GREMLIN Database
Q9HNS4 - Glycerol-3-phosphate dehydrogenase
UniProt: Q9HNS4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 570 (475)
Sequences: 3787 (2506)
Seq/√Len: 115.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_V183_V5.1751.00
122_A136_A4.0691.00
35_Q169_T3.6671.00
5_P31_T3.6401.00
157_A162_A3.3321.00
186_E202_T3.2871.00
33_V185_V3.2551.00
169_T186_E3.1741.00
241_M271_L3.1011.00
454_E489_T3.1001.00
184_E204_V3.0441.00
292_D296_D3.0401.00
8_V207_A3.0351.00
8_V205_I2.9431.00
33_V170_V2.9381.00
17_A154_A2.8921.00
288_Q307_D2.8891.00
185_V205_I2.8811.00
184_E202_T2.8411.00
119_G123_R2.7021.00
171_T186_E2.6921.00
288_Q292_D2.6401.00
5_P163_R2.5871.00
18_G363_Y2.5741.00
172_D184_E2.5721.00
458_T463_V2.5691.00
168_S185_V2.5691.00
12_G32_L2.5441.00
211_V374_V2.5391.00
237_V294_V2.5231.00
169_T188_A2.5191.00
36_G40_H2.5121.00
292_D307_D2.5101.00
38_L166_T2.4701.00
493_D496_T2.4391.00
4_E208_D2.3791.00
249_V252_R2.3411.00
8_V31_T2.3411.00
446_R450_Q2.3281.00
121_E124_Q2.2151.00
20_A30_V2.1681.00
174_V182_G2.1281.00
69_I368_E2.0961.00
8_V33_V2.0861.00
449_I463_V2.0861.00
4_E206_R2.0651.00
101_Q104_L2.0431.00
101_Q105_A1.9961.00
10_V221_L1.9641.00
187_H199_E1.9601.00
35_Q282_E1.9591.00
31_T205_I1.9591.00
453_I487_L1.9571.00
342_A377_R1.9291.00
158_Q164_I1.9221.00
9_V19_V1.9081.00
299_A305_L1.8821.00
424_R451_D1.8791.00
251_N254_R1.8371.00
12_G34_E1.8351.00
232_R277_E1.8321.00
14_S153_N1.8221.00
214_A221_L1.8151.00
33_V205_I1.8111.00
427_S455_Q1.7541.00
446_R482_R1.7431.00
174_V204_V1.7391.00
21_R156_S1.7241.00
420_R467_T1.7161.00
155_A424_R1.7081.00
154_A164_I1.6991.00
95_D98_Q1.6911.00
249_V253_C1.6841.00
101_Q107_C1.6811.00
31_T165_E1.6761.00
115_K121_E1.6641.00
17_A150_V1.6581.00
7_V209_H1.6561.00
173_V210_V1.6271.00
39_T147_F1.6251.00
122_A133_V1.6241.00
355_I370_I1.6131.00
209_H374_V1.6051.00
171_T184_E1.6031.00
102_E105_A1.5991.00
453_I489_T1.5981.00
286_E313_S1.5891.00
15_T355_I1.5821.00
180_V210_V1.5711.00
121_E125_L1.5681.00
295_I307_D1.5601.00
107_C111_D1.5271.00
19_V371_T1.5181.00
115_K138_W1.5001.00
25_M385_R1.5001.00
373_H376_E1.4921.00
410_R413_V1.4881.00
252_R255_P1.4881.00
235_K276_E1.4821.00
353_T374_V1.4741.00
436_P446_R1.4701.00
437_T440_A1.4671.00
262_V269_C1.4641.00
165_E168_S1.4611.00
406_E426_G1.4601.00
165_E203_E1.4581.00
390_A394_S1.4561.00
174_V184_E1.4551.00
286_E291_V1.4511.00
33_V183_V1.4481.00
249_V254_R1.4421.00
243_T267_T1.4371.00
168_S203_E1.4331.00
251_N255_P1.4301.00
482_R485_N1.4251.00
374_V378_L1.4231.00
209_H378_L1.4091.00
237_V276_E1.4061.00
174_V181_V1.4011.00
118_S121_E1.3991.00
5_P29_G1.3871.00
95_D99_Y1.3831.00
29_G163_R1.3751.00
39_T150_V1.3721.00
6_H208_D1.3661.00
123_R131_D1.3641.00
38_L154_A1.3611.00
173_V180_V1.3571.00
295_I305_L1.3541.00
104_L108_E1.3491.00
320_L359_K1.3461.00
43_T150_V1.3411.00
22_D386_T1.3411.00
101_Q106_G1.3341.00
20_A157_A1.3341.00
25_M389_V1.3321.00
186_E200_G1.3321.00
291_V313_S1.3301.00
156_S160_H1.3231.00
185_V203_E1.3221.00
19_V211_V1.3201.00
291_V307_D1.3191.00
75_R84_E1.3161.00
295_I299_A1.3141.00
96_S99_Y1.3091.00
149_L360_L1.3091.00
25_M160_H1.3061.00
65_R69_I1.3021.00
235_K278_V1.3021.00
250_V255_P1.2870.99
92_R133_V1.2870.99
464_R470_T1.2830.99
22_D26_R1.2800.99
159_E424_R1.2800.99
175_V178_G1.2770.99
218_A231_V1.2710.99
52_S139_V1.2670.99
32_L154_A1.2660.99
232_R322_E1.2560.99
402_D406_E1.2530.99
450_Q488_H1.2520.99
62_A66_E1.2500.99
250_V254_R1.2490.99
248_T252_R1.2480.99
19_V213_A1.2440.99
20_A162_A1.2410.99
428_V447_A1.2350.99
14_S43_T1.2350.99
353_T370_I1.2330.99
221_L224_M1.2270.99
463_V483_L1.2220.99
173_V221_L1.2210.99
452_A463_V1.2170.99
427_S430_D1.2150.99
250_V253_C1.2100.99
171_T202_T1.2050.99
82_V142_A1.1970.99
436_P440_A1.1910.99
153_N363_Y1.1910.99
431_T450_Q1.1870.99
7_V23_L1.1830.99
107_C110_C1.1770.99
38_L164_I1.1740.99
222_G354_T1.1670.99
452_A458_T1.1660.99
66_E369_E1.1640.99
176_E182_G1.1620.99
403_Y407_F1.1550.99
176_E206_R1.1550.99
21_R153_N1.1510.99
225_A343_H1.1470.99
170_V183_V1.1430.99
440_A446_R1.1430.99
28_L375_C1.1420.99
86_G140_P1.1390.99
182_G206_R1.1380.99
420_R448_E1.1380.99
298_L305_L1.1370.99
280_D283_D1.1350.99
287_Q290_E1.1280.99
342_A353_T1.1260.99
172_D224_M1.1230.99
270_I314_F1.1170.99
145_D420_R1.1160.99
22_D384_C1.1120.98
240_V312_R1.1070.98
242_N268_T1.1020.98
84_E89_F1.0980.98
307_D310_T1.0980.98
117_L122_A1.0640.98
340_L370_I1.0610.98
236_G318_R1.0600.98
450_Q489_T1.0590.98
83_D143_A1.0470.98
33_V168_S1.0450.98
216_A317_V1.0440.98
12_G38_L1.0430.98
156_S159_E1.0410.98
235_K287_Q1.0390.98
94_E98_Q1.0340.98
101_Q111_D1.0330.98
460_L484_A1.0310.98
173_V224_M1.0260.97
340_L369_E1.0250.97
353_T373_H1.0240.97
86_G138_W1.0230.97
262_V298_L1.0230.97
249_V255_P1.0220.97
182_G204_V1.0200.97
23_L371_T1.0180.97
66_E365_M1.0180.97
15_T366_M1.0170.97
93_P98_Q1.0170.97
93_P96_S1.0130.97
372_D384_C1.0130.97
245_Q309_R1.0110.97
36_G41_G1.0090.97
323_P328_S1.0050.97
436_P439_C0.9960.97
209_H377_R0.9930.97
450_Q486_E0.9910.97
373_H377_R0.9890.97
464_R471_M0.9870.97
415_Q419_D0.9870.97
404_M407_F0.9870.97
118_S122_A0.9860.97
404_M411_S0.9850.97
74_L82_V0.9830.97
368_E387_A0.9790.97
97_E100_F0.9790.97
485_N488_H0.9790.97
59_S333_D0.9760.97
209_H353_T0.9710.96
105_A109_A0.9650.96
176_E181_V0.9630.96
5_P8_V0.9620.96
74_L149_L0.9610.96
71_N82_V0.9590.96
56_Y359_K0.9530.96
47_H263_V0.9460.96
105_A111_D0.9420.96
402_D405_T0.9410.96
122_A129_L0.9400.96
105_A108_E0.9270.95
6_H28_L0.9240.95
426_G430_D0.9230.95
374_V379_G0.9220.95
47_H261_I0.9160.95
450_Q454_E0.9150.95
394_S397_N0.9150.95
49_L143_A0.9150.95
78_A391_L0.9080.95
411_S415_Q0.9050.95
183_V207_A0.9020.95
17_A164_I0.8990.95
18_G153_N0.8960.94
368_E372_D0.8950.94
248_T254_R0.8940.94
24_A162_A0.8930.94
42_T216_A0.8930.94
306_D309_R0.8920.94
188_A198_T0.8870.94
84_E90_V0.8860.94
382_A385_R0.8830.94
90_V129_L0.8810.94
32_L164_I0.8800.94
123_R129_L0.8780.94
213_A355_I0.8780.94
172_D202_T0.8760.94
247_D252_R0.8730.94
245_Q262_V0.8730.94
154_A166_T0.8720.94
449_I480_A0.8680.93
102_E107_C0.8660.93
36_G167_H0.8630.93
225_A350_P0.8630.93
95_D100_F0.8610.93
91_K95_D0.8590.93
321_Y339_F0.8570.93
170_V221_L0.8570.93
75_R82_V0.8560.93
120_A124_Q0.8560.93
397_N400_L0.8540.93
80_H393_G0.8530.93
255_P300_E0.8520.93
187_H201_G0.8500.93
83_D419_D0.8500.93
64_A68_I0.8480.93
94_E99_Y0.8480.93
81_C152_A0.8460.93
10_V170_V0.8460.93
22_D367_A0.8450.92
425_A429_L0.8420.92
154_A158_Q0.8410.92
49_L261_I0.8390.92
66_E337_D0.8380.92
417_S428_V0.8360.92
474_C477_G0.8330.92
8_V210_V0.8320.92
375_C380_V0.8290.92
198_T201_G0.8280.92
492_Y496_T0.8280.92
486_E489_T0.8270.92
82_V89_F0.8240.92
239_T271_L0.8240.92
451_D455_Q0.8230.91
401_D404_M0.8210.91
107_C114_T0.8210.91
86_G89_F0.8170.91
63_S67_C0.8120.91
480_A484_A0.8090.91
97_E135_K0.8080.91
149_L153_N0.8080.91
323_P334_I0.8080.91
38_L457_G0.8070.91
378_L381_T0.8040.90
63_S359_K0.8030.90
117_L138_W0.8010.90
85_T143_A0.7980.90
41_G45_R0.7970.90
207_A210_V0.7960.90
70_E364_R0.7930.90
409_L414_A0.7910.90
169_T220_R0.7910.90
73_V77_I0.7900.90
78_A149_L0.7900.90
261_I273_T0.7890.90
187_H203_E0.7880.90
106_G111_D0.7860.89
55_R359_K0.7830.89
152_A391_L0.7820.89
274_T318_R0.7760.89
338_Y369_E0.7750.89
260_D297_E0.7730.89
242_N311_V0.7710.89
367_A384_C0.7690.88
61_Q337_D0.7690.88
262_V302_I0.7680.88
444_V467_T0.7680.88
278_V317_V0.7680.88
160_H389_V0.7680.88
446_R486_E0.7670.88
22_D368_E0.7660.88
96_S100_F0.7650.88
234_S320_L0.7650.88
69_I365_M0.7640.88
234_S277_E0.7640.88
442_E469_A0.7620.88
157_A164_I0.7620.88
220_R281_P0.7590.88
235_K315_W0.7590.88
168_S205_I0.7580.88
125_L138_W0.7570.88
6_H29_G0.7550.88
238_M274_T0.7550.88
24_A30_V0.7550.88
76_E108_E0.7550.88
120_A123_R0.7540.87
402_D407_F0.7540.87
242_N267_T0.7510.87
441_C444_V0.7490.87
268_T311_V0.7490.87
176_E179_A0.7470.87
372_D386_T0.7440.87
25_M156_S0.7430.87
158_Q457_G0.7430.87
355_I366_M0.7420.87
318_R336_R0.7410.87
145_D266_E0.7410.87
150_V360_L0.7390.86
82_V86_G0.7380.86
296_D300_E0.7380.86
246_V269_C0.7360.86
92_R98_Q0.7360.86
431_T447_A0.7350.86
55_R273_T0.7340.86
247_D251_N0.7330.86
94_E97_E0.7330.86
413_V445_T0.7310.86
333_D339_F0.7310.86
252_R262_V0.7310.86
342_A373_H0.7300.86
122_A125_L0.7300.86
19_V367_A0.7290.86
113_P119_G0.7280.86
85_T89_F0.7270.86
91_K96_S0.7270.86
50_L74_L0.7260.85
487_L492_Y0.7250.85
244_R303_P0.7240.85
20_A164_I0.7200.85
462_A465_I0.7200.85
219_G222_G0.7190.85
460_L480_A0.7160.85
63_S337_D0.7140.84
123_R130_A0.7140.84
267_T472_G0.7120.84
431_T454_E0.7110.84
119_G122_A0.7100.84
416_R444_V0.7090.84
238_M275_D0.7090.84
19_V370_I0.7080.84
133_V137_I0.7050.84
424_R427_S0.7040.84
417_S425_A0.7020.83
119_G125_L0.7010.83
89_F95_D0.7000.83
89_F92_R0.6990.83
136_A251_N0.6990.83
46_M146_P0.6980.83
179_A182_G0.6980.83
211_V353_T0.6960.83
14_S150_V0.6960.83
104_L107_C0.6950.83
396_D399_A0.6950.83
449_I483_L0.6940.83
240_V270_I0.6940.83
254_R260_D0.6930.83
42_T56_Y0.6930.83
248_T255_P0.6920.83
395_A423_S0.6910.83
92_R95_D0.6910.83
9_V371_T0.6900.82
155_A158_Q0.6880.82
444_V448_E0.6860.82
24_A160_H0.6850.82
365_M369_E0.6840.82
9_V21_R0.6840.82
137_I140_P0.6840.82
460_L483_L0.6830.82
481_H485_N0.6830.82
245_Q305_L0.6820.82
425_A428_V0.6760.81
21_R25_M0.6760.81
7_V371_T0.6750.81
277_E334_I0.6750.81
396_D400_L0.6720.81
186_E201_G0.6720.81
368_E384_C0.6700.81
4_E29_G0.6690.80
271_L298_L0.6690.80
236_G316_G0.6690.80
241_M305_L0.6670.80
274_T293_M0.6670.80
88_L122_A0.6670.80
72_R113_P0.6640.80
199_E202_T0.6630.80
276_E289_W0.6630.80
93_P97_E0.6630.80
330_D333_D0.6620.80
23_L30_V0.6620.80
186_E199_E0.6610.80
130_A304_M0.6610.80
87_G141_D0.6610.80
236_G274_T0.6610.80
85_T141_D0.6600.80
487_L490_A0.6600.80
82_V85_T0.6570.79
84_E87_G0.6560.79
102_E106_G0.6550.79
62_A369_E0.6550.79
79_T394_S0.6550.79
401_D405_T0.6540.79
18_G367_A0.6530.79
88_L136_A0.6530.79
82_V87_G0.6520.79
173_V183_V0.6520.79
276_E290_E0.6520.79
460_L463_V0.6510.79
248_T253_C0.6510.79
77_I390_A0.6480.78
47_H238_M0.6480.78
274_T290_E0.6480.78
375_C378_L0.6460.78
299_A304_M0.6450.78
237_V290_E0.6450.78
56_Y320_L0.6450.78
385_R389_V0.6440.78
32_L38_L0.6440.78
403_Y414_A0.6420.78
107_C113_P0.6410.78
7_V211_V0.6410.78
148_R456_S0.6410.78
404_M414_A0.6400.77
22_D25_M0.6390.77
64_A320_L0.6390.77
453_I458_T0.6390.77
179_A351_G0.6380.77
256_K261_I0.6380.77
476_G479_C0.6370.77
123_R133_V0.6330.77
85_T249_V0.6330.77
86_G90_V0.6330.77
371_T384_C0.6310.76
432_D445_T0.6310.76
157_A367_A0.6310.76
484_A487_L0.6280.76
473_N477_G0.6280.76
22_D372_D0.6270.76
85_T90_V0.6260.76
182_G207_A0.6240.76
13_G16_G0.6240.76
432_D447_A0.6230.76
31_T185_V0.6220.75
187_H198_T0.6220.75
116_V135_K0.6210.75
438_I449_I0.6200.75
437_T443_A0.6190.75
252_R301_L0.6190.75
71_N361_T0.6180.75
11_G16_G0.6180.75
62_A337_D0.6170.75
391_L394_S0.6110.74
51_H236_G0.6100.74
67_C362_T0.6100.74
210_V352_M0.6080.74
393_G422_G0.6060.74
386_T390_A0.6060.74
234_S275_D0.6040.73
428_V445_T0.6030.73
223_E226_G0.6030.73
367_A371_T0.6030.73
330_D334_I0.6010.73
281_P317_V0.6000.73
88_L235_K0.5990.73
331_P334_I0.5990.73
403_Y425_A0.5990.73
239_T291_V0.5990.73
182_G351_G0.5980.73
409_L413_V0.5980.73
342_A351_G0.5970.72
76_E388_D0.5970.72
43_T253_C0.5960.72
179_A206_R0.5950.72
53_G236_G0.5920.72
91_K99_Y0.5920.72
320_L336_R0.5910.72
318_R359_K0.5910.72
100_F135_K0.5900.72
258_D261_I0.5900.72
234_S331_P0.5900.72
48_G54_G0.5890.71
405_T410_R0.5880.71
365_M368_E0.5880.71
403_Y406_E0.5880.71
232_R334_I0.5870.71
141_D144_I0.5870.71
28_L381_T0.5850.71
76_E80_H0.5850.71
29_G208_D0.5850.71
28_L379_G0.5820.71
113_P116_V0.5810.70
101_Q108_E0.5810.70
102_E111_D0.5810.70
37_N465_I0.5800.70
117_L136_A0.5800.70
104_L111_D0.5790.70
91_K97_E0.5790.70
156_S395_A0.5770.70
343_H349_L0.5770.70
260_D294_V0.5770.70
159_E392_P0.5750.70
230_E322_E0.5740.69
447_A450_Q0.5740.69
131_D303_P0.5730.69
247_D250_V0.5730.69
103_K107_C0.5730.69
256_K273_T0.5720.69
86_G96_S0.5710.69
295_I310_T0.5710.69
30_V162_A0.5700.69
242_N473_N0.5700.69
441_C479_C0.5700.69
336_R359_K0.5680.69
386_T393_G0.5660.68
225_A352_M0.5630.68
47_H262_V0.5620.68
56_Y275_D0.5620.68
188_A200_G0.5620.68
55_R261_I0.5610.68
275_D359_K0.5610.68
82_V90_V0.5600.68
284_Y317_V0.5590.67
290_E362_T0.5590.67
171_T224_M0.5590.67
439_C476_G0.5580.67
410_R414_A0.5580.67
18_G22_D0.5580.67
108_E111_D0.5560.67
22_D371_T0.5540.67
406_E434_P0.5520.67
89_F97_E0.5520.67
160_H385_R0.5520.67
7_V30_V0.5510.66
48_G147_F0.5510.66
59_S332_T0.5500.66
430_D433_D0.5500.66
434_P450_Q0.5460.66
52_S238_M0.5460.66
479_C482_R0.5440.65
33_V165_E0.5440.65
50_L360_L0.5430.65
435_N446_R0.5430.65
245_Q269_C0.5430.65
9_V225_A0.5410.65
341_L354_T0.5410.65
114_T117_L0.5400.65
198_T459_D0.5400.65
286_E290_E0.5400.65
105_A110_C0.5400.65
83_D89_F0.5390.65
20_A154_A0.5390.65
268_T472_G0.5380.65
437_T445_T0.5370.64
234_S334_I0.5370.64
416_R448_E0.5370.64
324_P329_D0.5360.64
23_L28_L0.5360.64
428_V432_D0.5360.64
65_R387_A0.5330.64
433_D491_G0.5330.64
51_H55_R0.5320.64
417_S445_T0.5320.64
178_G204_V0.5300.63
48_G55_R0.5300.63
256_K293_M0.5290.63
117_L121_E0.5280.63
168_S188_A0.5280.63
130_A300_E0.5280.63
155_A451_D0.5270.63
222_G352_M0.5260.63
238_M258_D0.5260.63
152_A392_P0.5260.63
289_W292_D0.5260.63
251_N259_A0.5260.63
56_Y236_G0.5250.63
274_T336_R0.5250.63
369_E372_D0.5250.63
199_E206_R0.5250.63
279_A284_Y0.5250.63
413_V443_A0.5240.63
50_L144_I0.5230.62
278_V284_Y0.5230.62
151_V166_T0.5230.62
15_T367_A0.5220.62
219_G223_E0.5220.62
299_A303_P0.5210.62
22_D364_R0.5210.62
43_T48_G0.5210.62
82_V97_E0.5200.62
42_T320_L0.5190.62
174_V180_V0.5190.62
50_L82_V0.5180.62
86_G91_K0.5180.62
428_V431_T0.5170.62
374_V380_V0.5170.62
44_G146_P0.5170.62
218_A356_V0.5160.61
159_E456_S0.5160.61
446_R488_H0.5150.61
474_C478_F0.5150.61
56_Y319_P0.5140.61
188_A199_E0.5130.61
35_Q186_E0.5120.61
231_V356_V0.5100.60
113_P123_R0.5100.60
102_E108_E0.5090.60
220_R223_E0.5080.60
174_V177_D0.5080.60
24_A157_A0.5080.60
248_T251_N0.5070.60
414_A418_V0.5070.60
130_A133_V0.5070.60
336_R358_G0.5060.60
81_C360_L0.5060.60
88_L94_E0.5060.60
80_H394_S0.5050.60
204_V405_T0.5050.60
87_G90_V0.5050.60
239_T294_V0.5040.60
274_T359_K0.5040.60
12_G164_I0.5040.60
355_I358_G0.5040.60
219_G229_V0.5040.60
93_P99_Y0.5030.59
343_H350_P0.5010.59
48_G146_P0.5010.59
47_H360_L0.5010.59
53_G359_K0.5000.59
217_W220_R0.5000.59
165_E183_V0.5000.59
401_D411_S0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rghA 2 0.8614 100 0.463 Contact Map
3da1A 1 0.8018 100 0.481 Contact Map
2qcuA 2 0.8368 100 0.494 Contact Map
3dmeA 2 0.6088 100 0.735 Contact Map
4x9mA 1 0.6351 100 0.735 Contact Map
4h1bA 1 0.6351 100 0.744 Contact Map
3axbA 2 0.6439 100 0.762 Contact Map
1y56B 1 0.6386 100 0.763 Contact Map
1ryiA 4 0.6088 100 0.765 Contact Map
1c0pA 2 0.5667 100 0.767 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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