Q9HNU0 - HALSA - GREMLIN Contacts

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Q9HNU0 - Formyltetrahydrofolate deformylase

UniProt:	Q9HNU0	Sequences: MSSEQHSRSVAENDYTEVTVVGADRTGIVAAVTGLLFEHGANIEDVEQTVRDGVFRMTLLADCGFADGADPVTDRAAFQAALDDTGDELGVDVRVRFPDERDDGIAVLVTKEDHCLRALLEADLGAPVNVVIGNHDTLEAVADEHDVPFHDIGDDTGTPDEERLLELLAAYDTDLVVLARYMRILSPDVVFRYAGHIVNVHPSLLPAFPGAQAYRQAVEAGVRVAGVTAHYVTTDLDQGPILTQRAFTVPPNASVAAVKDRGQPLEADALVAAVRAHLAGDTTVRRGAVAVDGPHEYGALADD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	303 (274)
Sequences:	2280 (1214)
Seq/√Len:	73.3

ECOLI - PURU
BACSU - PURU
HALSA - Q9HNU0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
139_E	143_D	5.462	1.00
231_Y	277_H	5.427	1.00
163_R	166_E	5.057	1.00
136_D	139_E	4.699	1.00
131_V	142_A	4.227	1.00
243_T	248_T	3.930	1.00
152_I	160_D	3.906	1.00
212_Q	215_R	3.569	1.00
36_L	41_A	3.379	1.00
105_I	126_A	3.365	1.00
35_L	82_L	3.242	1.00
103_D	280_G	2.890	1.00
187_P	234_T	2.772	1.00
126_A	278_L	2.763	1.00
106_A	130_V	2.743	1.00
104_G	127_P	2.583	1.00
109_V	133_G	2.545	1.00
75_R	79_Q	2.544	1.00
245_R	269_A	2.538	1.00
165_L	192_R	2.512	1.00
253_A	261_R	2.383	1.00
166_E	170_A	2.356	1.00
169_A	192_R	2.318	1.00
129_N	173_T	2.283	1.00
193_Y	197_I	2.134	1.00
102_D	127_P	2.133	1.00
235_D	238_Q	2.102	1.00
104_G	172_D	2.092	1.00
108_L	164_L	2.091	1.00
24_D	42_N	2.088	1.00
119_L	274_V	2.072	1.00
161_E	186_S	1.907	1.00
96_R	280_G	1.907	1.00
106_A	173_T	1.892	1.00
130_V	171_Y	1.871	1.00
113_D	138_L	1.865	1.00
156_T	159_P	1.862	1.00
39_H	81_A	1.835	1.00
24_D	50_V	1.814	1.00
132_I	164_L	1.796	1.00
229_A	273_A	1.774	1.00
35_L	81_A	1.754	1.00
136_D	151_D	1.727	1.00
194_A	197_I	1.698	1.00
175_L	274_V	1.662	1.00
265_L	269_A	1.649	1.00
168_L	176_V	1.626	0.99
178_L	232_V	1.616	0.99
111_K	137_T	1.598	0.99
105_I	175_L	1.552	0.99
165_L	193_Y	1.540	0.99
45_D	62_D	1.518	0.99
150_H	171_Y	1.512	0.99
157_G	186_S	1.510	0.99
32_V	59_L	1.502	0.99
30_A	34_G	1.498	0.99
83_D	87_D	1.491	0.99
15_Y	62_D	1.483	0.99
31_A	88_E	1.482	0.99
195_G	284_V	1.480	0.99
247_F	265_L	1.465	0.99
285_R	290_A	1.463	0.99
28_I	89_L	1.462	0.99
255_V	259_K	1.449	0.99
188_D	191_F	1.437	0.99
255_V	258_V	1.429	0.99
140_A	143_D	1.425	0.99
250_P	253_A	1.416	0.99
31_A	89_L	1.408	0.99
130_V	173_T	1.392	0.98
86_G	93_V	1.388	0.98
34_G	38_E	1.379	0.98
74_D	77_A	1.362	0.98
17_E	280_G	1.355	0.98
21_V	92_D	1.320	0.98
104_G	129_N	1.319	0.98
106_A	168_L	1.299	0.98
158_T	162_E	1.294	0.97
158_T	188_D	1.290	0.97
118_A	264_P	1.280	0.97
215_R	259_K	1.260	0.97
77_A	80_A	1.235	0.97
75_R	97_F	1.228	0.96
275_R	279_A	1.225	0.96
136_D	143_D	1.196	0.96
187_P	191_F	1.189	0.96
82_L	86_G	1.187	0.96
33_T	46_V	1.180	0.96
162_E	166_E	1.173	0.95
25_R	88_E	1.164	0.95
152_I	167_L	1.160	0.95
209_P	238_Q	1.160	0.95
157_G	183_R	1.157	0.95
30_A	37_F	1.155	0.95
152_I	163_R	1.154	0.95
41_A	65_F	1.145	0.95
102_D	125_G	1.145	0.95
150_H	167_L	1.139	0.95
126_A	129_N	1.139	0.95
118_A	271_V	1.138	0.95
216_Q	238_Q	1.137	0.95
141_V	145_H	1.135	0.95
123_D	263_Q	1.131	0.94
277_H	282_T	1.127	0.94
48_Q	61_A	1.106	0.94
35_L	39_H	1.095	0.93
17_E	98_P	1.093	0.93
106_A	132_I	1.090	0.93
108_L	176_V	1.088	0.93
191_F	194_A	1.077	0.93
32_V	91_V	1.073	0.93
165_L	188_D	1.070	0.93
103_D	174_D	1.060	0.92
82_L	95_V	1.057	0.92
140_A	146_D	1.055	0.92
162_E	188_D	1.052	0.92
159_P	163_R	1.051	0.92
254_S	257_A	1.051	0.92
215_R	219_E	1.047	0.92
113_D	117_R	1.042	0.92
84_D	88_E	1.039	0.92
18_V	63_C	1.023	0.91
133_G	181_Y	1.022	0.91
224_V	248_T	1.013	0.90
198_V	242_L	1.008	0.90
245_R	272_A	1.001	0.90
177_V	270_L	0.997	0.90
16_T	63_C	0.995	0.90
117_R	141_V	0.992	0.90
190_V	197_I	0.990	0.89
80_A	83_D	0.978	0.89
110_T	133_G	0.977	0.89
18_V	95_V	0.973	0.89
28_I	48_Q	0.969	0.88
165_L	169_A	0.961	0.88
243_T	272_A	0.952	0.87
108_L	132_I	0.950	0.87
105_I	129_N	0.949	0.87
25_R	90_G	0.947	0.87
42_N	64_G	0.936	0.87
56_R	285_R	0.930	0.86
125_G	278_L	0.928	0.86
46_V	61_A	0.928	0.86
164_L	189_V	0.921	0.86
176_V	193_Y	0.920	0.86
53_G	219_E	0.917	0.85
42_N	48_Q	0.917	0.85
160_D	164_L	0.915	0.85
19_T	94_R	0.914	0.85
260_D	275_R	0.907	0.85
79_Q	93_V	0.898	0.84
36_L	63_C	0.887	0.83
25_R	31_A	0.884	0.83
29_V	33_T	0.883	0.83
76_A	79_Q	0.878	0.83
103_D	278_L	0.876	0.83
28_I	42_N	0.867	0.82
224_V	243_T	0.858	0.81
131_V	143_D	0.857	0.81
56_R	92_D	0.852	0.81
129_N	171_Y	0.852	0.81
28_I	32_V	0.850	0.81
245_R	248_T	0.850	0.81
105_I	278_L	0.847	0.81
84_D	87_D	0.846	0.80
106_A	167_L	0.841	0.80
257_A	260_D	0.839	0.80
82_L	93_V	0.838	0.80
77_A	81_A	0.836	0.80
117_R	267_A	0.833	0.79
38_E	81_A	0.829	0.79
45_D	252_N	0.819	0.78
26_T	37_F	0.818	0.78
166_E	169_A	0.817	0.78
247_F	261_R	0.813	0.78
264_P	268_D	0.810	0.78
131_V	147_V	0.808	0.77
33_T	37_F	0.806	0.77
24_D	46_V	0.804	0.77
42_N	197_I	0.804	0.77
44_E	64_G	0.803	0.77
20_V	32_V	0.793	0.76
190_V	234_T	0.791	0.76
142_A	147_V	0.787	0.75
107_V	128_V	0.784	0.75
190_V	195_G	0.784	0.75
185_L	189_V	0.782	0.75
218_V	288_A	0.782	0.75
104_G	173_T	0.778	0.75
191_F	234_T	0.776	0.74
26_T	42_N	0.776	0.74
188_D	192_R	0.773	0.74
212_Q	259_K	0.772	0.74
107_V	119_L	0.771	0.74
164_L	168_L	0.768	0.74
21_V	56_R	0.765	0.73
130_V	167_L	0.763	0.73
113_D	123_D	0.761	0.73
85_T	89_L	0.761	0.73
171_Y	174_D	0.761	0.73
209_P	235_D	0.761	0.73
96_R	101_R	0.760	0.73
186_S	273_A	0.760	0.73
105_I	174_D	0.759	0.73
112_E	216_Q	0.757	0.73
190_V	196_H	0.756	0.73
23_A	90_G	0.754	0.72
161_E	273_A	0.752	0.72
154_D	183_R	0.746	0.72
81_A	84_D	0.745	0.71
15_Y	44_E	0.743	0.71
130_V	150_H	0.743	0.71
203_S	232_V	0.742	0.71
24_D	28_I	0.739	0.71
138_L	149_F	0.738	0.71
36_L	61_A	0.738	0.71
22_G	91_V	0.737	0.71
109_V	116_L	0.736	0.71
129_N	132_I	0.735	0.70
184_I	284_V	0.734	0.70
215_R	255_V	0.730	0.70
131_V	146_D	0.728	0.70
112_E	259_K	0.724	0.69
48_Q	59_L	0.719	0.69
161_E	165_L	0.719	0.69
112_E	138_L	0.717	0.69
202_P	227_V	0.716	0.68
138_L	141_V	0.715	0.68
35_L	93_V	0.710	0.68
97_F	101_R	0.706	0.67
15_Y	64_G	0.706	0.67
152_I	164_L	0.704	0.67
18_V	93_V	0.702	0.67
143_D	146_D	0.700	0.67
35_L	85_T	0.699	0.67
75_R	95_V	0.687	0.65
185_L	197_I	0.685	0.65
175_L	278_L	0.684	0.65
53_G	218_V	0.682	0.65
161_E	229_A	0.676	0.64
225_A	292_D	0.672	0.63
214_Y	262_G	0.672	0.63
148_P	171_Y	0.667	0.63
68_G	74_D	0.666	0.63
16_T	75_R	0.666	0.63
202_P	213_A	0.660	0.62
63_C	133_G	0.660	0.62
268_D	272_A	0.659	0.62
82_L	85_T	0.656	0.62
162_E	172_D	0.651	0.61
36_L	89_L	0.651	0.61
225_A	233_T	0.651	0.61
133_G	147_V	0.644	0.60
186_S	189_V	0.643	0.60
163_R	170_A	0.639	0.60
39_H	84_D	0.634	0.59
105_I	177_V	0.633	0.59
187_P	249_V	0.633	0.59
274_V	277_H	0.632	0.59
91_V	180_R	0.631	0.59
132_I	167_L	0.630	0.59
125_G	279_A	0.629	0.58
204_L	220_A	0.629	0.58
31_A	37_F	0.628	0.58
26_T	66_A	0.626	0.58
42_N	207_A	0.623	0.58
110_T	180_R	0.622	0.58
250_P	261_R	0.621	0.57
145_H	207_A	0.619	0.57
51_R	54_V	0.619	0.57
33_T	224_V	0.617	0.57
125_G	131_V	0.615	0.57
26_T	40_G	0.614	0.57
79_Q	97_F	0.614	0.57
169_A	172_D	0.614	0.57
31_A	34_G	0.612	0.56
245_R	265_L	0.612	0.56
216_Q	219_E	0.611	0.56
108_L	168_L	0.611	0.56
256_A	263_Q	0.605	0.55
189_V	193_Y	0.605	0.55
94_R	280_G	0.603	0.55
42_N	50_V	0.602	0.55
108_L	197_I	0.602	0.55
117_R	121_E	0.601	0.55
139_E	142_A	0.601	0.55
213_A	227_V	0.600	0.55
119_L	271_V	0.598	0.55
126_A	175_L	0.596	0.54
177_V	274_V	0.593	0.54
102_D	105_I	0.591	0.54
202_P	251_P	0.591	0.54
117_R	250_P	0.591	0.54
120_L	147_V	0.591	0.54
219_E	287_G	0.590	0.54
131_V	144_E	0.589	0.54
24_D	57_M	0.587	0.53
112_E	263_Q	0.586	0.53
149_F	233_T	0.582	0.53
29_V	43_I	0.580	0.52
248_T	276_A	0.580	0.52
165_L	176_V	0.579	0.52
168_L	173_T	0.578	0.52
21_V	46_V	0.577	0.52
193_Y	196_H	0.574	0.52
50_V	207_A	0.572	0.51
175_L	277_H	0.572	0.51
129_N	147_V	0.571	0.51
98_P	249_V	0.571	0.51
31_A	38_E	0.571	0.51
186_S	229_A	0.570	0.51
26_T	258_V	0.569	0.51
37_F	282_T	0.569	0.51
253_A	257_A	0.568	0.51
62_D	98_P	0.568	0.51
28_I	50_V	0.567	0.51
166_E	192_R	0.567	0.51
16_T	68_G	0.563	0.50
176_V	197_I	0.561	0.50
110_T	135_H	0.561	0.50
249_V	253_A	0.561	0.50
161_E	185_L	0.560	0.50
116_L	131_V	0.560	0.50
23_A	86_G	0.558	0.50
131_V	169_A	0.557	0.50
75_R	99_D	0.556	0.49
36_L	78_F	0.556	0.49
146_D	150_H	0.555	0.49
169_A	193_Y	0.554	0.49
29_V	61_A	0.554	0.49
63_C	189_V	0.553	0.49
167_L	170_A	0.552	0.49
37_F	288_A	0.552	0.49
131_V	235_D	0.551	0.49
194_A	284_V	0.551	0.49
138_L	207_A	0.550	0.49
29_V	57_M	0.549	0.49
233_T	248_T	0.549	0.49
137_T	142_A	0.546	0.48
60_L	227_V	0.546	0.48
44_E	52_D	0.546	0.48
139_E	146_D	0.545	0.48
137_T	249_V	0.544	0.48
185_L	190_V	0.544	0.48
218_V	225_A	0.543	0.48
14_D	97_F	0.543	0.48
75_R	101_R	0.543	0.48
216_Q	259_K	0.543	0.48
88_E	101_R	0.542	0.48
156_T	186_S	0.540	0.47
19_T	283_T	0.540	0.47
160_D	247_F	0.540	0.47
117_R	145_H	0.539	0.47
201_H	237_D	0.538	0.47
19_T	207_A	0.536	0.47
123_D	260_D	0.536	0.47
159_P	162_E	0.536	0.47
104_G	170_A	0.536	0.47
129_N	177_V	0.535	0.47
150_H	170_A	0.533	0.47
79_Q	83_D	0.533	0.47
19_T	45_D	0.532	0.46
288_A	292_D	0.532	0.46
167_L	171_Y	0.531	0.46
133_G	151_D	0.531	0.46
245_R	268_D	0.529	0.46
197_I	207_A	0.527	0.46
22_G	82_L	0.527	0.46
223_R	251_P	0.527	0.46
204_L	246_A	0.526	0.46
132_I	168_L	0.525	0.46
42_N	161_E	0.524	0.45
224_V	269_A	0.524	0.45
137_T	149_F	0.524	0.45
105_I	274_V	0.523	0.45
60_L	251_P	0.523	0.45
131_V	139_E	0.522	0.45
37_F	207_A	0.522	0.45
123_D	267_A	0.519	0.45
247_F	268_D	0.518	0.45
21_V	285_R	0.517	0.45
184_I	234_T	0.517	0.45
113_D	141_V	0.517	0.45
224_V	288_A	0.516	0.44
86_G	91_V	0.516	0.44
108_L	160_D	0.515	0.44
118_A	211_A	0.514	0.44
51_R	290_A	0.514	0.44
52_D	101_R	0.513	0.44
135_H	154_D	0.513	0.44
257_A	269_A	0.512	0.44
32_V	82_L	0.510	0.44
90_G	196_H	0.510	0.44
229_A	288_A	0.510	0.44
283_T	292_D	0.509	0.44
112_E	184_I	0.509	0.44
234_T	249_V	0.508	0.44
289_V	292_D	0.507	0.43
20_V	39_H	0.506	0.43
136_D	149_F	0.506	0.43
120_L	145_H	0.504	0.43
107_V	126_A	0.504	0.43
20_V	59_L	0.504	0.43
115_C	118_A	0.503	0.43
46_V	50_V	0.502	0.43
189_V	192_R	0.502	0.43
20_V	28_I	0.502	0.43
202_P	223_R	0.501	0.43
76_A	172_D	0.500	0.43
61_A	229_A	0.500	0.43
142_A	146_D	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3louA	3	0.9043	100	0.332	Contact Map
3obiA	4	0.9175	100	0.336	Contact Map
3nrbA	4	0.9142	100	0.338	Contact Map
3o1lA	3	0.9406	100	0.349	Contact Map
3n0vA	4	0.9043	100	0.349	Contact Map
3w7bA	3	0.9142	100	0.354	Contact Map
3tqrA	2	0.6634	100	0.62	Contact Map
3aufA	2	0.67	100	0.62	Contact Map
2ywrA	2	0.6634	100	0.623	Contact Map
1jkxA	2	0.6502	100	0.624	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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