GREMLIN Database
G6PI - Probable glucose-6-phosphate isomerase
UniProt: Q9HNQ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (402)
Sequences: 3525 (1807)
Seq/√Len: 90.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
387_G394_T4.8781.00
62_T210_G4.6351.00
218_D370_R4.4351.00
146_D150_D4.2831.00
315_S366_A4.2731.00
73_T101_H3.3161.00
59_D62_T3.2681.00
253_L296_L3.2221.00
193_A212_L3.1111.00
211_E370_R2.9311.00
126_H162_T2.8571.00
269_L383_C2.8211.00
227_L233_Y2.8081.00
168_P171_A2.7921.00
128_V197_V2.7761.00
58_V61_I2.7621.00
72_D122_T2.7591.00
21_A27_D2.6311.00
111_V143_V2.6151.00
242_L245_R2.5731.00
73_T99_D2.4781.00
69_A121_S2.4601.00
311_L364_V2.4341.00
175_T178_L2.1831.00
75_V118_I2.1731.00
75_V125_V2.1711.00
17_V224_A2.1551.00
169_L180_V2.1481.00
372_V376_L2.0791.00
212_L372_V2.0371.00
252_M266_F2.0341.00
89_L212_L2.0131.00
235_Y378_D1.9391.00
336_D339_A1.9271.00
71_A124_A1.9221.00
54_R220_R1.9211.00
253_L308_V1.9211.00
261_T264_E1.9191.00
22_L31_H1.9041.00
41_D56_V1.9041.00
91_D260_E1.8851.00
314_A363_E1.8791.00
15_P20_D1.8741.00
34_D44_E1.8731.00
313_P364_V1.8661.00
73_T122_T1.8601.00
202_A207_V1.8421.00
58_V62_T1.8291.00
314_A365_P1.8251.00
123_S147_A1.8221.00
286_A295_Q1.8011.00
64_A71_A1.7981.00
247_A305_D1.7961.00
154_D157_A1.7951.00
328_D361_R1.7801.00
120_L147_A1.7701.00
335_G343_A1.7571.00
208_D211_E1.7491.00
49_A54_R1.7441.00
194_L216_A1.7421.00
39_G217_A1.7301.00
261_T286_A1.7101.00
38_A52_L1.6931.00
39_G56_V1.6791.00
89_L201_A1.6721.00
193_A201_A1.6721.00
128_V162_T1.6701.00
226_S229_D1.6631.00
113_R258_R1.6511.00
291_D296_L1.6191.00
114_L118_I1.5981.00
90_V102_A1.5751.00
312_R363_E1.5751.00
214_A370_R1.5571.00
260_E287_L1.5551.00
274_L394_T1.5471.00
338_G342_D1.5431.00
248_G303_P1.5421.00
163_T169_L1.5421.00
74_L126_H1.5401.00
214_A218_D1.5381.00
219_G378_D1.5371.00
31_H394_T1.5351.00
248_G304_R1.5331.00
239_A270_W1.5291.00
240_Y389_L1.5251.00
410_L413_G1.5201.00
83_A87_A1.5171.00
211_E214_A1.5051.00
219_G374_R1.4941.00
370_R374_R1.4671.00
103_L111_V1.4600.99
89_L376_L1.4600.99
344_E351_S1.4500.99
368_D371_S1.4500.99
165_D168_P1.4430.99
270_W280_G1.4420.99
166_D180_V1.4400.99
217_A221_A1.4390.99
34_D38_A1.4380.99
60_A179_P1.4250.99
33_H37_T1.4230.99
149_D152_G1.4080.99
135_A411_L1.4050.99
77_V144_V1.4020.99
344_E348_T1.4010.99
212_L376_L1.3980.99
43_D52_L1.3900.99
126_H160_L1.3820.99
249_V284_A1.3780.99
87_A261_T1.3760.99
222_A374_R1.3410.99
221_A224_A1.3400.99
233_Y385_L1.3320.99
207_V369_A1.3310.99
66_D69_A1.3280.99
231_S378_D1.3280.99
89_L372_V1.3200.99
223_L232_A1.3140.99
52_L56_V1.3130.99
243_D390_Y1.3110.99
44_E53_P1.3010.99
315_S365_P1.2990.99
25_L350_A1.2920.99
237_A389_L1.2850.99
231_S234_A1.2840.99
51_N55_T1.2820.99
299_Y306_K1.2820.99
50_L53_P1.2780.99
211_E369_A1.2740.99
365_P371_S1.2740.99
262_F375_L1.2720.99
103_L144_V1.2620.98
148_M159_T1.2540.98
101_H117_R1.2440.98
68_V121_S1.2410.98
43_D50_L1.2220.98
120_L151_A1.2080.98
255_Y310_M1.2070.98
298_L303_P1.2030.98
214_A217_A1.1940.98
253_L291_D1.1910.98
70_D160_L1.1870.98
278_G304_R1.1860.98
241_A244_Q1.1850.98
329_I413_G1.1790.98
91_D261_T1.1770.98
335_G339_A1.1680.98
37_T381_A1.1650.97
38_A217_A1.1630.97
239_A386_A1.1600.97
183_A196_T1.1600.97
210_G214_A1.1590.97
166_D176_H1.1580.97
62_T207_V1.1540.97
284_A295_Q1.1500.97
95_D316_R1.1490.97
125_V144_V1.1490.97
109_A317_P1.1440.97
40_M59_D1.1440.97
337_L341_L1.1420.97
239_A382_A1.1410.97
16_G22_L1.1350.97
92_A367_V1.1240.97
92_A372_V1.1230.97
40_M56_V1.1230.97
48_A55_T1.1170.97
271_A295_Q1.1160.97
112_T317_P1.1150.97
219_G231_S1.1070.97
250_N270_W1.1030.96
116_D317_P1.1000.96
73_T119_D1.0960.96
109_A256_A1.0880.96
111_V115_L1.0860.96
39_G52_L1.0840.96
21_A47_Y1.0820.96
225_G229_D1.0800.96
73_T118_I1.0790.96
330_D333_T1.0770.96
309_T360_V1.0710.96
106_V289_A1.0670.96
110_H257_E1.0650.96
256_A313_P1.0630.96
146_D322_P1.0520.95
211_E368_D1.0520.95
48_A51_N1.0520.95
115_L147_A1.0510.95
236_G240_Y1.0490.95
338_G341_L1.0490.95
44_E47_Y1.0470.95
328_D359_T1.0420.95
72_D101_H1.0400.95
170_R176_H1.0400.95
253_L288_G1.0380.95
39_G43_D1.0350.95
316_R366_A1.0350.95
248_G305_D1.0350.95
89_L92_A1.0340.95
239_A250_N1.0320.95
64_A179_P1.0320.95
329_I332_L1.0290.95
114_L117_R1.0260.95
166_D170_R1.0250.95
145_R149_D1.0210.95
327_A334_G1.0210.95
44_E52_L1.0180.94
345_F349_A1.0170.94
310_M359_T1.0150.94
218_D374_R1.0110.94
31_H387_G1.0080.94
249_V305_D1.0020.94
298_L306_K1.0010.94
325_E363_E0.9960.94
76_T128_V0.9950.94
296_L308_V0.9910.94
262_F376_L0.9890.94
66_D71_A0.9880.94
257_E260_E0.9870.94
51_N220_R0.9800.93
329_I333_T0.9790.93
52_L187_V0.9790.93
48_A53_P0.9760.93
313_P367_V0.9740.93
254_P287_L0.9730.93
266_F269_L0.9720.93
202_A212_L0.9700.93
344_E347_A0.9700.93
64_A160_L0.9690.93
58_V213_V0.9680.93
87_A260_E0.9650.93
105_N289_A0.9590.93
164_G183_A0.9580.92
42_G221_A0.9550.92
166_D169_L0.9540.92
24_R393_E0.9530.92
127_V141_F0.9400.92
90_V100_Y0.9390.92
366_A371_S0.9370.92
40_M43_D0.9300.91
101_H114_L0.9300.91
331_Y334_G0.9290.91
16_G31_H0.9270.91
250_N309_T0.9250.91
89_L193_A0.9240.91
163_T180_V0.9230.91
259_L311_L0.9230.91
65_A68_V0.9220.91
16_G34_D0.9170.91
263_A285_R0.9150.91
308_V359_T0.9060.90
43_D56_V0.9040.90
72_D99_D0.9030.90
264_E286_A0.8900.89
236_G385_L0.8900.89
164_G169_L0.8810.89
92_A376_L0.8800.89
330_D334_G0.8800.89
38_A42_G0.8790.89
184_P196_T0.8780.89
143_V322_P0.8750.89
259_L262_F0.8740.89
251_A286_A0.8680.88
170_R180_V0.8660.88
405_N408_R0.8530.87
223_L231_S0.8510.87
76_T83_A0.8450.87
99_D117_R0.8450.87
376_L380_E0.8440.87
106_V139_A0.8410.87
39_G214_A0.8400.87
170_R174_D0.8370.86
19_P23_D0.8360.86
318_D336_D0.8360.86
103_L114_L0.8350.86
40_M52_L0.8320.86
38_A56_V0.8290.86
249_V282_T0.8280.86
109_A258_R0.8240.85
57_D60_A0.8230.85
350_A409_E0.8220.85
252_M269_L0.8220.85
321_I324_A0.8220.85
48_A186_G0.8210.85
135_A408_R0.8180.85
90_V204_I0.8170.85
70_D122_T0.8160.85
92_A259_L0.8060.84
212_L216_A0.8050.84
162_T197_V0.8050.84
28_R31_H0.8010.84
48_A52_L0.8000.84
280_G298_L0.7990.84
54_R221_A0.7990.84
124_A160_L0.7950.83
258_R316_R0.7950.83
201_A212_L0.7920.83
46_G50_L0.7920.83
350_A398_P0.7910.83
39_G42_G0.7870.83
64_A181_L0.7860.83
292_Q403_G0.7860.83
238_T242_L0.7850.83
21_A29_V0.7830.82
326_L331_Y0.7820.82
327_A330_D0.7800.82
91_D94_G0.7800.82
317_P320_A0.7800.82
218_D221_A0.7770.82
118_I147_A0.7750.82
250_N386_A0.7740.82
73_T117_R0.7710.81
235_Y360_V0.7690.81
254_P263_A0.7690.81
215_G373_G0.7680.81
288_G299_Y0.7680.81
33_H233_Y0.7680.81
128_V200_P0.7630.81
21_A24_R0.7600.80
111_V144_V0.7600.80
51_N54_R0.7600.80
345_F348_T0.7580.80
115_L118_I0.7580.80
152_G155_W0.7560.80
57_D182_D0.7530.80
138_L142_L0.7530.80
133_T408_R0.7520.80
24_R27_D0.7510.80
109_A113_R0.7460.79
255_Y288_G0.7430.79
74_L100_Y0.7390.79
327_A332_L0.7390.79
149_D155_W0.7370.78
131_S183_A0.7360.78
87_A110_H0.7350.78
135_A139_A0.7350.78
123_S148_M0.7340.78
47_Y51_N0.7320.78
83_A102_A0.7310.78
343_A346_E0.7280.78
283_P382_A0.7280.78
409_E413_G0.7260.77
93_L369_A0.7260.77
33_H381_A0.7250.77
350_A393_E0.7250.77
90_V201_A0.7240.77
240_Y243_D0.7230.77
300_R399_A0.7210.77
17_V34_D0.7200.77
70_D157_A0.7180.77
277_D391_G0.7160.76
191_F383_C0.7160.76
18_P21_A0.7150.76
270_W382_A0.7130.76
320_A323_E0.7120.76
148_M154_D0.7090.76
326_L334_G0.7080.76
44_E50_L0.7060.75
384_V388_E0.7050.75
282_T304_R0.7040.75
219_G362_V0.7040.75
335_G405_N0.7040.75
216_A373_G0.7030.75
312_R342_D0.7020.75
43_D46_G0.7010.75
397_Q400_V0.7000.75
270_W283_P0.6990.75
364_V371_S0.6990.75
167_G171_A0.6960.74
270_W386_A0.6960.74
56_V217_A0.6950.74
167_G170_R0.6900.74
69_A122_T0.6900.74
384_V395_F0.6890.74
258_R317_P0.6890.74
349_A361_R0.6860.73
223_L385_L0.6860.73
371_S374_R0.6850.73
252_M379_F0.6850.73
39_G51_N0.6840.73
107_D256_A0.6820.73
315_S368_D0.6800.73
44_E54_R0.6800.73
411_L415_D0.6780.72
48_A58_V0.6770.72
397_Q404_K0.6770.72
44_E48_A0.6760.72
365_P374_R0.6760.72
148_M155_W0.6740.72
311_L367_V0.6730.72
288_G292_Q0.6720.72
71_A158_R0.6710.72
367_V372_V0.6700.72
201_A205_A0.6690.71
41_D388_E0.6670.71
309_T382_A0.6660.71
239_A281_Q0.6660.71
271_A284_A0.6640.71
68_V124_A0.6610.71
176_H180_V0.6590.70
341_L347_A0.6580.70
330_D406_A0.6560.70
270_W383_C0.6560.70
96_D116_D0.6550.70
337_L352_L0.6550.70
203_A209_V0.6550.70
72_D123_S0.6540.70
40_M217_A0.6530.70
46_G51_N0.6530.70
69_A119_D0.6530.70
219_G235_Y0.6520.69
61_I203_A0.6510.69
250_N382_A0.6500.69
56_V210_G0.6480.69
90_V202_A0.6480.69
76_T88_T0.6480.69
321_I340_L0.6480.69
38_A43_D0.6470.69
58_V210_G0.6470.69
260_E286_A0.6470.69
270_W281_Q0.6430.68
333_T339_A0.6420.68
388_E394_T0.6410.68
279_V390_Y0.6410.68
77_V137_T0.6410.68
265_W269_L0.6390.68
113_R317_P0.6390.68
385_L389_L0.6380.68
111_V319_C0.6380.68
274_L386_A0.6380.68
166_D182_D0.6370.68
44_E51_N0.6360.68
125_V148_M0.6360.68
39_G210_G0.6340.67
207_V210_G0.6280.67
49_A53_P0.6280.67
88_T372_V0.6280.67
134_T189_G0.6270.66
222_A232_A0.6260.66
195_S375_L0.6250.66
235_Y382_A0.6240.66
197_V200_P0.6190.66
163_T170_R0.6190.66
240_Y390_Y0.6180.65
38_A44_E0.6180.65
45_F49_A0.6140.65
87_A91_D0.6140.65
175_T180_V0.6130.65
113_R116_D0.6120.65
108_P256_A0.6100.64
320_A324_A0.6080.64
146_D149_D0.6080.64
45_F50_L0.6070.64
167_G417_L0.6070.64
130_R188_P0.6050.64
273_S293_H0.6040.64
382_A386_A0.6040.64
133_T138_L0.6040.64
43_D48_A0.6020.63
339_A342_D0.6020.63
332_L344_E0.5990.63
94_G205_A0.5980.63
408_R412_R0.5970.63
232_A381_A0.5970.63
308_V328_D0.5970.63
87_A104_D0.5960.63
125_V159_T0.5960.63
247_A304_R0.5950.62
219_G223_L0.5940.62
199_L209_V0.5940.62
74_L204_I0.5920.62
393_E396_T0.5920.62
130_R134_T0.5910.62
326_L329_I0.5900.62
405_N410_L0.5860.61
79_I294_S0.5840.61
295_Q299_Y0.5840.61
108_P318_D0.5830.61
74_L98_L0.5820.61
340_L343_A0.5820.61
343_A405_N0.5820.61
20_D23_D0.5820.61
67_A179_P0.5810.61
353_A359_T0.5800.61
236_G382_A0.5780.60
77_V127_V0.5770.60
18_P24_R0.5720.59
101_H122_T0.5720.59
341_L345_F0.5710.59
22_L29_V0.5710.59
67_A70_D0.5690.59
32_A35_R0.5680.59
108_P143_V0.5680.59
100_Y204_I0.5680.59
293_H297_Q0.5670.59
50_L56_V0.5670.59
52_L55_T0.5650.59
67_A149_D0.5620.58
400_V404_K0.5610.58
342_D346_E0.5600.58
41_D44_E0.5600.58
47_Y50_L0.5590.58
386_A390_Y0.5590.58
68_V126_H0.5580.58
23_D26_D0.5580.58
243_D303_P0.5580.58
219_G222_A0.5580.58
164_G182_D0.5570.57
250_N307_L0.5570.57
325_E329_I0.5550.57
75_V115_L0.5550.57
240_Y386_A0.5550.57
65_A70_D0.5540.57
26_D29_V0.5530.57
189_G268_Q0.5520.57
296_L299_Y0.5510.57
255_Y359_T0.5500.56
316_R320_A0.5500.56
327_A331_Y0.5490.56
79_I289_A0.5490.56
75_V123_S0.5470.56
135_A340_L0.5470.56
67_A157_A0.5460.56
82_S293_H0.5450.56
285_R295_Q0.5440.56
268_Q397_Q0.5430.56
240_Y244_Q0.5430.56
250_N393_E0.5430.56
403_G407_A0.5410.55
110_H290_T0.5400.55
134_T293_H0.5400.55
325_E331_Y0.5400.55
249_V306_K0.5370.55
233_Y389_L0.5370.55
15_P24_R0.5370.55
340_L344_E0.5370.55
254_P286_A0.5360.55
97_D391_G0.5350.54
291_D294_S0.5350.54
98_L204_I0.5350.54
83_A290_T0.5340.54
264_E267_A0.5340.54
133_T164_G0.5340.54
247_A307_L0.5340.54
39_G44_E0.5330.54
162_T183_A0.5310.54
74_L162_T0.5300.54
325_E330_D0.5290.54
283_P294_S0.5290.54
68_V162_T0.5290.54
113_R316_R0.5290.54
304_R357_V0.5290.54
265_W376_L0.5280.53
160_L179_P0.5280.53
42_G45_F0.5270.53
79_I136_E0.5270.53
44_E55_T0.5270.53
406_A410_L0.5270.53
312_R361_R0.5260.53
301_A399_A0.5250.53
41_D52_L0.5250.53
220_R377_F0.5250.53
187_V380_E0.5250.53
143_V319_C0.5230.53
189_G293_H0.5230.53
336_D340_L0.5220.53
173_A180_V0.5220.53
27_D31_H0.5210.53
83_A104_D0.5210.53
148_M158_R0.5200.52
234_A238_T0.5190.52
142_L146_D0.5180.52
282_T305_D0.5150.52
242_L247_A0.5150.52
251_A306_K0.5140.52
32_A44_E0.5130.51
110_H114_L0.5130.51
120_L123_S0.5130.51
42_G56_V0.5130.51
296_L300_R0.5120.51
297_Q302_G0.5110.51
262_F379_F0.5100.51
251_A299_Y0.5100.51
94_G113_R0.5090.51
118_I123_S0.5090.51
410_L414_E0.5080.51
72_D119_D0.5070.51
269_L395_F0.5070.51
194_L380_E0.5060.50
183_A195_S0.5060.50
248_G278_G0.5060.50
347_A351_S0.5050.50
238_T360_V0.5040.50
147_A151_A0.5030.50
131_S138_L0.5030.50
308_V357_V0.5020.50
194_L212_L0.5020.50
364_V368_D0.5010.50
329_I409_E0.5010.50
181_L202_A0.5010.50
15_P388_E0.5010.50
244_Q390_Y0.5000.50
68_V158_R0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ljkA 2 0.9953 100 0.11 Contact Map
2o2cA 2 0.9953 100 0.111 Contact Map
1t10A 2 0.9953 100 0.113 Contact Map
2cxnA 2 0.9953 100 0.115 Contact Map
3qkiA 2 0.993 100 0.118 Contact Map
3ujhA 2 0.993 100 0.122 Contact Map
2wu8A 2 0.9953 100 0.122 Contact Map
3hjbA 4 0.9953 100 0.127 Contact Map
3ff1A 4 0.9953 100 0.183 Contact Map
4em6D 2 0.9953 100 0.194 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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