GREMLIN Database
Q9HNR0 - Protein-export membrane protein SecD
UniProt: Q9HNR0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 509 (458)
Sequences: 2298 (1591)
Seq/√Len: 74.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
349_Q353_P6.1961.00
397_F484_L5.5871.00
380_A383_M5.3351.00
381_I384_V4.6971.00
380_A384_V4.6301.00
230_D234_R4.6021.00
378_K381_I4.5341.00
20_S393_I4.3271.00
380_A387_A3.9071.00
378_K384_V3.7391.00
227_P238_P3.6581.00
239_V303_F3.4631.00
378_K382_P3.4521.00
378_K383_M3.3661.00
63_T173_H3.2841.00
461_I483_I3.2681.00
220_E242_S3.2301.00
490_V494_R3.2241.00
381_I387_A3.2001.00
378_K387_A3.0431.00
419_T460_T2.9971.00
384_V387_A2.9861.00
272_G292_P2.9561.00
380_A386_T2.9531.00
291_G306_N2.8861.00
101_P104_G2.8601.00
383_M387_A2.8561.00
271_N274_Y2.8471.00
206_S209_T2.8401.00
381_I385_F2.8361.00
379_I383_M2.7731.00
137_Q163_D2.7561.00
236_F304_V2.7431.00
379_I382_P2.7281.00
389_A496_A2.6781.00
185_S189_S2.6181.00
251_G255_Q2.5961.00
104_G107_E2.4521.00
360_L364_I2.4461.00
383_M386_T2.4341.00
431_V442_F2.3891.00
234_R291_G2.3761.00
201_A252_D2.2351.00
236_F306_N2.2321.00
11_A15_V2.2271.00
216_L248_R2.1881.00
13_L496_A2.1311.00
186_Q321_N2.1221.00
28_G399_A2.0841.00
381_I386_T2.0531.00
382_P387_A2.0481.00
188_Q340_S2.0391.00
378_K385_F2.0281.00
394_L484_L2.0201.00
428_A464_M2.0171.00
254_T297_T2.0011.00
203_Y211_V2.0011.00
17_V389_A1.9811.00
450_L454_G1.9631.00
457_A490_V1.9081.00
380_A385_F1.9051.00
431_V445_R1.8611.00
64_V333_A1.8461.00
240_Q302_K1.8411.00
464_M482_T1.8281.00
215_V252_D1.8171.00
40_A44_D1.8021.00
273_G291_G1.7821.00
298_L303_F1.7811.00
361_A365_A1.7711.00
359_G417_I1.7591.00
68_T71_G1.7411.00
382_P386_T1.7411.00
423_D489_G1.7411.00
379_I384_V1.7371.00
148_G152_D1.7251.00
154_T190_L1.7041.00
38_Q42_T1.6961.00
182_Q187_V1.6931.00
444_S448_K1.6791.00
84_T88_T1.6751.00
363_A391_V1.6661.00
464_M483_I1.6551.00
428_A482_T1.6471.00
419_T482_T1.6451.00
15_V19_A1.6171.00
107_E110_Q1.6000.99
442_F505_L1.5950.99
357_V361_A1.5910.99
382_P385_F1.5890.99
483_I487_L1.5830.99
204_P275_C1.5740.99
105_S109_Y1.5660.99
378_K386_T1.5490.99
183_N186_Q1.4990.99
26_A29_I1.4930.99
216_L220_E1.4810.99
489_G494_R1.4800.99
466_P470_L1.4720.99
250_T299_S1.4660.99
410_L414_I1.4480.99
16_L19_A1.4360.99
277_L280_L1.4330.99
24_L29_I1.4280.99
379_I387_A1.4160.99
454_G458_A1.4150.99
298_L301_G1.4110.99
278_T286_Y1.4080.99
134_G138_A1.4070.99
303_F309_F1.3830.98
309_F315_S1.3740.98
227_P236_F1.3560.98
494_R497_Y1.3490.98
364_I368_I1.3440.98
425_V482_T1.3370.98
291_G304_V1.3350.98
115_S118_R1.3340.98
99_A108_V1.3290.98
186_Q189_S1.3260.98
448_K451_W1.3220.98
112_V121_L1.3220.98
359_G410_L1.3120.98
112_V115_S1.3070.98
73_S77_D1.2960.98
37_G40_A1.2810.97
292_P306_N1.2660.97
463_A466_P1.2590.97
353_P357_V1.2550.97
199_L305_N1.2430.97
292_P297_T1.2410.97
394_L488_I1.2370.97
238_P304_V1.2300.97
104_G108_V1.2180.96
416_V485_G1.2140.96
272_G277_L1.2140.96
422_D459_T1.2130.96
10_I14_V1.2080.96
366_V417_I1.1980.96
431_V460_T1.1980.96
286_Y322_L1.1950.96
132_R136_T1.1940.96
306_N309_F1.1900.96
137_Q141_D1.1840.96
350_K354_L1.1780.96
184_A192_Q1.1730.96
223_E240_Q1.1660.95
19_A400_V1.1560.95
446_F501_L1.1530.95
228_K235_P1.1510.95
285_V325_N1.1450.95
288_A301_G1.1420.95
10_I15_V1.1360.95
440_R444_S1.1280.95
273_G277_L1.1260.95
82_I88_T1.1260.95
271_N277_L1.1140.94
189_S321_N1.1090.94
80_G213_A1.1050.94
68_T334_E1.1020.94
59_R160_E1.1020.94
285_V288_A1.1000.94
415_A445_R1.0990.94
359_G414_I1.0960.94
39_Q43_G1.0890.93
39_Q42_T1.0850.93
133_R137_Q1.0800.93
244_E248_R1.0710.93
102_A106_V1.0680.93
303_F308_S1.0660.93
275_C289_S1.0640.93
417_I428_A1.0620.93
371_L379_I1.0620.93
228_K316_M1.0610.93
359_G362_A1.0580.92
453_I489_G1.0570.92
246_A249_F1.0520.92
405_L408_S1.0520.92
272_G297_T1.0510.92
379_I386_T1.0480.92
413_F433_T1.0480.92
299_S303_F1.0480.92
272_G275_C1.0470.92
203_Y208_G1.0470.92
20_S24_L1.0400.92
386_T497_Y1.0380.92
120_T125_G1.0350.92
156_L179_V1.0340.92
324_V327_Q1.0310.91
109_Y113_S1.0290.91
289_S292_P1.0280.91
286_Y300_S1.0240.91
99_A104_G1.0230.91
131_V134_G1.0200.91
422_D430_E1.0180.91
366_V418_G1.0060.90
204_P441_I1.0040.90
85_R88_T1.0010.90
67_V70_D0.9990.90
58_V63_T0.9980.90
66_G136_T0.9960.90
456_A494_R0.9900.90
70_D136_T0.9840.89
58_V184_A0.9820.89
36_S42_T0.9800.89
106_V110_Q0.9790.89
246_A250_T0.9780.89
277_L288_A0.9760.89
224_V323_Q0.9750.89
190_L324_V0.9730.89
187_V335_I0.9720.89
422_D475_L0.9690.89
13_L16_L0.9680.89
67_V72_V0.9670.89
89_A107_E0.9660.89
65_T68_T0.9650.89
250_T297_T0.9620.88
449_A453_I0.9560.88
274_Y277_L0.9520.88
246_A301_G0.9510.88
465_S483_I0.9510.88
272_G276_L0.9450.87
419_T464_M0.9420.87
374_Y415_A0.9360.87
359_G363_A0.9350.87
38_Q41_A0.9290.87
96_D100_R0.9280.86
105_S108_V0.9270.86
216_L250_T0.9200.86
19_A23_A0.9180.86
394_L417_I0.9170.86
443_Q447_R0.9100.85
428_A450_L0.9060.85
419_T428_A0.8940.84
425_V464_M0.8920.84
394_L463_A0.8920.84
14_V18_V0.8900.84
419_T425_V0.8890.84
423_D457_A0.8890.84
51_G54_L0.8870.84
74_V78_N0.8850.84
16_L26_A0.8810.84
202_Y287_N0.8800.83
499_D502_R0.8780.83
12_A16_L0.8750.83
104_G111_N0.8720.83
78_N85_R0.8680.83
22_V43_G0.8670.83
102_A105_S0.8660.82
468_A476_R0.8620.82
362_A367_A0.8610.82
95_G100_R0.8610.82
414_I428_A0.8590.82
404_A407_L0.8580.82
276_L279_K0.8560.82
303_F306_N0.8560.82
398_A402_G0.8510.81
120_T124_A0.8510.81
112_V117_L0.8490.81
203_Y206_S0.8450.81
412_G481_V0.8440.81
438_S441_I0.8370.80
300_S305_N0.8360.80
43_G46_T0.8330.80
39_Q47_N0.8330.80
464_M497_Y0.8310.80
230_D236_F0.8300.80
412_G421_V0.8290.80
39_Q44_D0.8290.80
239_V246_A0.8280.80
9_R13_L0.8270.79
231_Q234_R0.8270.79
416_V460_T0.8260.79
271_N276_L0.8250.79
106_V109_Y0.8240.79
15_V18_V0.8240.79
91_D94_R0.8210.79
59_R339_N0.8200.79
278_T281_D0.8190.79
138_A142_N0.8110.78
18_V22_V0.8100.78
405_L409_H0.8050.78
113_S117_L0.8040.78
367_A470_L0.8020.77
414_I420_G0.8020.77
272_G299_S0.8020.77
391_V490_V0.7980.77
398_A403_L0.7970.77
367_A371_L0.7960.77
16_L393_I0.7940.77
63_T338_Q0.7930.77
416_V488_I0.7920.76
37_G47_N0.7920.76
69_A139_T0.7900.76
356_L360_L0.7900.76
414_I444_S0.7870.76
419_T486_V0.7870.76
44_D47_N0.7870.76
429_D453_I0.7860.76
41_A45_P0.7850.76
24_L28_G0.7840.76
36_S47_N0.7820.76
10_I13_L0.7810.75
393_I397_F0.7790.75
371_L384_V0.7780.75
37_G42_T0.7780.75
448_K463_A0.7780.75
30_G35_T0.7770.75
444_S447_R0.7770.75
114_T122_E0.7750.75
438_S444_S0.7750.75
492_V497_Y0.7730.75
45_P66_G0.7730.75
78_N82_I0.7720.75
309_F322_L0.7710.75
151_I159_A0.7700.74
414_I456_A0.7670.74
179_V187_V0.7670.74
69_A136_T0.7670.74
145_S148_G0.7660.74
457_A462_L0.7650.74
430_E434_E0.7630.74
420_G489_G0.7620.74
412_G453_I0.7620.74
446_F489_G0.7610.74
16_L496_A0.7570.73
241_L303_F0.7560.73
249_F303_F0.7560.73
366_V370_V0.7510.73
49_N402_G0.7480.72
35_T41_A0.7470.72
109_Y112_V0.7470.72
380_A504_L0.7450.72
18_V38_Q0.7450.72
36_S44_D0.7440.72
412_G482_T0.7430.72
398_A418_G0.7430.72
68_T72_V0.7420.72
460_T483_I0.7420.72
404_A408_S0.7420.72
475_L480_L0.7420.72
203_Y209_T0.7420.72
430_E433_T0.7410.72
279_K287_N0.7390.71
11_A14_V0.7370.71
396_G400_V0.7370.71
228_K234_R0.7370.71
349_Q368_I0.7340.71
71_G364_I0.7340.71
450_L494_R0.7330.71
10_I23_A0.7310.71
19_A46_T0.7280.70
297_T300_S0.7280.70
223_E327_Q0.7280.70
280_L288_A0.7280.70
46_T49_N0.7260.70
317_T320_R0.7250.70
222_V240_Q0.7220.70
415_A455_A0.7200.69
132_R221_L0.7200.69
119_T125_G0.7190.69
70_D139_T0.7180.69
373_R458_A0.7180.69
20_S28_G0.7170.69
88_T124_A0.7170.69
411_A478_F0.7130.69
37_G41_A0.7130.69
23_A362_A0.7130.69
415_A422_D0.7120.69
460_T482_T0.7110.68
382_P501_L0.7110.68
118_R123_D0.7090.68
153_A327_Q0.7080.68
151_I156_L0.7080.68
456_A464_M0.7050.68
69_A346_S0.7050.68
228_K233_G0.7020.67
287_N301_G0.7020.67
144_V148_G0.7000.67
308_S315_S0.6970.67
200_D214_T0.6970.67
92_V108_V0.6960.67
393_I488_I0.6960.67
15_V110_Q0.6940.67
93_D493_T0.6930.66
280_L298_L0.6920.66
216_L252_D0.6920.66
37_G44_D0.6890.66
211_V215_V0.6880.66
211_V274_Y0.6860.66
119_T126_Y0.6850.66
284_E287_N0.6850.66
51_G56_G0.6840.65
431_V441_I0.6820.65
249_F298_L0.6810.65
460_T480_L0.6790.65
93_D96_D0.6790.65
355_S452_V0.6790.65
18_V109_Y0.6780.65
387_A445_R0.6770.65
238_P302_K0.6750.64
111_N115_S0.6750.64
499_D503_R0.6740.64
23_A45_P0.6730.64
359_G391_V0.6670.63
151_I187_V0.6660.63
366_V463_A0.6660.63
457_A488_I0.6650.63
91_D96_D0.6640.63
286_Y291_G0.6610.63
272_G280_L0.6600.63
10_I21_S0.6590.63
380_A501_L0.6560.62
83_A87_S0.6550.62
120_T126_Y0.6530.62
401_S484_L0.6530.62
81_E84_T0.6530.62
382_P500_V0.6520.62
18_V103_T0.6510.62
222_V242_S0.6500.61
219_D240_Q0.6490.61
155_G161_V0.6490.61
120_T123_D0.6480.61
446_F497_Y0.6480.61
143_I332_P0.6470.61
216_L232_N0.6460.61
371_L382_P0.6460.61
289_S306_N0.6450.61
111_N114_T0.6450.61
428_A446_F0.6440.61
406_D409_H0.6430.61
456_A475_L0.6430.61
375_G417_I0.6420.61
389_A503_R0.6420.61
457_A461_I0.6400.60
54_L57_G0.6390.60
41_A44_D0.6390.60
155_G326_L0.6380.60
422_D460_T0.6380.60
420_G493_T0.6340.60
121_L124_A0.6330.59
426_I456_A0.6330.59
250_T298_L0.6330.59
30_G47_N0.6330.59
199_L253_M0.6320.59
201_A276_L0.6310.59
305_N308_S0.6310.59
16_L20_S0.6310.59
380_A427_I0.6300.59
40_A60_L0.6300.59
40_A45_P0.6290.59
346_S373_R0.6290.59
95_G99_A0.6280.59
338_Q413_F0.6280.59
48_L395_L0.6270.59
111_N116_S0.6260.59
118_R125_G0.6260.59
422_D455_A0.6240.58
118_R131_V0.6240.58
292_P299_S0.6210.58
410_L462_L0.6200.58
297_T303_F0.6200.58
235_P238_P0.6190.58
130_S134_G0.6190.58
288_A291_G0.6190.58
321_N324_V0.6190.58
66_G69_A0.6190.58
72_V196_Q0.6180.58
101_P105_S0.6180.58
414_I464_M0.6180.58
70_D132_R0.6170.57
468_A480_L0.6170.57
365_A418_G0.6170.57
214_T217_R0.6160.57
113_S120_T0.6150.57
254_T299_S0.6130.57
14_V19_A0.6120.57
343_V463_A0.6120.57
145_S196_Q0.6110.57
370_V382_P0.6110.57
249_F301_G0.6100.57
96_D101_P0.6080.56
21_S91_D0.6080.56
211_V225_D0.6070.56
385_F500_V0.6060.56
367_A488_I0.6060.56
303_F307_P0.6050.56
374_Y432_M0.6040.56
95_G98_R0.6020.56
68_T75_T0.6010.56
85_R89_A0.6000.55
476_R480_L0.6000.55
457_A493_T0.6000.55
359_G369_M0.6000.55
457_A486_V0.5990.55
364_I367_A0.5990.55
13_L22_V0.5990.55
36_S39_Q0.5980.55
81_E85_R0.5980.55
73_S276_L0.5970.55
79_E95_G0.5960.55
219_D244_E0.5960.55
459_T478_F0.5950.55
180_P407_L0.5940.55
203_Y207_N0.5940.55
278_T288_A0.5930.55
201_A215_V0.5930.55
457_A489_G0.5920.54
371_L391_V0.5910.54
112_V119_T0.5910.54
105_S125_G0.5900.54
370_V421_V0.5900.54
13_L499_D0.5890.54
240_Q243_A0.5890.54
374_Y478_F0.5880.54
428_A489_G0.5870.54
141_D163_D0.5870.54
59_R458_A0.5860.54
160_E176_V0.5860.54
362_A366_V0.5850.54
73_S221_L0.5850.54
215_V476_R0.5840.53
66_G140_R0.5840.53
357_V366_V0.5840.53
20_S23_A0.5800.53
23_A400_V0.5800.53
241_L249_F0.5780.53
91_D101_P0.5780.53
83_A90_L0.5780.53
351_Y471_S0.5760.52
456_A483_I0.5760.52
63_T239_V0.5750.52
398_A450_L0.5740.52
192_Q221_L0.5740.52
464_M488_I0.5730.52
14_V371_L0.5730.52
239_V245_A0.5700.52
35_T38_Q0.5700.52
230_D398_A0.5690.52
363_A469_V0.5690.52
35_T39_Q0.5690.52
315_S318_A0.5680.51
10_I503_R0.5670.51
359_G366_V0.5670.51
404_A415_A0.5660.51
13_L82_I0.5660.51
449_A478_F0.5650.51
152_D161_V0.5640.51
91_D363_A0.5640.51
40_A47_N0.5630.51
278_T298_L0.5630.51
186_Q337_V0.5610.51
424_L455_A0.5610.51
428_A466_P0.5610.51
458_A462_L0.5600.50
288_A298_L0.5600.50
247_Q251_G0.5590.50
451_W456_A0.5580.50
109_Y121_L0.5570.50
175_I181_G0.5570.50
323_Q327_Q0.5560.50
98_R103_T0.5560.50
12_A21_S0.5550.50
20_S27_P0.5550.50
227_P304_V0.5540.50
440_R483_I0.5540.50
473_G477_G0.5540.50
272_G289_S0.5540.50
416_V419_T0.5520.49
65_T80_G0.5510.49
232_N235_P0.5500.49
101_P360_L0.5500.49
18_V21_S0.5500.49
117_L125_G0.5490.49
37_G45_P0.5490.49
348_A415_A0.5480.49
460_T464_M0.5480.49
10_I499_D0.5480.49
88_T487_L0.5480.49
117_L120_T0.5480.49
403_L407_L0.5470.49
90_L107_E0.5470.49
251_G254_T0.5470.49
285_V299_S0.5470.49
100_R108_V0.5460.49
220_E244_E0.5460.49
389_A456_A0.5460.49
102_A108_V0.5460.49
61_R164_I0.5450.49
10_I22_V0.5440.48
359_G483_I0.5440.48
74_V205_G0.5440.48
286_Y309_F0.5440.48
302_K305_N0.5440.48
67_V367_A0.5430.48
398_A452_V0.5430.48
133_R140_R0.5430.48
464_M474_D0.5420.48
59_R176_V0.5410.48
363_A388_L0.5410.48
250_T254_T0.5400.48
398_A415_A0.5400.48
10_I45_P0.5400.48
129_D133_R0.5400.48
151_I162_K0.5400.48
387_A390_E0.5400.48
390_E455_A0.5390.48
211_V255_Q0.5390.48
225_D238_P0.5390.48
95_G101_P0.5380.48
199_L322_L0.5380.48
357_V417_I0.5380.48
373_R422_D0.5370.48
417_I480_L0.5350.47
103_T106_V0.5350.47
23_A43_G0.5350.47
105_S110_Q0.5340.47
15_V124_A0.5340.47
213_A465_S0.5340.47
178_E342_Y0.5330.47
149_S198_T0.5330.47
11_A368_I0.5330.47
21_S26_A0.5310.47
461_I487_L0.5310.47
450_L501_L0.5300.47
22_V71_G0.5300.47
358_T425_V0.5300.47
446_F478_F0.5300.47
359_G448_K0.5290.47
124_A127_S0.5290.47
17_V98_R0.5280.46
275_C287_N0.5270.46
153_A328_A0.5270.46
191_I435_Q0.5270.46
246_A253_M0.5260.46
150_K181_G0.5260.46
288_A303_F0.5260.46
82_I95_G0.5240.46
63_T67_V0.5220.46
358_T479_A0.5210.46
291_G297_T0.5200.45
50_Y54_L0.5200.45
279_K283_E0.5200.45
22_V40_A0.5190.45
411_A455_A0.5190.45
326_L479_A0.5180.45
77_D80_G0.5170.45
441_I489_G0.5170.45
109_Y123_D0.5160.45
18_V92_V0.5150.45
20_S26_A0.5140.45
12_A26_A0.5140.45
174_Y358_T0.5140.45
18_V37_G0.5130.45
54_L58_V0.5120.44
50_Y352_K0.5120.44
96_D251_G0.5120.44
69_A135_V0.5120.44
155_G345_P0.5120.44
120_T436_V0.5110.44
97_V368_I0.5100.44
12_A23_A0.5100.44
379_I385_F0.5090.44
96_D104_G0.5080.44
73_S78_N0.5080.44
164_I176_V0.5080.44
235_P369_M0.5080.44
478_F489_G0.5060.44
249_F253_M0.5060.44
353_P356_L0.5060.44
301_G309_F0.5060.44
63_T336_T0.5060.44
36_S40_A0.5050.44
426_I460_T0.5040.43
241_L252_D0.5040.43
271_N280_L0.5040.43
102_A127_S0.5040.43
16_L23_A0.5040.43
154_T285_V0.5040.43
352_K420_G0.5030.43
187_V490_V0.5030.43
59_R65_T0.5020.43
19_A122_E0.5020.43
159_A321_N0.5020.43
14_V24_L0.5010.43
147_I404_A0.5010.43
67_V134_G0.5000.43
245_A328_A0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqpA 1 0.776 100 0.395 Contact Map
4k0jA 3 0.8978 100 0.473 Contact Map
3w9iA 3 0.9018 100 0.49 Contact Map
3ne5A 3 0.9077 100 0.495 Contact Map
4mt1A 3 0.8939 100 0.502 Contact Map
4dx5A 3 0.9018 100 0.505 Contact Map
3aqoA 1 0.3772 99.9 0.764 Contact Map
4r86A 1 0.501 98.2 0.9 Contact Map
4ea3A 2 0.5147 14 0.97 Contact Map
1in0A 1 0.3143 12.8 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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