Q9HNS7 - HALSA - GREMLIN Contacts

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Q9HNS7 - Uncharacterized protein

UniProt:	Q9HNS7	Sequences: MDLDARITRRQRRSTDAALITDFEPLSPVAHITEPSDRGPAFERLLDHFSPAFDGALPPNAYLHGPPGAGKSAVVSALFARLARHATGDAVIHTSTRAGTPQPSTPASAMPAFVYVDRRTATTPFAFSHAVLDALVSESVPTHGVSTAAIRDRLADAVAAHPTGVVVAVDHTTTAAPVAELLTALPDRARWLAVGRSEPSDAALTAHTDRDLRIDAYQRQTLVGVVTTRASLALGQHAFTQQHARRIAAWSDGNAHDALAALAVAAHAADSAGRSRLTDADIEAGIQDVPRGGVVLGRPLAVSDAKQRVLAALLDTDATHGSVTEAADAVTATPGVSLSQSTVTRLLYELSGDGIVERVRATTTDSAGRPPSRVAVRFAPTAFRRLRARA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	390 (340)
Sequences:	1532 (1083)
Seq/√Len:	58.8

HALSA - Q9HNS7 CDC6A CDC68 CDC64 CDC65 CDC66 CDC67 CDC69 CDC62
SULSO - CDC62 CDC61 CDC63

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
222_L	255_A	6.129	1.00
173_T	176_A	5.679	1.00
272_A	281_D	4.752	1.00
118_R	169_V	4.262	1.00
313_L	356_V	4.022	1.00
274_R	281_D	3.920	1.00
206_A	209_D	3.912	1.00
79_F	168_A	3.761	1.00
234_L	266_A	3.665	1.00
45_L	61_A	3.602	1.00
305_A	327_A	3.576	1.00
37_D	224_G	3.283	1.00
35_P	73_A	3.265	1.00
239_F	277_L	2.959	1.00
245_R	249_A	2.956	1.00
41_A	215_D	2.906	1.00
303_S	306_K	2.829	1.00
23_F	267_H	2.774	1.00
117_D	180_E	2.740	1.00
199_P	203_A	2.696	1.00
20_I	266_A	2.644	1.00
180_E	207_H	2.499	1.00
272_A	284_A	2.414	1.00
246_R	283_E	2.348	1.00
26_L	233_A	2.299	1.00
38_R	217_Y	2.297	1.00
219_R	249_A	2.253	1.00
342_T	345_R	2.157	1.00
42_F	74_V	2.153	1.00
312_A	330_V	2.146	1.00
130_A	133_D	2.094	1.00
261_A	286_I	1.999	1.00
127_F	178_V	1.964	1.00
154_L	158_V	1.918	1.00
130_A	134_A	1.893	1.00
48_H	61_A	1.891	1.00
171_H	256_H	1.855	1.00
76_S	115_Y	1.855	1.00
218_Q	221_T	1.850	1.00
171_H	196_R	1.847	1.00
118_R	305_A	1.804	0.99
263_A	267_H	1.785	0.99
131_V	154_L	1.777	0.99
226_V	244_A	1.771	0.99
128_S	185_L	1.768	0.99
113_F	168_A	1.767	0.99
265_A	285_G	1.687	0.99
74_V	214_I	1.671	0.99
173_T	196_R	1.667	0.99
117_D	171_H	1.657	0.99
313_L	373_R	1.657	0.99
268_A	281_D	1.655	0.99
217_Y	225_V	1.650	0.99
253_G	256_H	1.606	0.99
223_V	248_A	1.560	0.98
239_F	245_R	1.543	0.98
114_V	134_A	1.540	0.98
37_D	254_N	1.504	0.98
324_T	340_Q	1.495	0.98
68_G	171_H	1.488	0.98
226_V	248_A	1.465	0.98
149_A	153_R	1.458	0.98
67_P	196_R	1.452	0.97
255_A	258_A	1.445	0.97
151_R	182_L	1.445	0.97
146_S	151_R	1.435	0.97
169_V	173_T	1.426	0.97
240_T	276_R	1.423	0.97
172_T	175_A	1.398	0.97
202_A	207_H	1.391	0.97
72_S	256_H	1.387	0.97
223_V	245_R	1.373	0.96
265_A	277_L	1.367	0.96
196_R	214_I	1.353	0.96
260_A	263_A	1.351	0.96
122_T	126_A	1.350	0.96
166_V	281_D	1.349	0.96
229_R	259_L	1.344	0.96
118_R	127_F	1.343	0.96
180_E	206_A	1.337	0.96
227_T	241_Q	1.331	0.96
223_V	227_T	1.331	0.96
205_T	208_T	1.326	0.96
42_F	77_A	1.316	0.95
52_A	164_G	1.313	0.95
312_A	315_D	1.311	0.95
374_V	382_A	1.308	0.95
265_A	281_D	1.305	0.95
203_A	208_T	1.280	0.95
201_D	211_D	1.278	0.95
254_N	307_Q	1.274	0.95
196_R	254_N	1.268	0.94
180_E	184_A	1.266	0.94
193_A	209_D	1.255	0.94
198_E	254_N	1.251	0.94
299_P	310_L	1.241	0.94
43_E	47_D	1.240	0.94
321_G	370_P	1.238	0.94
46_L	81_R	1.236	0.94
45_L	111_P	1.232	0.94
23_F	270_D	1.226	0.93
44_R	278_T	1.213	0.93
351_S	356_V	1.212	0.93
151_R	154_L	1.204	0.93
237_H	241_Q	1.202	0.93
234_L	239_F	1.200	0.93
217_Y	256_H	1.200	0.93
318_A	383_F	1.189	0.92
380_P	384_R	1.188	0.92
38_R	253_G	1.181	0.92
65_G	70_G	1.177	0.92
324_T	327_A	1.174	0.92
327_A	331_T	1.169	0.92
268_A	285_G	1.161	0.91
116_V	131_V	1.155	0.91
39_G	382_A	1.154	0.91
66_P	198_E	1.153	0.91
141_P	145_V	1.151	0.91
132_L	154_L	1.145	0.91
279_D	283_E	1.143	0.91
62_Y	195_G	1.142	0.91
338_L	342_T	1.141	0.91
323_V	373_R	1.141	0.91
214_I	254_N	1.137	0.90
340_Q	344_T	1.137	0.90
246_R	279_D	1.120	0.90
302_V	355_I	1.103	0.89
214_I	256_H	1.100	0.89
225_V	263_A	1.098	0.89
224_G	227_T	1.094	0.89
172_T	176_A	1.088	0.88
246_R	250_W	1.087	0.88
66_P	259_L	1.084	0.88
68_G	170_D	1.082	0.88
61_A	192_L	1.079	0.88
72_S	316_T	1.075	0.88
196_R	256_H	1.074	0.88
69_A	221_T	1.074	0.88
21_T	232_L	1.073	0.88
49_F	78_L	1.059	0.87
114_V	165_V	1.058	0.87
226_V	258_A	1.057	0.87
179_A	193_A	1.053	0.87
300_L	356_V	1.046	0.86
151_R	181_L	1.042	0.86
118_R	175_A	1.032	0.86
268_A	288_D	1.030	0.86
381_T	384_R	1.026	0.85
67_P	243_H	1.023	0.85
323_V	343_V	1.023	0.85
117_D	254_N	1.020	0.85
61_A	315_D	1.019	0.85
75_V	194_V	1.019	0.85
206_A	258_A	1.019	0.85
302_V	350_L	1.016	0.85
217_Y	253_G	1.015	0.85
362_T	367_A	1.013	0.85
64_H	211_D	1.008	0.84
251_S	261_A	1.006	0.84
63_L	192_L	1.006	0.84
196_R	253_G	1.000	0.84
183_T	186_P	0.999	0.84
50_S	356_V	0.992	0.83
172_T	193_A	0.986	0.83
69_A	117_D	0.980	0.83
185_L	189_A	0.977	0.82
324_T	343_V	0.974	0.82
45_L	74_V	0.972	0.82
118_R	327_A	0.972	0.82
23_F	51_P	0.971	0.82
243_H	282_I	0.971	0.82
82_L	307_Q	0.970	0.82
50_S	85_H	0.968	0.82
121_A	148_A	0.967	0.82
48_H	212_L	0.966	0.82
62_Y	128_S	0.965	0.82
40_P	43_E	0.962	0.81
145_V	149_A	0.961	0.81
248_A	258_A	0.959	0.81
141_P	144_G	0.956	0.81
238_A	266_A	0.955	0.81
72_S	171_H	0.949	0.80
67_P	256_H	0.946	0.80
199_P	202_A	0.938	0.80
36_S	228_T	0.936	0.80
227_T	230_A	0.933	0.79
19_L	266_A	0.930	0.79
373_R	381_T	0.929	0.79
338_L	346_L	0.928	0.79
339_S	345_R	0.924	0.79
68_G	253_G	0.921	0.78
77_A	299_P	0.917	0.78
41_A	221_T	0.915	0.78
49_F	327_A	0.915	0.78
242_Q	245_R	0.915	0.78
207_H	257_D	0.908	0.77
227_T	231_S	0.899	0.77
22_D	30_A	0.898	0.77
34_E	228_T	0.892	0.76
341_S	355_I	0.890	0.76
225_V	255_A	0.889	0.76
269_A	285_G	0.887	0.76
62_Y	205_T	0.885	0.76
66_P	195_G	0.883	0.75
248_A	253_G	0.881	0.75
21_T	25_P	0.874	0.75
87_T	280_A	0.874	0.75
224_G	300_L	0.869	0.74
344_T	371_P	0.869	0.74
201_D	209_D	0.866	0.74
127_F	131_V	0.863	0.74
67_P	352_G	0.862	0.74
178_V	356_V	0.861	0.74
78_L	244_A	0.861	0.74
250_W	283_E	0.859	0.73
309_V	313_L	0.857	0.73
222_L	226_V	0.857	0.73
192_L	315_D	0.856	0.73
201_D	346_L	0.852	0.73
226_V	229_R	0.850	0.73
40_P	239_F	0.849	0.73
299_P	382_A	0.845	0.72
309_V	346_L	0.842	0.72
321_G	340_Q	0.840	0.72
281_D	285_G	0.839	0.72
125_F	204_L	0.837	0.71
354_G	369_R	0.837	0.71
48_H	193_A	0.836	0.71
342_T	346_L	0.834	0.71
83_A	113_F	0.833	0.71
216_A	260_A	0.833	0.71
136_V	153_R	0.830	0.71
190_R	262_L	0.829	0.71
153_R	263_A	0.829	0.71
135_L	312_A	0.829	0.71
132_L	138_E	0.828	0.71
113_F	131_V	0.828	0.71
220_Q	238_A	0.825	0.70
282_I	338_L	0.821	0.70
38_R	229_R	0.820	0.70
247_I	282_I	0.819	0.70
19_L	22_D	0.818	0.70
122_T	301_A	0.807	0.69
269_A	281_D	0.806	0.69
255_A	259_L	0.804	0.68
60_N	64_H	0.803	0.68
253_G	258_A	0.799	0.68
314_L	379_A	0.799	0.68
140_V	189_A	0.797	0.68
362_T	368_G	0.797	0.68
23_F	263_A	0.797	0.68
225_V	256_H	0.795	0.68
234_L	262_L	0.792	0.67
58_P	190_R	0.792	0.67
170_D	253_G	0.789	0.67
67_P	206_A	0.788	0.67
151_R	155_A	0.782	0.66
63_L	225_V	0.781	0.66
42_F	78_L	0.780	0.66
262_L	285_G	0.778	0.66
272_A	356_V	0.778	0.66
311_A	314_L	0.777	0.66
238_A	241_Q	0.773	0.65
60_N	169_V	0.771	0.65
166_V	190_R	0.768	0.65
321_G	369_R	0.766	0.65
251_S	258_A	0.763	0.64
72_S	80_A	0.760	0.64
26_L	32_I	0.758	0.64
204_L	208_T	0.756	0.64
194_V	216_A	0.754	0.63
73_A	352_G	0.753	0.63
122_T	191_W	0.752	0.63
243_H	277_L	0.752	0.63
240_T	243_H	0.748	0.63
124_P	175_A	0.738	0.62
20_I	234_L	0.737	0.62
132_L	137_S	0.735	0.61
39_G	380_P	0.731	0.61
38_R	225_V	0.731	0.61
218_Q	336_V	0.729	0.61
193_A	247_I	0.728	0.61
18_A	22_D	0.726	0.60
280_A	319_T	0.726	0.60
129_H	314_L	0.723	0.60
63_L	356_V	0.719	0.60
319_T	326_A	0.718	0.60
347_L	358_R	0.717	0.60
49_F	192_L	0.715	0.59
262_L	277_L	0.713	0.59
377_R	383_F	0.712	0.59
217_Y	254_N	0.712	0.59
135_L	192_L	0.711	0.59
45_L	75_V	0.710	0.59
172_T	347_L	0.709	0.59
217_Y	229_R	0.708	0.59
56_A	156_D	0.707	0.58
73_A	245_R	0.707	0.58
62_Y	200_S	0.704	0.58
243_H	262_L	0.704	0.58
157_A	178_V	0.703	0.58
277_L	282_I	0.702	0.58
266_A	269_A	0.701	0.58
206_A	313_L	0.700	0.58
146_S	194_V	0.700	0.58
259_L	286_I	0.700	0.58
39_G	224_G	0.699	0.58
146_S	149_A	0.697	0.57
239_F	262_L	0.697	0.57
65_G	71_K	0.695	0.57
150_I	158_V	0.695	0.57
44_R	284_A	0.693	0.57
269_A	277_L	0.691	0.57
116_V	328_D	0.689	0.56
36_S	73_A	0.689	0.56
29_V	146_S	0.686	0.56
285_G	344_T	0.683	0.56
169_V	327_A	0.682	0.56
165_V	340_Q	0.680	0.55
280_A	283_E	0.677	0.55
38_R	41_A	0.677	0.55
376_V	381_T	0.676	0.55
357_E	376_V	0.675	0.55
173_T	214_I	0.675	0.55
65_G	68_G	0.674	0.55
183_T	205_T	0.672	0.55
182_L	247_I	0.672	0.55
133_D	356_V	0.672	0.55
36_S	252_D	0.667	0.54
262_L	282_I	0.666	0.54
75_V	120_T	0.665	0.54
191_W	331_T	0.662	0.54
222_L	258_A	0.662	0.54
78_L	285_G	0.662	0.54
138_E	222_L	0.661	0.53
193_A	206_A	0.657	0.53
131_V	311_A	0.655	0.53
191_W	343_V	0.655	0.53
21_T	235_G	0.653	0.53
64_H	199_P	0.653	0.53
379_A	382_A	0.653	0.53
357_E	374_V	0.652	0.52
165_V	191_W	0.652	0.52
73_A	216_A	0.651	0.52
156_D	192_L	0.648	0.52
305_A	338_L	0.647	0.52
170_D	217_Y	0.647	0.52
306_K	349_E	0.647	0.52
43_E	269_A	0.644	0.52
63_L	110_M	0.644	0.52
69_A	214_I	0.643	0.51
316_T	326_A	0.641	0.51
17_A	24_E	0.641	0.51
130_A	240_T	0.637	0.51
79_F	113_F	0.637	0.51
116_V	127_F	0.637	0.51
74_V	201_D	0.636	0.51
35_P	72_S	0.636	0.51
148_A	174_T	0.635	0.51
196_R	249_A	0.635	0.51
17_A	270_D	0.633	0.50
123_T	239_F	0.633	0.50
112_A	163_T	0.631	0.50
42_F	189_A	0.630	0.50
64_H	197_S	0.630	0.50
210_R	313_L	0.628	0.50
222_L	274_R	0.626	0.50
33_T	228_T	0.625	0.49
146_S	355_I	0.622	0.49
294_V	382_A	0.622	0.49
228_T	231_S	0.621	0.49
54_D	312_A	0.621	0.49
269_A	273_G	0.621	0.49
211_D	266_A	0.619	0.49
214_I	225_V	0.619	0.49
221_T	229_R	0.618	0.49
203_A	243_H	0.618	0.49
80_A	84_R	0.617	0.49
171_H	195_G	0.615	0.48
41_A	214_I	0.614	0.48
205_T	209_D	0.608	0.48
146_S	150_I	0.606	0.47
251_S	259_L	0.605	0.47
166_V	221_T	0.602	0.47
174_T	338_L	0.601	0.47
67_P	230_A	0.600	0.47
224_G	274_R	0.599	0.47
257_D	267_H	0.597	0.46
38_R	256_H	0.596	0.46
74_V	124_P	0.596	0.46
63_L	340_Q	0.595	0.46
215_D	367_A	0.595	0.46
243_H	250_W	0.594	0.46
191_W	278_T	0.594	0.46
276_R	343_V	0.594	0.46
37_D	74_V	0.593	0.46
40_P	329_A	0.593	0.46
19_L	270_D	0.592	0.46
83_A	86_A	0.589	0.45
166_V	262_L	0.588	0.45
36_S	72_S	0.587	0.45
242_Q	255_A	0.586	0.45
328_D	332_A	0.585	0.45
29_V	246_R	0.583	0.45
270_D	377_R	0.580	0.44
311_A	343_V	0.579	0.44
304_D	308_R	0.579	0.44
80_A	114_V	0.578	0.44
222_L	253_G	0.578	0.44
26_L	229_R	0.577	0.44
66_P	349_E	0.577	0.44
47_D	356_V	0.576	0.44
67_P	197_S	0.576	0.44
131_V	138_E	0.575	0.44
81_R	84_R	0.574	0.44
143_H	212_L	0.574	0.44
80_A	166_V	0.573	0.44
229_R	255_A	0.572	0.44
206_A	247_I	0.572	0.44
74_V	141_P	0.571	0.43
240_T	333_T	0.571	0.43
178_V	355_I	0.571	0.43
112_A	134_A	0.570	0.43
45_L	123_T	0.567	0.43
80_A	282_I	0.565	0.43
117_D	256_H	0.565	0.43
264_V	267_H	0.564	0.43
64_H	251_S	0.564	0.43
368_G	381_T	0.564	0.43
377_R	380_P	0.563	0.43
171_H	182_L	0.562	0.42
210_R	213_R	0.559	0.42
221_T	228_T	0.558	0.42
179_A	226_V	0.557	0.42
67_P	254_N	0.556	0.42
47_D	134_A	0.555	0.42
32_I	37_D	0.554	0.42
309_V	343_V	0.553	0.41
72_S	257_D	0.553	0.41
303_S	372_S	0.553	0.41
72_S	225_V	0.553	0.41
83_A	356_V	0.552	0.41
32_I	229_R	0.551	0.41
196_R	217_Y	0.550	0.41
166_V	284_A	0.549	0.41
377_R	381_T	0.549	0.41
378_F	381_T	0.548	0.41
181_L	185_L	0.547	0.41
40_P	51_P	0.547	0.41
243_H	279_D	0.545	0.41
136_V	149_A	0.545	0.41
248_A	357_E	0.545	0.41
271_S	288_D	0.544	0.41
132_L	136_V	0.544	0.41
328_D	355_I	0.543	0.40
145_V	158_V	0.543	0.40
167_V	302_V	0.542	0.40
34_E	380_P	0.540	0.40
329_A	332_A	0.539	0.40
172_T	237_H	0.539	0.40
42_F	67_P	0.538	0.40
119_R	174_T	0.538	0.40
373_R	378_F	0.537	0.40
191_W	247_I	0.536	0.40
380_P	383_F	0.536	0.40
116_V	177_P	0.534	0.39
272_A	280_A	0.532	0.39
38_R	248_A	0.532	0.39
69_A	216_A	0.531	0.39
127_F	182_L	0.531	0.39
121_A	130_A	0.530	0.39
29_V	57_L	0.530	0.39
27_S	130_A	0.529	0.39
133_D	166_V	0.529	0.39
165_V	380_P	0.527	0.39
85_H	272_A	0.527	0.39
306_K	345_R	0.527	0.39
146_S	288_D	0.526	0.39
299_P	302_V	0.526	0.39
302_V	340_Q	0.524	0.38
73_A	183_T	0.523	0.38
254_N	261_A	0.521	0.38
218_Q	242_Q	0.521	0.38
147_T	157_A	0.519	0.38
347_L	378_F	0.518	0.38
379_A	383_F	0.518	0.38
137_S	143_H	0.517	0.38
160_A	192_L	0.516	0.38
202_A	211_D	0.516	0.38
128_S	190_R	0.515	0.37
121_A	128_S	0.513	0.37
20_I	24_E	0.512	0.37
198_E	303_S	0.512	0.37
179_A	204_L	0.511	0.37
51_P	61_A	0.509	0.37
78_L	82_L	0.507	0.37
172_T	253_G	0.506	0.37
128_S	209_D	0.506	0.37
77_A	80_A	0.506	0.37
125_F	180_E	0.505	0.36
225_V	229_R	0.505	0.36
229_R	263_A	0.503	0.36
222_L	229_R	0.503	0.36
170_D	254_N	0.503	0.36
134_A	310_L	0.502	0.36
200_S	205_T	0.502	0.36
73_A	121_A	0.502	0.36
167_V	317_D	0.501	0.36
52_A	190_R	0.500	0.36
195_G	202_A	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qbyA	1	0.8846	100	0.436	Contact Map
4xgcA	1	0.7462	100	0.437	Contact Map
2v1uA	1	0.9077	100	0.443	Contact Map
2qbyB	1	0.8872	100	0.465	Contact Map
1w5sA	1	0.8846	100	0.469	Contact Map
1fnnA	1	0.8718	100	0.512	Contact Map
4xgcD	1	0.8872	100	0.528	Contact Map
3te6A	1	0.6564	100	0.63	Contact Map
4xgcE	1	0.8051	100	0.653	Contact Map
2c9oA	3	0.6436	99.9	0.712	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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