Q9HNT8 - HALSA - GREMLIN Contacts

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Q9HNT8 - Inosine-5'-monophosphate dehydrogenase-like

UniProt:	Q9HNT8	Sequences: MTTAVVAVPADASLHDAADRMLATGVGSVVVTRDDNPAGILTEHDFVAAGHEHDRPFDEIPVYAAASRPLETVSLSATANRAAHTLRDAGVSHLPVADGLDLVGIVTTTDLVGVRDHLDADAEHALRERTAWEQTPD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	137 (114)
Sequences:	13392 (9894)
Seq/√Len:	926.6

ECOLI - KDSD IMDH GUTQ YFJD
BACSU - ACUB YLBB CCPN YHCV YKUL YTOI IMDH MGTE YRKA YHDT YQHB YUGS YHDP
HALSA - Q9HNT8 Q9HQD0 Q9HRK9 Q9HPF4 Q9HMW8 Q9HNB6 Q9HR38 IMDH Q9HPN8 Q9HRX1 Q9HHN9
SULSO - Q97U20 Q981B7 Q7LXN6 Q97V95 Q97U00 Q7LXY4 Q97VN1 Q97Z58 Q97VD7 Q97U50 Q97U23

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
12_A	16_D	2.797	1.00
77_A	81_R	2.350	1.00
73_V	96_V	2.313	1.00
71_E	89_A	2.271	1.00
73_V	77_A	2.254	1.00
75_L	98_D	2.216	1.00
28_S	93_H	2.177	1.00
10_A	63_Y	2.108	1.00
9_P	12_A	2.053	1.00
60_I	64_A	1.948	1.00
75_L	103_V	1.895	1.00
17_A	62_V	1.849	1.00
74_S	77_A	1.828	1.00
61_P	64_A	1.822	1.00
8_V	12_A	1.751	1.00
10_A	38_A	1.689	1.00
8_V	17_A	1.668	1.00
30_V	37_P	1.623	1.00
8_V	31_V	1.614	1.00
11_D	63_Y	1.607	1.00
8_V	29_V	1.533	1.00
73_V	82_A	1.523	1.00
95_P	102_L	1.505	1.00
20_R	24_T	1.491	1.00
82_A	94_L	1.460	1.00
17_A	41_L	1.452	1.00
85_T	89_A	1.438	1.00
19_D	23_A	1.434	1.00
33_R	36_N	1.428	1.00
98_D	101_D	1.426	1.00
10_A	33_R	1.423	1.00
71_E	91_V	1.412	1.00
72_T	97_A	1.318	1.00
73_V	94_L	1.311	1.00
84_H	88_D	1.307	1.00
6_V	24_T	1.296	1.00
9_P	34_D	1.293	1.00
41_L	46_F	1.290	1.00
7_A	32_T	1.285	1.00
77_A	85_T	1.284	1.00
78_T	81_R	1.284	1.00
13_S	16_D	1.283	1.00
8_V	62_V	1.270	1.00
17_A	29_V	1.253	1.00
33_R	38_A	1.236	1.00
15_H	58_D	1.232	1.00
92_S	108_T	1.228	1.00
15_H	19_D	1.216	1.00
16_D	19_D	1.200	1.00
82_A	106_V	1.188	1.00
60_I	65_A	1.161	1.00
56_P	59_E	1.160	1.00
45_D	67_S	1.149	1.00
30_V	102_L	1.140	1.00
12_A	20_R	1.139	1.00
41_L	62_V	1.129	1.00
28_S	40_I	1.114	1.00
37_P	102_L	1.100	1.00
43_E	47_V	1.088	1.00
31_V	66_A	1.078	1.00
35_D	101_D	1.068	1.00
30_V	95_P	1.062	1.00
20_R	23_A	1.040	1.00
39_G	66_A	1.034	1.00
37_P	95_P	1.030	1.00
49_A	65_A	1.024	1.00
93_H	107_T	1.022	1.00
41_L	65_A	1.003	1.00
79_A	111_L	1.002	1.00
11_D	61_P	0.998	1.00
43_E	92_S	0.995	1.00
32_T	38_A	0.986	1.00
18_A	46_F	0.985	1.00
81_R	85_T	0.979	1.00
98_D	103_V	0.976	1.00
37_P	70_L	0.970	1.00
6_V	20_R	0.967	1.00
74_S	98_D	0.960	1.00
27_G	43_E	0.938	1.00
47_V	92_S	0.931	1.00
40_I	95_P	0.924	1.00
17_A	21_M	0.919	1.00
85_T	94_L	0.917	1.00
100_L	103_V	0.910	1.00
71_E	85_T	0.905	1.00
14_L	65_A	0.896	1.00
6_V	26_V	0.861	1.00
81_R	84_H	0.848	1.00
9_P	32_T	0.834	1.00
27_G	108_T	0.817	1.00
92_S	109_T	0.813	1.00
27_G	92_S	0.808	1.00
36_N	100_L	0.808	1.00
8_V	20_R	0.806	1.00
28_S	92_S	0.802	1.00
21_M	29_V	0.783	1.00
9_P	33_R	0.781	1.00
28_S	105_I	0.771	1.00
36_N	101_D	0.762	1.00
92_S	107_T	0.753	1.00
97_A	100_L	0.751	1.00
73_V	85_T	0.742	1.00
77_A	82_A	0.740	1.00
72_T	100_L	0.734	1.00
16_D	20_R	0.730	1.00
58_D	61_P	0.723	1.00
97_A	102_L	0.712	1.00
106_V	111_L	0.709	1.00
86_L	94_L	0.706	1.00
20_R	29_V	0.704	1.00
87_R	113_G	0.694	1.00
109_T	113_G	0.685	1.00
43_E	109_T	0.682	1.00
26_V	29_V	0.680	1.00
26_V	30_V	0.674	1.00
62_V	66_A	0.673	1.00
79_A	83_A	0.658	1.00
80_N	84_H	0.654	1.00
96_V	103_V	0.651	1.00
87_R	90_G	0.648	1.00
46_F	51_H	0.647	1.00
13_S	61_P	0.644	1.00
63_Y	68_R	0.643	1.00
57_F	60_I	0.642	1.00
53_H	60_I	0.634	1.00
49_A	60_I	0.634	1.00
93_H	105_I	0.633	1.00
46_F	49_A	0.632	1.00
110_D	113_G	0.632	1.00
30_V	38_A	0.625	1.00
26_V	107_T	0.624	1.00
32_T	37_P	0.618	1.00
44_H	92_S	0.609	1.00
15_H	59_E	0.607	1.00
6_V	29_V	0.606	1.00
32_T	35_D	0.602	1.00
87_R	109_T	0.600	1.00
38_A	66_A	0.591	1.00
79_A	114_V	0.589	1.00
83_A	111_L	0.586	1.00
74_S	100_L	0.584	1.00
55_R	58_D	0.574	1.00
30_V	105_I	0.572	1.00
108_T	112_V	0.570	1.00
85_T	88_D	0.569	1.00
28_S	107_T	0.568	1.00
55_R	60_I	0.563	1.00
83_A	112_V	0.549	1.00
54_D	58_D	0.544	1.00
74_S	97_A	0.543	1.00
40_I	93_H	0.543	1.00
10_A	34_D	0.540	1.00
93_H	108_T	0.537	1.00
22_L	53_H	0.536	1.00
18_A	41_L	0.535	1.00
63_Y	66_A	0.527	1.00
112_V	116_D	0.525	1.00
14_L	49_A	0.524	1.00
109_T	112_V	0.522	1.00
7_A	35_D	0.520	1.00
14_L	41_L	0.519	1.00
43_E	48_A	0.518	1.00
107_T	110_D	0.517	1.00
72_T	95_P	0.517	1.00
22_L	48_A	0.515	1.00
86_L	91_V	0.514	1.00
37_P	97_A	0.513	1.00
61_P	65_A	0.505	1.00
79_A	106_V	0.503	1.00
18_A	43_E	0.502	1.00
70_L	95_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l2bA	2	0.7956	99.8	0.294	Contact Map
3orgA	2	0.7883	99.8	0.308	Contact Map
2qrdG	1	0.9197	99.8	0.308	Contact Map
2o16A	2	0.9197	99.8	0.314	Contact Map
3t4nC	1	0.8686	99.8	0.314	Contact Map
2rc3A	3	0.854	99.8	0.316	Contact Map
4cooA	2	0.854	99.8	0.316	Contact Map
3fhmA	2	0.8613	99.8	0.32	Contact Map
2nycA	2	0.8175	99.8	0.323	Contact Map
3pc3A	2	0.8613	99.8	0.323	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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