GREMLIN Database
Q9HNT8 - Inosine-5'-monophosphate dehydrogenase-like
UniProt: Q9HNT8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (114)
Sequences: 13392 (9894)
Seq/√Len: 926.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_A16_D2.7971.00
77_A81_R2.3501.00
73_V96_V2.3131.00
71_E89_A2.2711.00
73_V77_A2.2541.00
75_L98_D2.2161.00
28_S93_H2.1771.00
10_A63_Y2.1081.00
9_P12_A2.0531.00
60_I64_A1.9481.00
75_L103_V1.8951.00
17_A62_V1.8491.00
74_S77_A1.8281.00
61_P64_A1.8221.00
8_V12_A1.7511.00
10_A38_A1.6891.00
8_V17_A1.6681.00
30_V37_P1.6231.00
8_V31_V1.6141.00
11_D63_Y1.6071.00
8_V29_V1.5331.00
73_V82_A1.5231.00
95_P102_L1.5051.00
20_R24_T1.4911.00
82_A94_L1.4601.00
17_A41_L1.4521.00
85_T89_A1.4381.00
19_D23_A1.4341.00
33_R36_N1.4281.00
98_D101_D1.4261.00
10_A33_R1.4231.00
71_E91_V1.4121.00
72_T97_A1.3181.00
73_V94_L1.3111.00
84_H88_D1.3071.00
6_V24_T1.2961.00
9_P34_D1.2931.00
41_L46_F1.2901.00
7_A32_T1.2851.00
77_A85_T1.2841.00
78_T81_R1.2841.00
13_S16_D1.2831.00
8_V62_V1.2701.00
17_A29_V1.2531.00
33_R38_A1.2361.00
15_H58_D1.2321.00
92_S108_T1.2281.00
15_H19_D1.2161.00
16_D19_D1.2001.00
82_A106_V1.1881.00
60_I65_A1.1611.00
56_P59_E1.1601.00
45_D67_S1.1491.00
30_V102_L1.1401.00
12_A20_R1.1391.00
41_L62_V1.1291.00
28_S40_I1.1141.00
37_P102_L1.1001.00
43_E47_V1.0881.00
31_V66_A1.0781.00
35_D101_D1.0681.00
30_V95_P1.0621.00
20_R23_A1.0401.00
39_G66_A1.0341.00
37_P95_P1.0301.00
49_A65_A1.0241.00
93_H107_T1.0221.00
41_L65_A1.0031.00
79_A111_L1.0021.00
11_D61_P0.9981.00
43_E92_S0.9951.00
32_T38_A0.9861.00
18_A46_F0.9851.00
81_R85_T0.9791.00
98_D103_V0.9761.00
37_P70_L0.9701.00
6_V20_R0.9671.00
74_S98_D0.9601.00
27_G43_E0.9381.00
47_V92_S0.9311.00
40_I95_P0.9241.00
17_A21_M0.9191.00
85_T94_L0.9171.00
100_L103_V0.9101.00
71_E85_T0.9051.00
14_L65_A0.8961.00
6_V26_V0.8611.00
81_R84_H0.8481.00
9_P32_T0.8341.00
27_G108_T0.8171.00
92_S109_T0.8131.00
27_G92_S0.8081.00
36_N100_L0.8081.00
8_V20_R0.8061.00
28_S92_S0.8021.00
21_M29_V0.7831.00
9_P33_R0.7811.00
28_S105_I0.7711.00
36_N101_D0.7621.00
92_S107_T0.7531.00
97_A100_L0.7511.00
73_V85_T0.7421.00
77_A82_A0.7401.00
72_T100_L0.7341.00
16_D20_R0.7301.00
58_D61_P0.7231.00
97_A102_L0.7121.00
106_V111_L0.7091.00
86_L94_L0.7061.00
20_R29_V0.7041.00
87_R113_G0.6941.00
109_T113_G0.6851.00
43_E109_T0.6821.00
26_V29_V0.6801.00
26_V30_V0.6741.00
62_V66_A0.6731.00
79_A83_A0.6581.00
80_N84_H0.6541.00
96_V103_V0.6511.00
87_R90_G0.6481.00
46_F51_H0.6471.00
13_S61_P0.6441.00
63_Y68_R0.6431.00
57_F60_I0.6421.00
53_H60_I0.6341.00
49_A60_I0.6341.00
93_H105_I0.6331.00
46_F49_A0.6321.00
110_D113_G0.6321.00
30_V38_A0.6251.00
26_V107_T0.6241.00
32_T37_P0.6181.00
44_H92_S0.6091.00
15_H59_E0.6071.00
6_V29_V0.6061.00
32_T35_D0.6021.00
87_R109_T0.6001.00
38_A66_A0.5911.00
79_A114_V0.5891.00
83_A111_L0.5861.00
74_S100_L0.5841.00
55_R58_D0.5741.00
30_V105_I0.5721.00
108_T112_V0.5701.00
85_T88_D0.5691.00
28_S107_T0.5681.00
55_R60_I0.5631.00
83_A112_V0.5491.00
54_D58_D0.5441.00
74_S97_A0.5431.00
40_I93_H0.5431.00
10_A34_D0.5401.00
93_H108_T0.5371.00
22_L53_H0.5361.00
18_A41_L0.5351.00
63_Y66_A0.5271.00
112_V116_D0.5251.00
14_L49_A0.5241.00
109_T112_V0.5221.00
7_A35_D0.5201.00
14_L41_L0.5191.00
43_E48_A0.5181.00
107_T110_D0.5171.00
72_T95_P0.5171.00
22_L48_A0.5151.00
86_L91_V0.5141.00
37_P97_A0.5131.00
61_P65_A0.5051.00
79_A106_V0.5031.00
18_A43_E0.5021.00
70_L95_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l2bA 2 0.7956 99.8 0.294 Contact Map
3orgA 2 0.7883 99.8 0.308 Contact Map
2qrdG 1 0.9197 99.8 0.308 Contact Map
2o16A 2 0.9197 99.8 0.314 Contact Map
3t4nC 1 0.8686 99.8 0.314 Contact Map
2rc3A 3 0.854 99.8 0.316 Contact Map
4cooA 2 0.854 99.8 0.316 Contact Map
3fhmA 2 0.8613 99.8 0.32 Contact Map
2nycA 2 0.8175 99.8 0.323 Contact Map
3pc3A 2 0.8613 99.8 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.