Q9HNQ4 - HALSA - GREMLIN Contacts

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Q9HNQ4 - Uncharacterized protein

UniProt:	Q9HNQ4	Sequences: MRVHVPAQDAREAVRQAAATTGDADVLSETDRRLLATAHELDGTLVSDDYAMQNVAAELAVTVESISQDGITERRDWRLQCQGCGREFDDTDHDRCPVCGSPLERKNPS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	109 (95)
Sequences:	433 (303)
Seq/√Len:	31.0

HALSA - Q9HNQ4
SULSO - Q97WJ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
45_L	56_A	5.100	1.00
78_R	87_E	3.972	1.00
26_V	31_D	3.087	1.00
36_A	39_H	2.047	0.98
77_W	106_K	1.990	0.97
27_L	31_D	1.971	0.97
45_L	68_Q	1.921	0.97
60_A	74_R	1.824	0.95
50_Y	72_T	1.806	0.95
63_V	70_G	1.791	0.95
47_S	52_M	1.781	0.95
86_R	98_V	1.684	0.93
43_G	56_A	1.667	0.93
21_T	27_L	1.664	0.93
50_Y	77_W	1.571	0.90
28_S	31_D	1.553	0.90
34_L	39_H	1.541	0.89
35_L	39_H	1.533	0.89
68_Q	101_S	1.509	0.88
90_D	93_H	1.484	0.87
18_A	38_A	1.460	0.87
58_E	83_G	1.457	0.86
104_E	107_N	1.385	0.83
18_A	21_T	1.371	0.83
16_Q	20_T	1.344	0.82
17_A	21_T	1.299	0.79
48_D	66_I	1.268	0.78
57_A	63_V	1.258	0.77
38_A	41_L	1.210	0.74
30_T	33_R	1.203	0.74
24_A	31_D	1.187	0.73
46_V	59_L	1.183	0.72
22_G	25_D	1.175	0.72
98_V	102_P	1.158	0.71
26_V	29_E	1.154	0.71
70_G	80_Q	1.150	0.70
20_T	31_D	1.129	0.69
60_A	68_Q	1.112	0.68
88_F	91_T	1.096	0.66
87_E	105_R	1.091	0.66
22_G	31_D	1.080	0.65
103_L	107_N	1.068	0.64
16_Q	24_A	1.065	0.64
14_V	17_A	1.061	0.64
56_A	92_D	1.053	0.63
21_T	31_D	1.048	0.63
51_A	82_Q	1.038	0.62
64_E	78_R	1.026	0.61
36_A	41_L	1.019	0.61
51_A	75_R	1.002	0.59
32_R	36_A	0.999	0.59
14_V	18_A	0.997	0.59
96_C	99_C	0.997	0.59
57_A	79_L	0.996	0.59
55_V	63_V	0.971	0.57
66_I	82_Q	0.962	0.56
52_M	79_L	0.950	0.55
34_L	41_L	0.947	0.55
86_R	97_P	0.922	0.53
80_Q	105_R	0.921	0.53
24_A	28_S	0.920	0.53
42_D	62_T	0.903	0.52
47_S	63_V	0.895	0.51
19_A	22_G	0.881	0.50
18_A	37_T	0.879	0.50
21_T	24_A	0.878	0.50
68_Q	76_D	0.877	0.49
41_L	51_A	0.874	0.49
19_A	23_D	0.874	0.49
35_L	40_E	0.866	0.49
48_D	91_T	0.861	0.48
77_W	107_N	0.856	0.48
45_L	89_D	0.829	0.46
94_D	106_K	0.826	0.45
27_L	34_L	0.817	0.45
20_T	35_L	0.814	0.44
77_W	93_H	0.810	0.44
34_L	38_A	0.810	0.44
46_V	76_D	0.807	0.44
50_Y	53_Q	0.800	0.43
42_D	60_A	0.784	0.42
62_T	76_D	0.775	0.41
23_D	37_T	0.774	0.41
59_L	62_T	0.757	0.40
17_A	20_T	0.753	0.40
87_E	107_N	0.734	0.38
37_T	41_L	0.725	0.37
17_A	23_D	0.723	0.37
21_T	39_H	0.716	0.37
78_R	107_N	0.707	0.36
57_A	71_I	0.700	0.36
50_Y	67_S	0.695	0.35
24_A	27_L	0.693	0.35
44_T	85_G	0.687	0.35
96_C	100_G	0.686	0.35
54_N	84_C	0.685	0.34
17_A	42_D	0.684	0.34
46_V	101_S	0.681	0.34
19_A	27_L	0.679	0.34
88_F	104_E	0.675	0.34
35_L	38_A	0.673	0.34
54_N	71_I	0.672	0.34
56_A	83_G	0.672	0.34
19_A	59_L	0.665	0.33
44_T	48_D	0.664	0.33
50_Y	65_S	0.663	0.33
33_R	36_A	0.645	0.32
25_D	28_S	0.640	0.31
47_S	57_A	0.635	0.31
46_V	73_E	0.626	0.30
57_A	69_D	0.620	0.30
33_R	42_D	0.620	0.30
25_D	31_D	0.616	0.30
52_M	66_I	0.611	0.29
76_D	85_G	0.608	0.29
57_A	82_Q	0.606	0.29
81_C	84_C	0.602	0.29
95_R	104_E	0.601	0.29
22_G	27_L	0.589	0.28
75_R	94_D	0.586	0.28
14_V	36_A	0.565	0.26
57_A	70_G	0.564	0.26
58_E	68_Q	0.558	0.26
79_L	93_H	0.557	0.26
85_G	95_R	0.552	0.25
94_D	102_P	0.543	0.25
75_R	105_R	0.543	0.25
17_A	22_G	0.536	0.25
80_Q	85_G	0.536	0.25
76_D	82_Q	0.534	0.24
20_T	40_E	0.532	0.24
69_D	101_S	0.532	0.24
19_A	35_L	0.528	0.24
13_A	16_Q	0.521	0.24
82_Q	97_P	0.521	0.24
22_G	37_T	0.518	0.23
38_A	77_W	0.517	0.23
56_A	85_G	0.513	0.23
81_C	99_C	0.509	0.23
19_A	31_D	0.508	0.23
38_A	59_L	0.505	0.23
26_V	43_G	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2lcqA	1	0.9908	99.9	0.516	Contact Map
2conA	1	0.422	99.7	0.6	Contact Map
2kdxA	1	0.8257	96.8	0.843	Contact Map
3ix7A	2	0.7064	90.8	0.884	Contact Map
2apoB	1	0.2936	88.7	0.889	Contact Map
4aybP	1	0.2752	88.3	0.889	Contact Map
4qiwP	1	0.2661	85.3	0.894	Contact Map
3i8oA	2	0.7156	83.7	0.897	Contact Map
2ausD	2	0.2752	79.6	0.901	Contact Map
3irbA	3	0.6422	79.6	0.901	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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