GREMLIN Database
Q9HNQ4 - Uncharacterized protein
UniProt: Q9HNQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 109 (95)
Sequences: 433 (303)
Seq/√Len: 31.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_L56_A5.1001.00
78_R87_E3.9721.00
26_V31_D3.0871.00
36_A39_H2.0470.98
77_W106_K1.9900.97
27_L31_D1.9710.97
45_L68_Q1.9210.97
60_A74_R1.8240.95
50_Y72_T1.8060.95
63_V70_G1.7910.95
47_S52_M1.7810.95
86_R98_V1.6840.93
43_G56_A1.6670.93
21_T27_L1.6640.93
50_Y77_W1.5710.90
28_S31_D1.5530.90
34_L39_H1.5410.89
35_L39_H1.5330.89
68_Q101_S1.5090.88
90_D93_H1.4840.87
18_A38_A1.4600.87
58_E83_G1.4570.86
104_E107_N1.3850.83
18_A21_T1.3710.83
16_Q20_T1.3440.82
17_A21_T1.2990.79
48_D66_I1.2680.78
57_A63_V1.2580.77
38_A41_L1.2100.74
30_T33_R1.2030.74
24_A31_D1.1870.73
46_V59_L1.1830.72
22_G25_D1.1750.72
98_V102_P1.1580.71
26_V29_E1.1540.71
70_G80_Q1.1500.70
20_T31_D1.1290.69
60_A68_Q1.1120.68
88_F91_T1.0960.66
87_E105_R1.0910.66
22_G31_D1.0800.65
103_L107_N1.0680.64
16_Q24_A1.0650.64
14_V17_A1.0610.64
56_A92_D1.0530.63
21_T31_D1.0480.63
51_A82_Q1.0380.62
64_E78_R1.0260.61
36_A41_L1.0190.61
51_A75_R1.0020.59
32_R36_A0.9990.59
14_V18_A0.9970.59
96_C99_C0.9970.59
57_A79_L0.9960.59
55_V63_V0.9710.57
66_I82_Q0.9620.56
52_M79_L0.9500.55
34_L41_L0.9470.55
86_R97_P0.9220.53
80_Q105_R0.9210.53
24_A28_S0.9200.53
42_D62_T0.9030.52
47_S63_V0.8950.51
19_A22_G0.8810.50
18_A37_T0.8790.50
21_T24_A0.8780.50
68_Q76_D0.8770.49
41_L51_A0.8740.49
19_A23_D0.8740.49
35_L40_E0.8660.49
48_D91_T0.8610.48
77_W107_N0.8560.48
45_L89_D0.8290.46
94_D106_K0.8260.45
27_L34_L0.8170.45
20_T35_L0.8140.44
77_W93_H0.8100.44
34_L38_A0.8100.44
46_V76_D0.8070.44
50_Y53_Q0.8000.43
42_D60_A0.7840.42
62_T76_D0.7750.41
23_D37_T0.7740.41
59_L62_T0.7570.40
17_A20_T0.7530.40
87_E107_N0.7340.38
37_T41_L0.7250.37
17_A23_D0.7230.37
21_T39_H0.7160.37
78_R107_N0.7070.36
57_A71_I0.7000.36
50_Y67_S0.6950.35
24_A27_L0.6930.35
44_T85_G0.6870.35
96_C100_G0.6860.35
54_N84_C0.6850.34
17_A42_D0.6840.34
46_V101_S0.6810.34
19_A27_L0.6790.34
88_F104_E0.6750.34
35_L38_A0.6730.34
54_N71_I0.6720.34
56_A83_G0.6720.34
19_A59_L0.6650.33
44_T48_D0.6640.33
50_Y65_S0.6630.33
33_R36_A0.6450.32
25_D28_S0.6400.31
47_S57_A0.6350.31
46_V73_E0.6260.30
57_A69_D0.6200.30
33_R42_D0.6200.30
25_D31_D0.6160.30
52_M66_I0.6110.29
76_D85_G0.6080.29
57_A82_Q0.6060.29
81_C84_C0.6020.29
95_R104_E0.6010.29
22_G27_L0.5890.28
75_R94_D0.5860.28
14_V36_A0.5650.26
57_A70_G0.5640.26
58_E68_Q0.5580.26
79_L93_H0.5570.26
85_G95_R0.5520.25
94_D102_P0.5430.25
75_R105_R0.5430.25
17_A22_G0.5360.25
80_Q85_G0.5360.25
76_D82_Q0.5340.24
20_T40_E0.5320.24
69_D101_S0.5320.24
19_A35_L0.5280.24
13_A16_Q0.5210.24
82_Q97_P0.5210.24
22_G37_T0.5180.23
38_A77_W0.5170.23
56_A85_G0.5130.23
81_C99_C0.5090.23
19_A31_D0.5080.23
38_A59_L0.5050.23
26_V43_G0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lcqA 1 0.9908 99.9 0.516 Contact Map
2conA 1 0.422 99.7 0.6 Contact Map
2kdxA 1 0.8257 96.8 0.843 Contact Map
3ix7A 2 0.7064 90.8 0.884 Contact Map
2apoB 1 0.2936 88.7 0.889 Contact Map
4aybP 1 0.2752 88.3 0.889 Contact Map
4qiwP 1 0.2661 85.3 0.894 Contact Map
3i8oA 2 0.7156 83.7 0.897 Contact Map
2ausD 2 0.2752 79.6 0.901 Contact Map
3irbA 3 0.6422 79.6 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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