GREMLIN Database
Q9HNT9 - Uncharacterized protein
UniProt: Q9HNT9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (260)
Sequences: 222 (200)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_T163_Y8.4131.00
140_P215_V4.2961.00
81_S251_P4.2311.00
79_P90_V3.8930.99
58_V240_N3.6390.99
147_A161_V3.6340.99
192_W240_N3.3930.98
170_T240_N3.3450.98
50_V235_T3.2870.98
43_A76_A3.2830.98
47_M227_V3.0860.97
172_F211_R3.0120.96
83_S110_Y2.9440.96
241_A256_V2.8350.95
83_S164_M2.7690.94
140_P172_F2.4830.89
47_M232_T2.4430.89
240_N251_P2.4140.88
206_W240_N2.3770.87
195_L205_A2.2860.85
73_G265_C2.2400.84
293_V296_R2.1270.80
192_W249_G1.9910.75
135_Q139_P1.9470.74
144_T223_L1.9410.74
56_A73_G1.8820.71
218_E224_R1.8630.70
83_S260_R1.8430.69
83_S91_L1.8120.68
106_T109_P1.7870.67
103_S150_A1.7370.65
159_L293_V1.7200.64
224_R232_T1.6890.62
109_P296_R1.6800.62
175_D211_R1.6760.62
75_T261_E1.6590.61
127_W131_W1.6360.60
50_V86_W1.5930.58
197_F203_A1.5900.58
201_S204_D1.5810.57
62_V214_E1.5760.57
170_T192_W1.5660.56
70_F267_T1.5560.56
137_T168_F1.5430.55
44_E231_R1.5310.55
83_S115_I1.5240.54
100_A280_G1.5130.54
63_V69_D1.5130.54
209_Y240_N1.5090.54
58_V206_W1.5050.53
83_S127_W1.4910.53
109_P131_W1.4770.52
87_L131_W1.4770.52
148_I226_N1.4730.52
212_N240_N1.4570.51
162_H166_P1.4530.51
241_A259_L1.4380.50
106_T131_W1.4220.49
131_W296_R1.4120.49
83_S124_E1.4090.48
58_V170_T1.4020.48
56_A75_T1.3770.47
213_L217_L1.3760.47
206_W242_F1.3680.46
132_D225_S1.3650.46
102_V120_L1.3600.46
52_D55_R1.3530.46
53_A240_N1.3520.46
297_L301_G1.3230.44
297_L302_Y1.3230.44
79_P89_A1.3080.43
155_D272_E1.2990.43
172_F215_V1.2960.43
41_L120_L1.2940.43
40_I134_A1.2850.42
152_R277_P1.2790.42
103_S157_D1.2640.41
45_W78_S1.2630.41
83_S108_N1.2550.41
290_A299_Q1.2310.40
157_D229_A1.2160.39
33_S79_P1.2160.39
147_A159_L1.2030.38
71_D265_C1.1990.38
41_L99_L1.1960.38
53_A162_H1.1950.38
45_W54_C1.1860.37
57_D244_E1.1760.37
101_D157_D1.1730.37
137_T192_W1.1680.36
225_S266_E1.1530.36
81_S248_Y1.1490.36
126_V130_G1.1490.36
83_S236_A1.1490.36
87_L127_W1.1280.35
106_T127_W1.1260.35
83_S100_A1.1260.35
69_D234_L1.1200.34
47_M86_W1.1180.34
39_P43_A1.1160.34
78_S85_E1.1100.34
33_S38_D1.1080.34
226_N271_D1.1080.34
107_G143_V1.1060.34
131_W137_T1.1000.33
295_D299_Q1.0980.33
192_W206_W1.0930.33
163_Y216_V1.0920.33
224_R271_D1.0840.33
39_P90_V1.0770.32
87_L111_S1.0530.31
141_G251_P1.0470.31
297_L300_L1.0330.30
51_L55_R1.0280.30
141_G219_D1.0200.30
131_W138_I1.0170.30
87_L110_Y1.0130.30
85_E253_G1.0110.29
144_T226_N1.0020.29
155_D233_V0.9900.29
37_P40_I0.9870.28
86_W268_T0.9870.28
102_V106_T0.9840.28
70_F270_S0.9820.28
106_T120_L0.9780.28
261_E299_Q0.9750.28
78_S236_A0.9700.28
59_F63_V0.9650.28
153_T203_A0.9650.28
123_Y131_W0.9630.27
134_A171_V0.9600.27
87_L160_I0.9500.27
39_P42_D0.9440.27
33_S37_P0.9440.27
58_V210_E0.9420.27
290_A298_E0.9420.27
121_G124_E0.9390.26
289_D292_V0.9380.26
211_R234_L0.9350.26
54_C166_P0.9320.26
166_P264_W0.9280.26
194_Q198_G0.9270.26
157_D272_E0.9210.26
291_S295_D0.9200.26
216_V234_L0.9180.26
240_N249_G0.9090.25
212_N216_V0.8950.25
163_Y232_T0.8940.25
220_V225_S0.8850.24
54_C264_W0.8830.24
61_D210_E0.8810.24
129_Y153_T0.8810.24
156_T273_R0.8750.24
85_E235_T0.8700.24
192_W198_G0.8700.24
43_A233_V0.8660.24
147_A223_L0.8550.23
226_N277_P0.8500.23
165_Q264_W0.8500.23
167_H250_H0.8450.23
169_P263_P0.8450.23
169_P250_H0.8450.23
169_P237_D0.8450.23
167_H263_P0.8450.23
169_P238_H0.8450.23
237_D263_P0.8450.23
167_H238_H0.8450.23
238_H263_P0.8450.23
237_D250_H0.8450.23
250_H263_P0.8450.23
238_H250_H0.8450.23
167_H237_D0.8450.23
106_T198_G0.8400.23
191_V195_L0.8380.23
72_S126_V0.8370.23
131_W192_W0.8310.22
51_L233_V0.8240.22
71_D86_W0.8210.22
120_L251_P0.8190.22
164_M240_N0.8190.22
56_A71_D0.8190.22
131_W134_A0.8180.22
54_C165_Q0.8130.22
125_A170_T0.8030.21
40_I145_D0.7950.21
37_P164_M0.7940.21
81_S160_I0.7920.21
46_D54_C0.7830.21
148_I275_R0.7820.21
277_P280_G0.7820.21
109_P120_L0.7780.21
130_G142_P0.7780.21
38_D80_A0.7740.20
141_G222_V0.7740.20
82_T164_M0.7710.20
139_P257_P0.7700.20
177_G181_L0.7700.20
77_T261_E0.7690.20
80_A252_G0.7680.20
101_D155_D0.7670.20
140_P160_I0.7660.20
168_F240_N0.7640.20
168_F293_V0.7630.20
47_M163_Y0.7600.20
52_D57_D0.7590.20
105_V259_L0.7570.20
288_T291_S0.7550.20
81_S235_T0.7540.20
45_W108_N0.7510.20
38_D76_A0.7500.20
116_D217_L0.7450.20
86_W90_V0.7430.19
98_A102_V0.7380.19
217_L264_W0.7350.19
93_S224_R0.7260.19
143_V299_Q0.7210.19
103_S121_G0.7160.19
52_D263_P0.7140.19
52_D237_D0.7140.19
52_D169_P0.7140.19
52_D238_H0.7140.19
52_D167_H0.7140.19
52_D250_H0.7140.19
210_E298_E0.7120.18
290_A295_D0.7100.18
254_V259_L0.7070.18
165_Q213_L0.7060.18
101_D272_E0.7050.18
104_Y140_P0.7050.18
33_S89_A0.7040.18
83_S87_L0.7020.18
55_R209_Y0.6990.18
144_T148_I0.6960.18
58_V242_F0.6920.18
205_A219_D0.6880.18
160_I203_A0.6860.18
159_L186_D0.6850.18
106_T113_R0.6840.18
79_P259_L0.6840.18
144_T219_D0.6810.18
141_G275_R0.6780.17
109_P198_G0.6780.17
104_Y168_F0.6780.17
103_S155_D0.6760.17
132_D147_A0.6750.17
191_V242_F0.6720.17
78_S235_T0.6720.17
171_V215_V0.6710.17
86_W264_W0.6710.17
41_L277_P0.6690.17
272_E275_R0.6680.17
50_V119_R0.6680.17
115_I236_A0.6670.17
129_Y146_A0.6660.17
134_A192_W0.6660.17
107_G138_I0.6650.17
289_D294_D0.6650.17
107_G176_S0.6600.17
111_S188_P0.6580.17
172_F236_A0.6580.17
283_G299_Q0.6570.17
111_S270_S0.6550.17
231_R273_R0.6530.17
206_W213_L0.6530.17
131_W198_G0.6510.17
41_L102_V0.6500.17
59_F73_G0.6490.17
107_G211_R0.6480.17
281_R288_T0.6470.17
60_A73_G0.6470.17
205_A240_N0.6470.17
83_S278_S0.6430.16
78_S86_W0.6400.16
51_L264_W0.6400.16
153_T182_D0.6390.16
205_A248_Y0.6370.16
47_M231_R0.6300.16
194_Q200_R0.6300.16
131_W170_T0.6280.16
36_T89_A0.6240.16
138_I165_Q0.6240.16
160_I166_P0.6180.16
71_D158_R0.6170.16
159_L227_V0.6150.16
140_P171_V0.6140.16
40_I83_S0.6130.16
87_L219_D0.6110.16
159_L232_T0.6110.16
158_R264_W0.6090.16
42_D291_S0.6080.15
128_E136_G0.6070.15
160_I242_F0.6070.15
193_E248_Y0.6060.15
84_T87_L0.6040.15
45_W51_L0.6040.15
127_W198_G0.6030.15
165_Q217_L0.6010.15
46_D53_A0.5990.15
103_S222_V0.5970.15
54_C217_L0.5960.15
216_V226_N0.5930.15
54_C158_R0.5920.15
70_F256_V0.5920.15
171_V231_R0.5900.15
120_L198_G0.5860.15
229_A268_T0.5850.15
164_M278_S0.5850.15
86_W100_A0.5840.15
241_A247_I0.5840.15
109_P170_T0.5810.15
58_V61_D0.5770.15
140_P165_Q0.5730.15
213_L264_W0.5720.15
76_A87_L0.5700.15
35_S299_Q0.5650.14
145_D276_E0.5640.14
144_T161_V0.5640.14
38_D43_A0.5630.14
71_D150_A0.5630.14
49_V220_V0.5620.14
154_H231_R0.5620.14
169_P262_V0.5610.14
237_D262_V0.5610.14
167_H262_V0.5610.14
238_H262_V0.5610.14
250_H262_V0.5610.14
170_T218_E0.5600.14
57_D209_Y0.5580.14
235_T290_A0.5560.14
126_V129_Y0.5560.14
287_A290_A0.5540.14
69_D267_T0.5510.14
73_G273_R0.5490.14
153_T292_V0.5490.14
77_T144_T0.5470.14
167_H239_G0.5450.14
239_G263_P0.5450.14
239_G250_H0.5450.14
169_P239_G0.5450.14
80_A85_E0.5420.14
126_V136_G0.5420.14
264_W297_L0.5410.14
76_A299_Q0.5400.14
228_D277_P0.5400.14
82_T110_Y0.5390.14
108_N166_P0.5370.14
143_V227_V0.5360.14
34_H89_A0.5360.14
101_D221_A0.5350.14
45_W264_W0.5350.14
77_T174_A0.5340.14
80_A83_S0.5340.14
221_A224_R0.5340.14
75_T79_P0.5330.14
271_D277_P0.5320.14
130_G241_A0.5310.14
41_L221_A0.5280.13
172_F175_D0.5260.13
149_R153_T0.5260.13
129_Y149_R0.5260.13
44_E218_E0.5250.13
54_C213_L0.5240.13
83_S148_I0.5230.13
202_V206_W0.5210.13
34_H260_R0.5200.13
289_D293_V0.5200.13
38_D79_P0.5190.13
282_G293_V0.5180.13
89_A299_Q0.5160.13
55_R238_H0.5150.13
55_R250_H0.5150.13
55_R169_P0.5150.13
55_R167_H0.5150.13
55_R237_D0.5150.13
55_R263_P0.5150.13
53_A292_V0.5110.13
100_A155_D0.5100.13
173_D293_V0.5090.13
50_V160_I0.5080.13
125_A128_E0.5070.13
109_P138_I0.5070.13
121_G157_D0.5050.13
124_E146_A0.5050.13
269_A295_D0.5040.13
45_W50_V0.5030.13
257_P261_E0.5020.13
53_A104_Y0.5020.13
70_F160_I0.5010.13
109_P192_W0.5000.13
169_P209_Y0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vqrA 3 0.8289 99.8 0.799 Contact Map
4upkA 3 0.8322 99.8 0.8 Contact Map
2qzuA 2 0.8487 99.8 0.803 Contact Map
4tn0A 1 0.8355 99.8 0.804 Contact Map
4upiA 2 0.8322 99.8 0.804 Contact Map
4uphA 2 0.8289 99.8 0.806 Contact Map
4uplA 2 0.8421 99.8 0.807 Contact Map
4kavA 1 0.875 99.8 0.81 Contact Map
3b5qA 1 0.8421 99.8 0.811 Contact Map
1aukA 3 0.7599 99.7 0.813 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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