Q9HNT9 - HALSA - GREMLIN Contacts

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Q9HNT9 - Uncharacterized protein

UniProt:	Q9HNT9	Sequences: MISDLAAAARSLRYAGFDAVREFASRTYYGLRSHSTPDPILDAEWDMLVVLDACRADVFADVVGGGEYDFDSGGTATSPASTSTEWLTAVLGSASDDALADVSYVTGNPYSSRTIDTSRLGGYEAVWEYGWDDAQGTIPPGPVTDAAIRAGRTHDTDRLIVHYMQPHFPTVFDADSGGVALDDWGDQPMSVWEQLRFGRRSVADAWRDYERNLEVVLEDVAVLRSNVDADRTVLTADHGNAFGEHAIYGHPGGVDVPALREVPWCETTASDERTREPSGGRGGSVEATDASVVDDRLEQLGYKT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	304 (260)
Sequences:	222 (200)
Seq/√Len:	12.4

HALSA - Q9HNT9 Q9HQP7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
144_T	163_Y	8.413	1.00
140_P	215_V	4.296	1.00
81_S	251_P	4.231	1.00
79_P	90_V	3.893	0.99
58_V	240_N	3.639	0.99
147_A	161_V	3.634	0.99
192_W	240_N	3.393	0.98
170_T	240_N	3.345	0.98
50_V	235_T	3.287	0.98
43_A	76_A	3.283	0.98
47_M	227_V	3.086	0.97
172_F	211_R	3.012	0.96
83_S	110_Y	2.944	0.96
241_A	256_V	2.835	0.95
83_S	164_M	2.769	0.94
140_P	172_F	2.483	0.89
47_M	232_T	2.443	0.89
240_N	251_P	2.414	0.88
206_W	240_N	2.377	0.87
195_L	205_A	2.286	0.85
73_G	265_C	2.240	0.84
293_V	296_R	2.127	0.80
192_W	249_G	1.991	0.75
135_Q	139_P	1.947	0.74
144_T	223_L	1.941	0.74
56_A	73_G	1.882	0.71
218_E	224_R	1.863	0.70
83_S	260_R	1.843	0.69
83_S	91_L	1.812	0.68
106_T	109_P	1.787	0.67
103_S	150_A	1.737	0.65
159_L	293_V	1.720	0.64
224_R	232_T	1.689	0.62
109_P	296_R	1.680	0.62
175_D	211_R	1.676	0.62
75_T	261_E	1.659	0.61
127_W	131_W	1.636	0.60
50_V	86_W	1.593	0.58
197_F	203_A	1.590	0.58
201_S	204_D	1.581	0.57
62_V	214_E	1.576	0.57
170_T	192_W	1.566	0.56
70_F	267_T	1.556	0.56
137_T	168_F	1.543	0.55
44_E	231_R	1.531	0.55
83_S	115_I	1.524	0.54
100_A	280_G	1.513	0.54
63_V	69_D	1.513	0.54
209_Y	240_N	1.509	0.54
58_V	206_W	1.505	0.53
83_S	127_W	1.491	0.53
109_P	131_W	1.477	0.52
87_L	131_W	1.477	0.52
148_I	226_N	1.473	0.52
212_N	240_N	1.457	0.51
162_H	166_P	1.453	0.51
241_A	259_L	1.438	0.50
106_T	131_W	1.422	0.49
131_W	296_R	1.412	0.49
83_S	124_E	1.409	0.48
58_V	170_T	1.402	0.48
56_A	75_T	1.377	0.47
213_L	217_L	1.376	0.47
206_W	242_F	1.368	0.46
132_D	225_S	1.365	0.46
102_V	120_L	1.360	0.46
52_D	55_R	1.353	0.46
53_A	240_N	1.352	0.46
297_L	301_G	1.323	0.44
297_L	302_Y	1.323	0.44
79_P	89_A	1.308	0.43
155_D	272_E	1.299	0.43
172_F	215_V	1.296	0.43
41_L	120_L	1.294	0.43
40_I	134_A	1.285	0.42
152_R	277_P	1.279	0.42
103_S	157_D	1.264	0.41
45_W	78_S	1.263	0.41
83_S	108_N	1.255	0.41
290_A	299_Q	1.231	0.40
157_D	229_A	1.216	0.39
33_S	79_P	1.216	0.39
147_A	159_L	1.203	0.38
71_D	265_C	1.199	0.38
41_L	99_L	1.196	0.38
53_A	162_H	1.195	0.38
45_W	54_C	1.186	0.37
57_D	244_E	1.176	0.37
101_D	157_D	1.173	0.37
137_T	192_W	1.168	0.36
225_S	266_E	1.153	0.36
81_S	248_Y	1.149	0.36
126_V	130_G	1.149	0.36
83_S	236_A	1.149	0.36
87_L	127_W	1.128	0.35
106_T	127_W	1.126	0.35
83_S	100_A	1.126	0.35
69_D	234_L	1.120	0.34
47_M	86_W	1.118	0.34
39_P	43_A	1.116	0.34
78_S	85_E	1.110	0.34
33_S	38_D	1.108	0.34
226_N	271_D	1.108	0.34
107_G	143_V	1.106	0.34
131_W	137_T	1.100	0.33
295_D	299_Q	1.098	0.33
192_W	206_W	1.093	0.33
163_Y	216_V	1.092	0.33
224_R	271_D	1.084	0.33
39_P	90_V	1.077	0.32
87_L	111_S	1.053	0.31
141_G	251_P	1.047	0.31
297_L	300_L	1.033	0.30
51_L	55_R	1.028	0.30
141_G	219_D	1.020	0.30
131_W	138_I	1.017	0.30
87_L	110_Y	1.013	0.30
85_E	253_G	1.011	0.29
144_T	226_N	1.002	0.29
155_D	233_V	0.990	0.29
37_P	40_I	0.987	0.28
86_W	268_T	0.987	0.28
102_V	106_T	0.984	0.28
70_F	270_S	0.982	0.28
106_T	120_L	0.978	0.28
261_E	299_Q	0.975	0.28
78_S	236_A	0.970	0.28
59_F	63_V	0.965	0.28
153_T	203_A	0.965	0.28
123_Y	131_W	0.963	0.27
134_A	171_V	0.960	0.27
87_L	160_I	0.950	0.27
39_P	42_D	0.944	0.27
33_S	37_P	0.944	0.27
58_V	210_E	0.942	0.27
290_A	298_E	0.942	0.27
121_G	124_E	0.939	0.26
289_D	292_V	0.938	0.26
211_R	234_L	0.935	0.26
54_C	166_P	0.932	0.26
166_P	264_W	0.928	0.26
194_Q	198_G	0.927	0.26
157_D	272_E	0.921	0.26
291_S	295_D	0.920	0.26
216_V	234_L	0.918	0.26
240_N	249_G	0.909	0.25
212_N	216_V	0.895	0.25
163_Y	232_T	0.894	0.25
220_V	225_S	0.885	0.24
54_C	264_W	0.883	0.24
61_D	210_E	0.881	0.24
129_Y	153_T	0.881	0.24
156_T	273_R	0.875	0.24
85_E	235_T	0.870	0.24
192_W	198_G	0.870	0.24
43_A	233_V	0.866	0.24
147_A	223_L	0.855	0.23
226_N	277_P	0.850	0.23
165_Q	264_W	0.850	0.23
167_H	250_H	0.845	0.23
169_P	263_P	0.845	0.23
169_P	250_H	0.845	0.23
169_P	237_D	0.845	0.23
167_H	263_P	0.845	0.23
169_P	238_H	0.845	0.23
237_D	263_P	0.845	0.23
167_H	238_H	0.845	0.23
238_H	263_P	0.845	0.23
237_D	250_H	0.845	0.23
250_H	263_P	0.845	0.23
238_H	250_H	0.845	0.23
167_H	237_D	0.845	0.23
106_T	198_G	0.840	0.23
191_V	195_L	0.838	0.23
72_S	126_V	0.837	0.23
131_W	192_W	0.831	0.22
51_L	233_V	0.824	0.22
71_D	86_W	0.821	0.22
120_L	251_P	0.819	0.22
164_M	240_N	0.819	0.22
56_A	71_D	0.819	0.22
131_W	134_A	0.818	0.22
54_C	165_Q	0.813	0.22
125_A	170_T	0.803	0.21
40_I	145_D	0.795	0.21
37_P	164_M	0.794	0.21
81_S	160_I	0.792	0.21
46_D	54_C	0.783	0.21
148_I	275_R	0.782	0.21
277_P	280_G	0.782	0.21
109_P	120_L	0.778	0.21
130_G	142_P	0.778	0.21
38_D	80_A	0.774	0.20
141_G	222_V	0.774	0.20
82_T	164_M	0.771	0.20
139_P	257_P	0.770	0.20
177_G	181_L	0.770	0.20
77_T	261_E	0.769	0.20
80_A	252_G	0.768	0.20
101_D	155_D	0.767	0.20
140_P	160_I	0.766	0.20
168_F	240_N	0.764	0.20
168_F	293_V	0.763	0.20
47_M	163_Y	0.760	0.20
52_D	57_D	0.759	0.20
105_V	259_L	0.757	0.20
288_T	291_S	0.755	0.20
81_S	235_T	0.754	0.20
45_W	108_N	0.751	0.20
38_D	76_A	0.750	0.20
116_D	217_L	0.745	0.20
86_W	90_V	0.743	0.19
98_A	102_V	0.738	0.19
217_L	264_W	0.735	0.19
93_S	224_R	0.726	0.19
143_V	299_Q	0.721	0.19
103_S	121_G	0.716	0.19
52_D	263_P	0.714	0.19
52_D	237_D	0.714	0.19
52_D	169_P	0.714	0.19
52_D	238_H	0.714	0.19
52_D	167_H	0.714	0.19
52_D	250_H	0.714	0.19
210_E	298_E	0.712	0.18
290_A	295_D	0.710	0.18
254_V	259_L	0.707	0.18
165_Q	213_L	0.706	0.18
101_D	272_E	0.705	0.18
104_Y	140_P	0.705	0.18
33_S	89_A	0.704	0.18
83_S	87_L	0.702	0.18
55_R	209_Y	0.699	0.18
144_T	148_I	0.696	0.18
58_V	242_F	0.692	0.18
205_A	219_D	0.688	0.18
160_I	203_A	0.686	0.18
159_L	186_D	0.685	0.18
106_T	113_R	0.684	0.18
79_P	259_L	0.684	0.18
144_T	219_D	0.681	0.18
141_G	275_R	0.678	0.17
109_P	198_G	0.678	0.17
104_Y	168_F	0.678	0.17
103_S	155_D	0.676	0.17
132_D	147_A	0.675	0.17
191_V	242_F	0.672	0.17
78_S	235_T	0.672	0.17
171_V	215_V	0.671	0.17
86_W	264_W	0.671	0.17
41_L	277_P	0.669	0.17
272_E	275_R	0.668	0.17
50_V	119_R	0.668	0.17
115_I	236_A	0.667	0.17
129_Y	146_A	0.666	0.17
134_A	192_W	0.666	0.17
107_G	138_I	0.665	0.17
289_D	294_D	0.665	0.17
107_G	176_S	0.660	0.17
111_S	188_P	0.658	0.17
172_F	236_A	0.658	0.17
283_G	299_Q	0.657	0.17
111_S	270_S	0.655	0.17
231_R	273_R	0.653	0.17
206_W	213_L	0.653	0.17
131_W	198_G	0.651	0.17
41_L	102_V	0.650	0.17
59_F	73_G	0.649	0.17
107_G	211_R	0.648	0.17
281_R	288_T	0.647	0.17
60_A	73_G	0.647	0.17
205_A	240_N	0.647	0.17
83_S	278_S	0.643	0.16
78_S	86_W	0.640	0.16
51_L	264_W	0.640	0.16
153_T	182_D	0.639	0.16
205_A	248_Y	0.637	0.16
47_M	231_R	0.630	0.16
194_Q	200_R	0.630	0.16
131_W	170_T	0.628	0.16
36_T	89_A	0.624	0.16
138_I	165_Q	0.624	0.16
160_I	166_P	0.618	0.16
71_D	158_R	0.617	0.16
159_L	227_V	0.615	0.16
140_P	171_V	0.614	0.16
40_I	83_S	0.613	0.16
87_L	219_D	0.611	0.16
159_L	232_T	0.611	0.16
158_R	264_W	0.609	0.16
42_D	291_S	0.608	0.15
128_E	136_G	0.607	0.15
160_I	242_F	0.607	0.15
193_E	248_Y	0.606	0.15
84_T	87_L	0.604	0.15
45_W	51_L	0.604	0.15
127_W	198_G	0.603	0.15
165_Q	217_L	0.601	0.15
46_D	53_A	0.599	0.15
103_S	222_V	0.597	0.15
54_C	217_L	0.596	0.15
216_V	226_N	0.593	0.15
54_C	158_R	0.592	0.15
70_F	256_V	0.592	0.15
171_V	231_R	0.590	0.15
120_L	198_G	0.586	0.15
229_A	268_T	0.585	0.15
164_M	278_S	0.585	0.15
86_W	100_A	0.584	0.15
241_A	247_I	0.584	0.15
109_P	170_T	0.581	0.15
58_V	61_D	0.577	0.15
140_P	165_Q	0.573	0.15
213_L	264_W	0.572	0.15
76_A	87_L	0.570	0.15
35_S	299_Q	0.565	0.14
145_D	276_E	0.564	0.14
144_T	161_V	0.564	0.14
38_D	43_A	0.563	0.14
71_D	150_A	0.563	0.14
49_V	220_V	0.562	0.14
154_H	231_R	0.562	0.14
169_P	262_V	0.561	0.14
237_D	262_V	0.561	0.14
167_H	262_V	0.561	0.14
238_H	262_V	0.561	0.14
250_H	262_V	0.561	0.14
170_T	218_E	0.560	0.14
57_D	209_Y	0.558	0.14
235_T	290_A	0.556	0.14
126_V	129_Y	0.556	0.14
287_A	290_A	0.554	0.14
69_D	267_T	0.551	0.14
73_G	273_R	0.549	0.14
153_T	292_V	0.549	0.14
77_T	144_T	0.547	0.14
167_H	239_G	0.545	0.14
239_G	263_P	0.545	0.14
239_G	250_H	0.545	0.14
169_P	239_G	0.545	0.14
80_A	85_E	0.542	0.14
126_V	136_G	0.542	0.14
264_W	297_L	0.541	0.14
76_A	299_Q	0.540	0.14
228_D	277_P	0.540	0.14
82_T	110_Y	0.539	0.14
108_N	166_P	0.537	0.14
143_V	227_V	0.536	0.14
34_H	89_A	0.536	0.14
101_D	221_A	0.535	0.14
45_W	264_W	0.535	0.14
77_T	174_A	0.534	0.14
80_A	83_S	0.534	0.14
221_A	224_R	0.534	0.14
75_T	79_P	0.533	0.14
271_D	277_P	0.532	0.14
130_G	241_A	0.531	0.14
41_L	221_A	0.528	0.13
172_F	175_D	0.526	0.13
149_R	153_T	0.526	0.13
129_Y	149_R	0.526	0.13
44_E	218_E	0.525	0.13
54_C	213_L	0.524	0.13
83_S	148_I	0.523	0.13
202_V	206_W	0.521	0.13
34_H	260_R	0.520	0.13
289_D	293_V	0.520	0.13
38_D	79_P	0.519	0.13
282_G	293_V	0.518	0.13
89_A	299_Q	0.516	0.13
55_R	238_H	0.515	0.13
55_R	250_H	0.515	0.13
55_R	169_P	0.515	0.13
55_R	167_H	0.515	0.13
55_R	237_D	0.515	0.13
55_R	263_P	0.515	0.13
53_A	292_V	0.511	0.13
100_A	155_D	0.510	0.13
173_D	293_V	0.509	0.13
50_V	160_I	0.508	0.13
125_A	128_E	0.507	0.13
109_P	138_I	0.507	0.13
121_G	157_D	0.505	0.13
124_E	146_A	0.505	0.13
269_A	295_D	0.504	0.13
45_W	50_V	0.503	0.13
257_P	261_E	0.502	0.13
53_A	104_Y	0.502	0.13
70_F	160_I	0.501	0.13
109_P	192_W	0.500	0.13
169_P	209_Y	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vqrA	3	0.8289	99.8	0.799	Contact Map
4upkA	3	0.8322	99.8	0.8	Contact Map
2qzuA	2	0.8487	99.8	0.803	Contact Map
4tn0A	1	0.8355	99.8	0.804	Contact Map
4upiA	2	0.8322	99.8	0.804	Contact Map
4uphA	2	0.8289	99.8	0.806	Contact Map
4uplA	2	0.8421	99.8	0.807	Contact Map
4kavA	1	0.875	99.8	0.81	Contact Map
3b5qA	1	0.8421	99.8	0.811	Contact Map
1aukA	3	0.7599	99.7	0.813	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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