GREMLIN Database
Q9HNS9 - Uncharacterized protein
UniProt: Q9HNS9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 180 (168)
Sequences: 5915 (4209)
Seq/√Len: 324.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_E30_R3.1001.00
49_V77_L2.8741.00
54_T59_E2.5781.00
14_T26_R2.4531.00
89_A93_R2.4301.00
18_D23_V2.3971.00
106_T130_T2.3521.00
97_R103_E2.2731.00
12_A28_E2.0951.00
59_E152_P2.0921.00
75_R149_D2.0811.00
158_A162_D2.0801.00
156_L174_V2.0621.00
13_T25_R2.0621.00
15_T18_D2.0481.00
108_E130_T2.0381.00
87_S90_A2.0101.00
64_E147_R1.9581.00
59_E150_T1.9351.00
28_E36_E1.9351.00
26_R38_D1.9321.00
109_Q125_H1.9311.00
61_V150_T1.9311.00
112_T123_V1.9291.00
54_T150_T1.9231.00
25_R43_H1.8621.00
105_A131_D1.8291.00
43_H121_D1.8221.00
109_Q112_T1.7661.00
82_V91_A1.7581.00
159_A164_D1.7331.00
86_E94_R1.7221.00
30_R36_E1.7011.00
64_E149_D1.6981.00
105_A133_T1.6951.00
93_R107_I1.6731.00
13_T27_D1.6701.00
50_V92_A1.6311.00
65_E76_A1.6311.00
88_L125_H1.6071.00
19_C40_D1.6071.00
28_E38_D1.5891.00
56_D59_E1.5861.00
151_E159_A1.5831.00
11_T30_R1.5361.00
106_T131_D1.5301.00
152_P155_D1.5291.00
10_T68_Q1.5191.00
112_T125_H1.5141.00
27_D68_Q1.4571.00
155_D158_A1.4551.00
72_R166_R1.4131.00
89_A107_I1.3951.00
114_E166_R1.3871.00
51_L173_G1.3851.00
90_A93_R1.3531.00
91_A94_R1.3441.00
77_L173_G1.3341.00
61_V102_Y1.3321.00
103_E133_T1.3201.00
82_V88_L1.3121.00
26_R40_D1.3041.00
96_F104_P1.2991.00
113_Y172_L1.2751.00
15_T25_R1.2291.00
97_R135_T1.2281.00
78_P100_T1.2091.00
102_Y134_P1.1991.00
93_R97_R1.1751.00
103_E135_T1.1701.00
15_T23_V1.1581.00
151_E156_L1.1481.00
11_T36_E1.1411.00
70_V114_E1.1361.00
88_L127_F1.1301.00
70_V74_N1.1201.00
68_Q71_G1.1101.00
97_R139_T1.1061.00
113_Y126_Y1.1021.00
61_V148_V1.0991.00
160_V171_A1.0981.00
14_T28_E1.0831.00
52_G96_F1.0571.00
86_E91_A1.0501.00
116_A122_A1.0491.00
157_V161_R1.0441.00
109_Q127_F1.0361.00
158_A161_R1.0351.00
46_P82_V1.0121.00
64_E73_V0.9981.00
155_D159_A0.9921.00
66_W71_G0.9601.00
27_D41_Y0.9511.00
110_Y128_R0.9471.00
126_Y173_G0.9431.00
51_L177_H0.9381.00
74_N117_N0.9381.00
48_V92_A0.9281.00
54_T57_G0.9281.00
89_A109_Q0.8971.00
16_A24_I0.8971.00
32_P145_T0.8861.00
16_A26_R0.8811.00
47_A124_H0.8681.00
172_L175_L0.8601.00
104_P107_I0.8571.00
53_F128_R0.8561.00
51_L60_V0.8551.00
167_D170_T0.8471.00
55_P131_D0.8461.00
92_A107_I0.8451.00
22_F42_L0.8391.00
46_P123_V0.8341.00
67_R76_A0.8341.00
157_V174_V0.8311.00
50_V129_A0.8191.00
60_V177_H0.8191.00
107_I129_A0.8151.00
60_V77_L0.8111.00
10_T27_D0.8061.00
107_I127_F0.8031.00
62_L151_E0.7901.00
60_V174_V0.7841.00
17_Y24_I0.7811.00
93_R103_E0.7761.00
115_P119_I0.7721.00
53_F153_Y0.7701.00
42_L119_I0.7701.00
114_E123_V0.7671.00
54_T102_Y0.7641.00
51_L77_L0.7600.99
49_V126_Y0.7590.99
44_D122_A0.7560.99
159_A162_D0.7490.99
49_V124_H0.7470.99
23_V43_H0.7460.99
62_L149_D0.7420.99
62_L75_R0.7420.99
77_L174_V0.7350.99
140_L143_D0.7350.99
49_V169_R0.7350.99
55_P130_T0.7340.99
78_P96_F0.7330.99
41_Y68_Q0.7270.99
75_R151_E0.7230.99
104_P129_A0.7140.99
53_F60_V0.7080.99
10_T71_G0.7070.99
132_C135_T0.7030.99
63_I146_I0.7020.99
46_P125_H0.6960.99
73_V145_T0.6850.99
108_E128_R0.6850.99
62_L156_L0.6830.99
111_A176_Q0.6820.99
156_L160_V0.6800.99
116_A120_S0.6740.99
111_A172_L0.6730.99
113_Y168_G0.6720.99
160_V165_I0.6720.99
14_T38_D0.6680.99
24_I42_L0.6640.99
134_P137_S0.6550.98
53_F130_T0.6510.98
52_G128_R0.6500.98
106_T109_Q0.6460.98
97_R137_S0.6430.98
19_C26_R0.6420.98
137_S140_L0.6410.98
60_V153_Y0.6390.98
123_V166_R0.6360.98
64_E75_R0.6340.98
152_P157_V0.6330.98
52_G63_I0.6320.98
141_D144_E0.6280.98
104_P131_D0.6260.98
124_H169_R0.6250.98
153_Y157_V0.6250.98
52_G57_G0.6200.98
8_W29_T0.6190.98
92_A127_F0.6160.98
165_I170_T0.6160.98
139_T144_E0.6150.98
12_A15_T0.6140.98
13_T43_H0.6130.98
112_T166_R0.6110.98
31_L37_T0.6090.98
92_A96_F0.6010.97
15_T43_H0.6010.97
79_A169_R0.6010.97
11_T28_E0.5990.97
154_D157_V0.5950.97
131_D135_T0.5940.97
115_P168_G0.5920.97
46_P81_S0.5920.97
45_G81_S0.5910.97
47_A81_S0.5900.97
156_L165_I0.5880.97
53_F177_H0.5880.97
115_P120_S0.5850.97
60_V156_L0.5830.97
74_N114_E0.5830.97
48_V88_L0.5830.97
37_T143_D0.5820.97
89_A127_F0.5810.97
54_T61_V0.5800.97
52_G77_L0.5770.97
67_R118_G0.5760.97
55_P133_T0.5730.97
33_D145_T0.5710.96
93_R104_P0.5710.96
79_A118_G0.5670.96
113_Y171_A0.5650.96
10_T13_T0.5630.96
49_V79_A0.5580.96
135_T138_Q0.5580.96
50_V96_F0.5530.96
128_R176_Q0.5520.96
151_E155_D0.5520.96
75_R159_A0.5480.96
111_A126_Y0.5460.95
29_T37_T0.5460.95
50_V78_P0.5450.95
83_E91_A0.5450.95
155_D164_D0.5420.95
111_A163_D0.5380.95
59_E155_D0.5340.95
138_Q148_V0.5320.95
159_A165_I0.5320.95
16_A40_D0.5310.95
172_L176_Q0.5290.95
140_L144_E0.5270.95
111_A171_A0.5250.94
149_D159_A0.5240.94
21_G44_D0.5230.94
82_V125_H0.5220.94
170_T174_V0.5200.94
160_V174_V0.5200.94
87_S127_F0.5190.94
31_L141_D0.5160.94
61_V100_T0.5150.94
29_T68_Q0.5140.94
41_Y69_A0.5100.94
27_D71_G0.5080.93
44_D119_I0.5070.93
140_L146_I0.5060.93
44_D120_S0.5050.93
157_V160_V0.5040.93
88_L109_Q0.5030.93
44_D79_A0.5020.93
33_D143_D0.5020.93
137_S154_D0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g0sA 2 0.9944 100 0.286 Contact Map
2dscA 2 0.9667 100 0.297 Contact Map
1vhzA 2 0.9833 100 0.299 Contact Map
1mk1A 2 0.8778 100 0.354 Contact Map
3o6zA 2 0.9611 100 0.388 Contact Map
2yvpA 2 0.9556 100 0.4 Contact Map
1v8yA 2 0.8167 100 0.439 Contact Map
3q91A 2 0.7056 100 0.47 Contact Map
2w4eA 2 0.7222 99.9 0.531 Contact Map
2fvvA 1 0.75 99.9 0.558 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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