GREMLIN Database
GLPK - Glycerol kinase
UniProt: Q9HNS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 510 (473)
Sequences: 12481 (8592)
Seq/√Len: 395.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
209_D219_R4.0841.00
111_R146_D3.8161.00
22_D26_D3.4841.00
18_F59_V3.3061.00
114_S146_D3.2621.00
235_G238_D2.9571.00
399_R493_Y2.8861.00
201_N204_D2.8521.00
439_D481_E2.8091.00
399_R403_A2.7991.00
127_K208_D2.7961.00
406_E438_T2.7531.00
33_E58_S2.7211.00
430_Q434_D2.6631.00
426_N478_R2.6271.00
38_H99_N2.6141.00
374_L386_I2.6131.00
466_S469_D2.5821.00
200_Y225_V2.5741.00
415_T441_A2.5731.00
31_T62_A2.5681.00
33_E62_A2.5631.00
227_P230_D2.5231.00
465_D469_D2.5191.00
98_H148_A2.4671.00
20_V63_G2.4191.00
53_W182_N2.4151.00
97_I151_L2.4121.00
346_V385_H2.3921.00
50_L182_N2.3911.00
206_E219_R2.3711.00
399_R490_D2.2711.00
90_D93_S2.2701.00
212_L219_R2.2651.00
201_N208_D2.2521.00
91_A168_G2.2281.00
335_N338_Q2.2241.00
334_N338_Q2.1921.00
186_E224_E2.1561.00
57_K240_D2.1531.00
253_L258_A2.0941.00
209_D213_E2.0861.00
9_I56_T2.0801.00
19_I450_A2.0791.00
180_I252_A2.0731.00
350_D385_H2.0191.00
483_E486_P1.9801.00
323_A390_T1.9581.00
15_G32_Y1.9511.00
114_S118_N1.9471.00
234_Y237_T1.9211.00
50_L95_R1.9111.00
184_T249_V1.9101.00
123_R126_E1.9011.00
382_R385_H1.8891.00
169_E187_H1.8891.00
406_E412_S1.8751.00
6_V458_G1.8721.00
444_E475_R1.8651.00
338_Q341_E1.8551.00
41_E44_W1.8531.00
36_E51_E1.8521.00
5_Y28_V1.8441.00
353_Y495_R1.8441.00
354_M374_L1.8341.00
279_S320_T1.8311.00
7_G60_V1.8191.00
418_V429_C1.8131.00
437_Q487_S1.8061.00
345_S384_A1.8011.00
493_Y497_E1.7881.00
250_T460_A1.7771.00
62_A66_A1.7751.00
11_Q16_T1.7651.00
7_G18_F1.7611.00
142_E146_D1.7531.00
188_I226_R1.7211.00
327_L390_T1.7171.00
441_A479_S1.7081.00
123_R210_W1.6911.00
127_K210_W1.6861.00
123_R127_K1.6841.00
234_Y238_D1.6651.00
233_V238_D1.6571.00
113_E117_E1.6551.00
94_G181_Y1.6501.00
233_V236_H1.6421.00
325_E329_D1.6381.00
434_D483_E1.6331.00
336_A339_T1.6201.00
226_R230_D1.6161.00
434_D486_P1.6141.00
5_Y20_V1.6061.00
439_D479_S1.6001.00
88_V144_L1.5871.00
110_S114_S1.5871.00
268_A286_G1.5831.00
90_D95_R1.5641.00
396_Y492_K1.5621.00
371_R378_T1.5551.00
270_D415_T1.5401.00
87_V175_I1.5401.00
88_V221_M1.5271.00
116_E121_I1.5241.00
403_A497_E1.4981.00
6_V463_Y1.4831.00
38_H51_E1.4641.00
403_A406_E1.4591.00
485_D488_E1.4571.00
48_D51_E1.4541.00
487_S490_D1.4421.00
63_G67_A1.4331.00
341_E345_S1.4251.00
31_T59_V1.4211.00
53_W57_K1.4131.00
29_A63_G1.3941.00
340_A344_S1.3891.00
122_E126_E1.3841.00
388_R392_E1.3821.00
354_M358_F1.3821.00
50_L54_E1.3801.00
427_F431_L1.3761.00
426_N442_R1.3721.00
31_T63_G1.3661.00
244_G247_V1.3661.00
444_E477_D1.3631.00
458_G464_W1.3611.00
29_A66_A1.3611.00
143_W147_E1.3531.00
426_N480_F1.3381.00
64_L71_A1.3221.00
178_W182_N1.3131.00
337_A340_A1.3131.00
239_P245_A1.3121.00
317_I397_Q1.3071.00
76_A457_A1.3071.00
9_I60_V1.3021.00
486_P489_A1.2991.00
342_L384_A1.2951.00
275_Y432_Q1.2911.00
70_D73_D1.2811.00
395_A431_L1.2781.00
83_R254_G1.2731.00
148_A151_L1.2701.00
180_I188_I1.2681.00
415_T439_D1.2661.00
191_V205_L1.2641.00
342_L345_S1.2631.00
339_T387_V1.2631.00
442_R480_F1.2561.00
395_A435_I1.2561.00
109_T113_E1.2531.00
271_A413_T1.2501.00
218_P221_M1.2491.00
111_R142_E1.2421.00
23_Q463_Y1.2391.00
361_L364_P1.2351.00
273_N432_Q1.2311.00
395_A432_Q1.2261.00
437_Q489_A1.2231.00
91_A171_L1.2211.00
424_K446_D1.2131.00
54_E58_S1.2111.00
29_A67_A1.2111.00
16_T56_T1.2111.00
123_R214_E1.2101.00
343_A427_F1.1951.00
226_R234_Y1.1931.00
235_G239_P1.1881.00
354_M390_T1.1851.00
341_E344_S1.1851.00
20_V67_A1.1841.00
138_A215_F1.1831.00
85_T100_A1.1771.00
429_C480_F1.1741.00
124_I132_A1.1661.00
16_T55_N1.1611.00
233_V250_T1.1611.00
48_D99_N1.1601.00
253_L456_A1.1571.00
437_Q490_D1.1561.00
210_W213_E1.1541.00
9_I18_F1.1511.00
403_A493_Y1.1511.00
488_E491_S1.1491.00
431_L435_I1.1451.00
212_L222_L1.1431.00
352_V381_T1.1421.00
319_V323_A1.1381.00
267_D270_D1.1361.00
118_N214_E1.1361.00
342_L383_K1.1361.00
191_V225_V1.1351.00
94_G187_H1.1331.00
21_F27_V1.1311.00
236_H246_A1.1291.00
267_D471_R1.1281.00
319_V322_A1.1241.00
372_G377_M1.1201.00
61_T240_D1.1191.00
58_S62_A1.1191.00
56_T179_L1.1181.00
399_R436_I1.1171.00
377_M381_T1.1161.00
330_V386_I1.1161.00
400_D497_E1.1131.00
230_D234_Y1.1101.00
233_V237_T1.0981.00
287_E308_P1.0941.00
483_E487_S1.0881.00
180_I234_Y1.0831.00
203_T289_A1.0821.00
490_D494_G1.0811.00
336_A340_A1.0811.00
46_E99_N1.0811.00
5_Y73_D1.0801.00
120_K123_R1.0781.00
375_V499_A1.0781.00
120_K214_E1.0751.00
110_S113_E1.0721.00
88_V141_T1.0681.00
62_A65_S1.0641.00
21_F454_A1.0601.00
495_R498_D1.0591.00
20_V69_L1.0581.00
49_P87_V1.0581.00
64_L67_A1.0511.00
6_V461_V1.0451.00
88_V167_D1.0431.00
191_V200_Y1.0411.00
144_L151_L1.0401.00
267_D468_D1.0331.00
112_V132_A1.0321.00
52_I175_I1.0311.00
76_A461_V1.0301.00
56_T60_V1.0221.00
402_A436_I1.0201.00
270_D417_R1.0201.00
381_T385_H1.0191.00
459_L470_L1.0181.00
79_I180_I1.0171.00
111_R147_E1.0131.00
113_E116_E1.0101.00
455_Y470_L1.0031.00
98_H151_L1.0031.00
340_A426_N1.0021.00
396_Y435_I1.0021.00
269_G414_T1.0011.00
37_Q47_H0.9991.00
417_R441_A0.9991.00
77_I247_V0.9971.00
184_T235_G0.9971.00
271_A283_M0.9921.00
212_L217_I0.9911.00
111_R114_S0.9901.00
455_Y473_N0.9871.00
394_I422_A0.9821.00
114_S117_E0.9781.00
35_H55_N0.9771.00
51_E54_E0.9741.00
107_R143_W0.9681.00
22_D28_V0.9681.00
205_L227_P0.9661.00
399_R435_I0.9641.00
181_Y187_H0.9591.00
6_V76_A0.9581.00
57_K61_T0.9561.00
323_A354_M0.9561.00
31_T66_A0.9551.00
69_L73_D0.9541.00
250_T461_V0.9531.00
45_V104_Q0.9521.00
458_G463_Y0.9511.00
267_D414_T0.9491.00
64_L74_L0.9471.00
303_Q309_V0.9461.00
5_Y69_L0.9441.00
388_R427_F0.9391.00
76_A250_T0.9371.00
354_M389_A0.9321.00
267_D472_E0.9281.00
476_V479_S0.9281.00
95_R182_N0.9271.00
340_A343_A0.9251.00
138_A198_M0.9221.00
469_D472_E0.9211.00
124_I198_M0.9201.00
200_Y204_D0.9201.00
422_A428_L0.9121.00
272_K419_D0.9101.00
436_I439_D0.9101.00
281_Y402_A0.9081.00
18_F63_G0.9061.00
79_I179_L0.9051.00
415_T479_S0.9051.00
7_G20_V0.9021.00
72_D244_G0.9001.00
364_P367_D0.8991.00
233_V460_A0.8981.00
286_G310_Q0.8981.00
75_A461_V0.8921.00
171_L187_H0.8921.00
484_M487_S0.8901.00
377_M386_I0.8881.00
396_Y493_Y0.8831.00
167_D170_L0.8831.00
279_S398_T0.8821.00
333_I339_T0.8801.00
207_W222_L0.8801.00
21_F451_L0.8791.00
484_M488_E0.8791.00
177_S189_T0.8741.00
114_S142_E0.8731.00
7_G74_L0.8721.00
20_V74_L0.8721.00
484_M489_A0.8691.00
78_G250_T0.8671.00
80_T449_T0.8671.00
189_T194_A0.8661.00
142_E145_L0.8641.00
464_W470_L0.8631.00
416_L436_I0.8621.00
403_A407_A0.8601.00
126_E203_T0.8591.00
340_A425_N0.8591.00
348_T351_G0.8521.00
284_N310_Q0.8491.00
191_V227_P0.8451.00
205_L309_V0.8441.00
98_H144_L0.8411.00
89_W94_G0.8381.00
326_W329_D0.8341.00
11_Q179_L0.8281.00
33_E59_V0.8281.00
371_R375_V0.8251.00
61_T65_S0.8251.00
110_S147_E0.8221.00
342_L387_V0.8211.00
259_A419_D0.8181.00
374_L390_T0.8171.00
191_V303_Q0.8151.00
349_T353_Y0.8121.00
188_I224_E0.8121.00
459_L466_S0.8101.00
391_L431_L0.8071.00
459_L467_L0.8041.00
79_I183_L0.8031.00
112_V139_T0.8021.00
283_M405_M0.8001.00
346_V349_T0.8001.00
206_E224_E0.7991.00
213_E219_R0.7971.00
116_E132_A0.7961.00
51_E55_N0.7951.00
90_D169_E0.7951.00
138_A199_L0.7941.00
360_G364_P0.7941.00
338_Q342_L0.7921.00
280_F316_S0.7921.00
194_A207_W0.7901.00
206_E209_D0.7851.00
84_E196_R0.7851.00
74_L247_V0.7841.00
34_K325_E0.7841.00
491_S495_R0.7841.00
110_S146_D0.7831.00
21_F445_V0.7831.00
370_A373_T0.7821.00
237_T241_G0.7811.00
75_A463_Y0.7791.00
91_A166_R0.7781.00
83_R193_N0.7771.00
106_R133_D0.7771.00
86_T172_M0.7761.00
343_A346_V0.7751.00
233_V248_P0.7751.00
11_Q56_T0.7751.00
441_A476_V0.7701.00
189_T223_P0.7701.00
141_T199_L0.7691.00
27_V30_N0.7681.00
112_V134_A0.7681.00
402_A406_E0.7681.00
430_Q483_E0.7651.00
185_G238_D0.7601.00
40_P44_W0.7581.00
361_L367_D0.7561.00
189_T225_V0.7561.00
188_I234_Y0.7561.00
353_Y375_V0.7541.00
418_V442_R0.7541.00
351_G492_K0.7531.00
126_E291_S0.7521.00
273_N279_S0.7521.00
89_W171_L0.7521.00
488_E492_K0.7511.00
239_P246_A0.7501.00
200_Y205_L0.7501.00
89_W187_H0.7481.00
256_Q280_F0.7481.00
127_K201_N0.7481.00
418_V432_Q0.7451.00
263_Q272_K0.7451.00
344_S427_F0.7441.00
271_A416_L0.7431.00
404_A407_A0.7401.00
46_E107_R0.7401.00
60_V64_L0.7401.00
332_L338_Q0.7391.00
399_R497_E0.7381.00
33_E55_N0.7371.00
391_L425_N0.7361.00
210_W214_E0.7361.00
491_S494_G0.7361.00
30_N447_E0.7331.00
226_R251_A0.7321.00
327_L386_I0.7321.00
8_A78_G0.7311.00
167_D221_M0.7311.00
423_V446_D0.7311.00
205_L303_Q0.7301.00
49_P99_N0.7301.00
90_D168_G0.7281.00
83_R314_E0.7281.00
435_I489_A0.7281.00
273_N398_T0.7281.00
192_S302_F0.7261.00
358_F361_L0.7231.00
103_W278_G0.7231.00
90_D166_R0.7231.00
400_D493_Y0.7211.00
71_A74_L0.7191.00
395_A428_L0.7181.00
50_L178_W0.7161.00
346_V350_D0.7151.00
34_K328_E0.7151.00
285_T313_L0.7151.00
474_W477_D0.7141.00
54_E57_K0.7131.00
492_K495_R0.7121.00
13_T102_V0.7101.00
396_Y489_A0.7091.00
208_D211_L0.7071.00
263_Q419_D0.7061.00
35_H47_H0.7051.00
176_D252_A0.7031.00
320_T394_I0.7021.00
142_E216_D0.7011.00
16_T35_H0.6991.00
357_A361_L0.6981.00
87_V100_A0.6971.00
468_D471_R0.6971.00
486_P490_D0.6951.00
113_E369_R0.6941.00
192_S253_L0.6931.00
259_A449_T0.6911.00
423_V429_C0.6911.00
201_N206_E0.6901.00
367_D370_A0.6880.99
350_D381_T0.6870.99
50_L96_P0.6850.99
458_G462_G0.6830.99
124_I211_L0.6820.99
315_G401_I0.6820.99
327_L387_V0.6810.99
236_H239_P0.6780.99
76_A248_P0.6760.99
60_V241_G0.6750.99
337_A341_E0.6730.99
416_L438_T0.6700.99
180_I184_T0.6670.99
245_A248_P0.6660.99
64_L69_L0.6650.99
57_K182_N0.6650.99
151_L170_L0.6640.99
418_V440_L0.6640.99
351_G388_R0.6620.99
94_G168_G0.6610.99
265_C272_K0.6600.99
224_E230_D0.6600.99
332_L336_A0.6580.99
334_N339_T0.6550.99
333_I338_Q0.6540.99
481_E484_M0.6540.99
58_S61_T0.6540.99
81_N193_N0.6530.99
237_T242_F0.6520.99
56_T59_V0.6520.99
90_D97_I0.6520.99
171_L181_Y0.6510.99
473_N476_V0.6510.99
88_V97_I0.6500.99
6_V75_A0.6500.99
122_E125_R0.6500.99
273_N416_L0.6500.99
60_V63_G0.6480.99
178_W181_Y0.6470.99
11_Q55_N0.6460.99
331_D334_N0.6450.99
228_S252_A0.6450.99
490_D493_Y0.6440.99
128_T211_L0.6420.99
101_L107_R0.6390.99
243_L246_A0.6370.99
344_S347_D0.6370.99
50_L99_N0.6370.99
349_T385_H0.6370.99
317_I401_I0.6360.99
342_L346_V0.6360.99
360_G363_A0.6340.99
365_H400_D0.6300.99
415_T438_T0.6280.99
236_H248_P0.6280.99
227_P303_Q0.6280.99
89_W178_W0.6270.99
243_L247_V0.6270.99
21_F450_A0.6260.99
334_N383_K0.6250.99
237_T247_V0.6250.99
255_D277_T0.6250.99
416_L440_L0.6250.99
177_S187_H0.6240.99
372_G375_V0.6240.99
442_R477_D0.6230.99
23_Q75_A0.6210.99
392_E431_L0.6210.99
296_L299_T0.6200.99
176_D193_N0.6190.99
455_Y459_L0.6170.99
213_E218_P0.6160.99
89_W181_Y0.6150.99
145_L216_D0.6150.99
464_W473_N0.6140.99
467_L471_R0.6130.99
248_P461_V0.6130.99
344_S426_N0.6130.99
279_S432_Q0.6120.99
470_L473_N0.6120.99
109_T134_A0.6100.99
39_Y45_V0.6090.99
82_Q103_W0.6090.99
414_T438_T0.6080.99
141_T221_M0.6070.99
115_L215_F0.6070.99
57_K241_G0.6060.99
426_N430_Q0.6050.99
50_L53_W0.6040.99
142_E215_F0.6030.99
264_T474_W0.6020.99
359_T379_R0.6020.99
335_N340_A0.6010.99
241_G247_V0.6010.99
192_S228_S0.6000.99
254_G257_Q0.5980.99
439_D482_P0.5980.99
358_F364_P0.5980.99
49_P100_A0.5970.99
327_L330_V0.5960.99
388_R431_L0.5950.99
282_L312_A0.5940.99
331_D383_K0.5930.99
54_E240_D0.5930.99
494_G497_E0.5920.98
86_T137_S0.5920.98
57_K60_V0.5910.98
68_G71_A0.5900.98
27_V445_V0.5900.98
352_V386_I0.5900.98
199_L222_L0.5870.98
19_I27_V0.5870.98
132_A198_M0.5870.98
348_T385_H0.5860.98
429_C442_R0.5850.98
81_N175_I0.5840.98
358_F362_G0.5840.98
304_L307_E0.5840.98
320_T323_A0.5840.98
355_V373_T0.5830.98
26_D444_E0.5820.98
186_E226_R0.5820.98
94_G169_E0.5820.98
346_V384_A0.5800.98
238_D246_A0.5800.98
238_D241_G0.5800.98
351_G385_H0.5790.98
349_T388_R0.5790.98
264_T471_R0.5790.98
430_Q480_F0.5780.98
431_L489_A0.5770.98
325_E328_E0.5770.98
88_V170_L0.5770.98
108_T139_T0.5760.98
407_A497_E0.5760.98
265_C270_D0.5760.98
144_L148_A0.5760.98
168_G220_E0.5750.98
347_D350_D0.5740.98
87_V96_P0.5710.98
5_Y67_A0.5710.98
437_Q484_M0.5680.98
101_L144_L0.5680.98
261_F455_Y0.5670.98
115_L139_T0.5670.98
139_T198_M0.5670.98
275_Y418_V0.5660.98
213_E216_D0.5650.98
136_F196_R0.5650.98
343_A391_L0.5650.98
230_D233_V0.5650.98
324_I339_T0.5650.98
203_T288_D0.5640.98
262_G448_T0.5640.98
430_Q433_S0.5630.98
425_N428_L0.5620.98
74_L243_L0.5620.98
365_H500_V0.5610.98
197_T207_W0.5590.98
451_L455_Y0.5590.98
445_V451_L0.5590.98
166_R169_E0.5580.98
46_E98_H0.5580.98
354_M393_S0.5570.98
77_I237_T0.5570.98
256_Q274_T0.5570.98
130_L136_F0.5570.98
281_Y401_I0.5560.98
351_G392_E0.5550.98
344_S430_Q0.5550.98
355_V500_V0.5530.98
350_D380_G0.5520.98
394_I428_L0.5520.98
86_T144_L0.5510.98
468_D472_E0.5480.98
489_A492_K0.5480.98
229_S460_A0.5480.98
365_H497_E0.5480.98
107_R147_E0.5460.97
392_E396_Y0.5460.97
25_G473_N0.5450.97
233_V461_V0.5450.97
301_G311_Y0.5450.97
423_V442_R0.5450.97
336_A342_L0.5450.97
77_I249_V0.5440.97
321_G325_E0.5440.97
48_D54_E0.5440.97
466_S472_E0.5430.97
273_N281_Y0.5430.97
118_N142_E0.5420.97
260_L282_L0.5420.97
413_T438_T0.5380.97
370_A374_L0.5360.97
88_V98_H0.5360.97
340_A427_F0.5360.97
332_L335_N0.5330.97
279_S317_I0.5320.97
349_T392_E0.5320.97
459_L464_W0.5310.97
203_T206_E0.5300.97
336_A343_A0.5280.97
172_M197_T0.5280.97
192_S257_Q0.5270.97
285_T289_A0.5260.97
283_M413_T0.5250.97
6_V464_W0.5250.97
455_Y474_W0.5250.97
217_I222_L0.5240.97
83_R196_R0.5230.97
85_T102_V0.5220.97
228_S253_L0.5220.97
364_P368_G0.5220.97
450_A453_A0.5220.97
96_P99_N0.5210.97
274_T419_D0.5210.97
211_L215_F0.5190.97
433_S440_L0.5190.97
260_L301_G0.5180.97
14_T17_R0.5180.97
343_A387_V0.5180.97
89_W169_E0.5170.96
150_P166_R0.5170.96
80_T453_A0.5160.96
134_A368_G0.5160.96
45_V102_V0.5150.96
348_T388_R0.5150.96
13_T103_W0.5150.96
369_R372_G0.5140.96
171_L221_M0.5140.96
312_A316_S0.5130.96
398_T432_Q0.5120.96
281_Y398_T0.5100.96
459_L462_G0.5090.96
141_T172_M0.5080.96
30_N66_A0.5070.96
277_T322_A0.5070.96
432_Q436_I0.5060.96
360_G367_D0.5060.96
490_D497_E0.5060.96
270_D414_T0.5060.96
363_A366_W0.5050.96
355_V361_L0.5050.96
244_G248_P0.5040.96
237_T243_L0.5030.96
272_K282_L0.5020.96
255_D421_G0.5010.96
310_Q467_L0.5010.96
44_W101_L0.5010.96
369_R373_T0.5010.96
335_N339_T0.5010.96
343_A388_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ezwA 3 0.9667 100 0.144 Contact Map
3g25A 3 0.9667 100 0.152 Contact Map
3ll3A 2 0.9451 100 0.152 Contact Map
2d4wA 2 0.9647 100 0.155 Contact Map
2zf5O 3 0.9569 100 0.157 Contact Map
3h3nX 3 0.9686 100 0.157 Contact Map
3wxlA 2 0.9647 100 0.159 Contact Map
2dpnA 2 0.9569 100 0.16 Contact Map
2w40A 3 0.9647 100 0.175 Contact Map
2itmA 2 0.9196 100 0.178 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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