GREMLIN Database
Q9HNR9 - Uncharacterized protein
UniProt: Q9HNR9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 77 (76)
Sequences: 108 (72)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_L48_F3.1110.90
65_F70_V2.1390.64
12_Y48_F2.1260.64
20_S23_I2.0160.59
72_P76_E1.9950.58
14_D49_K1.7620.49
19_A32_R1.7240.47
11_F17_I1.7120.47
44_E73_N1.6410.44
24_V29_D1.6350.44
6_Y41_A1.6070.43
60_D76_E1.5730.41
11_F28_I1.5700.41
69_E74_E1.5590.41
61_L69_E1.5060.38
52_G59_S1.4660.37
70_V74_E1.4540.36
57_S73_N1.4500.36
17_I48_F1.4330.36
4_I72_P1.4010.34
20_S69_E1.3570.33
30_Y45_A1.3510.33
11_F19_A1.3440.32
15_H58_L1.3200.31
25_A32_R1.3170.31
16_D57_S1.3100.31
61_L73_N1.3000.31
6_Y38_R1.2730.30
39_L54_G1.2610.29
17_I23_I1.2340.28
4_I34_Y1.1960.27
26_A52_G1.1780.27
60_D63_R1.1700.26
67_S70_V1.1450.26
47_L70_V1.1430.25
20_S25_A1.1410.25
3_P33_Q1.1380.25
28_I42_L1.1320.25
26_A55_I1.1310.25
1_M30_Y1.1140.25
20_S36_G1.1040.24
4_I32_R1.0580.23
7_H44_E1.0530.23
63_R74_E1.0480.23
22_K64_G1.0340.22
35_T73_N1.0250.22
47_L75_L0.9850.21
6_Y65_F0.9800.21
12_Y72_P0.9720.20
21_P72_P0.9650.20
9_L12_Y0.9470.20
16_D45_A0.9360.20
38_R58_L0.9350.19
27_N42_L0.9190.19
34_Y39_L0.9070.19
67_S71_D0.8940.18
11_F30_Y0.8830.18
3_P30_Y0.8620.18
28_I40_K0.8570.18
60_D72_P0.8410.17
3_P32_R0.8260.17
28_I46_G0.8240.17
19_A24_V0.8180.17
15_H19_A0.8100.16
16_D24_V0.8010.16
6_Y12_Y0.7860.16
43_A50_R0.7800.16
71_D75_L0.7780.16
24_V55_I0.7760.16
21_P32_R0.7620.15
25_A43_A0.7550.15
35_T54_G0.7480.15
24_V69_E0.7430.15
18_Q41_A0.7380.15
13_E69_E0.7290.15
39_L58_L0.7280.15
28_I68_G0.7140.14
17_I49_K0.7130.14
28_I38_R0.7080.14
7_H15_H0.7060.14
1_M28_I0.7000.14
49_K57_S0.6980.14
22_K53_D0.6910.14
22_K74_E0.6890.14
21_P70_V0.6750.14
16_D30_Y0.6650.13
7_H58_L0.6540.13
16_D55_I0.6530.13
28_I33_Q0.6390.13
7_H36_G0.6290.13
27_N62_G0.6240.13
11_F34_Y0.6140.12
30_Y55_I0.6130.12
3_P44_E0.6050.12
31_D37_R0.6030.12
3_P31_D0.6020.12
22_K34_Y0.5940.12
14_D33_Q0.5930.12
25_A51_E0.5920.12
26_A45_A0.5790.12
4_I30_Y0.5690.12
10_E58_L0.5660.12
21_P75_L0.5620.12
35_T59_S0.5470.11
51_E63_R0.5450.11
8_I57_S0.5330.11
20_S26_A0.5310.11
30_Y34_Y0.5280.11
16_D65_F0.5080.11
30_Y40_K0.5070.11
5_D9_L0.5070.11
14_D41_A0.5030.11
6_Y31_D0.5000.11
1_M41_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b73A 2 0.987 98.5 0.708 Contact Map
1xmkA 1 0.8831 98.4 0.713 Contact Map
1s3jA 2 0.987 98.3 0.724 Contact Map
3bddA 2 0.987 98.3 0.725 Contact Map
1bjaA 1 0.974 98.3 0.726 Contact Map
1r7jA 2 0.9481 98.2 0.727 Contact Map
2lnbA 1 0.8312 98.2 0.729 Contact Map
1oyiA 1 0.7532 98.2 0.729 Contact Map
2ethA 4 0.987 98.2 0.73 Contact Map
2nyxA 2 0.987 98.2 0.73 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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