GREMLIN Database
Q9HNS0 - Uncharacterized protein
UniProt: Q9HNS0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 173 (142)
Sequences: 115 (108)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_V24_V3.3180.94
15_A20_L2.8950.89
28_T32_T2.6510.84
9_A17_V2.6120.83
11_V15_A2.5120.80
17_V23_T2.4750.79
11_V14_V2.4460.79
24_V28_T2.3160.74
10_V17_V2.2340.72
33_D37_S2.1840.70
8_T13_M2.0210.64
10_V23_T2.0130.63
4_A8_T1.9670.61
4_A22_G1.9120.59
26_V34_T1.8420.56
8_T28_T1.8090.55
31_S34_T1.8040.54
5_T12_L1.7710.53
14_V24_V1.7390.52
20_L29_L1.7140.51
19_V28_T1.6900.49
16_V20_L1.6720.49
16_V24_V1.6510.48
7_V21_A1.6420.47
4_A7_V1.6390.47
63_L78_V1.6290.47
15_A29_L1.6260.47
18_V28_T1.5340.43
100_L106_D1.5280.42
14_V28_T1.5130.42
34_T49_L1.4920.41
33_D36_S1.4760.40
5_T8_T1.4570.39
3_A39_A1.4550.39
19_V22_G1.4350.39
107_G112_D1.4320.38
11_V16_V1.4060.37
3_A12_L1.3950.37
11_V20_L1.3800.36
6_S9_A1.3530.35
25_A28_T1.3460.35
15_A24_V1.3450.35
18_V29_L1.3380.35
8_T22_G1.3300.34
30_G34_T1.2940.33
140_A145_S1.2880.33
47_G61_V1.2730.32
67_A139_I1.2620.32
19_V24_V1.2420.31
58_D70_D1.2410.31
24_V32_T1.2350.31
25_A66_I1.2310.31
28_T48_E1.2240.30
13_M39_A1.2180.30
67_A145_S1.2080.30
40_P65_H1.2040.30
18_V32_T1.1960.29
6_S12_L1.1860.29
40_P68_G1.1720.28
16_V27_F1.1720.28
49_L61_V1.1710.28
6_S19_V1.1670.28
41_L44_Q1.1640.28
6_S11_V1.1610.28
67_A71_V1.1580.28
100_L104_T1.0910.26
71_V137_F1.0840.25
8_T26_V1.0830.25
5_T9_A1.0770.25
5_T19_V1.0670.25
14_V18_V1.0630.25
97_T104_T1.0530.24
93_V135_A1.0470.24
14_V20_L1.0450.24
29_L64_T1.0430.24
16_V29_L1.0330.24
77_D80_V1.0330.24
13_M27_F1.0330.24
3_A8_T1.0250.24
7_V10_V1.0230.23
93_V109_K1.0070.23
11_V19_V0.9950.23
25_A36_S0.9650.22
13_M22_G0.9530.21
98_S110_L0.9360.21
21_A43_G0.9310.21
13_M28_T0.9260.21
25_A79_V0.9260.21
5_T10_V0.9240.21
92_I107_G0.9210.20
9_A23_T0.9110.20
17_V43_G0.9100.20
18_V24_V0.9010.20
62_R73_V0.8990.20
17_V67_A0.8970.20
10_V13_M0.8940.20
92_I137_F0.8920.20
15_A27_F0.8880.20
17_V25_A0.8760.19
113_F116_P0.8680.19
39_A43_G0.8640.19
11_V28_T0.8550.19
14_V29_L0.8520.19
19_V71_V0.8520.19
61_V75_D0.8450.18
66_I75_D0.8380.18
37_S70_D0.8340.18
8_T11_V0.8330.18
9_A43_G0.8150.18
29_L49_L0.8020.17
73_V138_R0.8010.17
15_A32_T0.7990.17
30_G44_Q0.7930.17
59_Q133_E0.7930.17
87_G104_T0.7900.17
30_G40_P0.7880.17
61_V132_G0.7860.17
9_A25_A0.7850.17
15_A18_V0.7840.17
16_V25_A0.7780.17
41_L142_R0.7770.17
136_T139_I0.7760.17
44_Q71_V0.7740.17
117_D133_E0.7650.16
31_S44_Q0.7580.16
65_H68_G0.7550.16
46_S66_I0.7500.16
26_V30_G0.7440.16
3_A18_V0.7370.16
23_T38_P0.7290.16
5_T17_V0.7270.15
7_V19_V0.7230.15
114_Y118_G0.7170.15
45_T69_D0.7060.15
57_G145_S0.7050.15
45_T138_R0.6960.15
9_A67_A0.6960.15
8_T38_P0.6940.15
24_V115_S0.6930.15
29_L76_L0.6920.15
116_P119_G0.6890.15
105_Y108_D0.6800.14
56_G103_S0.6740.14
24_V119_G0.6720.14
39_A45_T0.6720.14
27_F43_G0.6690.14
29_L48_E0.6620.14
74_S126_D0.6610.14
7_V11_V0.6580.14
13_M19_V0.6420.14
57_G74_S0.6410.14
6_S10_V0.6400.14
61_V135_A0.6390.14
61_V133_E0.6320.13
45_T64_T0.6290.13
62_R106_D0.6280.13
5_T38_P0.6250.13
115_S120_A0.6250.13
5_T32_T0.6230.13
20_L28_T0.6190.13
15_A19_V0.6170.13
12_L17_V0.6170.13
5_T24_V0.6100.13
21_A41_L0.6100.13
15_A28_T0.6070.13
3_A6_S0.6060.13
9_A12_L0.6000.13
82_A139_I0.6000.13
5_T18_V0.5990.13
25_A32_T0.5950.13
63_L109_K0.5870.13
122_D128_V0.5830.12
7_V12_L0.5830.12
10_V21_A0.5810.12
30_G36_S0.5750.12
76_L111_F0.5750.12
81_D101_G0.5730.12
47_G91_R0.5710.12
47_G63_L0.5690.12
69_D108_D0.5680.12
26_V31_S0.5640.12
102_P109_K0.5630.12
13_M26_V0.5620.12
72_A97_T0.5610.12
89_R95_L0.5560.12
6_S24_V0.5530.12
25_A67_A0.5520.12
23_T27_F0.5510.12
62_R81_D0.5470.12
13_M47_G0.5470.12
17_V26_V0.5460.12
129_W132_G0.5460.12
17_V21_A0.5440.12
135_A141_N0.5440.12
100_L107_G0.5410.12
63_L147_D0.5400.12
11_V18_V0.5390.12
31_S38_P0.5320.12
19_V32_T0.5270.11
104_T122_D0.5230.11
55_G88_K0.5220.11
123_A134_T0.5220.11
51_R78_V0.5210.11
11_V32_T0.5170.11
11_V29_L0.5150.11
4_A10_V0.5150.11
26_V38_P0.5140.11
70_D74_S0.5130.11
38_P44_Q0.5120.11
79_V90_A0.5090.11
13_M18_V0.5080.11
19_V27_F0.5020.11
116_P121_F0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1rA 5 0.1503 21.3 0.943 Contact Map
3isyA 1 0.6243 15 0.947 Contact Map
1g43A 1 0.7341 13.3 0.948 Contact Map
2p9rA 1 0.3295 13.1 0.948 Contact Map
2wnxA 2 0.711 9.8 0.951 Contact Map
2xbtA 1 0.6994 3.8 0.96 Contact Map
3vmnA 1 0.3295 3.7 0.96 Contact Map
3zjaA 1 0.6185 3.4 0.961 Contact Map
3umnA 1 0.6705 3.1 0.961 Contact Map
4tp9P 1 0.2659 2.8 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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