GREMLIN Database
Q9HNS2 - Glycerol-3-phosphate dehydrogenase chain C
UniProt: Q9HNS2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 465 (394)
Sequences: 4304 (3012)
Seq/√Len: 151.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_R460_E5.0221.00
227_K257_E4.8311.00
334_A456_L4.5971.00
453_R461_A4.5801.00
246_A457_E4.4621.00
360_E389_G4.3681.00
332_F340_I3.9911.00
247_M303_S3.4501.00
339_R380_E3.2821.00
197_W245_Q3.1071.00
360_E391_D2.9591.00
312_R336_E2.7971.00
242_E457_E2.7931.00
256_Y337_Y2.7111.00
302_A308_S2.6321.00
434_L458_L2.6301.00
361_F458_L2.5991.00
226_K256_Y2.5331.00
265_C307_C2.4011.00
379_V392_D2.3371.00
172_W176_K2.3351.00
266_S307_C2.3111.00
283_A315_Y2.3061.00
114_S117_Q2.2991.00
227_K259_V2.2721.00
411_Y415_M2.2241.00
379_V383_G2.2001.00
275_M278_D2.1941.00
236_A244_G2.1281.00
301_I337_Y2.1161.00
418_G422_F2.0791.00
415_M447_G1.9751.00
327_V331_T1.9491.00
325_E329_S1.9441.00
422_F447_G1.9171.00
158_P161_A1.9111.00
243_V457_E1.9061.00
419_D426_E1.8841.00
280_R284_D1.8701.00
247_M334_A1.8591.00
171_R175_E1.8551.00
256_Y341_H1.8361.00
201_R252_E1.8341.00
359_D432_T1.8321.00
172_W175_E1.8121.00
228_V258_I1.7561.00
361_F388_V1.7441.00
230_Y303_S1.7401.00
192_E197_W1.7361.00
250_V456_L1.7261.00
194_F198_W1.6791.00
153_I156_T1.6681.00
174_M177_T1.6611.00
117_Q317_E1.6451.00
316_P328_A1.6341.00
270_M278_D1.6281.00
284_D288_S1.6241.00
380_E383_G1.5961.00
140_R409_E1.5951.00
264_G285_I1.5851.00
227_K298_Y1.5711.00
154_A158_P1.5591.00
293_L296_E1.5431.00
247_M251_Y1.5331.00
295_E326_T1.5301.00
80_R83_E1.5211.00
139_W142_R1.5091.00
422_F426_E1.5051.00
151_A154_A1.4971.00
248_V252_E1.4921.00
56_D70_G1.4871.00
316_P325_E1.4841.00
229_A297_G1.4831.00
69_P98_E1.4771.00
248_V258_I1.4761.00
337_Y341_H1.4691.00
229_A298_Y1.4431.00
178_L181_T1.4351.00
253_H460_E1.4311.00
332_F336_E1.4181.00
93_D97_T1.4141.00
229_A293_L1.4111.00
453_R458_L1.4091.00
234_C265_C1.4081.00
197_W201_R1.3991.00
268_T306_S1.3971.00
161_A164_A1.3871.00
425_M444_M1.3841.00
418_G447_G1.3761.00
164_A167_F1.3741.00
240_T243_V1.3741.00
340_I377_Q1.3631.00
270_M282_H1.3621.00
359_D431_D1.3541.00
138_Y141_N1.3541.00
291_S295_E1.3541.00
174_M178_L1.3471.00
246_A460_E1.3471.00
359_D461_A1.3431.00
271_F279_A1.3321.00
234_C307_C1.3251.00
365_A379_V1.3231.00
175_E182_S1.3231.00
198_W248_V1.3211.00
361_F432_T1.3191.00
228_V337_Y1.3121.00
271_F310_A1.3091.00
319_F322_D1.3071.00
299_D337_Y1.3051.00
360_E431_D1.2951.00
157_L161_A1.2921.00
432_T453_R1.2881.00
67_D72_K1.2881.00
366_P435_T1.2861.00
326_T330_N1.2841.00
58_N108_A1.2821.00
411_Y446_H1.2801.00
436_E455_P1.2761.00
304_C437_C1.2751.00
152_R155_S1.2731.00
149_T152_R1.2711.00
234_C266_S1.2701.00
291_S326_T1.2701.00
284_D322_D1.2681.00
412_E416_E1.2651.00
302_A311_L1.2641.00
326_T329_S1.2631.00
61_V74_Q1.2611.00
336_E377_Q1.2591.00
137_K141_N1.2531.00
293_L297_G1.2411.00
389_G392_D1.2391.00
361_F434_L1.2361.00
106_D114_S1.2331.00
143_I146_N1.2291.00
195_R237_N1.2191.00
332_F337_Y1.2151.00
128_D277_D1.2131.00
271_F276_L1.2051.00
376_R379_V1.2021.00
171_R174_M1.1991.00
93_D126_Y1.1961.00
62_A65_D1.1791.00
146_N149_T1.1751.00
262_K292_D1.1731.00
291_S294_I1.1731.00
75_G115_L1.1711.00
425_M433_G1.1711.00
228_V251_Y1.1651.00
139_W143_I1.1631.00
161_A165_M1.1591.00
334_A338_L1.1591.00
247_M456_L1.1571.00
79_W83_E1.1521.00
240_T438_P1.1471.00
159_R162_N1.1361.00
194_F197_W1.1331.00
63_E420_D1.1220.99
338_L381_L1.1220.99
156_T160_L1.1210.99
250_V459_L1.1180.99
226_K341_H1.1150.99
150_S153_I1.1130.99
294_I327_V1.1100.99
415_M419_D1.1090.99
376_R380_E1.1080.99
152_R156_T1.1080.99
309_M371_S1.1030.99
124_G276_L1.0920.99
308_S331_T1.0910.99
156_T161_A1.0890.99
288_S291_S1.0870.99
441_A452_V1.0800.99
157_L168_G1.0780.99
414_S443_Q1.0780.99
67_D73_F1.0770.99
282_H285_I1.0770.99
232_H244_G1.0760.99
190_A241_P1.0740.99
53_S72_K1.0730.99
225_D257_E1.0700.99
224_A257_E1.0680.99
422_F448_T1.0650.99
194_F248_V1.0550.99
194_F244_G1.0540.99
451_E461_A1.0500.99
294_I330_N1.0460.99
250_V460_E1.0450.99
306_S437_C1.0440.99
41_D44_P1.0430.99
192_E200_A1.0420.99
81_L86_D1.0410.99
141_N145_A1.0400.99
166_N188_A1.0350.99
66_D69_P1.0340.99
299_D332_F1.0330.99
193_T196_E1.0330.99
293_L298_Y1.0300.99
251_Y334_A1.0280.99
136_L142_R1.0270.99
176_K182_S1.0250.99
336_E374_L1.0190.99
282_H286_T1.0140.99
223_D226_K1.0140.99
453_R457_E1.0130.99
272_A306_S1.0100.99
249_R252_E1.0080.99
268_T272_A1.0030.99
106_D116_S1.0000.99
100_S417_I0.9990.99
248_V260_V0.9960.99
198_W202_G0.9950.99
165_M168_G0.9930.99
157_L160_L0.9870.99
252_E258_I0.9830.99
164_A168_G0.9820.99
193_T237_N0.9760.99
270_M275_M0.9760.99
220_E252_E0.9760.99
230_Y258_I0.9750.99
137_K275_M0.9720.99
124_G128_D0.9700.99
90_H93_D0.9660.98
120_N271_F0.9490.98
137_K145_A0.9490.98
292_D295_E0.9480.98
227_K296_E0.9460.98
160_L164_A0.9460.98
358_A389_G0.9430.98
400_I405_G0.9390.98
292_D296_E0.9360.98
341_H346_E0.9330.98
221_P224_A0.9300.98
70_G73_F0.9290.98
163_A167_F0.9230.98
160_L163_A0.9230.98
294_I300_A0.9230.98
300_A327_V0.9190.98
89_D92_I0.9150.98
419_D423_D0.9150.98
249_R253_H0.9040.98
435_T441_A0.8950.98
379_V390_I0.8950.98
365_A375_D0.8920.97
172_W182_S0.8890.97
349_Q384_D0.8880.97
226_K347_T0.8870.97
142_R146_N0.8850.97
419_D422_F0.8850.97
185_E188_A0.8850.97
382_F388_V0.8840.97
357_L462_A0.8800.97
141_N144_L0.8780.97
339_R381_L0.8760.97
125_E128_D0.8720.97
232_H260_V0.8700.97
283_A319_F0.8700.97
283_A318_L0.8680.97
362_A428_A0.8590.97
134_R141_N0.8590.97
169_P172_W0.8590.97
168_G172_W0.8570.97
64_V413_T0.8570.97
287_V291_S0.8560.97
103_M106_D0.8550.97
154_A161_A0.8550.97
302_A331_T0.8530.97
140_R144_L0.8520.97
245_Q249_R0.8500.97
287_V324_I0.8490.97
101_N119_H0.8470.97
232_H263_Q0.8460.97
404_Y410_K0.8460.97
393_V425_M0.8420.96
288_S322_D0.8390.96
138_Y145_A0.8390.96
287_V319_F0.8370.96
164_A170_A0.8350.96
155_S158_P0.8280.96
81_L87_D0.8270.96
184_R187_P0.8250.96
137_K142_R0.8250.96
338_L459_L0.8210.96
385_L388_V0.8190.96
423_D427_S0.8180.96
193_T197_W0.8140.96
107_S370_R0.8130.96
172_W178_L0.8130.96
121_T125_E0.8120.96
320_D323_G0.8120.96
157_L163_A0.8110.96
279_A310_A0.8100.96
122_A126_Y0.8090.96
400_I443_Q0.8080.95
148_R151_A0.8070.95
103_M114_S0.8060.95
418_G448_T0.8060.95
77_E81_L0.8040.95
363_Y390_I0.8040.95
175_E179_G0.8020.95
429_E432_T0.8010.95
365_A392_D0.8010.95
457_E460_E0.8010.95
308_S372_Q0.7980.95
69_P95_S0.7970.95
341_H347_T0.7970.95
377_Q380_E0.7960.95
325_E328_A0.7940.95
243_V246_A0.7930.95
336_E340_I0.7900.95
142_R145_A0.7870.95
162_N165_M0.7870.95
458_L461_A0.7850.95
223_D257_E0.7840.95
444_M448_T0.7820.95
420_D424_H0.7820.95
167_F170_A0.7740.94
240_T457_E0.7710.94
165_M175_E0.7700.94
451_E457_E0.7700.94
418_G443_Q0.7670.94
62_A67_D0.7660.94
187_P190_A0.7660.94
226_K298_Y0.7650.94
230_Y247_M0.7640.94
137_K144_L0.7630.94
188_A191_T0.7630.94
159_R191_T0.7590.94
45_E48_S0.7590.94
197_W200_A0.7580.94
195_R198_W0.7570.94
183_E411_Y0.7570.94
286_T315_Y0.7560.94
365_A378_A0.7550.94
285_I289_S0.7540.93
233_G304_C0.7540.93
278_D281_R0.7530.93
58_N396_S0.7510.93
188_A193_T0.7510.93
433_G444_M0.7500.93
88_E93_D0.7490.93
158_P162_N0.7480.93
294_I326_T0.7450.93
185_E189_F0.7440.93
305_T366_P0.7420.93
80_R84_Q0.7410.93
260_V263_Q0.7400.93
162_N166_N0.7400.93
192_E195_R0.7390.93
74_Q437_C0.7390.93
232_H261_P0.7360.93
366_P437_C0.7350.93
382_F434_L0.7340.93
286_T289_S0.7330.93
49_C55_C0.7330.93
394_G424_H0.7320.92
219_G224_A0.7320.92
308_S333_E0.7280.92
251_Y256_Y0.7270.92
424_H428_A0.7270.92
357_L360_E0.7240.92
226_K299_D0.7240.92
305_T371_S0.7200.92
93_D135_S0.7190.92
358_A387_G0.7190.92
194_F241_P0.7180.92
445_E451_E0.7180.92
154_A157_L0.7170.92
134_R137_K0.7160.92
170_A173_V0.7160.92
312_R372_Q0.7140.92
143_I147_Y0.7140.92
363_Y379_V0.7110.91
175_E178_L0.7100.91
198_W201_R0.7080.91
98_E413_T0.7070.91
362_A433_G0.7060.91
140_R143_I0.7010.91
88_E134_R0.6980.91
228_V256_Y0.6970.91
362_A425_M0.6960.90
55_C59_C0.6960.90
173_V176_K0.6940.90
241_P245_Q0.6920.90
135_S142_R0.6920.90
390_I455_P0.6920.90
340_I345_R0.6900.90
276_L280_R0.6890.90
72_K75_G0.6890.90
236_A303_S0.6870.90
153_I157_L0.6870.90
280_R320_D0.6860.90
95_S98_E0.6860.90
61_V437_C0.6830.90
70_G75_G0.6800.89
380_E384_D0.6800.89
144_L147_Y0.6770.89
135_S138_Y0.6770.89
73_F100_S0.6740.89
124_G277_D0.6740.89
346_E384_D0.6710.89
243_V441_A0.6690.89
56_D62_A0.6680.89
285_I288_S0.6680.89
333_E436_E0.6670.89
176_K179_G0.6660.88
304_C435_T0.6630.88
424_H427_S0.6620.88
103_M371_S0.6610.88
423_D426_E0.6600.88
259_V293_L0.6590.88
312_R374_L0.6580.88
231_F311_L0.6550.88
264_G289_S0.6530.87
175_E180_V0.6520.87
398_S440_C0.6520.87
240_T442_M0.6520.87
151_A189_F0.6510.87
126_Y135_S0.6500.87
197_W202_G0.6500.87
433_G448_T0.6480.87
120_N276_L0.6470.87
78_Q118_M0.6460.87
185_E446_H0.6430.87
41_D121_T0.6430.87
56_D67_D0.6420.87
245_Q248_V0.6420.87
229_A261_P0.6400.86
300_A331_T0.6390.86
357_L388_V0.6390.86
138_Y142_R0.6340.86
64_V67_D0.6330.86
315_Y324_I0.6320.86
157_L164_A0.6320.86
168_G175_E0.6310.86
259_V262_K0.6300.86
278_D282_H0.6300.86
187_P191_T0.6280.85
231_F263_Q0.6270.85
286_T311_L0.6250.85
315_Y318_L0.6240.85
301_I456_L0.6230.85
428_A432_T0.6220.85
158_P165_M0.6220.85
151_A155_S0.6220.85
304_C438_P0.6190.85
163_A169_P0.6180.84
252_E257_E0.6180.84
323_G326_T0.6160.84
50_Y79_W0.6160.84
196_E200_A0.6150.84
335_V436_E0.6130.84
345_R349_Q0.6130.84
50_Y111_S0.6110.84
63_E396_S0.6110.84
339_R384_D0.6100.84
115_L119_H0.6080.83
304_C366_P0.6060.83
87_D91_E0.6050.83
128_D134_R0.6040.83
250_V254_F0.6040.83
250_V381_L0.6040.83
155_S165_M0.6040.83
240_T441_A0.6020.83
293_L299_D0.6010.83
104_R108_A0.6010.83
155_S238_Y0.5990.83
224_A252_E0.5970.82
198_W245_Q0.5900.82
135_S144_L0.5900.82
229_A290_M0.5900.82
186_F190_A0.5890.82
88_E91_E0.5890.82
136_L139_W0.5880.81
87_D134_R0.5880.81
115_L118_M0.5870.81
415_M446_H0.5860.81
251_Y258_I0.5860.81
50_Y56_D0.5860.81
376_R383_G0.5860.81
90_H94_D0.5810.81
425_M428_A0.5790.80
336_E372_Q0.5780.80
70_G74_Q0.5780.80
61_V100_S0.5760.80
56_D108_A0.5760.80
277_D281_R0.5750.80
345_R384_D0.5750.80
381_L459_L0.5740.80
106_D117_Q0.5740.80
197_W248_V0.5730.80
357_L461_A0.5720.80
227_K258_I0.5710.80
85_S88_E0.5700.79
231_F286_T0.5690.79
226_K252_E0.5670.79
150_S154_A0.5660.79
92_I96_I0.5640.79
73_F77_E0.5640.79
134_R138_Y0.5620.78
192_E196_E0.5610.78
391_D428_A0.5610.78
363_Y375_D0.5600.78
169_P175_E0.5600.78
363_Y434_L0.5600.78
374_L378_A0.5590.78
97_T410_K0.5590.78
154_A159_R0.5580.78
40_F43_R0.5570.78
156_T159_R0.5550.78
254_F346_E0.5530.77
148_R269_P0.5530.77
363_Y378_A0.5520.77
137_K140_R0.5520.77
220_E224_A0.5510.77
393_V428_A0.5500.77
52_C55_C0.5500.77
136_L144_L0.5490.77
51_K79_W0.5490.77
177_T180_V0.5470.77
49_C59_C0.5470.77
101_N104_R0.5460.76
421_M425_M0.5460.76
386_D389_G0.5460.76
404_Y413_T0.5460.76
233_G437_C0.5460.76
329_S332_F0.5450.76
233_G366_P0.5440.76
169_P173_V0.5440.76
426_E448_T0.5430.76
96_I119_H0.5410.76
56_D72_K0.5410.76
103_M314_E0.5410.76
421_M426_E0.5400.76
170_A188_A0.5400.76
253_H462_A0.5400.76
258_I261_P0.5390.76
165_M170_A0.5390.76
67_D74_Q0.5380.75
40_F45_E0.5380.75
171_R179_G0.5370.75
288_S323_G0.5330.75
57_T108_A0.5320.75
341_H345_R0.5310.74
81_L125_E0.5300.74
120_N272_A0.5300.74
246_A250_V0.5280.74
330_N340_I0.5280.74
444_M447_G0.5260.74
306_S368_H0.5260.74
76_P80_R0.5250.74
189_F194_F0.5240.73
417_I420_D0.5240.73
46_S118_M0.5230.73
146_N278_D0.5230.73
357_L383_G0.5210.73
322_D325_E0.5210.73
106_D371_S0.5200.73
228_V301_I0.5200.73
191_T197_W0.5200.73
52_C59_C0.5190.73
434_L455_P0.5190.73
224_A255_G0.5190.73
416_E420_D0.5170.73
161_A168_G0.5170.73
153_I161_A0.5160.72
362_A430_G0.5150.72
309_M314_E0.5150.72
244_G306_S0.5140.72
73_F113_V0.5110.72
353_I384_D0.5110.72
320_D325_E0.5110.72
363_Y436_E0.5110.72
195_R199_Q0.5090.71
219_G225_D0.5090.71
171_R181_T0.5090.71
218_R221_P0.5080.71
263_Q290_M0.5080.71
365_A394_G0.5080.71
127_V274_G0.5070.71
406_W441_A0.5060.71
50_Y406_W0.5060.71
284_D287_V0.5050.71
181_T184_R0.5040.71
333_E369_A0.5040.71
71_P74_Q0.5040.71
77_E80_R0.5030.70
141_N148_R0.5010.70
225_D255_G0.5010.70
366_P405_G0.5010.70
168_G176_K0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.7591 100 0.569 Contact Map
3cf4A 2 0.7742 100 0.627 Contact Map
3c8yA 1 0.7376 99.6 0.859 Contact Map
2h88B 1 0.2796 99.4 0.878 Contact Map
1kf6B 1 0.2946 99.3 0.88 Contact Map
2wdqB 1 0.2817 99.3 0.881 Contact Map
2bs2B 1 0.2774 99.2 0.887 Contact Map
4ysxB 1 0.3054 99.2 0.887 Contact Map
4p6vA 1 0.2022 98.9 0.9 Contact Map
1hfeL 2 0.6688 98.3 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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