GREMLIN Database
Q9HNR4 - tRNA pseudouridine synthase Pus10
UniProt: Q9HNR4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 425 (384)
Sequences: 396 (302)
Seq/√Len: 15.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_I282_V5.9421.00
372_G378_I4.0971.00
227_G255_V3.9201.00
172_R281_E3.8171.00
335_E346_H3.4600.99
185_C192_G3.0870.98
362_D365_H2.9470.98
306_R367_T2.8940.98
60_C63_C2.7920.97
170_R250_P2.7410.97
311_F366_A2.6620.96
221_V253_I2.5410.95
132_V136_T2.4410.93
17_C20_C2.3550.92
368_V393_L2.3180.91
228_T257_E2.2730.91
385_D388_R2.2140.89
225_M263_P2.1920.89
183_W343_R2.1700.88
165_A225_M2.1660.88
380_E388_R2.1330.87
78_V135_R2.0560.85
377_Y380_E2.0500.85
126_R130_K2.0410.85
312_D400_G2.0370.85
390_N395_G2.0240.84
380_E406_L1.9860.83
380_E389_T1.9550.82
377_Y406_L1.8990.80
339_R349_R1.8930.80
237_R339_R1.8920.80
251_F340_V1.8910.80
237_R380_E1.8880.80
77_V149_A1.8800.80
232_F251_F1.8560.79
388_R406_L1.8550.79
302_R371_E1.8260.78
306_R369_E1.7990.76
380_E408_V1.7870.76
237_R303_K1.7830.76
237_R377_Y1.7660.75
218_A230_A1.7320.74
339_R406_L1.7240.73
241_D339_R1.7230.73
349_R406_L1.7150.73
303_K339_R1.6970.72
380_E385_D1.6590.70
237_R241_D1.6580.70
19_A67_S1.6520.70
311_F401_A1.6430.70
237_R406_L1.6340.69
336_T406_L1.6320.69
241_D406_L1.6320.69
377_Y408_V1.6300.69
385_D406_L1.6230.69
237_R305_Y1.6190.68
67_S411_V1.6100.68
182_K402_V1.6020.67
241_D336_T1.5990.67
242_A403_V1.5980.67
241_D305_Y1.5820.66
340_V344_R1.5570.65
379_K406_L1.5560.65
288_A292_M1.5550.65
178_I346_H1.5490.65
336_T339_R1.5380.64
40_A43_T1.5300.64
336_T340_V1.5180.63
241_D349_R1.5180.63
312_D394_A1.5160.63
305_Y334_Q1.5130.63
237_R408_V1.5090.63
69_R72_E1.5060.63
22_G38_G1.5010.62
181_T234_G1.4910.62
339_R408_V1.4840.61
37_R129_G1.4820.61
258_P297_K1.4610.60
90_Q148_L1.4560.60
237_R349_R1.4550.60
183_W215_Q1.4490.59
242_A301_A1.4400.59
305_Y377_Y1.4350.59
241_D303_K1.4340.59
305_Y380_E1.4290.58
388_R408_V1.4290.58
183_W342_H1.4150.58
383_S404_T1.4090.57
158_V320_L1.4030.57
10_V24_C1.3910.56
334_Q349_R1.3870.56
303_K379_K1.3830.56
185_C190_G1.3770.55
237_R334_Q1.3720.55
88_T139_E1.3630.55
389_T406_L1.3610.55
339_R377_Y1.3610.55
17_C23_R1.3580.54
303_K406_L1.3540.54
309_V401_A1.3530.54
236_G249_R1.3520.54
323_A403_V1.3480.54
311_F315_V1.3460.54
306_R370_I1.3410.53
182_K214_E1.3400.53
241_D337_P1.3380.53
41_L47_L1.3370.53
237_R336_T1.3270.53
118_E123_E1.3220.52
79_D82_A1.3200.52
389_T408_V1.3150.52
291_E351_R1.3070.51
268_L271_A1.3000.51
383_S403_V1.3000.51
377_Y388_R1.2940.51
238_E375_G1.2910.51
244_M408_V1.2890.50
376_L383_S1.2870.50
179_P365_H1.2860.50
312_D370_I1.2850.50
22_G37_R1.2660.49
304_R369_E1.2550.49
377_Y389_T1.2540.48
60_C65_G1.2540.48
303_K349_R1.2490.48
190_G209_Y1.2430.48
385_D408_V1.2350.47
349_R408_V1.2330.47
247_T410_A1.2290.47
241_D408_V1.2270.47
349_R377_Y1.2270.47
216_L268_L1.2220.47
336_T377_Y1.2210.47
18_D21_L1.2200.47
303_K408_V1.2200.47
89_Y133_G1.2170.46
336_T349_R1.2110.46
99_V120_F1.2100.46
192_G234_G1.2100.46
307_A373_E1.2070.46
93_T125_N1.2040.46
244_M336_T1.2030.46
252_V351_R1.2020.45
375_G379_K1.1970.45
169_G251_F1.1960.45
122_S125_N1.1950.45
341_D403_V1.1940.45
209_Y297_K1.1930.45
162_V234_G1.1820.44
305_Y339_R1.1790.44
307_A378_I1.1770.44
167_V287_V1.1770.44
136_T223_D1.1740.44
244_M406_L1.1660.43
23_R60_C1.1660.43
336_T408_V1.1650.43
334_Q377_Y1.1620.43
238_E303_K1.1530.43
241_D380_E1.1510.43
214_E218_A1.1500.43
239_D375_G1.1500.43
287_V394_A1.1490.43
16_V394_A1.1440.42
289_G355_D1.1430.42
336_T380_E1.1400.42
34_N37_R1.1380.42
352_D373_E1.1360.42
269_A283_E1.1350.42
337_P408_V1.1340.42
354_Y370_I1.1310.42
334_Q380_E1.1300.41
238_E379_K1.1280.41
237_R389_T1.1260.41
237_R388_R1.1230.41
180_Q344_R1.1220.41
339_R380_E1.1180.41
183_W349_R1.1170.41
242_A349_R1.1090.40
305_Y349_R1.1090.40
134_D332_I1.1030.40
346_H364_T1.1000.40
379_K408_V1.0980.40
239_D385_D1.0980.40
20_C23_R1.0870.39
379_K385_D1.0810.39
240_I254_E1.0800.39
147_V255_V1.0710.38
133_G137_G1.0610.38
209_Y345_A1.0600.38
376_L411_V1.0600.38
121_K297_K1.0590.38
79_D128_V1.0580.38
303_K380_E1.0550.37
244_M339_R1.0490.37
34_N38_G1.0490.37
241_D388_R1.0480.37
95_A378_I1.0480.37
315_V366_A1.0470.37
192_G209_Y1.0470.37
15_P81_V1.0450.37
183_W344_R1.0410.37
372_G376_L1.0310.36
77_V128_V1.0270.36
385_D389_T1.0270.36
123_E126_R1.0250.36
168_Y296_V1.0240.36
132_V143_G1.0230.36
241_D377_Y1.0230.36
237_R337_P1.0200.36
337_P349_R1.0150.35
70_F128_V1.0070.35
303_K377_Y1.0030.35
215_Q342_H1.0010.35
10_V13_E1.0010.35
375_G385_D0.9930.34
241_D334_Q0.9920.34
32_L73_F0.9900.34
305_Y337_P0.9860.34
19_A119_P0.9860.34
65_G400_G0.9800.33
183_W297_K0.9780.33
15_P46_A0.9770.33
22_G130_K0.9730.33
308_D405_A0.9690.33
162_V258_P0.9680.33
336_T388_R0.9670.33
169_G379_K0.9660.33
13_E262_H0.9660.33
81_V149_A0.9660.33
238_E241_D0.9660.33
241_D385_D0.9640.33
125_N179_P0.9560.32
282_V285_V0.9510.32
237_R343_R0.9500.32
123_E129_G0.9440.32
166_F290_Y0.9430.32
379_K388_R0.9400.31
303_K336_T0.9390.31
166_F272_I0.9380.31
239_D249_R0.9370.31
236_G239_D0.9370.31
168_Y286_A0.9350.31
227_G256_A0.9330.31
181_T406_L0.9320.31
156_E164_S0.9310.31
270_D274_D0.9300.31
384_S392_S0.9290.31
267_A316_G0.9290.31
239_D379_K0.9260.31
237_R254_E0.9250.31
255_V278_G0.9160.30
94_Q384_S0.9150.30
305_Y343_R0.9140.30
323_A393_L0.9140.30
251_F344_R0.9120.30
336_T389_T0.9120.30
33_S136_T0.9100.30
127_E130_K0.9050.30
126_R129_G0.9040.30
331_T350_E0.9020.30
383_S402_V0.9020.30
244_M385_D0.8990.30
136_T308_D0.8970.29
100_E106_L0.8960.29
132_V217_T0.8940.29
391_P407_D0.8940.29
96_P102_N0.8930.29
337_P388_R0.8910.29
43_T47_L0.8870.29
341_D346_H0.8850.29
100_E392_S0.8800.29
175_E298_E0.8790.29
161_T166_F0.8780.29
268_L357_T0.8770.28
239_D303_K0.8770.28
343_R377_Y0.8720.28
238_E249_R0.8710.28
73_F80_A0.8710.28
237_R244_M0.8690.28
167_V213_V0.8680.28
321_R384_S0.8680.28
233_H309_V0.8640.28
339_R388_R0.8620.28
271_A274_D0.8600.28
334_Q337_P0.8580.28
334_Q339_R0.8570.28
242_A334_Q0.8560.28
82_A291_E0.8550.27
22_G34_N0.8510.27
121_K185_C0.8500.27
118_E126_R0.8500.27
95_A215_Q0.8490.27
214_E342_H0.8460.27
338_N386_D0.8420.27
289_G325_D0.8370.27
71_D131_R0.8330.26
304_R371_E0.8320.26
343_R349_R0.8310.26
317_D360_R0.8300.26
375_G388_R0.8280.26
238_E339_R0.8270.26
237_R242_A0.8240.26
339_R389_T0.8220.26
305_Y406_L0.8190.26
84_A88_T0.8180.26
37_R118_E0.8170.26
175_E353_V0.8170.26
337_P406_L0.8140.26
93_T124_C0.8120.26
134_D167_V0.8100.25
394_A400_G0.8100.25
346_H402_V0.8060.25
310_E351_R0.8060.25
243_L351_R0.8050.25
31_G37_R0.8050.25
80_A83_D0.8030.25
37_R130_K0.7980.25
153_V396_L0.7980.25
122_S130_K0.7950.25
70_F155_A0.7920.25
359_D393_L0.7920.25
383_S401_A0.7900.25
308_D365_H0.7880.25
377_Y385_D0.7870.25
172_R283_E0.7860.24
174_L278_G0.7850.24
42_R45_V0.7830.24
308_D373_E0.7800.24
176_R245_L0.7800.24
103_E123_E0.7790.24
170_R340_V0.7780.24
22_G118_E0.7770.24
375_G406_L0.7740.24
42_R47_L0.7730.24
215_Q343_R0.7680.24
361_E382_V0.7680.24
349_R380_E0.7650.24
213_V280_A0.7620.23
52_P332_I0.7620.23
378_I401_A0.7620.23
339_R343_R0.7610.23
337_P385_D0.7610.23
157_T370_I0.7610.23
13_E24_C0.7570.23
250_P340_V0.7570.23
86_F133_G0.7560.23
99_V315_V0.7550.23
16_V22_G0.7540.23
337_P380_E0.7530.23
253_I333_E0.7530.23
117_G124_C0.7520.23
223_D378_I0.7510.23
242_A339_R0.7490.23
229_E341_D0.7470.23
163_N256_A0.7460.23
249_R375_G0.7440.23
236_G375_G0.7440.23
360_R364_T0.7410.23
349_R388_R0.7370.22
288_A372_G0.7370.22
22_G25_F0.7370.22
308_D378_I0.7320.22
344_R349_R0.7300.22
334_Q406_L0.7300.22
318_D321_R0.7300.22
224_A267_A0.7290.22
244_M303_K0.7280.22
250_P336_T0.7240.22
11_L147_V0.7230.22
316_G320_L0.7220.22
298_E307_A0.7200.22
234_G242_A0.7190.22
334_Q389_T0.7180.22
76_L158_V0.7180.22
167_V370_I0.7170.22
92_G145_P0.7160.22
374_G403_V0.7150.22
99_V155_A0.7130.22
143_G158_V0.7120.21
379_K391_P0.7070.21
69_R165_A0.7070.21
327_L392_S0.7070.21
334_Q343_R0.7060.21
169_G181_T0.7030.21
181_T237_R0.7030.21
267_A357_T0.7020.21
238_E406_L0.7020.21
266_D269_A0.7000.21
140_V221_V0.6980.21
242_A377_Y0.6970.21
334_Q388_R0.6970.21
149_A312_D0.6940.21
19_A66_A0.6920.21
313_A319_D0.6920.21
182_K293_V0.6890.21
216_L411_V0.6870.21
192_G383_S0.6850.20
231_S286_A0.6850.20
211_E279_K0.6840.20
222_V227_G0.6840.20
183_W339_R0.6830.20
68_G100_E0.6820.20
129_G151_I0.6790.20
349_R385_D0.6760.20
184_P232_F0.6720.20
218_A295_R0.6710.20
321_R392_S0.6710.20
22_G123_E0.6690.20
182_K341_D0.6680.20
237_R385_D0.6670.20
150_V382_V0.6670.20
239_D337_P0.6640.20
44_A47_L0.6620.20
41_L44_A0.6610.20
77_V132_V0.6590.20
143_G398_G0.6590.20
11_L24_C0.6570.19
394_A401_A0.6570.19
40_A353_V0.6570.19
359_D369_E0.6530.19
107_R244_M0.6520.19
241_D244_M0.6500.19
301_A383_S0.6470.19
349_R389_T0.6450.19
259_Q412_A0.6440.19
179_P279_K0.6420.19
353_V376_L0.6400.19
305_Y408_V0.6370.19
235_A286_A0.6360.19
176_R246_G0.6360.19
103_E218_A0.6360.19
297_K370_I0.6360.19
22_G33_S0.6330.19
361_E369_E0.6310.19
320_L370_I0.6310.19
317_D321_R0.6290.18
123_E127_E0.6290.18
305_Y388_R0.6270.18
25_F37_R0.6260.18
180_Q236_G0.6250.18
180_Q249_R0.6250.18
244_M377_Y0.6240.18
268_L273_N0.6220.18
75_D221_V0.6210.18
228_T357_T0.6180.18
179_P234_G0.6160.18
273_N408_V0.6150.18
320_L358_A0.6140.18
313_A348_V0.6140.18
40_A47_L0.6130.18
272_I362_D0.6130.18
44_A316_G0.6130.18
169_G239_D0.6110.18
181_T377_Y0.6110.18
56_P266_D0.6090.18
359_D363_D0.6050.18
223_D270_D0.6040.18
65_G405_A0.6040.18
209_Y381_L0.6040.18
162_V381_L0.6040.18
137_G314_P0.6030.18
170_R251_F0.6030.18
373_E381_L0.6020.18
238_E336_T0.6010.18
371_E395_G0.5920.17
141_D268_L0.5890.17
361_E396_L0.5880.17
354_Y373_E0.5860.17
235_A401_A0.5850.17
292_M296_V0.5850.17
23_R103_E0.5840.17
339_R385_D0.5830.17
97_P214_E0.5810.17
216_L279_K0.5790.17
192_G242_A0.5780.17
183_W408_V0.5760.17
238_E408_V0.5740.17
356_I368_V0.5740.17
212_S215_Q0.5740.17
134_D226_G0.5720.17
345_A386_D0.5720.17
237_R379_K0.5720.17
103_E411_V0.5710.17
175_E279_K0.5710.17
301_A403_V0.5710.17
304_R412_A0.5700.17
241_D379_K0.5700.17
255_V296_V0.5690.16
165_A361_E0.5680.16
241_D389_T0.5680.16
87_D213_V0.5650.16
232_F253_I0.5640.16
306_R409_V0.5630.16
136_T139_E0.5630.16
244_M349_R0.5620.16
243_L334_Q0.5600.16
84_A160_V0.5590.16
244_M380_E0.5580.16
341_D386_D0.5570.16
120_F247_T0.5560.16
227_G244_M0.5560.16
181_T339_R0.5560.16
303_K388_R0.5550.16
173_K249_R0.5530.16
173_K236_G0.5530.16
161_T313_A0.5520.16
78_V82_A0.5500.16
65_G410_A0.5500.16
368_V394_A0.5470.16
217_T282_V0.5460.16
254_E377_Y0.5450.16
268_L363_D0.5450.16
310_E364_T0.5440.16
364_T409_V0.5430.16
347_L382_V0.5430.16
271_A317_D0.5430.16
38_G123_E0.5420.16
125_N192_G0.5420.16
56_P338_N0.5400.16
238_E349_R0.5400.16
8_R90_Q0.5390.16
393_L403_V0.5390.16
211_E296_V0.5390.16
87_D262_H0.5390.16
52_P128_V0.5370.16
308_D366_A0.5360.15
14_T42_R0.5360.15
314_P364_T0.5360.15
132_V287_V0.5330.15
242_A406_L0.5320.15
336_T341_D0.5280.15
167_V300_D0.5270.15
244_M347_L0.5260.15
65_G341_D0.5220.15
38_G130_K0.5220.15
277_D288_A0.5210.15
183_W377_Y0.5210.15
126_R146_D0.5210.15
168_Y288_A0.5200.15
182_K218_A0.5190.15
259_Q263_P0.5170.15
242_A305_Y0.5170.15
119_P151_I0.5170.15
375_G408_V0.5160.15
380_E383_S0.5160.15
81_V135_R0.5160.15
186_S208_L0.5150.15
134_D147_V0.5140.15
95_A370_I0.5130.15
21_L38_G0.5130.15
266_D382_V0.5120.15
175_E307_A0.5120.15
336_T379_K0.5110.15
239_D406_L0.5110.15
231_S235_A0.5110.15
181_T408_V0.5100.15
9_A12_A0.5100.15
305_Y336_T0.5090.15
335_E384_S0.5080.15
273_N340_V0.5080.15
36_E47_L0.5070.15
55_E80_A0.5060.15
96_P358_A0.5060.15
82_A282_V0.5040.15
331_T352_D0.5040.15
31_G34_N0.5040.15
405_A413_G0.5040.15
251_F375_G0.5030.15
209_Y233_H0.5030.15
301_A374_G0.5030.15
90_Q351_R0.5030.15
254_E334_Q0.5030.15
312_D364_T0.5020.15
178_I209_Y0.5010.14
74_A242_A0.5000.14
66_A259_Q0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v9kA 1 0.9176 100 0.27 Contact Map
2ausC 1 0.4071 99 0.913 Contact Map
2apoA 1 0.4047 99 0.914 Contact Map
1k8wA 1 0.3929 98.8 0.921 Contact Map
1r3eA 1 0.3906 98.7 0.923 Contact Map
3u28A 1 0.5035 98.7 0.923 Contact Map
1sgvA 1 0.3671 96 0.953 Contact Map
1dj0A 2 0.5059 88.7 0.964 Contact Map
1vs3A 2 0.5082 83.2 0.967 Contact Map
2dirA 1 0.2259 43.6 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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