G181_Y1.0220.91
224_V248_T1.0130.90
198_V242_L1.0080.90
245_R272_A1.0010.90
177_V270_L0.9970.90
16_T63_C0.9950.90
117_R141_V0.9920.90
190_V197_I0.9900.89
80_A83_D0.9780.89
110_T133_G0.9770.89
18_V95_V0.9730.89
28_I48_Q0.9690.88
165_L169_A0.9610.88
243_T272_A0.9520.87
108_L132_I0.9500.87
105_I129_N0.9490.87
25_R90_G0.9470.87
42_N64_G0.9360.87
56_R285_R0.9300.86
125_G278_L0.9280.86
46_V61_A0.9280.86
164_L189_V0.9210.86
176_V193_Y0.9200.86
53_G219_E0.9170.85
42_N48_Q0.9170.85
160_D164_L0.9150.85
19_T94_R0.9140.85
260_D275_R0.9070.85
79_Q93_V0.8980.84
36_L63_C0.8870.83
25_R31_A0.8840.83
29_V33_T0.8830.83
76_A79_Q0.8780.83
103_D278_L0.8760.83
28_I42_N0.8670.82
224_V243_T0.8580.81
131_V143_D0.8570.81
56_R92_D0.8520.81
129_N171_Y0.8520.81
28_I32_V0.8500.81
245_R248_T0.8500.81
105_I278_L0.8470.81
84_D87_D0.8460.80
106_A167_L0.8410.80
257_A260_D0.8390.80
82_L93_V0.8380.80
77_A81_A0.8360.80
117_R267_A0.8330.79
38_E81_A0.8290.79
45_D252_N0.8190.78
26_T37_F0.8180.78
166_E169_A0.8170.78
247_F261_R0.8130.78
264_P268_D0.8100.78
131_V147_V0.8080.77
33_T37_F0.8060.77
24_D46_V0.8040.77
42_N197_I0.8040.77
44_E64_G0.8030.77
20_V32_V0.7930.76
190_V234_T0.7910.76
142_A147_V0.7870.75
107_V128_V0.7840.75
190_V195_G0.7840.75
185_L189_V0.7820.75
218_V288_A0.7820.75
104_G173_T0.7780.75
191_F234_T0.7760.74
26_T42_N0.7760.74
188_D192_R0.7730.74
212_Q259_K0.7720.74
107_V119_L0.7710.74
164_L168_L0.7680.74
21_V56_R0.7650.73
130_V167_L0.7630.73
113_D123_D0.7610.73
85_T89_L0.7610.73
171_Y174_D0.7610.73
209_P235_D0.7610.73
96_R101_R0.7600.73
186_S273_A0.7600.73
105_I174_D0.7590.73
112_E216_Q0.7570.73
190_V196_H0.7560.73
23_A90_G0.7540.72
161_E273_A0.7520.72
154_D183_R0.7460.72
81_A84_D0.7450.71
15_Y44_E0.7430.71
130_V150_H0.7430.71
203_S232_V0.7420.71
24_D28_I0.7390.71
138_L149_F0.7380.71
36_L61_A0.7380.71
22_G91_V0.7370.71
109_V116_L0.7360.71
129_N132_I0.7350.70
184_I284_V0.7340.70
215_R255_V0.7300.70
131_V146_D0.7280.70
112_E259_K0.7240.69
48_Q59_L0.7190.69
161_E165_L0.7190.69
112_E138_L0.7170.69
202_P227_V0.7160.68
138_L141_V0.7150.68
35_L93_V0.7100.68
97_F101_R0.7060.67
15_Y64_G0.7060.67
152_I164_L0.7040.67
18_V93_V0.7020.67
143_D146_D0.7000.67
35_L85_T0.6990.67
75_R95_V0.6870.65
185_L197_I0.6850.65
175_L278_L0.6840.65
53_G218_V0.6820.65
161_E229_A0.6760.64
225_A292_D0.6720.63
214_Y262_G0.6720.63
148_P171_Y0.6670.63
68_G74_D0.6660.63
16_T75_R0.6660.63
202_P213_A0.6600.62
63_C133_G0.6600.62
268_D272_A0.6590.62
82_L85_T0.6560.62
162_E172_D0.6510.61
36_L89_L0.6510.61
225_A233_T0.6510.61
133_G147_V0.6440.60
186_S189_V0.6430.60
163_R170_A0.6390.60
39_H84_D0.6340.59
105_I177_V0.6330.59
187_P249_V0.6330.59
274_V277_H0.6320.59
91_V180_R0.6310.59
132_I167_L0.6300.59
125_G279_A0.6290.58
204_L220_A0.6290.58
31_A37_F0.6280.58
26_T66_A0.6260.58
42_N207_A0.6230.58
110_T180_R0.6220.58
250_P261_R0.6210.57
145_H207_A0.6190.57
51_R54_V0.6190.57
33_T224_V0.6170.57
125_G131_V0.6150.57
26_T40_G0.6140.57
79_Q97_F0.6140.57
169_A172_D0.6140.57
31_A34_G0.6120.56
245_R265_L0.6120.56
216_Q219_E0.6110.56
108_L168_L0.6110.56
256_A263_Q0.6050.55
189_V193_Y0.6050.55
94_R280_G0.6030.55
42_N50_V0.6020.55
108_L197_I0.6020.55
117_R121_E0.6010.55
139_E142_A0.6010.55
213_A227_V0.6000.55
119_L271_V0.5980.55
126_A175_L0.5960.54
177_V274_V0.5930.54
102_D105_I0.5910.54
202_P251_P0.5910.54
117_R250_P0.5910.54
120_L147_V0.5910.54
219_E287_G0.5900.54
131_V144_E0.5890.54
24_D57_M0.5870.53
112_E263_Q0.5860.53
149_F233_T0.5820.53
29_V43_I0.5800.52
248_T276_A0.5800.52
165_L176_V0.5790.52
168_L173_T0.5780.52
21_V46_V0.5770.52
193_Y196_H0.5740.52
50_V207_A0.5720.51
175_L277_H0.5720.51
129_N147_V0.5710.51
98_P249_V0.5710.51
31_A38_E0.5710.51
186_S229_A0.5700.51
26_T258_V0.5690.51
37_F282_T0.5690.51
253_A257_A0.5680.51
62_D98_P0.5680.51
28_I50_V0.5670.51
166_E192_R0.5670.51
16_T68_G0.5630.50
176_V197_I0.5610.50
110_T135_H0.5610.50
249_V253_A0.5610.50
161_E185_L0.5600.50
116_L131_V0.5600.50
23_A86_G0.5580.50
131_V169_A0.5570.50
75_R99_D0.5560.49
36_L78_F0.5560.49
146_D150_H0.5550.49
169_A193_Y0.5540.49
29_V61_A0.5540.49
63_C189_V0.5530.49
167_L170_A0.5520.49
37_F288_A0.5520.49
131_V235_D0.5510.49
194_A284_V0.5510.49
138_L207_A0.5500.49
29_V57_M0.5490.49
233_T248_T0.5490.49
137_T142_A0.5460.48
60_L227_V0.5460.48
44_E52_D0.5460.48
139_E146_D0.5450.48
137_T249_V0.5440.48
185_L190_V0.5440.48
218_V225_A0.5430.48
14_D97_F0.5430.48
75_R101_R0.5430.48
216_Q259_K0.5430.48
88_E101_R0.5420.48
156_T186_S0.5400.47
19_T283_T0.5400.47
160_D247_F0.5400.47
117_R145_H0.5390.47
201_H237_D0.5380.47
19_T207_A0.5360.47
123_D260_D0.5360.47
159_P162_E0.5360.47
104_G170_A0.5360.47
129_N177_V0.5350.47
150_H170_A0.5330.47
79_Q83_D0.5330.47
19_T45_D0.5320.46
288_A292_D0.5320.46
167_L171_Y0.5310.46
133_G151_D0.5310.46
245_R268_D0.5290.46
197_I207_A0.5270.46
22_G82_L0.5270.46
223_R251_P0.5270.46
204_L246_A0.5260.46
132_I168_L0.5250.46
42_N161_E0.5240.45
224_V269_A0.5240.45
137_T149_F0.5240.45
105_I274_V0.5230.45
60_L251_P0.5230.45
131_V139_E0.5220.45
37_F207_A0.5220.45
123_D267_A0.5190.45
247_F268_D0.5180.45
21_V285_R0.5170.45
184_I234_T0.5170.45
113_D141_V0.5170.45
224_V288_A0.5160.44
86_G91_V0.5160.44
108_L160_D0.5150.44
118_A211_A0.5140.44
51_R290_A0.5140.44
52_D101_R0.5130.44
135_H154_D0.5130.44
257_A269_A0.5120.44
32_V82_L0.5100.44
90_G196_H0.5100.44
229_A288_A0.5100.44
283_T292_D0.5090.44
112_E184_I0.5090.44
234_T249_V0.5080.44
289_V292_D0.5070.43
20_V39_H0.5060.43
136_D149_F0.5060.43
120_L145_H0.5040.43
107_V126_A0.5040.43
20_V59_L0.5040.43
115_C118_A0.5030.43
46_V50_V0.5020.43
189_V192_R0.5020.43
20_V28_I0.5020.43
202_P223_R0.5010.43
76_A172_D0.5000.43
61_A229_A0.5000.43
142_A146_D0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3louA 3 0.9043 100 0.332 Contact Map
3obiA 4 0.9175 100 0.336 Contact Map
3nrbA 4 0.9142 100 0.338 Contact Map
3o1lA 3 0.9406 100 0.349 Contact Map
3n0vA 4 0.9043 100 0.349 Contact Map
3w7bA 3 0.9142 100 0.354 Contact Map
3tqrA 2 0.6634 100 0.62 Contact Map
3aufA 2 0.67 100 0.62 Contact Map
2ywrA 2 0.6634 100 0.623 Contact Map
1jkxA 2 0.6502 100 0.624 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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