GREMLIN Database
Q9HNQ9 - Protein-export membrane protein SecF
UniProt: Q9HNQ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 284 (264)
Sequences: 52905 (38346)
Seq/√Len: 2360.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_K73_D2.7811.00
71_A75_E2.7751.00
170_L257_M2.7221.00
98_A102_S2.6991.00
215_V219_M2.5741.00
21_A24_L2.5421.00
97_N102_S2.5411.00
94_Q97_N2.4531.00
216_D219_M2.3891.00
208_S213_E2.3241.00
166_V261_T2.2711.00
97_N100_G2.2221.00
152_P206_R2.1681.00
215_V218_A2.1181.00
37_W41_T2.1081.00
95_S99_P2.0411.00
99_P102_S2.0381.00
234_V256_V2.0181.00
65_S68_V2.0071.00
234_V260_V2.0061.00
82_V87_N1.9901.00
214_S217_R1.9541.00
94_Q102_S1.9531.00
208_S211_F1.9271.00
67_Q71_A1.8431.00
26_V276_W1.8421.00
38_M41_T1.8371.00
222_G225_M1.8341.00
17_R20_V1.8211.00
82_V93_F1.8061.00
66_A69_K1.8051.00
68_V71_A1.7991.00
65_S69_K1.7921.00
94_Q98_A1.7641.00
38_M42_G1.7591.00
42_G172_N1.7241.00
230_I263_L1.7241.00
189_L258_G1.7141.00
82_V89_Y1.7001.00
68_V75_E1.6951.00
196_S230_I1.6871.00
49_I56_E1.6831.00
206_R210_G1.6781.00
77_T80_R1.6781.00
66_A70_A1.6741.00
96_E100_G1.6581.00
82_V86_G1.6351.00
87_N93_F1.6311.00
133_A137_L1.6271.00
126_G130_L1.6231.00
129_L133_A1.6181.00
140_S153_S1.6141.00
72_F75_E1.6121.00
118_P122_S1.6091.00
130_L134_A1.5921.00
126_G129_L1.5861.00
174_F253_L1.5841.00
203_H221_T1.5751.00
16_M216_D1.5611.00
70_A73_D1.5581.00
213_E217_R1.5401.00
17_R21_A1.5321.00
71_A74_A1.5241.00
65_S75_E1.5161.00
22_P275_R1.4841.00
211_F214_S1.4481.00
171_M254_V1.4411.00
16_M20_V1.4361.00
52_T56_E1.4331.00
83_G88_R1.4331.00
99_P103_G1.4261.00
95_S102_S1.4081.00
95_S98_A1.4041.00
70_A74_A1.3971.00
140_S157_V1.3921.00
246_T249_S1.3881.00
87_N91_A1.3711.00
22_P276_W1.3701.00
83_G87_N1.3701.00
227_L263_L1.3671.00
144_F153_S1.3641.00
193_S262_D1.3621.00
203_H207_R1.3591.00
82_V85_N1.3591.00
98_A101_I1.3571.00
89_Y93_F1.3521.00
81_S85_N1.3371.00
18_Q25_A1.3351.00
76_P80_R1.3091.00
262_D266_T1.3071.00
88_R92_T1.3031.00
39_A42_G1.2931.00
67_Q70_A1.2901.00
203_H208_S1.2881.00
24_L27_L1.2851.00
130_L133_A1.2841.00
226_T230_I1.2491.00
110_I113_S1.2381.00
97_N101_I1.2341.00
174_F257_M1.2221.00
65_S71_A1.2221.00
241_Y256_V1.2031.00
23_P276_W1.2011.00
69_K75_E1.1881.00
100_G104_D1.1871.00
76_P79_F1.1751.00
31_L35_G1.1601.00
196_S229_S1.1561.00
216_D275_R1.1511.00
116_V119_T1.1481.00
241_Y253_L1.1461.00
84_T87_N1.1411.00
88_R91_A1.1391.00
94_Q99_P1.1331.00
222_G230_I1.1271.00
204_V274_L1.1251.00
96_E99_P1.1131.00
122_S126_G1.1071.00
137_L141_V1.1011.00
49_I60_Q1.1011.00
34_I38_M1.0971.00
225_M229_S1.0971.00
20_V216_D1.0951.00
57_V60_Q1.0911.00
225_M230_I1.0901.00
263_L267_Y1.0831.00
56_E59_A1.0831.00
106_A109_E1.0821.00
127_L130_L1.0821.00
171_M182_T1.0731.00
49_I58_V1.0631.00
212_W216_D1.0571.00
35_G38_M1.0501.00
26_V30_A1.0491.00
19_L275_R1.0461.00
81_S84_T1.0411.00
82_V92_T1.0361.00
46_S177_K1.0271.00
52_T55_S1.0251.00
223_V227_L1.0211.00
169_A172_N1.0201.00
238_I256_V1.0191.00
119_T123_S1.0181.00
23_P27_L1.0161.00
176_I253_L1.0151.00
227_L231_A1.0091.00
100_G103_G1.0091.00
35_G39_A1.0061.00
45_V48_G1.0031.00
83_G86_G1.0021.00
167_P258_G0.9921.00
210_G213_E0.9691.00
86_G93_F0.9671.00
84_T93_F0.9641.00
49_I52_T0.9641.00
233_M259_L0.9551.00
82_V90_L0.9541.00
272_T275_R0.9541.00
162_S265_N0.9531.00
120_F123_S0.9431.00
155_A273_L0.9271.00
39_A172_N0.9241.00
217_R220_N0.9231.00
208_S214_S0.9201.00
55_S60_Q0.9201.00
109_E112_Q0.9171.00
208_S221_T0.9121.00
29_V269_L0.9111.00
140_S144_F0.9071.00
73_D76_P0.8981.00
51_F54_G0.8971.00
208_S212_W0.8931.00
15_S19_L0.8901.00
84_T89_Y0.8891.00
249_S253_L0.8871.00
176_I250_S0.8871.00
224_T228_T0.8861.00
52_T58_V0.8841.00
81_S88_R0.8841.00
274_L278_K0.8841.00
139_M194_V0.8831.00
30_A34_I0.8821.00
85_N88_R0.8801.00
60_Q63_A0.8781.00
39_A169_A0.8781.00
86_G89_Y0.8771.00
20_V212_W0.8691.00
33_V37_W0.8671.00
69_K74_A0.8601.00
71_A76_P0.8591.00
50_E53_G0.8541.00
197_D270_N0.8501.00
53_G59_A0.8481.00
207_R211_F0.8471.00
179_S182_T0.8421.00
88_R93_F0.8371.00
49_I53_G0.8351.00
253_L257_M0.8311.00
113_S116_V0.8301.00
256_V260_V0.8271.00
94_Q100_G0.8271.00
225_M228_T0.8261.00
155_A277_Y0.8261.00
59_A62_S0.8221.00
27_L31_L0.8201.00
108_I111_V0.8201.00
222_G226_T0.8201.00
36_G39_A0.8151.00
212_W215_V0.8111.00
149_T152_P0.8091.00
237_T256_V0.8061.00
170_L174_F0.8031.00
86_G90_L0.8021.00
28_V35_G0.8021.00
90_L93_F0.7971.00
166_V265_N0.7961.00
106_A110_I0.7951.00
51_F55_S0.7951.00
74_A78_S0.7941.00
222_G229_S0.7941.00
220_N224_T0.7921.00
33_V166_V0.7911.00
221_T225_M0.7891.00
134_A138_G0.7861.00
209_G214_S0.7831.00
83_G92_T0.7821.00
25_A29_V0.7801.00
178_L182_T0.7781.00
176_I249_S0.7771.00
19_L272_T0.7771.00
179_S250_S0.7671.00
29_V162_S0.7651.00
83_G90_L0.7621.00
51_F59_A0.7601.00
87_N92_T0.7581.00
27_L34_I0.7551.00
85_N89_Y0.7541.00
112_Q115_E0.7511.00
28_V32_A0.7391.00
109_E116_V0.7381.00
69_K72_F0.7381.00
171_M176_I0.7381.00
185_A255_L0.7291.00
82_V88_R0.7281.00
84_T88_R0.7211.00
107_D110_I0.7201.00
56_E60_Q0.7171.00
122_S125_Q0.7141.00
24_L28_V0.7121.00
155_A270_N0.7121.00
50_E54_G0.7121.00
230_I259_L0.7101.00
118_P121_G0.7101.00
85_N93_F0.7081.00
75_E78_S0.7071.00
106_A112_Q0.7061.00
112_Q116_V0.7051.00
98_A104_D0.6971.00
65_S73_D0.6961.00
163_D167_P0.6941.00
159_S270_N0.6941.00
81_S86_G0.6911.00
23_P26_V0.6901.00
170_L261_T0.6901.00
223_V267_Y0.6821.00
272_T276_W0.6801.00
153_S156_V0.6781.00
227_L230_I0.6781.00
152_P278_K0.6761.00
17_R25_A0.6761.00
144_F148_R0.6731.00
115_E119_T0.6701.00
108_I112_Q0.6701.00
207_R210_G0.6701.00
53_G56_E0.6691.00
48_G53_G0.6671.00
74_A80_R0.6671.00
150_F153_S0.6661.00
82_V91_A0.6621.00
125_Q129_L0.6601.00
85_N90_L0.6601.00
20_V23_P0.6581.00
209_G212_W0.6581.00
68_V79_F0.6571.00
39_A173_V0.6561.00
41_T44_P0.6551.00
44_P47_P0.6551.00
39_A43_A0.6521.00
237_T255_L0.6501.00
101_I104_D0.6471.00
49_I55_S0.6451.00
159_S265_N0.6451.00
134_A137_L0.6431.00
57_V62_S0.6381.00
25_A28_V0.6371.00
81_S87_N0.6361.00
215_V275_R0.6351.00
86_G92_T0.6341.00
222_G228_T0.6331.00
101_I105_T0.6321.00
31_L34_I0.6301.00
49_I54_G0.6281.00
169_A173_V0.6271.00
200_L226_T0.6191.00
95_S101_I0.6191.00
135_A139_M0.6161.00
192_Y196_S0.6161.00
89_Y92_T0.6131.00
68_V73_D0.6121.00
94_Q101_I0.6111.00
73_D80_R0.6101.00
87_N90_L0.6091.00
67_Q75_E0.6091.00
185_A254_V0.6091.00
56_E63_A0.6071.00
162_S269_L0.6051.00
156_V201_N0.6041.00
204_V218_A0.6041.00
96_E101_I0.6031.00
53_G60_Q0.6021.00
192_Y233_M0.6021.00
22_P26_V0.6011.00
15_S220_N0.5991.00
66_A71_A0.5981.00
131_G134_A0.5981.00
20_V24_L0.5971.00
241_Y249_S0.5971.00
18_Q272_T0.5951.00
241_Y252_G0.5951.00
68_V72_F0.5941.00
167_P171_M0.5871.00
217_R221_T0.5861.00
33_V165_V0.5841.00
33_V36_G0.5831.00
34_I37_W0.5811.00
119_T122_S0.5801.00
71_A77_T0.5791.00
238_I241_Y0.5781.00
50_E58_V0.5781.00
55_S58_V0.5771.00
121_G125_Q0.5741.00
123_S126_G0.5741.00
212_W275_R0.5731.00
209_G213_E0.5711.00
85_N92_T0.5711.00
216_D220_N0.5671.00
53_G58_V0.5661.00
65_S72_F0.5631.00
44_P48_G0.5621.00
181_G247_L0.5611.00
51_F56_E0.5601.00
68_V74_A0.5571.00
81_S92_T0.5541.00
53_G57_V0.5541.00
165_V169_A0.5541.00
182_T250_S0.5531.00
81_S90_L0.5511.00
65_S74_A0.5511.00
209_G278_K0.5501.00
96_E102_S0.5501.00
214_S218_A0.5501.00
111_V116_V0.5451.00
158_V161_F0.5451.00
40_A43_A0.5421.00
65_S78_S0.5401.00
111_V114_Q0.5391.00
149_T206_R0.5391.00
52_T59_A0.5371.00
260_V264_M0.5341.00
223_V230_I0.5331.00
97_N104_D0.5331.00
156_V197_D0.5321.00
83_G93_F0.5321.00
30_A37_W0.5311.00
141_V145_A0.5311.00
68_V80_R0.5311.00
54_G58_V0.5271.00
167_P186_L0.5271.00
180_L183_V0.5251.00
229_S263_L0.5221.00
263_L266_T0.5201.00
67_Q73_D0.5191.00
191_G195_D0.5191.00
55_S59_A0.5181.00
17_R216_D0.5161.00
16_M220_N0.5161.00
28_V31_L0.5151.00
81_S102_S0.5141.00
50_E55_S0.5131.00
170_L253_L0.5121.00
81_S93_F0.5111.00
106_A111_V0.5101.00
86_G91_A0.5051.00
192_Y195_D0.5031.00
141_V144_F0.5021.00
51_F60_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqpA 1 0.9648 100 0.382 Contact Map
4k0jA 3 0.9437 100 0.385 Contact Map
3ne5A 3 0.9789 100 0.404 Contact Map
3w9iA 3 0.993 100 0.414 Contact Map
4dx5A 3 0.9965 100 0.415 Contact Map
4mt1A 3 0.9648 100 0.42 Contact Map
4or2A 2 0.7007 29.2 0.931 Contact Map
3qrxB 2 0.0704 10.2 0.944 Contact Map
4twkA 2 0.8134 9.8 0.945 Contact Map
2kluA 1 0.1303 9.6 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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