GREMLIN Database
Q9HNQ5 - Uncharacterized protein
UniProt: Q9HNQ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (325)
Sequences: 146 (130)
Seq/√Len: 7.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_V161_P4.5300.98
156_P161_P3.8590.95
168_S172_G3.3710.91
49_T52_F3.0400.85
160_Y165_A3.0010.84
161_P165_A2.9670.84
156_P159_A2.8450.81
93_G97_A2.8330.81
160_Y163_R2.8040.80
19_A29_D2.7470.78
19_A22_G2.5050.71
210_L311_V2.4920.71
197_V201_A2.4540.70
44_C67_V2.4150.68
130_A232_E2.4040.68
53_A56_R2.4020.68
111_A126_A2.3470.66
165_A168_S2.3330.66
159_A165_A2.2770.64
16_F29_D2.1770.60
27_L46_A2.1420.59
159_A166_V2.1380.58
99_F284_V2.1280.58
212_L315_V2.0730.56
19_A28_L2.0540.55
194_R217_V2.0450.55
16_F19_A2.0090.53
128_G145_A2.0080.53
93_G144_L1.9710.52
133_V284_V1.9520.51
19_A24_A1.9150.50
26_T55_R1.8980.49
187_I281_A1.8540.47
132_V341_F1.8190.46
156_P160_Y1.7650.44
161_P166_V1.7580.44
25_A315_V1.7460.43
28_L56_R1.7440.43
179_V284_V1.7370.43
86_M104_V1.7330.43
39_H96_V1.7160.42
23_L36_A1.6980.41
161_P168_S1.6880.41
156_P165_A1.6690.40
86_M92_A1.6690.40
210_L232_E1.6510.40
22_G28_L1.6210.39
156_P166_V1.6130.38
273_S277_A1.6020.38
85_S334_G1.5890.37
305_A340_Q1.5750.37
250_V259_L1.5530.36
13_T206_A1.5510.36
158_V165_A1.5390.36
160_Y166_V1.5370.36
217_V251_F1.5280.35
198_G259_L1.4970.34
130_A341_F1.4970.34
27_L55_R1.4920.34
240_M259_L1.4850.34
176_V182_S1.4820.34
158_V168_S1.4720.33
51_A54_G1.4690.33
158_V166_V1.4660.33
26_T221_L1.4590.33
76_S179_V1.4380.32
35_D86_M1.4220.32
159_A162_V1.4130.31
8_D39_H1.3950.31
102_I106_G1.3840.30
133_V139_V1.3840.30
48_A282_S1.3810.30
13_T46_A1.3670.30
211_H288_S1.3620.30
227_Q340_Q1.3520.29
156_P163_R1.3520.29
45_A237_T1.3500.29
232_E237_T1.3430.29
27_L48_A1.3380.29
281_A313_S1.3290.29
130_A210_L1.3270.28
225_Q309_V1.3250.28
100_A103_G1.3250.28
13_T27_L1.3140.28
273_S276_S1.2990.28
227_Q305_A1.2970.28
80_A247_V1.2900.27
155_A158_V1.2760.27
22_G34_A1.2730.27
248_S264_V1.2710.27
56_R208_F1.2580.26
16_F28_L1.2580.26
28_L54_G1.2530.26
151_I192_V1.2480.26
123_R305_A1.2480.26
136_G235_R1.2400.26
166_V172_G1.2310.26
71_A221_L1.2290.25
19_A25_A1.2230.25
114_G173_I1.2230.25
10_Y109_L1.2230.25
111_A222_A1.2150.25
261_R333_H1.2100.25
285_F333_H1.2100.25
261_R285_F1.2100.25
256_E261_R1.2100.25
285_F289_H1.2100.25
256_E285_F1.2100.25
257_E333_H1.2100.25
256_E289_H1.2100.25
257_E285_F1.2100.25
257_E261_R1.2100.25
256_E333_H1.2100.25
289_H333_H1.2100.25
257_E289_H1.2100.25
261_R289_H1.2100.25
149_A178_F1.1980.25
30_W206_A1.1970.25
95_A274_R1.1950.24
250_V310_F1.1890.24
209_A229_G1.1800.24
234_A248_S1.1730.24
234_A345_Y1.1730.24
64_L175_G1.1720.24
144_L280_V1.1670.24
282_S315_V1.1640.24
83_L205_G1.1630.24
90_V102_I1.1610.24
249_L305_A1.1600.23
88_G233_A1.1550.23
193_T213_G1.1510.23
131_V180_R1.1490.23
8_D48_A1.1470.23
27_L173_I1.1420.23
266_K336_Y1.1410.23
153_P237_T1.1320.23
17_V21_V1.1300.23
193_T329_P1.1230.22
11_A49_T1.1220.22
135_A139_V1.1210.22
29_D53_A1.1180.22
52_F276_S1.1130.22
19_A54_G1.1120.22
248_S340_Q1.1110.22
30_W45_A1.1100.22
76_S282_S1.1010.22
191_T194_R1.0910.22
113_A282_S1.0900.22
17_V20_G1.0880.22
172_G251_F1.0710.21
317_G326_L1.0710.21
159_A171_L1.0670.21
148_A276_S1.0660.21
155_A163_R1.0560.21
90_V346_W1.0540.21
104_V169_V1.0500.21
156_P162_V1.0470.20
159_A163_R1.0470.20
12_S36_A1.0450.20
115_V176_V1.0440.20
55_R259_L1.0390.20
27_L36_A1.0380.20
19_A53_A1.0380.20
129_V144_L1.0360.20
79_A180_R1.0340.20
253_A281_A1.0270.20
268_L317_G1.0220.20
9_R65_S1.0190.20
265_Q323_T1.0190.20
211_H344_A1.0170.20
33_A37_V1.0130.20
165_A172_G1.0130.20
169_V221_L1.0110.20
86_M255_G1.0080.19
255_G329_P1.0050.19
133_V227_Q1.0040.19
179_V346_W1.0030.19
45_A310_F0.9970.19
228_H344_A0.9930.19
153_P156_P0.9860.19
272_Y276_S0.9830.19
151_I258_L0.9790.19
44_C311_V0.9770.19
226_T344_A0.9730.19
96_V280_V0.9660.18
320_Y325_N0.9650.18
94_P283_F0.9630.18
335_V341_F0.9600.18
76_S144_L0.9600.18
203_G268_L0.9580.18
57_H110_A0.9580.18
90_V170_G0.9520.18
26_T162_V0.9480.18
149_A195_R0.9410.18
82_A100_A0.9400.18
31_A55_R0.9360.18
209_A260_A0.9350.18
33_A205_G0.9330.18
26_T35_D0.9330.18
98_L234_A0.9310.18
88_G238_P0.9310.18
61_P149_A0.9290.18
173_I210_L0.9260.18
136_G249_L0.9250.18
27_L92_A0.9240.18
160_Y258_L0.9220.17
314_L318_V0.9210.17
82_A126_A0.9200.17
31_A56_R0.9200.17
11_A16_F0.9120.17
259_L310_F0.9110.17
161_P167_S0.9080.17
52_F284_V0.9020.17
227_Q249_L0.8980.17
20_G188_D0.8980.17
140_A346_W0.8950.17
96_V181_A0.8940.17
8_D32_P0.8890.17
130_A245_A0.8860.17
195_R331_V0.8850.17
241_L313_S0.8830.17
168_S171_L0.8810.17
102_I230_L0.8810.17
28_L32_P0.8810.17
50_L54_G0.8720.16
214_L244_L0.8700.16
25_A53_A0.8690.16
21_V38_A0.8680.16
322_R327_L0.8670.16
214_L255_G0.8660.16
249_L340_Q0.8630.16
254_P257_E0.8620.16
254_P261_R0.8620.16
254_P285_F0.8620.16
254_P289_H0.8620.16
254_P333_H0.8620.16
201_A279_V0.8610.16
68_G338_A0.8600.16
226_T231_I0.8590.16
19_A26_T0.8580.16
258_L282_S0.8570.16
234_A242_V0.8560.16
153_P163_R0.8550.16
246_V338_A0.8510.16
12_S44_C0.8500.16
23_L45_A0.8490.16
19_A259_L0.8490.16
19_A56_R0.8460.16
259_L329_P0.8440.16
19_A35_D0.8410.16
49_T192_V0.8400.16
229_G308_R0.8360.16
80_A232_E0.8360.16
105_I164_A0.8350.16
229_G248_S0.8240.15
152_A283_F0.8240.15
19_A55_R0.8190.15
85_S250_V0.8150.15
37_V273_S0.8100.15
100_A151_I0.8080.15
130_A160_Y0.8080.15
209_A231_I0.8070.15
23_L212_L0.8070.15
133_V234_A0.8050.15
50_L53_A0.8050.15
158_V167_S0.8040.15
177_A249_L0.8030.15
273_S325_N0.8010.15
48_A151_I0.8010.15
253_A336_Y0.7990.15
69_T182_S0.7980.15
87_T92_A0.7970.15
88_G183_D0.7950.15
258_L329_P0.7950.15
124_E270_D0.7920.15
227_Q248_S0.7900.15
173_I287_A0.7890.15
44_C310_F0.7850.15
309_V312_V0.7850.15
163_R167_S0.7810.15
232_E259_L0.7770.14
44_C306_L0.7740.14
48_A52_F0.7710.14
80_A283_F0.7690.14
123_R270_D0.7680.14
79_A331_V0.7670.14
161_P164_A0.7660.14
261_R337_D0.7660.14
256_E337_D0.7660.14
285_F337_D0.7660.14
289_H337_D0.7660.14
257_E337_D0.7660.14
333_H337_D0.7660.14
317_G327_L0.7660.14
153_P161_P0.7650.14
100_A315_V0.7580.14
245_A340_Q0.7570.14
242_V252_V0.7560.14
10_Y144_L0.7520.14
117_A133_V0.7520.14
94_P166_V0.7500.14
198_G255_G0.7500.14
30_W36_A0.7490.14
59_T212_L0.7460.14
200_A209_A0.7460.14
265_Q313_S0.7450.14
124_E341_F0.7440.14
75_L213_G0.7430.14
130_A237_T0.7430.14
13_T43_A0.7420.14
230_L276_S0.7400.14
228_H231_I0.7350.14
8_D82_A0.7340.14
244_L247_V0.7340.14
120_V305_A0.7310.14
90_V273_S0.7290.14
277_A322_R0.7280.14
36_A48_A0.7270.14
241_L248_S0.7270.14
103_G171_L0.7260.14
30_W35_D0.7240.13
22_G103_G0.7230.13
31_A206_A0.7230.13
28_L31_A0.7220.13
49_T70_G0.7070.13
29_D55_R0.7060.13
153_P160_Y0.7060.13
23_L258_L0.7050.13
271_A278_V0.7040.13
136_G227_Q0.7030.13
148_A255_G0.7030.13
34_A182_S0.7020.13
61_P280_V0.7020.13
24_A279_V0.7000.13
221_L236_K0.7000.13
221_L284_V0.6990.13
66_G109_L0.6930.13
72_G243_P0.6930.13
291_L305_A0.6930.13
168_S205_G0.6930.13
255_G258_L0.6900.13
134_S227_Q0.6880.13
127_V235_R0.6880.13
25_A55_R0.6870.13
219_T344_A0.6860.13
30_W48_A0.6850.13
160_Y167_S0.6850.13
84_L228_H0.6820.13
9_R64_L0.6770.13
204_V263_A0.6770.13
59_T315_V0.6760.13
38_A41_A0.6760.13
73_G148_A0.6740.13
167_S247_V0.6710.13
164_A346_W0.6700.13
165_A169_V0.6700.13
69_T255_G0.6690.13
11_A279_V0.6670.12
10_Y16_F0.6660.12
313_S336_Y0.6660.12
120_V134_S0.6640.12
92_A258_L0.6630.12
234_A291_L0.6600.12
246_V255_G0.6600.12
200_A263_A0.6600.12
233_A238_P0.6570.12
215_N344_A0.6570.12
110_A128_G0.6550.12
12_S58_G0.6540.12
52_F342_G0.6520.12
81_A240_M0.6520.12
120_V249_L0.6510.12
82_A259_L0.6490.12
272_Y330_I0.6460.12
120_V263_A0.6450.12
215_N267_Y0.6440.12
307_A334_G0.6430.12
279_V314_L0.6420.12
227_Q264_V0.6390.12
62_A185_A0.6380.12
83_L88_G0.6370.12
265_Q336_Y0.6360.12
152_A212_L0.6360.12
308_R336_Y0.6350.12
207_I226_T0.6350.12
179_V240_M0.6310.12
141_S172_G0.6300.12
165_A170_G0.6280.12
39_H173_I0.6280.12
11_A15_G0.6280.12
18_V35_D0.6270.12
66_G148_A0.6260.12
175_G346_W0.6220.12
265_Q281_A0.6210.12
87_T175_G0.6190.12
53_A157_T0.6180.12
218_V340_Q0.6140.12
174_M322_R0.6120.12
30_W110_A0.6100.12
130_A133_V0.6100.12
134_S305_A0.6080.12
269_Y273_S0.6060.11
262_N336_Y0.6050.11
20_G58_G0.6050.11
97_A292_A0.6050.11
25_A174_M0.6040.11
45_A311_V0.6030.11
41_A47_V0.6030.11
189_T318_V0.6030.11
136_G245_A0.6010.11
134_S345_Y0.6000.11
89_P149_A0.6000.11
223_L248_S0.5950.11
187_I269_Y0.5930.11
315_V324_D0.5930.11
92_A224_P0.5910.11
130_A306_L0.5910.11
101_G263_A0.5910.11
144_L179_V0.5900.11
120_V137_A0.5880.11
82_A85_S0.5880.11
259_L287_A0.5860.11
230_L292_A0.5850.11
88_G212_L0.5840.11
45_A72_G0.5830.11
142_S223_L0.5790.11
103_G126_A0.5780.11
25_A28_L0.5740.11
96_V151_I0.5740.11
162_V291_L0.5730.11
104_V255_G0.5700.11
9_R15_G0.5690.11
8_D90_V0.5680.11
13_T49_T0.5660.11
83_L169_V0.5660.11
209_A308_R0.5630.11
62_A206_A0.5630.11
152_A311_V0.5620.11
130_A139_V0.5600.11
226_T245_A0.5600.11
331_V335_V0.5600.11
15_G93_G0.5590.11
98_L222_A0.5580.11
32_P154_D0.5570.11
156_P197_V0.5540.11
49_T59_T0.5530.11
28_L53_A0.5530.11
12_S26_T0.5510.11
87_T212_L0.5510.11
62_A153_P0.5490.11
56_R169_V0.5480.11
154_D160_Y0.5480.11
88_G116_G0.5470.11
254_P326_L0.5460.11
134_S249_L0.5450.11
268_L316_L0.5440.11
120_V248_S0.5420.11
120_V218_V0.5420.11
55_R172_G0.5410.10
11_A93_G0.5400.10
222_A273_S0.5400.10
28_L243_P0.5390.10
58_G64_L0.5380.10
18_V45_A0.5380.10
239_A248_S0.5370.10
50_L79_A0.5350.10
315_V320_Y0.5300.10
37_V48_A0.5300.10
317_G322_R0.5280.10
31_A49_T0.5270.10
130_A173_I0.5240.10
96_V182_S0.5220.10
233_A237_T0.5200.10
242_V305_A0.5190.10
202_G219_T0.5180.10
228_H336_Y0.5130.10
82_A282_S0.5100.10
61_P151_I0.5100.10
156_P188_D0.5100.10
281_A336_Y0.5080.10
28_L55_R0.5060.10
120_V341_F0.5050.10
47_V225_Q0.5040.10
48_A280_V0.5020.10
62_A97_A0.5010.10
60_G153_P0.5000.10
213_G237_T0.5000.10
155_A161_P0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cadC 1 0.6017 99.8 0.811 Contact Map
1afoA 2 0.1146 5.9 0.977 Contact Map
1wlxA 1 0.1232 4.1 0.979 Contact Map
2m20A 2 0.1576 2.8 0.981 Contact Map
4fasA 3 0.2006 2.7 0.981 Contact Map
4i0uA 4 0.4183 2.4 0.981 Contact Map
4ev6A 3 0.4241 2.4 0.981 Contact Map
4nreA 4 0.2493 2.2 0.982 Contact Map
4r0yA 1 0.1232 2.2 0.982 Contact Map
2w0cP 4 0.1777 2.1 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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