GREMLIN Database
Q9HNS7 - Uncharacterized protein
UniProt: Q9HNS7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 390 (340)
Sequences: 1532 (1083)
Seq/√Len: 58.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_L255_A6.1291.00
173_T176_A5.6791.00
272_A281_D4.7521.00
118_R169_V4.2621.00
313_L356_V4.0221.00
274_R281_D3.9201.00
206_A209_D3.9121.00
79_F168_A3.7611.00
234_L266_A3.6651.00
45_L61_A3.6021.00
305_A327_A3.5761.00
37_D224_G3.2831.00
35_P73_A3.2651.00
239_F277_L2.9591.00
245_R249_A2.9561.00
41_A215_D2.9061.00
303_S306_K2.8291.00
23_F267_H2.7741.00
117_D180_E2.7401.00
199_P203_A2.6961.00
20_I266_A2.6441.00
180_E207_H2.4991.00
272_A284_A2.4141.00
246_R283_E2.3481.00
26_L233_A2.2991.00
38_R217_Y2.2971.00
219_R249_A2.2531.00
342_T345_R2.1571.00
42_F74_V2.1531.00
312_A330_V2.1461.00
130_A133_D2.0941.00
261_A286_I1.9991.00
127_F178_V1.9641.00
154_L158_V1.9181.00
130_A134_A1.8931.00
48_H61_A1.8911.00
171_H256_H1.8551.00
76_S115_Y1.8551.00
218_Q221_T1.8501.00
171_H196_R1.8471.00
118_R305_A1.8040.99
263_A267_H1.7850.99
131_V154_L1.7770.99
226_V244_A1.7710.99
128_S185_L1.7680.99
113_F168_A1.7670.99
265_A285_G1.6870.99
74_V214_I1.6710.99
173_T196_R1.6670.99
117_D171_H1.6570.99
313_L373_R1.6570.99
268_A281_D1.6550.99
217_Y225_V1.6500.99
253_G256_H1.6060.99
223_V248_A1.5600.98
239_F245_R1.5430.98
114_V134_A1.5400.98
37_D254_N1.5040.98
324_T340_Q1.4950.98
68_G171_H1.4880.98
226_V248_A1.4650.98
149_A153_R1.4580.98
67_P196_R1.4520.97
255_A258_A1.4450.97
151_R182_L1.4450.97
146_S151_R1.4350.97
169_V173_T1.4260.97
240_T276_R1.4230.97
172_T175_A1.3980.97
202_A207_H1.3910.97
72_S256_H1.3870.97
223_V245_R1.3730.96
265_A277_L1.3670.96
196_R214_I1.3530.96
260_A263_A1.3510.96
122_T126_A1.3500.96
166_V281_D1.3490.96
229_R259_L1.3440.96
118_R127_F1.3430.96
180_E206_A1.3370.96
227_T241_Q1.3310.96
223_V227_T1.3310.96
205_T208_T1.3260.96
42_F77_A1.3160.95
52_A164_G1.3130.95
312_A315_D1.3110.95
374_V382_A1.3080.95
265_A281_D1.3050.95
203_A208_T1.2800.95
201_D211_D1.2780.95
254_N307_Q1.2740.95
196_R254_N1.2680.94
180_E184_A1.2660.94
193_A209_D1.2550.94
198_E254_N1.2510.94
299_P310_L1.2410.94
43_E47_D1.2400.94
321_G370_P1.2380.94
46_L81_R1.2360.94
45_L111_P1.2320.94
23_F270_D1.2260.93
44_R278_T1.2130.93
351_S356_V1.2120.93
151_R154_L1.2040.93
237_H241_Q1.2020.93
234_L239_F1.2000.93
217_Y256_H1.2000.93
318_A383_F1.1890.92
380_P384_R1.1880.92
38_R253_G1.1810.92
65_G70_G1.1770.92
324_T327_A1.1740.92
327_A331_T1.1690.92
268_A285_G1.1610.91
116_V131_V1.1550.91
39_G382_A1.1540.91
66_P198_E1.1530.91
141_P145_V1.1510.91
132_L154_L1.1450.91
279_D283_E1.1430.91
62_Y195_G1.1420.91
338_L342_T1.1410.91
323_V373_R1.1410.91
214_I254_N1.1370.90
340_Q344_T1.1370.90
246_R279_D1.1200.90
302_V355_I1.1030.89
214_I256_H1.1000.89
225_V263_A1.0980.89
224_G227_T1.0940.89
172_T176_A1.0880.88
246_R250_W1.0870.88
66_P259_L1.0840.88
68_G170_D1.0820.88
61_A192_L1.0790.88
72_S316_T1.0750.88
196_R256_H1.0740.88
69_A221_T1.0740.88
21_T232_L1.0730.88
49_F78_L1.0590.87
114_V165_V1.0580.87
226_V258_A1.0570.87
179_A193_A1.0530.87
300_L356_V1.0460.86
151_R181_L1.0420.86
118_R175_A1.0320.86
268_A288_D1.0300.86
381_T384_R1.0260.85
67_P243_H1.0230.85
323_V343_V1.0230.85
117_D254_N1.0200.85
61_A315_D1.0190.85
75_V194_V1.0190.85
206_A258_A1.0190.85
302_V350_L1.0160.85
217_Y253_G1.0150.85
362_T367_A1.0130.85
64_H211_D1.0080.84
251_S261_A1.0060.84
63_L192_L1.0060.84
196_R253_G1.0000.84
183_T186_P0.9990.84
50_S356_V0.9920.83
172_T193_A0.9860.83
69_A117_D0.9800.83
185_L189_A0.9770.82
324_T343_V0.9740.82
45_L74_V0.9720.82
118_R327_A0.9720.82
23_F51_P0.9710.82
243_H282_I0.9710.82
82_L307_Q0.9700.82
50_S85_H0.9680.82
121_A148_A0.9670.82
48_H212_L0.9660.82
62_Y128_S0.9650.82
40_P43_E0.9620.81
145_V149_A0.9610.81
248_A258_A0.9590.81
141_P144_G0.9560.81
238_A266_A0.9550.81
72_S171_H0.9490.80
67_P256_H0.9460.80
199_P202_A0.9380.80
36_S228_T0.9360.80
227_T230_A0.9330.79
19_L266_A0.9300.79
373_R381_T0.9290.79
338_L346_L0.9280.79
339_S345_R0.9240.79
68_G253_G0.9210.78
77_A299_P0.9170.78
41_A221_T0.9150.78
49_F327_A0.9150.78
242_Q245_R0.9150.78
207_H257_D0.9080.77
227_T231_S0.8990.77
22_D30_A0.8980.77
34_E228_T0.8920.76
341_S355_I0.8900.76
225_V255_A0.8890.76
269_A285_G0.8870.76
62_Y205_T0.8850.76
66_P195_G0.8830.75
248_A253_G0.8810.75
21_T25_P0.8740.75
87_T280_A0.8740.75
224_G300_L0.8690.74
344_T371_P0.8690.74
201_D209_D0.8660.74
127_F131_V0.8630.74
67_P352_G0.8620.74
178_V356_V0.8610.74
78_L244_A0.8610.74
250_W283_E0.8590.73
309_V313_L0.8570.73
222_L226_V0.8570.73
192_L315_D0.8560.73
201_D346_L0.8520.73
226_V229_R0.8500.73
40_P239_F0.8490.73
299_P382_A0.8450.72
309_V346_L0.8420.72
321_G340_Q0.8400.72
281_D285_G0.8390.72
125_F204_L0.8370.71
354_G369_R0.8370.71
48_H193_A0.8360.71
342_T346_L0.8340.71
83_A113_F0.8330.71
216_A260_A0.8330.71
136_V153_R0.8300.71
190_R262_L0.8290.71
153_R263_A0.8290.71
135_L312_A0.8290.71
132_L138_E0.8280.71
113_F131_V0.8280.71
220_Q238_A0.8250.70
282_I338_L0.8210.70
38_R229_R0.8200.70
247_I282_I0.8190.70
19_L22_D0.8180.70
122_T301_A0.8070.69
269_A281_D0.8060.69
255_A259_L0.8040.68
60_N64_H0.8030.68
253_G258_A0.7990.68
314_L379_A0.7990.68
140_V189_A0.7970.68
362_T368_G0.7970.68
23_F263_A0.7970.68
225_V256_H0.7950.68
234_L262_L0.7920.67
58_P190_R0.7920.67
170_D253_G0.7890.67
67_P206_A0.7880.67
151_R155_A0.7820.66
63_L225_V0.7810.66
42_F78_L0.7800.66
262_L285_G0.7780.66
272_A356_V0.7780.66
311_A314_L0.7770.66
238_A241_Q0.7730.65
60_N169_V0.7710.65
166_V190_R0.7680.65
321_G369_R0.7660.65
251_S258_A0.7630.64
72_S80_A0.7600.64
26_L32_I0.7580.64
204_L208_T0.7560.64
194_V216_A0.7540.63
73_A352_G0.7530.63
122_T191_W0.7520.63
243_H277_L0.7520.63
240_T243_H0.7480.63
124_P175_A0.7380.62
20_I234_L0.7370.62
132_L137_S0.7350.61
39_G380_P0.7310.61
38_R225_V0.7310.61
218_Q336_V0.7290.61
193_A247_I0.7280.61
18_A22_D0.7260.60
280_A319_T0.7260.60
129_H314_L0.7230.60
63_L356_V0.7190.60
319_T326_A0.7180.60
347_L358_R0.7170.60
49_F192_L0.7150.59
262_L277_L0.7130.59
377_R383_F0.7120.59
217_Y254_N0.7120.59
135_L192_L0.7110.59
45_L75_V0.7100.59
172_T347_L0.7090.59
217_Y229_R0.7080.59
56_A156_D0.7070.58
73_A245_R0.7070.58
62_Y200_S0.7040.58
243_H262_L0.7040.58
157_A178_V0.7030.58
277_L282_I0.7020.58
266_A269_A0.7010.58
206_A313_L0.7000.58
146_S194_V0.7000.58
259_L286_I0.7000.58
39_G224_G0.6990.58
146_S149_A0.6970.57
239_F262_L0.6970.57
65_G71_K0.6950.57
150_I158_V0.6950.57
44_R284_A0.6930.57
269_A277_L0.6910.57
116_V328_D0.6890.56
36_S73_A0.6890.56
29_V146_S0.6860.56
285_G344_T0.6830.56
169_V327_A0.6820.56
165_V340_Q0.6800.55
280_A283_E0.6770.55
38_R41_A0.6770.55
376_V381_T0.6760.55
357_E376_V0.6750.55
173_T214_I0.6750.55
65_G68_G0.6740.55
183_T205_T0.6720.55
182_L247_I0.6720.55
133_D356_V0.6720.55
36_S252_D0.6670.54
262_L282_I0.6660.54
75_V120_T0.6650.54
191_W331_T0.6620.54
222_L258_A0.6620.54
78_L285_G0.6620.54
138_E222_L0.6610.53
193_A206_A0.6570.53
131_V311_A0.6550.53
191_W343_V0.6550.53
21_T235_G0.6530.53
64_H199_P0.6530.53
379_A382_A0.6530.53
357_E374_V0.6520.52
165_V191_W0.6520.52
73_A216_A0.6510.52
156_D192_L0.6480.52
305_A338_L0.6470.52
170_D217_Y0.6470.52
306_K349_E0.6470.52
43_E269_A0.6440.52
63_L110_M0.6440.52
69_A214_I0.6430.51
316_T326_A0.6410.51
17_A24_E0.6410.51
130_A240_T0.6370.51
79_F113_F0.6370.51
116_V127_F0.6370.51
74_V201_D0.6360.51
35_P72_S0.6360.51
148_A174_T0.6350.51
196_R249_A0.6350.51
17_A270_D0.6330.50
123_T239_F0.6330.50
112_A163_T0.6310.50
42_F189_A0.6300.50
64_H197_S0.6300.50
210_R313_L0.6280.50
222_L274_R0.6260.50
33_T228_T0.6250.49
146_S355_I0.6220.49
294_V382_A0.6220.49
228_T231_S0.6210.49
54_D312_A0.6210.49
269_A273_G0.6210.49
211_D266_A0.6190.49
214_I225_V0.6190.49
221_T229_R0.6180.49
203_A243_H0.6180.49
80_A84_R0.6170.49
171_H195_G0.6150.48
41_A214_I0.6140.48
205_T209_D0.6080.48
146_S150_I0.6060.47
251_S259_L0.6050.47
166_V221_T0.6020.47
174_T338_L0.6010.47
67_P230_A0.6000.47
224_G274_R0.5990.47
257_D267_H0.5970.46
38_R256_H0.5960.46
74_V124_P0.5960.46
63_L340_Q0.5950.46
215_D367_A0.5950.46
243_H250_W0.5940.46
191_W278_T0.5940.46
276_R343_V0.5940.46
37_D74_V0.5930.46
40_P329_A0.5930.46
19_L270_D0.5920.46
83_A86_A0.5890.45
166_V262_L0.5880.45
36_S72_S0.5870.45
242_Q255_A0.5860.45
328_D332_A0.5850.45
29_V246_R0.5830.45
270_D377_R0.5800.44
311_A343_V0.5790.44
304_D308_R0.5790.44
80_A114_V0.5780.44
222_L253_G0.5780.44
26_L229_R0.5770.44
66_P349_E0.5770.44
47_D356_V0.5760.44
67_P197_S0.5760.44
131_V138_E0.5750.44
81_R84_R0.5740.44
143_H212_L0.5740.44
80_A166_V0.5730.44
229_R255_A0.5720.44
206_A247_I0.5720.44
74_V141_P0.5710.43
240_T333_T0.5710.43
178_V355_I0.5710.43
112_A134_A0.5700.43
45_L123_T0.5670.43
80_A282_I0.5650.43
117_D256_H0.5650.43
264_V267_H0.5640.43
64_H251_S0.5640.43
368_G381_T0.5640.43
377_R380_P0.5630.43
171_H182_L0.5620.42
210_R213_R0.5590.42
221_T228_T0.5580.42
179_A226_V0.5570.42
67_P254_N0.5560.42
47_D134_A0.5550.42
32_I37_D0.5540.42
309_V343_V0.5530.41
72_S257_D0.5530.41
303_S372_S0.5530.41
72_S225_V0.5530.41
83_A356_V0.5520.41
32_I229_R0.5510.41
196_R217_Y0.5500.41
166_V284_A0.5490.41
377_R381_T0.5490.41
378_F381_T0.5480.41
181_L185_L0.5470.41
40_P51_P0.5470.41
243_H279_D0.5450.41
136_V149_A0.5450.41
248_A357_E0.5450.41
271_S288_D0.5440.41
132_L136_V0.5440.41
328_D355_I0.5430.40
145_V158_V0.5430.40
167_V302_V0.5420.40
34_E380_P0.5400.40
329_A332_A0.5390.40
172_T237_H0.5390.40
42_F67_P0.5380.40
119_R174_T0.5380.40
373_R378_F0.5370.40
191_W247_I0.5360.40
380_P383_F0.5360.40
116_V177_P0.5340.39
272_A280_A0.5320.39
38_R248_A0.5320.39
69_A216_A0.5310.39
127_F182_L0.5310.39
121_A130_A0.5300.39
29_V57_L0.5300.39
27_S130_A0.5290.39
133_D166_V0.5290.39
165_V380_P0.5270.39
85_H272_A0.5270.39
306_K345_R0.5270.39
146_S288_D0.5260.39
299_P302_V0.5260.39
302_V340_Q0.5240.38
73_A183_T0.5230.38
254_N261_A0.5210.38
218_Q242_Q0.5210.38
147_T157_A0.5190.38
347_L378_F0.5180.38
379_A383_F0.5180.38
137_S143_H0.5170.38
160_A192_L0.5160.38
202_A211_D0.5160.38
128_S190_R0.5150.37
121_A128_S0.5130.37
20_I24_E0.5120.37
198_E303_S0.5120.37
179_A204_L0.5110.37
51_P61_A0.5090.37
78_L82_L0.5070.37
172_T253_G0.5060.37
128_S209_D0.5060.37
77_A80_A0.5060.37
125_F180_E0.5050.36
225_V229_R0.5050.36
229_R263_A0.5030.36
222_L229_R0.5030.36
170_D254_N0.5030.36
134_A310_L0.5020.36
200_S205_T0.5020.36
73_A121_A0.5020.36
167_V317_D0.5010.36
52_A190_R0.5000.36
195_G202_A0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbyA 1 0.8846 100 0.436 Contact Map
4xgcA 1 0.7462 100 0.437 Contact Map
2v1uA 1 0.9077 100 0.443 Contact Map
2qbyB 1 0.8872 100 0.465 Contact Map
1w5sA 1 0.8846 100 0.469 Contact Map
1fnnA 1 0.8718 100 0.512 Contact Map
4xgcD 1 0.8872 100 0.528 Contact Map
3te6A 1 0.6564 100 0.63 Contact Map
4xgcE 1 0.8051 100 0.653 Contact Map
2c9oA 3 0.6436 99.9 0.712 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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