GREMLIN Database
Q9HNR2 - Uncharacterized protein
UniProt: Q9HNR2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 536 (422)
Sequences: 4680 (3251)
Seq/√Len: 158.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_P18_L3.6361.00
224_D227_A3.2081.00
330_S333_E2.8061.00
215_V218_I2.6641.00
216_A219_V2.6291.00
215_V219_V2.5501.00
99_W102_T2.5311.00
212_V216_A2.5191.00
200_Q204_F2.5111.00
360_N364_A2.5041.00
272_P276_L2.4641.00
369_R373_G2.4491.00
216_A220_L2.4451.00
225_Y228_M2.4401.00
224_D228_M2.4401.00
17_A21_I2.3961.00
276_L280_T2.3711.00
52_W364_A2.3221.00
204_F208_S2.2661.00
199_L204_F2.2441.00
201_A204_F2.2241.00
199_L205_N2.2061.00
198_F204_F2.2001.00
16_I20_I2.1711.00
200_Q206_M2.1611.00
461_D464_D2.1451.00
227_A230_T2.1281.00
478_A482_V2.1271.00
276_L279_V2.0941.00
272_P280_T2.0831.00
200_Q203_P2.0711.00
225_Y229_L2.0591.00
11_P21_I2.0351.00
217_I221_S2.0221.00
18_L21_I2.0111.00
213_V217_I2.0091.00
295_L298_M1.9771.00
211_A216_A1.9651.00
318_S322_L1.9551.00
199_L203_P1.9421.00
12_P18_L1.9151.00
340_D343_G1.9141.00
187_S199_L1.9091.00
81_G84_V1.8891.00
217_I220_L1.8831.00
223_R226_G1.8551.00
295_L299_V1.8501.00
275_V318_S1.8491.00
202_I208_S1.8481.00
177_I434_V1.8391.00
13_L17_A1.8381.00
99_W103_H1.8251.00
271_V322_L1.8211.00
81_G85_A1.8081.00
45_G49_T1.8061.00
392_A409_V1.7921.00
389_M477_I1.7821.00
45_G48_Q1.7791.00
198_F203_P1.7731.00
219_V222_R1.7701.00
214_M218_I1.7651.00
211_A219_V1.7471.00
226_G229_L1.7331.00
212_V215_V1.7291.00
224_D230_T1.7241.00
198_F202_I1.7241.00
222_R225_Y1.7211.00
206_M210_L1.7081.00
212_V218_I1.7021.00
80_L84_V1.6911.00
208_S211_A1.6851.00
211_A217_I1.6471.00
208_S212_V1.6261.00
74_I81_G1.6171.00
74_I80_L1.6061.00
266_L270_F1.5931.00
373_G376_K1.5911.00
173_Q406_M1.5891.00
201_A205_N1.5741.00
204_F210_L1.5661.00
205_N208_S1.5531.00
94_H98_D1.5481.00
141_D147_R1.5331.00
226_G232_E1.5331.00
264_P276_L1.5311.00
211_A218_I1.5291.00
12_P19_A1.5211.00
89_R337_T1.5181.00
296_Y299_V1.5131.00
482_V486_V1.5121.00
51_S55_R1.5071.00
317_I321_V1.5061.00
417_A430_V1.4931.00
332_G336_D1.4931.00
474_G478_A1.4901.00
227_A231_A1.4861.00
151_S458_T1.4761.00
224_D229_L1.4741.00
386_V481_A1.4721.00
203_P207_Y1.4691.00
265_S268_S1.4621.00
11_P20_I1.4601.00
202_I206_M1.4441.00
99_W266_L1.4361.00
186_V199_L1.4281.00
228_M231_A1.4271.00
370_Y374_I1.4221.00
14_L18_L1.4211.00
75_V78_L1.4201.00
266_L272_P1.4181.00
218_I222_R1.4151.00
198_F201_A1.4151.00
393_A440_F1.4141.00
213_V216_A1.4111.00
233_H237_T1.4081.00
198_F205_N1.4071.00
214_M219_V1.4021.00
14_L35_S1.4021.00
212_V217_I1.3981.00
15_A21_I1.3871.00
214_M217_I1.3781.00
11_P17_A1.3681.00
199_L202_I1.3561.00
15_A18_L1.3481.00
444_A470_L1.3431.00
203_P206_M1.3431.00
229_L233_H1.3421.00
80_L85_A1.3401.00
35_S39_I1.3381.00
15_A19_A1.3381.00
73_I81_G1.3281.00
440_F477_I1.3241.00
389_M394_F1.3241.00
106_S109_S1.3231.00
231_A234_R1.3231.00
209_I213_V1.3211.00
53_V357_S1.3161.00
203_P208_S1.3151.00
267_V271_V1.3031.00
205_N209_I1.2921.00
436_S480_T1.2901.00
479_V483_L1.2821.00
75_V81_G1.2731.00
78_L81_G1.2721.00
11_P36_G1.2691.00
272_P279_V1.2661.00
229_L232_E1.2631.00
202_I205_N1.2621.00
10_V14_L1.2581.00
17_A20_I1.2571.00
48_Q51_S1.2531.00
212_V219_V1.2511.00
213_V220_L1.2471.00
263_N267_V1.2421.00
277_I280_T1.2401.00
124_D450_T1.2391.00
397_F444_A1.2381.00
213_V218_I1.2341.00
464_D467_R1.2331.00
226_G231_A1.2311.00
223_R227_A1.2281.00
79_L85_A1.2221.00
276_L284_A1.2111.00
176_M410_T1.2091.00
221_S224_D1.2081.00
268_S272_P1.2041.00
264_P269_F1.1851.00
366_G369_R1.1831.00
279_V314_A1.1831.00
222_R227_A1.1801.00
73_I80_L1.1781.00
269_F272_P1.1771.00
215_V220_L1.1691.00
11_P15_A1.1681.00
95_A99_W1.1671.00
384_L388_V1.1651.00
211_A214_M1.1631.00
455_A465_H1.1531.00
280_T284_A1.1511.00
465_H469_Q1.1511.00
271_V275_V1.1491.00
224_D231_A1.1461.00
389_M392_A1.1461.00
225_Y230_T1.1421.00
11_P19_A1.1401.00
359_G363_D1.1381.00
382_A385_P1.1361.00
220_L223_R1.1361.00
14_L21_I1.1361.00
48_Q52_W1.1331.00
440_F474_G1.1301.00
211_A215_V1.1291.00
200_Q205_N1.1201.00
230_T234_R1.1201.00
207_Y210_L1.1181.00
115_W119_V1.1181.00
74_I84_V1.1171.00
218_I221_S1.1121.00
212_V220_L1.1111.00
222_R229_L1.1031.00
223_R229_L1.1021.00
269_F280_T1.0850.99
220_L224_D1.0810.99
272_P284_A1.0800.99
73_I79_L1.0800.99
432_G436_S1.0710.99
123_F451_T1.0700.99
198_F208_S1.0670.99
337_T340_D1.0650.99
260_S264_P1.0640.99
44_L49_T1.0640.99
71_A75_V1.0610.99
211_A220_L1.0610.99
204_F209_I1.0600.99
83_S315_M1.0580.99
272_P283_T1.0580.99
74_I79_L1.0560.99
321_V326_Y1.0530.99
471_Y475_T1.0520.99
278_A282_A1.0500.99
187_S198_F1.0490.99
225_Y475_T1.0440.99
11_P358_I1.0440.99
203_P209_I1.0380.99
73_I84_V1.0360.99
320_Y334_S1.0320.99
231_A235_A1.0320.99
200_Q208_S1.0290.99
401_S404_G1.0220.99
208_S214_M1.0190.99
269_F276_L1.0190.99
10_V18_L1.0140.99
89_R333_E1.0130.99
79_L84_V1.0120.99
264_P272_P1.0090.99
272_P277_I1.0080.99
485_A488_G1.0080.99
75_V84_V1.0020.99
280_T283_T0.9970.99
345_M349_V0.9960.99
223_R230_T0.9950.99
227_A232_E0.9940.99
44_L52_W0.9910.99
197_I204_F0.9890.99
380_T383_L0.9840.99
224_D232_E0.9840.99
262_E276_L0.9840.99
455_A462_L0.9730.99
37_G49_T0.9730.99
210_L213_V0.9650.99
264_P279_V0.9620.99
44_L48_Q0.9520.99
75_V80_L0.9500.99
432_G484_L0.9490.99
276_L283_T0.9460.98
200_Q210_L0.9460.98
74_I85_A0.9430.98
159_A473_A0.9420.98
78_L85_A0.9400.98
226_G234_R0.9360.98
12_P21_I0.9340.98
198_F209_I0.9330.98
483_L487_W0.9310.98
55_R364_A0.9260.98
187_S200_Q0.9250.98
467_R471_Y0.9250.98
8_S12_P0.9240.98
230_T233_H0.9220.98
213_V221_S0.9190.98
283_T287_T0.9170.98
16_I19_A0.9160.98
228_M233_H0.9160.98
268_S326_Y0.9060.98
260_S263_N0.9040.98
352_L450_T0.9030.98
124_D352_L0.9010.98
75_V79_L0.9010.98
463_I467_R0.8990.98
436_S484_L0.8980.98
235_A239_G0.8970.98
160_P476_V0.8960.98
259_P263_N0.8950.98
74_I77_T0.8950.98
197_I203_P0.8950.98
225_Y231_A0.8930.98
69_F74_I0.8910.98
10_V21_I0.8910.98
223_R228_M0.8900.98
379_L385_P0.8890.98
71_A74_I0.8860.98
112_V116_L0.8850.98
82_S338_T0.8830.98
199_L206_M0.8820.98
232_E237_T0.8780.98
14_L32_G0.8760.98
233_H236_T0.8760.98
421_A426_M0.8720.97
202_I209_I0.8700.97
221_S228_M0.8690.97
172_F407_S0.8680.97
226_G230_T0.8670.97
34_W310_V0.8670.97
163_T439_I0.8670.97
215_V222_R0.8580.97
71_A80_L0.8570.97
197_I201_A0.8570.97
15_A32_G0.8560.97
124_D127_A0.8550.97
216_A221_S0.8550.97
480_T484_L0.8520.97
71_A81_G0.8520.97
378_F381_P0.8500.97
83_S338_T0.8500.97
333_E336_D0.8440.97
206_M211_A0.8440.97
86_M319_T0.8400.97
11_P14_L0.8370.97
210_L214_M0.8350.97
82_S85_A0.8350.97
52_W360_N0.8310.97
434_V438_A0.8300.97
197_I200_Q0.8270.96
228_M234_R0.8260.96
14_L20_I0.8250.96
221_S225_Y0.8250.96
145_L149_K0.8210.96
397_F440_F0.8210.96
380_T385_P0.8190.96
222_R228_M0.8150.96
204_F207_Y0.8100.96
266_L276_L0.8070.96
279_V282_A0.8070.96
473_A476_V0.8000.96
264_P280_T0.7980.96
69_F81_G0.7980.96
381_P386_V0.7980.96
360_N363_D0.7960.96
385_P388_V0.7960.96
123_F126_Y0.7950.96
42_G49_T0.7950.96
383_L386_V0.7930.96
32_G35_S0.7930.96
71_A79_L0.7930.96
201_A208_S0.7920.96
279_V284_A0.7900.95
212_V221_S0.7880.95
106_S142_H0.7880.95
159_A439_I0.7850.95
118_G122_F0.7840.95
78_L84_V0.7830.95
380_T386_V0.7820.95
200_Q207_Y0.7780.95
217_I222_R0.7770.95
14_L17_A0.7750.95
42_G45_G0.7740.95
384_L387_V0.7730.95
315_M319_T0.7730.95
227_A234_R0.7720.95
434_V437_G0.7720.95
445_S449_D0.7700.95
71_A84_V0.7660.95
47_Q51_S0.7610.94
388_V394_F0.7600.94
262_E266_L0.7580.94
279_V283_T0.7570.94
267_V272_P0.7560.94
218_I224_D0.7540.94
219_V224_D0.7530.94
406_M438_A0.7520.94
285_L289_Y0.7500.94
389_M481_A0.7490.94
444_A466_V0.7480.94
386_V389_M0.7480.94
234_R238_T0.7470.94
234_R237_T0.7440.94
96_V269_F0.7420.94
266_L269_F0.7400.94
222_R226_G0.7390.94
107_K236_T0.7370.93
264_P268_S0.7370.93
210_L218_I0.7340.93
329_L334_S0.7320.93
275_V315_M0.7280.93
198_F206_M0.7270.93
264_P284_A0.7260.93
266_L280_T0.7260.93
223_R231_A0.7230.93
428_S432_G0.7170.92
207_Y214_M0.7170.92
118_G167_S0.7160.92
235_A238_T0.7160.92
382_A386_V0.7140.92
125_D169_W0.7130.92
272_P281_I0.7120.92
210_L217_I0.7120.92
55_R69_F0.7120.92
263_N276_L0.7080.92
285_L288_G0.7040.92
263_N266_L0.7040.92
78_L349_V0.7030.92
269_F281_I0.7030.92
71_A78_L0.7010.92
12_P16_I0.7010.92
413_A434_V0.7000.92
206_M483_L0.6990.92
381_P385_P0.6980.91
90_L319_T0.6970.91
224_D234_R0.6970.91
231_A236_T0.6960.91
214_M221_S0.6950.91
218_I223_R0.6940.91
15_A20_I0.6920.91
447_I466_V0.6910.91
205_N210_L0.6900.91
156_S472_Y0.6890.91
354_L358_I0.6860.91
86_M316_V0.6850.91
221_S227_A0.6840.91
98_D102_T0.6840.91
468_T471_Y0.6830.91
218_I225_Y0.6820.91
203_P210_L0.6810.90
115_W153_V0.6810.90
209_I212_V0.6800.90
228_M232_E0.6800.90
70_H356_W0.6770.90
197_I202_I0.6760.90
226_G233_H0.6750.90
413_A430_V0.6730.90
209_I216_A0.6730.90
215_V221_S0.6730.90
219_V223_R0.6720.90
229_L234_R0.6720.90
79_L83_S0.6700.90
433_V437_G0.6680.90
200_Q209_I0.6680.90
271_V276_L0.6660.89
154_V158_A0.6660.89
163_T173_Q0.6650.89
210_L215_V0.6620.89
12_P20_I0.6610.89
481_A485_A0.6590.89
42_G365_L0.6560.89
262_E272_P0.6560.89
284_A288_G0.6540.89
13_L20_I0.6530.89
476_V480_T0.6530.89
186_V201_A0.6530.89
79_L82_S0.6530.89
75_V85_A0.6530.89
220_L225_Y0.6520.88
225_Y232_E0.6510.88
201_A206_M0.6490.88
208_S213_V0.6460.88
16_I21_I0.6450.88
117_L132_V0.6450.88
381_P384_L0.6440.88
204_F211_A0.6410.88
462_L466_V0.6410.88
146_S149_K0.6400.88
432_G437_G0.6400.88
23_R28_S0.6390.87
39_I42_G0.6380.87
208_S215_V0.6360.87
220_L226_G0.6360.87
260_S276_L0.6360.87
199_L209_I0.6350.87
106_S143_L0.6350.87
10_V19_A0.6350.87
199_L207_Y0.6290.87
361_V364_A0.6280.87
227_A233_H0.6280.87
36_G358_I0.6270.86
69_F80_L0.6240.86
383_L485_A0.6240.86
485_A490_T0.6240.86
206_M217_I0.6220.86
261_A264_P0.6180.86
123_F454_S0.6180.86
374_I378_F0.6180.86
45_G50_F0.6170.86
69_F85_A0.6160.85
258_E262_E0.6160.85
36_G367_T0.6160.85
445_S469_Q0.6130.85
273_V280_T0.6120.85
265_S272_P0.6120.85
71_A83_S0.6090.85
261_A276_L0.6090.85
186_V200_Q0.6080.85
232_E235_A0.6060.85
451_T469_Q0.6050.84
47_Q50_F0.6050.84
448_S452_V0.6040.84
336_D340_D0.6040.84
50_F310_V0.6030.84
73_I77_T0.6030.84
269_F273_V0.6030.84
10_V20_I0.6030.84
74_I82_S0.6020.84
87_I92_G0.6010.84
412_I433_V0.6000.84
46_I49_T0.5990.84
126_Y158_A0.5990.84
486_V490_T0.5980.84
30_F313_F0.5980.84
82_S316_V0.5980.84
161_V167_S0.5950.83
144_G230_T0.5930.83
68_V71_A0.5930.83
396_A402_S0.5920.83
275_V279_V0.5910.83
118_G157_T0.5910.83
152_Y156_S0.5900.83
217_I223_R0.5900.83
460_A465_H0.5890.83
70_H80_L0.5880.83
90_L323_G0.5870.83
51_S54_V0.5850.82
268_S276_L0.5850.82
201_A209_I0.5850.82
113_V117_L0.5840.82
212_V223_R0.5840.82
76_F80_L0.5820.82
170_V174_L0.5820.82
296_Y304_Y0.5810.82
151_S460_A0.5810.82
14_L19_A0.5810.82
68_V80_L0.5790.82
261_A272_P0.5790.82
265_S276_L0.5770.82
90_L328_I0.5760.81
162_A165_G0.5750.81
451_T465_H0.5750.81
93_S97_R0.5750.81
262_E280_T0.5740.81
38_I46_I0.5740.81
69_F73_I0.5740.81
389_M393_A0.5730.81
393_A477_I0.5730.81
397_F470_L0.5720.81
73_I85_A0.5710.81
198_F207_Y0.5710.81
136_M154_V0.5700.81
68_V81_G0.5700.81
174_L178_E0.5690.81
152_Y469_Q0.5690.81
259_P264_P0.5690.81
420_L425_T0.5680.81
173_Q431_V0.5670.80
111_G153_V0.5660.80
237_T240_A0.5650.80
230_T236_T0.5640.80
202_I207_Y0.5640.80
225_Y238_T0.5630.80
155_D469_Q0.5600.80
119_V161_V0.5590.80
483_L486_V0.5580.79
223_R233_H0.5570.79
206_M212_V0.5560.79
448_S451_T0.5560.79
270_F276_L0.5540.79
13_L16_I0.5520.79
404_G408_I0.5520.79
126_Y167_S0.5520.79
36_G361_V0.5510.79
276_L289_Y0.5500.78
219_V226_G0.5490.78
207_Y211_A0.5470.78
12_P15_A0.5460.78
9_V13_L0.5450.78
396_A448_S0.5420.77
371_V412_I0.5420.77
393_A397_F0.5410.77
368_A372_S0.5410.77
213_V219_V0.5400.77
49_T54_V0.5400.77
472_Y476_V0.5400.77
214_M220_L0.5390.77
55_R68_V0.5390.77
225_Y233_H0.5390.77
269_F279_V0.5390.77
133_G137_K0.5390.77
268_S271_V0.5380.77
415_P420_L0.5370.77
371_V375_A0.5350.77
440_F444_A0.5320.76
51_S390_F0.5310.76
209_I218_I0.5310.76
57_I75_V0.5300.76
72_Q85_A0.5300.76
234_R239_G0.5290.76
110_A143_L0.5270.75
85_A337_T0.5270.75
347_T351_I0.5250.75
421_A427_V0.5250.75
323_G334_S0.5250.75
339_V343_G0.5240.75
73_I78_L0.5220.75
206_M214_M0.5220.75
387_V391_T0.5200.75
10_V13_L0.5190.74
45_G56_S0.5190.74
199_L208_S0.5180.74
265_S271_V0.5170.74
466_V470_L0.5170.74
277_I281_I0.5160.74
478_A485_A0.5150.74
271_V318_S0.5150.74
187_S197_I0.5140.74
98_D142_H0.5120.73
204_F212_V0.5110.73
77_T457_F0.5110.73
86_M90_L0.5110.73
77_T348_A0.5080.73
123_F127_A0.5070.73
140_S145_L0.5070.73
384_L394_F0.5070.73
148_E231_A0.5070.73
92_G269_F0.5060.73
155_D454_S0.5060.73
236_T240_A0.5060.73
35_S38_I0.5050.72
299_V304_Y0.5050.72
219_V227_A0.5050.72
26_I350_T0.5040.72
75_V83_S0.5040.72
122_F126_Y0.5040.72
219_V228_M0.5030.72
198_F210_L0.5030.72
259_P265_S0.5020.72
259_P262_E0.5010.72
174_L197_I0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.8526 100 0.701 Contact Map
4r0cA 3 0.8302 100 0.71 Contact Map
4f35D 2 0.7388 100 0.733 Contact Map
2xq2A 2 0.8358 28.8 0.97 Contact Map
2cfqA 1 0.722 22.5 0.971 Contact Map
4pd6A 3 0.6194 19.2 0.972 Contact Map
2m20A 2 0.0914 15.2 0.974 Contact Map
3d31C 2 0.4235 14.4 0.974 Contact Map
3qe7A 2 0.4067 13 0.974 Contact Map
3zuxA 1 0.3134 11.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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