GREMLIN Database
Q9HNS6 - Uncharacterized protein
UniProt: Q9HNS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (295)
Sequences: 130 (98)
Seq/√Len: 5.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_L127_A9.0811.00
231_G292_A5.4060.99
247_S268_T4.7200.97
86_V161_A3.1390.79
271_G274_G3.1000.79
153_A157_T3.0970.78
136_I160_I2.9980.76
81_A84_G2.8790.73
41_S76_V2.6290.66
173_P177_G2.5700.64
291_A331_V2.4620.60
87_A154_V2.4530.60
43_I252_V2.4230.59
132_L160_I2.3900.58
24_L289_V2.2650.53
32_F36_I2.2380.52
279_F288_A2.0570.46
140_V143_L2.0260.45
274_G315_G2.0160.45
81_A276_V1.9990.44
270_L299_S1.9830.44
32_F299_S1.9400.42
137_A149_N1.9230.42
299_S324_A1.8150.38
147_T152_V1.7820.37
28_A210_L1.7750.37
74_P300_A1.7720.37
226_F268_T1.7690.37
247_S264_T1.7570.36
128_V163_P1.7540.36
90_A130_G1.7510.36
75_I267_I1.7280.35
42_F322_A1.7100.35
223_G227_G1.7010.34
244_Y315_G1.6980.34
44_F47_F1.6930.34
76_V93_G1.6890.34
281_V331_V1.6650.33
94_T334_G1.6610.33
34_A125_V1.6540.33
47_F249_A1.6520.33
304_E308_R1.6390.32
55_L267_I1.6200.32
271_G288_A1.6100.32
39_L251_L1.6060.31
127_A225_I1.5760.31
228_V232_F1.5610.30
271_G315_G1.5580.30
263_V314_S1.5570.30
290_V294_C1.5570.30
145_I169_I1.5460.30
83_A133_G1.5450.30
131_A221_L1.5410.30
129_F157_T1.5400.30
306_G327_T1.5210.29
160_I217_T1.5190.29
144_G337_Q1.5060.29
48_V76_V1.5040.29
223_G300_A1.4770.28
87_A129_F1.4430.27
247_S253_F1.4400.27
168_P314_S1.4290.26
158_A210_L1.4200.26
36_I136_I1.4170.26
112_I116_F1.4080.26
101_P156_A1.3970.26
89_S272_A1.3880.25
103_G106_Y1.3770.25
50_L327_T1.3670.25
31_A225_I1.3590.25
53_E67_T1.3530.24
116_F267_I1.3500.24
62_L68_N1.3360.24
297_V331_V1.3330.24
244_Y270_L1.3210.24
48_V93_G1.3210.24
155_V306_G1.3200.24
41_S44_F1.3000.23
132_L283_A1.2920.23
157_T244_Y1.2820.23
101_P131_A1.2780.23
228_V289_V1.2770.23
119_K299_S1.2650.22
87_A248_A1.2630.22
101_P161_A1.2630.22
80_I306_G1.2620.22
38_A74_P1.2220.21
86_V101_P1.2150.21
84_G293_G1.2150.21
90_A316_T1.2140.21
223_G296_G1.2100.21
54_S213_Q1.2090.21
24_L257_D1.2020.21
44_F76_V1.1950.21
70_I89_S1.1940.21
302_V330_L1.1940.21
129_F163_P1.1870.20
289_V292_A1.1670.20
27_L225_I1.1640.20
233_L290_V1.1610.20
30_G33_G1.1600.20
112_I118_T1.1560.20
328_L331_V1.1540.20
302_V331_V1.1500.20
134_M157_T1.1450.20
42_F46_G1.1440.19
47_F80_I1.1410.19
28_A149_N1.1410.19
29_G33_G1.1400.19
87_A157_T1.1350.19
50_L166_G1.1340.19
114_Y318_V1.1320.19
299_S329_M1.1300.19
28_A31_A1.1270.19
129_F154_V1.1100.19
71_G153_A1.1020.19
263_V271_G1.0990.19
242_L307_E1.0960.18
79_H135_L1.0930.18
93_G316_T1.0930.18
243_G268_T1.0930.18
252_V268_T1.0910.18
68_N275_G1.0880.18
96_Y244_Y1.0860.18
163_P331_V1.0860.18
209_W304_E1.0840.18
124_A221_L1.0810.18
304_E314_S1.0730.18
221_L299_S1.0720.18
278_G288_A1.0700.18
274_G284_S1.0700.18
285_P331_V1.0590.18
60_G295_F1.0550.18
187_D247_S1.0480.17
236_Q312_S1.0450.17
23_L290_V1.0420.17
38_A85_G1.0410.17
248_A300_A1.0410.17
271_G291_A1.0400.17
130_G244_Y1.0380.17
44_F316_T1.0300.17
56_T84_G1.0260.17
25_T80_I1.0240.17
162_R325_I1.0210.17
252_V256_F1.0200.17
73_G82_F1.0190.17
78_P82_F1.0190.17
73_G78_P1.0190.17
132_L213_Q1.0190.17
66_L160_I1.0160.17
135_L139_V1.0120.17
264_T316_T1.0050.17
270_L300_A1.0050.17
127_A282_F1.0000.17
22_L68_N1.0000.17
304_E317_H0.9970.16
121_D263_V0.9920.16
117_G237_T0.9900.16
146_P237_T0.9860.16
32_F93_G0.9850.16
281_V284_S0.9850.16
21_V286_L0.9830.16
48_V71_G0.9800.16
147_T326_A0.9790.16
31_A34_A0.9720.16
280_S285_P0.9710.16
132_L336_F0.9700.16
115_A268_T0.9690.16
50_L245_G0.9680.16
77_G135_L0.9680.16
49_V245_G0.9670.16
233_L243_G0.9650.16
150_I249_A0.9640.16
77_G147_T0.9630.16
47_F222_I0.9570.16
271_G283_A0.9530.16
132_L136_I0.9530.16
306_G323_M0.9520.16
305_C331_V0.9500.16
152_V160_I0.9490.16
161_A273_V0.9490.16
28_A170_V0.9470.16
250_S316_T0.9460.16
137_A141_T0.9430.15
101_P118_T0.9410.15
76_V81_A0.9400.15
91_Y121_D0.9400.15
115_A222_I0.9320.15
302_V327_T0.9300.15
127_A252_V0.9290.15
203_R207_E0.9230.15
30_G37_G0.9170.15
245_G290_V0.9150.15
75_I302_V0.9150.15
272_A333_G0.9060.15
35_A121_D0.9020.15
111_N116_F0.9000.15
44_F54_S0.8980.15
230_A294_C0.8970.15
161_A277_L0.8940.15
106_Y225_I0.8930.15
140_V326_A0.8930.15
71_G99_L0.8920.15
129_F316_T0.8900.15
81_A131_A0.8880.15
36_I305_C0.8850.14
50_L161_A0.8840.14
45_T119_K0.8780.14
152_V292_A0.8750.14
274_G277_L0.8720.14
130_G266_H0.8660.14
31_A188_E0.8650.14
57_L169_I0.8620.14
139_V300_A0.8610.14
27_L31_A0.8610.14
245_G270_L0.8550.14
226_F230_A0.8540.14
38_A324_A0.8530.14
86_V135_L0.8490.14
44_F284_S0.8420.14
150_I222_I0.8410.14
30_G34_A0.8410.14
166_G266_H0.8360.14
85_G253_F0.8350.14
47_F150_I0.8340.14
223_G267_I0.8340.14
154_V157_T0.8290.14
84_G287_L0.8260.13
103_G165_F0.8210.13
242_L301_L0.8190.13
221_L276_V0.8190.13
66_L169_I0.8180.13
59_P62_L0.8150.13
267_I312_S0.8150.13
153_A330_L0.8110.13
41_S130_G0.8110.13
86_V136_I0.8060.13
32_F316_T0.8030.13
272_A288_A0.8020.13
43_I282_F0.7990.13
31_A127_A0.7980.13
157_T161_A0.7950.13
57_L231_G0.7900.13
83_A150_I0.7900.13
86_V93_G0.7900.13
139_V160_I0.7880.13
208_P307_E0.7840.13
35_A324_A0.7830.13
129_F244_Y0.7800.13
90_A154_V0.7760.13
209_W227_G0.7680.13
72_F105_D0.7680.13
85_G150_I0.7650.13
35_A263_V0.7650.13
143_L314_S0.7630.12
163_P260_N0.7620.12
29_G52_G0.7620.12
287_L294_C0.7570.12
307_E312_S0.7540.12
159_L169_I0.7540.12
31_A327_T0.7530.12
240_V276_V0.7500.12
168_P315_G0.7500.12
116_F124_A0.7470.12
71_G231_G0.7470.12
150_I256_F0.7440.12
75_I313_H0.7420.12
172_S327_T0.7420.12
242_L315_G0.7370.12
294_C302_V0.7370.12
28_A85_G0.7360.12
87_A90_A0.7350.12
42_F247_S0.7300.12
41_S156_A0.7270.12
302_V332_I0.7250.12
139_V293_G0.7250.12
56_T81_A0.7240.12
150_I188_E0.7230.12
206_T216_W0.7220.12
101_P164_V0.7190.12
147_T292_A0.7180.12
80_I303_G0.7140.12
106_Y207_E0.7120.12
281_V287_L0.7120.12
232_F269_L0.7120.12
74_P172_S0.7110.12
143_L164_V0.7100.12
83_A248_A0.7010.12
40_P43_I0.7000.12
47_F210_L0.6940.11
160_I280_S0.6900.11
154_V244_Y0.6880.11
128_V290_V0.6880.11
147_T318_V0.6860.11
41_S48_V0.6850.11
182_G225_I0.6840.11
245_G249_A0.6760.11
155_V289_V0.6720.11
107_H255_Q0.6710.11
155_V230_A0.6680.11
32_F76_V0.6660.11
70_I139_V0.6660.11
156_A291_A0.6660.11
223_G298_L0.6660.11
209_W213_Q0.6630.11
150_I237_T0.6580.11
28_A308_R0.6580.11
143_L149_N0.6570.11
140_V147_T0.6570.11
116_F218_G0.6520.11
214_Y219_V0.6510.11
66_L324_A0.6490.11
210_L238_D0.6490.11
159_L318_V0.6460.11
228_V293_G0.6460.11
59_P240_V0.6450.11
269_L278_G0.6430.11
209_W311_Y0.6430.11
145_I152_V0.6420.11
238_D272_A0.6400.11
243_G332_I0.6400.11
20_A62_L0.6400.11
240_V278_G0.6390.11
61_D143_L0.6360.11
38_A264_T0.6350.11
308_R314_S0.6350.11
172_S300_A0.6330.11
45_T71_G0.6330.11
137_A153_A0.6330.11
272_A309_I0.6320.11
117_G313_H0.6310.11
96_Y314_S0.6280.11
258_V314_S0.6280.11
161_A270_L0.6270.11
212_Q311_Y0.6250.11
84_G289_V0.6250.11
51_I150_I0.6250.11
107_H117_G0.6230.11
128_V294_C0.6230.11
308_R317_H0.6210.10
96_Y99_L0.6200.10
28_A106_Y0.6190.10
121_D227_G0.6180.10
42_F45_T0.6140.10
299_S328_L0.6140.10
156_A228_V0.6130.10
66_L152_V0.6130.10
55_L330_L0.6100.10
180_D183_P0.6100.10
156_A159_L0.6100.10
244_Y266_H0.6070.10
24_L261_F0.6040.10
209_W263_V0.6040.10
132_L267_I0.6010.10
269_L303_G0.6010.10
35_A222_I0.6010.10
125_V151_A0.6010.10
188_E225_I0.5990.10
134_M143_L0.5960.10
111_N280_S0.5950.10
235_L282_F0.5950.10
289_V299_S0.5950.10
121_D228_V0.5950.10
50_L55_L0.5930.10
284_S287_L0.5900.10
176_S180_D0.5890.10
143_L153_A0.5880.10
74_P232_F0.5820.10
293_G334_G0.5800.10
149_N245_G0.5760.10
24_L225_I0.5760.10
131_A287_L0.5750.10
96_Y104_W0.5730.10
326_A330_L0.5710.10
44_F93_G0.5690.10
134_M231_G0.5690.10
147_T329_M0.5680.10
77_G153_A0.5680.10
131_A233_L0.5670.10
61_D291_A0.5650.10
264_T267_I0.5650.10
76_V315_G0.5640.10
86_V299_S0.5630.10
128_V136_I0.5630.10
214_Y239_S0.5620.10
268_T290_V0.5600.10
86_V294_C0.5590.10
33_G80_I0.5580.10
208_P219_V0.5580.10
275_G280_S0.5570.10
42_F248_A0.5530.10
29_G46_G0.5530.10
70_I210_L0.5520.10
150_I293_G0.5500.10
299_S332_I0.5490.10
115_A214_Y0.5470.10
32_F56_T0.5450.10
117_G181_M0.5440.10
112_I207_E0.5430.10
44_F48_V0.5420.10
70_I84_G0.5420.10
59_P297_V0.5400.09
20_A102_D0.5370.09
167_Y216_W0.5370.09
173_P294_C0.5370.09
115_A263_V0.5360.09
210_L264_T0.5350.09
45_T72_F0.5350.09
53_E239_S0.5340.09
20_A23_L0.5330.09
164_V303_G0.5330.09
187_D221_L0.5320.09
157_T292_A0.5290.09
140_V153_A0.5290.09
127_A251_L0.5290.09
89_S131_A0.5280.09
153_A326_A0.5260.09
185_E305_C0.5230.09
43_I80_I0.5230.09
41_S275_G0.5220.09
50_L287_L0.5210.09
45_T83_A0.5210.09
21_V268_T0.5210.09
72_F92_A0.5200.09
146_P238_D0.5200.09
178_L287_L0.5190.09
164_V331_V0.5160.09
53_E269_L0.5160.09
120_P317_H0.5130.09
281_V291_A0.5120.09
80_I222_I0.5110.09
103_G113_Q0.5110.09
233_L300_A0.5110.09
186_R318_V0.5090.09
80_I328_L0.5090.09
167_Y219_V0.5080.09
106_Y324_A0.5080.09
120_P303_G0.5060.09
297_V301_L0.5030.09
43_I152_V0.5020.09
43_I255_Q0.5020.09
106_Y112_I0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m7xA 1 0.086 4.8 0.983 Contact Map
2loqA 1 0.1203 2.8 0.985 Contact Map
4lrtB 1 0.1633 2.1 0.986 Contact Map
2mmjA 1 0.0573 2 0.986 Contact Map
3j1zP 8 0.404 1.9 0.986 Contact Map
2mdfA 1 0.149 1.9 0.986 Contact Map
4od4A 1 0.5759 1.9 0.986 Contact Map
2l0eA 1 0.0888 1.5 0.987 Contact Map
3numA 3 0 1.4 0.987 Contact Map
4fdyA 1 0.1719 1.4 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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