GREMLIN Database
ATGT - tRNA-guanine(15) transglycosylase
UniProt: Q9HNT1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 491 (460)
Sequences: 209 (163)
Seq/√Len: 7.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_V24_A6.1671.00
279_C284_C5.0980.99
277_F289_P4.3130.98
137_R141_A3.8390.96
146_T149_Q3.7900.96
281_C284_C3.6380.94
211_E348_A3.5860.94
8_G18_E3.5140.93
183_H186_G3.4380.93
276_Y320_K3.0950.88
29_E320_K3.0330.87
205_R208_D2.9970.86
260_D300_R2.9520.85
24_A89_A2.8230.82
99_L130_P2.7200.80
96_S99_L2.6790.79
252_A312_S2.6260.77
163_L190_D2.6210.77
274_L321_Q2.6150.77
217_K226_V2.5530.75
213_V320_K2.5450.75
201_M209_M2.5420.75
14_A241_A2.4910.73
241_A319_V2.4510.72
124_G162_M2.4370.72
100_A196_A2.3820.70
40_N65_I2.3760.69
55_A313_F2.3590.69
224_A319_V2.3580.69
18_E27_T2.3410.68
346_Y350_L2.3250.68
130_P255_I2.2750.66
214_L320_K2.2720.66
16_I320_K2.2690.66
204_Y339_H2.2500.65
96_S130_P2.1960.63
9_A16_I2.1620.62
137_R175_D2.1350.61
126_P151_L2.1040.60
91_M165_N2.0840.59
217_K229_F2.0500.57
177_R199_P2.0480.57
74_R78_E2.0390.57
242_A255_I2.0370.57
331_L335_R2.0100.56
149_Q201_M2.0000.56
97_F193_P1.9970.55
34_M57_L1.9900.55
166_A189_L1.9720.54
109_T153_L1.9280.53
71_L83_M1.9210.52
243_L320_K1.9040.52
51_D87_D1.8870.51
133_P199_P1.8720.50
21_V346_Y1.8690.50
100_A255_I1.8230.48
177_R216_A1.8130.48
220_L331_L1.7940.47
237_F312_S1.7930.47
139_Q143_E1.7890.47
281_C330_E1.7820.47
177_R196_A1.7710.46
97_F125_T1.7620.46
62_S65_I1.7590.46
80_L90_I1.7100.44
91_M121_S1.6880.43
320_K378_P1.6870.43
315_E335_R1.6740.43
163_L191_L1.6650.42
262_Y284_C1.6640.42
225_P378_P1.6550.42
228_L240_A1.6500.42
277_F295_M1.6360.41
100_A130_P1.6260.41
262_Y281_C1.6150.40
202_N329_M1.5950.39
226_V229_F1.5870.39
443_G447_A1.5780.39
96_S196_A1.5770.39
125_T165_N1.5570.38
76_L118_D1.5530.38
33_L194_V1.5510.38
262_Y279_C1.5470.38
130_P196_A1.5150.36
34_M171_A1.5090.36
29_E276_Y1.5070.36
79_G115_F1.5030.36
113_L327_T1.5020.36
133_P198_V1.4940.36
18_E90_I1.4800.35
67_S87_D1.4640.35
40_N68_D1.4610.34
316_I319_V1.4580.34
260_D297_A1.4580.34
280_D314_G1.4560.34
318_R322_A1.4550.34
279_C330_E1.4490.34
12_G125_T1.4450.34
168_V287_H1.4350.34
284_C326_G1.4210.33
58_L90_I1.4190.33
193_P197_V1.4190.33
12_G96_S1.4170.33
267_G331_L1.4000.32
24_A127_V1.3910.32
58_L80_L1.3890.32
284_C330_E1.3780.32
110_E153_L1.3770.32
155_E221_G1.3590.31
142_A156_T1.3590.31
299_D316_I1.3520.31
33_L312_S1.3500.31
140_A328_L1.3450.30
201_M256_Y1.3420.30
286_E325_S1.3410.30
34_M177_R1.3330.30
336_A377_R1.3330.30
252_A335_R1.3290.30
21_V89_A1.3280.30
67_S106_D1.3250.30
262_Y277_F1.3240.30
177_R197_V1.3240.30
262_Y276_Y1.3190.30
98_Q169_Q1.3090.29
281_C326_G1.2900.29
252_A263_L1.2850.28
271_L383_H1.2840.28
191_L247_L1.2820.28
227_H253_Y1.2760.28
193_P196_A1.2750.28
133_P177_R1.2690.28
425_L428_T1.2680.28
134_D205_R1.2670.28
128_D257_A1.2650.28
128_D249_D1.2650.28
249_D257_A1.2650.28
29_E325_S1.2600.28
441_R451_V1.2540.27
84_L154_A1.2540.27
265_V345_G1.2380.27
97_F199_P1.2380.27
8_G27_T1.2370.27
126_P167_P1.2310.27
178_E218_R1.2290.27
285_A288_S1.2240.26
165_N198_V1.2180.26
211_E357_E1.2130.26
206_Y386_R1.2100.26
130_P262_Y1.2080.26
58_L84_L1.2050.26
37_V295_M1.2030.26
65_I71_L1.1960.26
153_L451_V1.1950.26
97_F197_V1.1950.26
32_T85_G1.1920.26
181_G216_A1.1870.25
37_V58_L1.1850.25
447_A451_V1.1820.25
167_P229_F1.1780.25
435_T456_E1.1740.25
177_R198_V1.1740.25
47_S50_V1.1670.25
24_A346_Y1.1630.25
407_R458_N1.1590.25
360_D418_F1.1590.25
33_L349_L1.1560.24
442_A449_E1.1510.24
92_T169_Q1.1470.24
151_L407_R1.1430.24
54_G278_P1.1410.24
121_S165_N1.1370.24
314_G320_K1.1340.24
124_G361_P1.1310.24
136_D269_E1.1300.24
299_D421_Y1.1280.24
13_L416_P1.1270.24
396_D399_L1.1250.24
55_A252_A1.1190.23
71_L171_A1.1180.23
258_R350_L1.1180.23
82_E421_Y1.1090.23
349_L356_L1.1060.23
71_L193_P1.1060.23
42_I338_A1.1040.23
97_F238_A1.1000.23
93_D195_G1.0990.23
13_L426_A1.0950.23
14_A130_P1.0930.23
95_G195_G1.0870.22
235_M333_A1.0870.22
255_I264_T1.0840.22
320_K324_K1.0840.22
61_N169_Q1.0830.22
256_Y429_Y1.0830.22
386_R389_R1.0820.22
48_R185_Y1.0810.22
97_F177_R1.0800.22
174_P213_V1.0790.22
241_A320_K1.0730.22
71_L75_A1.0680.22
452_C462_A1.0670.22
287_H292_V1.0660.22
164_V177_R1.0660.22
283_V303_L1.0650.22
36_V93_D1.0520.21
343_L369_Y1.0500.21
169_Q232_G1.0490.21
433_A447_A1.0430.21
62_S364_K1.0220.21
196_A255_I1.0200.21
102_Y204_Y1.0110.20
97_F198_V1.0100.20
45_E270_H1.0050.20
129_I150_R1.0030.20
148_Q183_H0.9980.20
35_P232_G0.9960.20
455_A465_L0.9940.20
302_R306_E0.9920.20
315_E377_R0.9920.20
190_D306_E0.9850.20
74_R90_I0.9850.20
152_E183_H0.9850.20
36_V95_G0.9840.20
37_V84_L0.9810.20
449_E455_A0.9800.20
96_S193_P0.9790.20
171_A235_M0.9710.19
215_A432_T0.9700.19
244_G308_N0.9640.19
29_E378_P0.9630.19
34_M84_L0.9620.19
61_N92_T0.9590.19
37_V269_E0.9580.19
130_P281_C0.9570.19
97_F100_A0.9550.19
162_M190_D0.9550.19
70_D100_A0.9540.19
97_F206_Y0.9510.19
133_P193_P0.9450.19
28_V236_M0.9410.19
209_M421_Y0.9400.19
205_R240_A0.9400.19
40_N304_L0.9370.19
213_V258_R0.9360.19
102_Y261_R0.9360.19
142_A445_E0.9340.18
76_L168_V0.9320.18
166_A213_V0.9320.18
83_M237_F0.9320.18
213_V243_L0.9320.18
97_F133_P0.9280.18
136_D351_D0.9250.18
319_V387_L0.9250.18
148_Q152_E0.9250.18
444_Y452_C0.9210.18
36_V169_Q0.9200.18
15_R30_T0.9200.18
16_I29_E0.9190.18
227_H250_S0.9170.18
23_R334_A0.9160.18
103_G204_Y0.9150.18
14_A99_L0.9120.18
130_P242_A0.9100.18
133_P197_V0.9070.18
191_L362_A0.9030.18
262_Y304_L0.8990.18
198_V332_V0.8980.18
168_V325_S0.8980.18
109_T127_V0.8960.18
84_L264_T0.8950.18
67_S83_M0.8950.18
143_E196_A0.8940.18
49_F153_L0.8940.18
121_S231_A0.8930.18
75_A115_F0.8920.17
192_F220_L0.8920.17
339_H368_F0.8900.17
251_A255_I0.8900.17
279_C326_G0.8890.17
32_T398_L0.8890.17
391_D453_R0.8890.17
383_H431_L0.8880.17
382_R436_P0.8860.17
206_Y273_D0.8860.17
330_E419_G0.8820.17
94_S257_A0.8820.17
94_S249_D0.8820.17
94_S128_D0.8820.17
316_I385_Q0.8810.17
85_G353_S0.8770.17
95_G230_G0.8740.17
435_T441_R0.8740.17
165_N177_R0.8720.17
149_Q351_D0.8710.17
111_A293_R0.8710.17
93_D116_Q0.8700.17
19_L37_V0.8690.17
56_E215_A0.8690.17
64_I198_V0.8670.17
441_R445_E0.8670.17
106_D291_A0.8660.17
47_S73_E0.8650.17
193_P199_P0.8620.17
35_P93_D0.8600.17
16_I276_Y0.8550.17
442_A457_A0.8550.17
15_R31_P0.8540.17
165_N431_L0.8500.17
96_S100_A0.8490.17
189_L202_N0.8470.16
407_R415_L0.8460.16
69_D109_T0.8460.16
260_D295_M0.8450.16
22_P332_V0.8450.16
60_T102_Y0.8430.16
16_I345_G0.8410.16
63_Y92_T0.8390.16
252_A418_F0.8330.16
349_L408_Y0.8310.16
177_R193_P0.8310.16
130_P279_C0.8300.16
33_L425_L0.8290.16
19_L187_T0.8270.16
99_L113_L0.8260.16
61_N98_Q0.8260.16
46_P334_A0.8240.16
20_D295_M0.8240.16
414_V432_T0.8240.16
165_N197_V0.8230.16
83_M116_Q0.8220.16
34_M196_A0.8210.16
78_E406_H0.8200.16
45_E157_V0.8150.16
36_V98_Q0.8150.16
62_S306_E0.8130.16
449_E453_R0.8110.16
244_G307_H0.8100.16
119_I323_I0.8100.16
220_L267_G0.8100.16
38_N84_L0.8090.16
224_A365_D0.8080.16
92_T232_G0.8080.16
196_A247_L0.8070.16
95_G116_Q0.8050.16
9_A157_V0.8050.16
102_Y251_A0.8040.16
44_V125_T0.8040.16
20_D27_T0.8010.15
65_I75_A0.8010.15
333_A429_Y0.8000.15
113_L358_A0.8000.15
179_Q183_H0.7990.15
129_I143_E0.7980.15
68_D71_L0.7960.15
269_E274_L0.7950.15
36_V232_G0.7920.15
93_D230_G0.7890.15
92_T98_Q0.7890.15
60_T261_R0.7890.15
416_P419_G0.7890.15
407_R421_Y0.7890.15
178_E295_M0.7880.15
116_Q194_V0.7860.15
441_R452_C0.7850.15
406_H410_E0.7850.15
126_P146_T0.7790.15
338_A354_D0.7770.15
79_G332_V0.7740.15
6_E377_R0.7670.15
35_P95_G0.7660.15
11_D377_R0.7650.15
50_V208_D0.7650.15
459_P466_A0.7650.15
149_Q321_Q0.7640.15
16_I338_A0.7630.15
109_T269_E0.7620.15
100_A132_P0.7610.15
250_S253_Y0.7610.15
184_A263_L0.7590.15
102_Y233_H0.7590.15
113_L352_H0.7580.15
237_F316_I0.7580.15
336_A379_E0.7570.15
210_T243_L0.7560.15
409_D426_A0.7550.15
132_P139_Q0.7540.15
75_A193_P0.7540.15
152_E391_D0.7540.15
288_S421_Y0.7530.14
82_E358_A0.7510.14
102_Y169_Q0.7480.14
10_Q42_I0.7480.14
193_P238_A0.7480.14
115_F198_V0.7480.14
237_F252_A0.7470.14
9_A365_D0.7440.14
360_D382_R0.7440.14
302_R338_A0.7420.14
266_S350_L0.7420.14
120_G124_G0.7420.14
96_S255_I0.7410.14
281_C322_A0.7390.14
78_E288_S0.7380.14
64_I151_L0.7360.14
171_A333_A0.7360.14
170_G249_D0.7360.14
128_D170_G0.7360.14
170_G257_A0.7360.14
61_N232_G0.7360.14
357_E382_R0.7350.14
221_G414_V0.7330.14
57_L123_I0.7320.14
98_Q102_Y0.7300.14
206_Y312_S0.7300.14
130_P284_C0.7300.14
6_E11_D0.7290.14
276_Y407_R0.7270.14
267_G335_R0.7240.14
36_V92_T0.7230.14
60_T204_Y0.7210.14
115_F267_G0.7210.14
127_V189_L0.7200.14
108_D343_L0.7200.14
314_G325_S0.7190.14
110_E114_R0.7190.14
114_R194_V0.7180.14
79_G177_R0.7180.14
29_E163_L0.7120.14
29_E314_G0.7090.14
52_E90_I0.7090.14
98_Q195_G0.7080.14
14_A330_E0.7070.14
52_E354_D0.7070.14
82_E425_L0.7060.14
256_Y334_A0.7040.14
95_G169_Q0.7040.14
33_L212_A0.7030.14
156_T182_A0.7030.14
140_A364_K0.7020.14
112_I333_A0.7010.13
375_A433_A0.7000.13
107_T112_I0.6990.13
282_P310_H0.6980.13
366_A431_L0.6980.13
50_V286_E0.6970.13
155_E187_T0.6970.13
63_Y79_G0.6940.13
194_V312_S0.6940.13
100_A336_A0.6920.13
167_P180_A0.6910.13
165_N366_A0.6910.13
116_Q205_R0.6910.13
134_D304_L0.6900.13
168_V178_E0.6880.13
315_E339_H0.6880.13
202_N326_G0.6860.13
178_E182_A0.6860.13
90_I109_T0.6860.13
229_F253_Y0.6850.13
78_E82_E0.6840.13
407_R411_S0.6840.13
98_Q232_G0.6830.13
51_D58_L0.6810.13
448_A455_A0.6800.13
180_A184_A0.6790.13
390_L451_V0.6780.13
34_M365_D0.6780.13
70_D235_M0.6770.13
65_I80_L0.6770.13
97_F116_Q0.6760.13
295_M300_R0.6760.13
360_D379_E0.6740.13
185_Y221_G0.6740.13
147_T169_Q0.6740.13
192_F224_A0.6740.13
106_D458_N0.6720.13
455_A463_F0.6710.13
406_H456_E0.6690.13
99_L144_L0.6690.13
377_R418_F0.6680.13
213_V311_V0.6650.13
36_V195_G0.6630.13
173_Q386_R0.6630.13
150_R153_L0.6620.13
155_E394_G0.6620.13
393_D465_L0.6620.13
155_E457_A0.6600.13
384_H458_N0.6590.13
100_A193_P0.6590.13
12_G242_A0.6590.13
71_L197_V0.6590.13
224_A394_G0.6580.13
95_G98_Q0.6580.13
178_E219_G0.6570.13
353_S387_L0.6560.13
93_D169_Q0.6560.13
39_P233_H0.6550.13
116_Q121_S0.6540.13
179_Q408_Y0.6530.13
21_V209_M0.6520.13
95_G227_H0.6480.13
10_Q427_T0.6480.13
91_M102_Y0.6480.13
66_N280_D0.6480.13
34_M71_L0.6470.13
97_F196_A0.6470.13
362_A399_L0.6460.13
130_P379_E0.6460.13
399_L451_V0.6460.13
157_V187_T0.6460.13
125_T167_P0.6450.12
447_A459_P0.6420.12
31_P246_D0.6420.12
290_Q293_R0.6410.12
118_D393_D0.6400.12
8_G124_G0.6390.12
136_D161_D0.6390.12
454_L459_P0.6390.12
142_A394_G0.6380.12
204_Y251_A0.6360.12
33_L123_I0.6360.12
146_T191_L0.6360.12
394_G463_F0.6350.12
149_Q385_Q0.6340.12
164_V196_A0.6330.12
246_D308_N0.6320.12
193_P198_V0.6320.12
329_M383_H0.6320.12
54_G81_H0.6310.12
182_A388_D0.6300.12
130_P364_K0.6290.12
229_F243_L0.6290.12
394_G407_R0.6280.12
135_A220_L0.6280.12
206_Y278_P0.6270.12
126_P433_A0.6260.12
220_L335_R0.6250.12
94_S308_N0.6230.12
94_S244_G0.6230.12
211_E440_D0.6220.12
55_A317_R0.6220.12
354_D388_D0.6210.12
448_A463_F0.6200.12
165_N199_P0.6200.12
438_R448_A0.6200.12
53_F85_G0.6180.12
93_D227_H0.6180.12
86_F401_E0.6170.12
35_P98_Q0.6170.12
186_G285_A0.6160.12
258_R367_F0.6150.12
35_P230_G0.6150.12
48_R51_D0.6140.12
96_S125_T0.6140.12
262_Y416_P0.6140.12
116_Q199_P0.6130.12
72_R112_I0.6120.12
102_Y147_T0.6120.12
99_L196_A0.6120.12
448_A452_C0.6110.12
313_F317_R0.6110.12
372_A441_R0.6100.12
195_G230_G0.6100.12
140_A241_A0.6090.12
96_S143_E0.6080.12
421_Y458_N0.6080.12
337_H373_G0.6050.12
378_P429_Y0.6020.12
114_R137_R0.6000.12
189_L379_E0.6000.12
450_G458_N0.5990.12
138_E190_D0.5990.12
68_D428_T0.5970.12
78_E260_D0.5960.12
35_P169_Q0.5960.12
35_P92_T0.5940.12
213_V324_K0.5910.12
326_G330_E0.5900.12
396_D463_F0.5890.12
201_M243_L0.5880.12
29_E213_V0.5880.12
441_R453_R0.5860.11
7_V463_F0.5860.11
89_A318_R0.5850.11
211_E280_D0.5840.11
64_I199_P0.5830.11
170_G308_N0.5820.11
170_G244_G0.5820.11
383_H418_F0.5810.11
393_D397_V0.5810.11
281_C285_A0.5800.11
93_D232_G0.5790.11
39_P115_F0.5780.11
151_L447_A0.5770.11
109_T432_T0.5770.11
194_V243_L0.5760.11
119_I169_Q0.5750.11
168_V277_F0.5740.11
252_A367_F0.5730.11
173_Q314_G0.5730.11
54_G147_T0.5730.11
147_T261_R0.5730.11
421_Y455_A0.5720.11
75_A197_V0.5720.11
140_A283_V0.5710.11
138_E142_A0.5700.11
410_E460_D0.5670.11
79_G267_G0.5650.11
93_D229_F0.5640.11
93_D98_Q0.5640.11
183_H426_A0.5640.11
101_E319_V0.5620.11
102_Y250_S0.5610.11
318_R347_R0.5600.11
39_P60_T0.5590.11
91_M167_P0.5590.11
277_F329_M0.5590.11
7_V28_V0.5590.11
130_P264_T0.5580.11
50_V166_A0.5570.11
264_T364_K0.5560.11
92_T102_Y0.5560.11
45_E243_L0.5550.11
259_D346_Y0.5540.11
94_S195_G0.5520.11
258_R412_W0.5520.11
230_G250_S0.5520.11
38_N58_L0.5500.11
177_R247_L0.5500.11
415_L426_A0.5500.11
58_L178_E0.5490.11
452_C464_T0.5460.11
459_P463_F0.5460.11
293_R298_G0.5430.11
237_F327_T0.5430.11
89_A189_L0.5420.11
32_T313_F0.5420.11
32_T353_S0.5410.11
260_D399_L0.5400.11
63_Y267_G0.5380.11
168_V314_G0.5380.11
233_H256_Y0.5380.11
236_M304_L0.5380.11
38_N64_I0.5370.11
95_G257_A0.5370.11
95_G128_D0.5370.11
95_G249_D0.5370.11
381_H388_D0.5360.11
51_D424_A0.5330.11
80_L343_L0.5330.11
49_F347_R0.5310.11
290_Q356_L0.5300.11
13_L65_I0.5300.11
179_Q295_M0.5280.11
196_A206_Y0.5260.11
34_M199_P0.5260.11
218_R355_Q0.5260.11
395_D420_P0.5250.11
306_E334_A0.5240.11
60_T291_A0.5230.11
21_V127_V0.5230.11
78_E442_A0.5230.11
124_G408_Y0.5230.11
92_T121_S0.5220.10
115_F210_T0.5200.10
173_Q431_L0.5190.10
167_P231_A0.5190.10
184_A448_A0.5150.10
118_D162_M0.5140.10
18_E298_G0.5130.10
60_T233_H0.5120.10
46_P145_E0.5110.10
211_E353_S0.5100.10
262_Y364_K0.5090.10
283_V429_Y0.5080.10
106_D320_K0.5080.10
125_T193_P0.5070.10
36_V61_N0.5070.10
290_Q317_R0.5070.10
417_P436_P0.5050.10
63_Y232_G0.5040.10
130_P416_P0.5040.10
156_T272_D0.5030.10
29_E243_L0.5030.10
119_I315_E0.5020.10
13_L215_A0.5020.10
29_E225_P0.5010.10
110_E410_E0.5010.10
59_I102_Y0.5000.10
217_K354_D0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iq8A 2 0.947 100 0.336 Contact Map
4q8wA 2 0.6843 100 0.472 Contact Map
2ashA 3 0.6721 100 0.483 Contact Map
2q07A 1 0.2057 99.8 0.886 Contact Map
4oqvA 1 0.5377 88.5 0.971 Contact Map
1nvmA 2 0.6415 85.5 0.973 Contact Map
3vkjA 4 0.6191 83.2 0.973 Contact Map
3sgzA 4 0.5234 78.7 0.975 Contact Map
2qiwA 2 0.4297 77.2 0.975 Contact Map
1jubA 2 0.5418 74.3 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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