GREMLIN Database
GLPB - Probable anaerobic glycerol-3-phosphate dehydrogenase subunit B
UniProt: Q9HNS3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 427 (405)
Sequences: 314 (238)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
370_D374_R11.0151.00
9_V20_A5.3821.00
20_A272_L4.6801.00
20_A32_L4.5081.00
224_G250_F4.0700.99
19_S315_V3.5910.99
63_P106_N3.5520.98
66_A370_D3.1280.96
272_L277_V3.1050.96
25_D271_A2.9180.95
288_A295_V2.8430.94
413_G417_G2.8280.94
7_V28_A2.7000.92
23_A417_G2.6000.90
187_A190_L2.5860.90
207_L211_T2.5800.90
215_D245_L2.4580.88
227_A253_P2.3900.86
186_Y190_L2.3810.86
25_D93_A2.3770.86
100_G360_H2.3370.85
126_A260_P2.3240.85
340_C375_P2.2820.83
60_V70_L2.2530.83
139_L224_G2.1150.78
36_K147_D2.0990.78
23_A420_A2.0990.78
48_D119_T2.0910.77
397_Y408_V2.0470.76
84_V153_A2.0410.76
311_A314_Y2.0320.75
140_V213_V2.0310.75
269_F273_E2.0230.75
49_V190_L2.0070.74
73_A140_V2.0020.74
289_D299_Y1.9960.74
71_P77_R1.9370.72
88_M360_H1.9290.71
140_V169_V1.9080.70
66_A374_R1.8840.69
223_V247_A1.8430.68
230_G263_R1.8340.67
20_A277_V1.8220.67
276_G325_G1.7960.66
60_V323_G1.7800.65
251_E409_S1.7780.65
138_L220_A1.7750.65
353_D358_G1.7730.65
38_S357_F1.7440.63
325_G351_W1.7390.63
146_P360_H1.7370.63
369_T394_L1.7320.63
12_G185_R1.7290.62
52_Y118_P1.7270.62
72_D77_R1.7260.62
69_S315_V1.7210.62
292_A309_N1.7190.62
376_R383_A1.7010.61
147_D386_N1.6750.60
245_L249_V1.6640.59
210_A245_L1.6640.59
313_E420_A1.6370.58
39_T408_V1.6060.57
183_V190_L1.5960.56
13_G16_G1.5940.56
11_G16_G1.5940.56
206_R240_A1.5860.56
82_D119_T1.5800.55
51_G106_N1.5750.55
323_G417_G1.5580.54
318_T325_G1.5550.54
21_L271_A1.5370.53
271_A275_A1.5360.53
186_Y198_V1.5180.52
239_D243_D1.5110.52
66_A291_T1.5060.52
223_V249_V1.4950.51
36_K386_N1.4910.51
213_V243_D1.4900.51
338_F387_L1.4460.49
60_V63_P1.4390.48
80_G83_T1.4370.48
282_G356_A1.4270.48
259_L413_G1.4250.48
44_S408_V1.4220.47
188_G191_D1.4150.47
187_A198_V1.4130.47
107_A122_Y1.4060.47
264_L373_L1.3990.46
229_L342_I1.3960.46
180_G191_D1.3950.46
141_G396_G1.3920.46
222_R280_E1.3830.45
392_A408_V1.3830.45
285_V337_I1.3820.45
187_A191_D1.3700.45
169_V209_L1.3610.44
12_G336_P1.3580.44
178_R188_G1.3580.44
227_A254_M1.3560.44
355_D367_V1.3540.44
79_V372_T1.3510.44
206_R210_A1.3500.44
152_H369_T1.3440.44
42_N254_M1.3350.43
63_P66_A1.3330.43
108_L244_H1.3280.43
184_T228_V1.3260.43
36_K121_R1.3230.43
98_Y123_P1.3210.42
47_V413_G1.3140.42
147_D320_G1.3140.42
142_F228_V1.3080.42
362_F409_S1.3030.42
417_G420_A1.3020.42
71_P79_V1.3010.41
191_D199_D1.2990.41
139_L396_G1.2990.41
65_D93_A1.2980.41
33_V165_D1.2940.41
20_A30_T1.2930.41
44_S325_G1.2900.41
156_H251_E1.2860.41
349_Y370_D1.2790.40
46_L109_V1.2760.40
47_V164_F1.2600.40
131_A333_V1.2580.39
212_R215_D1.2540.39
78_T371_D1.2530.39
100_G389_A1.2510.39
34_S357_F1.2460.39
91_F410_I1.2430.39
146_P251_E1.2330.38
357_F398_N1.2320.38
65_D89_A1.2320.38
249_V410_I1.2310.38
357_F369_T1.2220.38
328_S403_H1.2160.37
325_G398_N1.2150.37
368_R396_G1.2070.37
17_I36_K1.1870.36
152_H387_L1.1870.36
276_G328_S1.1860.36
32_L272_L1.1830.36
296_E314_Y1.1720.35
360_H411_A1.1710.35
200_G205_L1.1700.35
333_V365_F1.1680.35
295_V387_L1.1640.35
63_P70_L1.1570.35
78_T339_D1.1510.34
125_S251_E1.1510.34
15_A209_L1.1500.34
140_V243_D1.1500.34
15_A50_L1.1440.34
342_I365_F1.1420.34
251_E411_A1.1390.34
272_L399_F1.1340.34
312_D334_Y1.1280.33
51_G118_P1.1260.33
63_P118_P1.1240.33
23_A188_G1.1240.33
315_V420_A1.1230.33
38_S185_R1.1200.33
84_V263_R1.1200.33
289_D294_G1.1180.33
6_E29_D1.1170.33
82_D354_D1.1140.33
6_E312_D1.1130.33
318_T337_I1.1120.33
90_F146_P1.1080.33
77_R211_T1.1050.32
62_D105_A1.1020.32
342_I346_D1.1020.32
17_I268_L1.1000.32
144_T325_G1.1000.32
126_A149_N1.1000.32
321_L326_I1.0960.32
141_G373_L1.0960.32
22_A282_G1.0960.32
91_F96_P1.0930.32
21_L275_A1.0920.32
229_L352_F1.0920.32
121_R417_G1.0910.32
198_V326_I1.0790.31
288_A338_F1.0730.31
142_F237_V1.0730.31
139_L416_A1.0720.31
139_L270_G1.0630.31
100_G276_G1.0580.30
135_R294_G1.0580.30
185_R320_G1.0500.30
66_A410_I1.0470.30
64_F360_H1.0460.30
220_A246_G1.0400.30
241_L328_S1.0400.30
240_A244_H1.0260.29
20_A229_L1.0260.29
131_A337_I1.0240.29
15_A339_D1.0170.29
91_F95_A1.0130.29
87_A369_T1.0130.29
173_F274_A1.0120.28
18_T161_G1.0040.28
46_L107_A1.0030.28
150_A184_T1.0030.28
112_H255_G0.9960.28
224_G252_V0.9930.28
289_D297_T0.9870.27
24_A275_A0.9790.27
352_F362_F0.9790.27
109_V300_V0.9790.27
223_V245_L0.9720.27
38_S341_R0.9720.27
332_A342_I0.9710.27
91_F237_V0.9690.27
217_A354_D0.9610.26
16_G405_G0.9600.26
100_G123_P0.9570.26
27_G256_P0.9560.26
218_A242_A0.9560.26
59_P65_D0.9530.26
185_R341_R0.9520.26
107_A241_L0.9490.26
217_A221_D0.9480.26
17_I277_V0.9440.26
38_S303_N0.9430.26
361_A398_N0.9390.26
46_L323_G0.9340.25
44_S351_W0.9320.25
348_R351_W0.9310.25
43_A328_S0.9310.25
298_V353_D0.9230.25
50_L54_P0.9220.25
136_D221_D0.9190.25
183_V186_Y0.9160.25
324_K369_T0.9080.24
106_N406_S0.9080.24
28_A420_A0.9060.24
227_A389_A0.9000.24
39_T322_V0.8970.24
205_L295_V0.8960.24
109_V277_V0.8930.24
129_G374_R0.8930.24
185_R283_N0.8920.24
33_V309_N0.8910.24
254_M348_R0.8900.24
160_A169_V0.8900.24
56_G297_T0.8890.24
24_A87_A0.8830.24
51_G63_P0.8810.23
22_A165_D0.8800.23
117_K404_S0.8790.23
322_V404_S0.8780.23
206_R237_V0.8730.23
110_P396_G0.8710.23
207_L296_E0.8700.23
120_A341_R0.8700.23
109_V122_Y0.8680.23
88_M251_E0.8680.23
364_Q398_N0.8650.23
146_P409_S0.8640.23
180_G183_V0.8630.23
231_D295_V0.8610.23
51_G403_H0.8610.23
19_S30_T0.8580.23
38_S365_F0.8560.23
153_A279_I0.8550.23
15_A214_A0.8500.22
333_V359_D0.8480.22
4_E33_V0.8450.22
314_Y328_S0.8440.22
117_K169_V0.8410.22
84_V252_V0.8380.22
146_P389_A0.8320.22
253_P387_L0.8300.22
183_V198_V0.8300.22
13_G45_G0.8300.22
11_G45_G0.8300.22
297_T314_Y0.8290.22
68_P326_I0.8290.22
120_A283_N0.8250.22
158_E163_P0.8170.21
250_F253_P0.8160.21
53_T404_S0.8150.21
50_L80_G0.8140.21
320_G363_A0.8130.21
190_L198_V0.8120.21
113_G356_A0.8100.21
149_N393_V0.8090.21
146_P341_R0.8020.21
56_G147_D0.8010.21
241_L339_D0.8000.21
283_N320_G0.7990.21
292_A371_D0.7980.21
61_V372_T0.7960.21
337_I384_H0.7950.21
39_T403_H0.7950.21
199_D231_D0.7950.21
230_G413_G0.7940.20
88_M95_A0.7940.20
215_D355_D0.7930.20
182_K413_G0.7920.20
206_R239_D0.7900.20
239_D312_D0.7870.20
267_H315_V0.7860.20
79_V413_G0.7840.20
87_A367_V0.7830.20
291_T296_E0.7830.20
5_S42_N0.7810.20
191_D198_V0.7810.20
90_F94_H0.7810.20
91_F98_Y0.7810.20
42_N120_A0.7810.20
77_R298_V0.7800.20
227_A413_G0.7770.20
210_A214_A0.7770.20
55_S60_V0.7750.20
129_G384_H0.7720.20
415_A419_A0.7710.20
224_G421_A0.7700.20
43_A46_L0.7700.20
38_S369_T0.7660.20
218_A246_G0.7660.20
147_D152_H0.7660.20
343_A412_T0.7650.20
78_T369_T0.7650.20
115_T155_A0.7640.20
52_Y403_H0.7610.19
183_V191_D0.7610.19
8_L309_N0.7580.19
15_A82_D0.7570.19
9_V297_T0.7560.19
378_D390_A0.7550.19
213_V217_A0.7550.19
351_W357_F0.7550.19
316_L393_V0.7480.19
79_V412_T0.7470.19
117_K357_F0.7450.19
325_G408_V0.7450.19
254_M326_I0.7420.19
360_H410_I0.7380.19
192_A200_G0.7350.19
321_L417_G0.7340.19
289_D410_I0.7330.19
9_V16_G0.7330.19
273_E285_V0.7320.19
26_A416_A0.7320.19
161_G178_R0.7320.19
165_D297_T0.7310.19
46_L185_R0.7310.19
21_L277_V0.7290.18
316_L326_I0.7290.18
183_V320_G0.7280.18
126_A253_P0.7280.18
6_E44_S0.7240.18
229_L389_A0.7230.18
154_A246_G0.7200.18
280_E405_G0.7190.18
18_T65_D0.7160.18
204_P315_V0.7160.18
374_R385_A0.7150.18
104_D370_D0.7150.18
70_L77_R0.7140.18
292_A333_V0.7130.18
146_P188_G0.7130.18
87_A421_A0.7120.18
54_P282_G0.7090.18
287_D299_Y0.7090.18
39_T186_Y0.7090.18
115_T414_Y0.7070.18
311_A367_V0.7070.18
88_M242_A0.7040.18
73_A171_V0.7000.18
187_A231_D0.6990.18
225_F275_A0.6990.18
100_G121_R0.6990.18
50_L60_V0.6980.18
264_L398_N0.6970.18
392_A406_S0.6940.17
342_I401_A0.6940.17
326_I380_G0.6930.17
90_F410_I0.6920.17
77_R328_S0.6880.17
175_G228_V0.6880.17
60_V66_A0.6850.17
115_T405_G0.6840.17
33_V170_T0.6840.17
99_Q124_A0.6820.17
351_W398_N0.6820.17
67_I216_A0.6820.17
5_S341_R0.6800.17
53_T60_V0.6790.17
389_A393_V0.6790.17
326_I342_I0.6770.17
375_P389_A0.6770.17
220_A387_L0.6750.17
41_R277_V0.6750.17
4_E337_I0.6730.17
14_L33_V0.6710.17
16_G394_L0.6710.17
363_A397_Y0.6710.17
141_G184_T0.6690.17
65_D294_G0.6680.17
126_A395_G0.6680.17
35_Y406_S0.6670.17
6_E13_G0.6660.17
6_E11_G0.6660.17
303_N307_I0.6660.17
66_A388_R0.6660.17
8_L33_V0.6660.17
64_F412_T0.6650.17
238_R249_V0.6650.17
109_V120_A0.6650.17
66_A210_A0.6640.17
138_L151_D0.6630.17
8_L388_R0.6620.17
223_V242_A0.6610.16
342_I345_S0.6590.16
221_D273_E0.6580.16
223_V418_T0.6580.16
249_V318_T0.6580.16
165_D239_D0.6570.16
266_D314_Y0.6560.16
42_N283_N0.6520.16
325_G328_S0.6510.16
321_L324_K0.6500.16
334_Y365_F0.6470.16
218_A292_A0.6450.16
9_V119_T0.6450.16
292_A385_A0.6420.16
171_V253_P0.6410.16
139_L153_A0.6400.16
312_D347_D0.6400.16
280_E360_H0.6380.16
185_R258_S0.6370.16
120_A300_V0.6370.16
118_P298_V0.6350.16
141_G150_A0.6350.16
76_Y80_G0.6330.16
178_R393_V0.6330.16
353_D412_T0.6320.16
115_T397_Y0.6320.16
22_A171_V0.6310.16
60_V380_G0.6310.16
232_D259_L0.6310.16
148_F282_G0.6300.16
83_T370_D0.6300.16
11_G15_A0.6300.16
30_T406_S0.6290.16
374_R384_H0.6290.16
188_G413_G0.6280.16
316_L325_G0.6280.16
351_W365_F0.6270.16
135_R339_D0.6260.16
95_A161_G0.6250.16
210_A244_H0.6250.16
230_G396_G0.6230.15
177_L395_G0.6230.15
79_V414_Y0.6220.15
145_L182_K0.6220.15
217_A247_A0.6170.15
171_V392_A0.6160.15
340_C349_Y0.6120.15
37_Q277_V0.6120.15
4_E145_L0.6110.15
307_I409_S0.6110.15
314_Y386_N0.6100.15
19_S23_A0.6100.15
213_V292_A0.6100.15
25_D117_K0.6090.15
38_S41_R0.6090.15
212_R281_T0.6080.15
217_A350_A0.6060.15
145_L254_M0.6050.15
111_T355_D0.6020.15
94_H312_D0.6020.15
140_V285_V0.6010.15
147_D268_L0.6010.15
173_F229_L0.6000.15
80_G402_E0.5990.15
35_Y63_P0.5990.15
62_D371_D0.5990.15
170_T327_D0.5980.15
37_Q185_R0.5970.15
36_K268_L0.5960.15
325_G335_E0.5960.15
132_S135_R0.5950.15
79_V422_E0.5950.15
79_V297_T0.5940.15
322_V356_A0.5930.15
302_K395_G0.5930.15
12_G276_G0.5910.15
336_P362_F0.5900.15
172_P227_A0.5890.15
139_L170_T0.5870.15
142_F153_A0.5850.15
12_G362_F0.5840.14
90_F100_G0.5820.14
88_M409_S0.5810.14
351_W408_V0.5810.14
42_N144_T0.5800.14
12_G144_T0.5780.14
176_D371_D0.5770.14
61_V68_P0.5760.14
125_S146_P0.5760.14
53_T56_G0.5750.14
122_Y184_T0.5740.14
206_R209_L0.5730.14
210_A246_G0.5720.14
42_N321_L0.5710.14
169_V212_R0.5710.14
275_A291_T0.5700.14
19_S375_P0.5690.14
31_R412_T0.5680.14
59_P63_P0.5670.14
92_D213_V0.5670.14
181_A191_D0.5670.14
198_V230_G0.5650.14
33_V267_H0.5630.14
62_D104_D0.5630.14
214_A245_L0.5620.14
135_R372_T0.5620.14
398_N401_A0.5620.14
248_A356_A0.5600.14
356_A397_Y0.5590.14
188_G231_D0.5580.14
47_V285_V0.5580.14
41_R325_G0.5580.14
90_F389_A0.5560.14
237_V246_G0.5560.14
139_L223_V0.5550.14
252_V255_G0.5550.14
49_V88_M0.5550.14
178_R282_G0.5540.14
134_D259_L0.5510.14
309_N402_E0.5510.14
326_I333_V0.5510.14
200_G268_L0.5500.14
21_L50_L0.5490.14
307_I397_Y0.5490.14
223_V293_G0.5460.14
153_A345_S0.5460.14
360_H396_G0.5450.14
84_V140_V0.5440.14
68_P333_V0.5430.14
310_S404_S0.5430.14
30_T245_L0.5420.13
74_H391_G0.5400.13
114_G319_G0.5390.13
33_V169_V0.5370.13
366_G391_G0.5370.13
7_V342_I0.5350.13
391_G407_G0.5350.13
213_V225_F0.5340.13
318_T350_A0.5330.13
41_R399_F0.5330.13
83_T385_A0.5320.13
79_V373_L0.5310.13
224_G345_S0.5300.13
218_A287_D0.5290.13
313_E409_S0.5290.13
36_K320_G0.5290.13
87_A192_A0.5290.13
190_L223_V0.5280.13
250_F392_A0.5270.13
59_P85_R0.5270.13
316_L389_A0.5250.13
33_V95_A0.5250.13
123_P251_E0.5240.13
200_G209_L0.5240.13
29_D222_R0.5230.13
299_Y308_P0.5200.13
21_L369_T0.5200.13
125_S360_H0.5190.13
116_V238_R0.5190.13
19_S229_L0.5180.13
42_N341_R0.5170.13
371_D393_V0.5160.13
80_G282_G0.5160.13
348_R406_S0.5160.13
373_L398_N0.5150.13
65_D243_D0.5140.13
110_P373_L0.5130.13
7_V229_L0.5120.13
106_N210_A0.5120.13
209_L339_D0.5110.13
59_P213_V0.5100.13
265_S342_I0.5100.13
241_L351_W0.5100.13
323_G359_D0.5090.13
23_A360_H0.5080.13
258_S276_G0.5080.13
79_V96_P0.5080.13
23_A231_D0.5070.13
133_D222_R0.5060.13
333_V358_G0.5050.13
394_L405_G0.5040.13
235_A247_A0.5040.13
105_A292_A0.5030.13
73_A364_Q0.5030.13
107_A120_A0.5020.13
294_G374_R0.5020.13
18_T239_D0.5020.13
144_T254_M0.5010.13
183_V188_G0.5010.13
363_A403_H0.5010.13
337_I393_V0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c3xA 4 0.7564 99.9 0.85 Contact Map
4at0A 2 0.7143 99.9 0.859 Contact Map
2h88A 2 0.6909 99.8 0.862 Contact Map
1qo8A 2 0.6862 99.8 0.863 Contact Map
2i0zA 1 0.6089 99.8 0.865 Contact Map
1y0pA 1 0.6768 99.8 0.867 Contact Map
2wdqA 1 0.6979 99.8 0.868 Contact Map
1trbA 2 0.726 99.8 0.873 Contact Map
3itjA 2 0.7213 99.8 0.874 Contact Map
3o0hA 2 0.7377 99.8 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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