PAN2 - HALSA - GREMLIN Contacts

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PAN2 - Proteasome-activating nucleotidase 2

UniProt:	Q9HNP9	Sequences: MSRSPSLPDRPTLDVDPESTPAERLNALQDHYVDIVAVNGELQAQLDDVEARREELREEVNRLQRENETLKTASLYLATVEDLPEDGSAVIKQHGNNQEVLTELSPRLADTLEVGDRVAINDSFSVQRVLDDETDARAQAMEVDESPSVTYADIGGLDDQLREVREAVEDPLVNPEKFDAVGVEPPSGVLLHGPPGTGKTMLAKAVANQTDASFIKMAGSELVRKFIGEGSRLVRDLFELAEQKDPAIIFIDEIDAVAAKRTDSKTSGDAEVQRTMMQLLSEMDGFDERGDIRIIAATNRFDMLDSAILRPGRFDRLIEVPNPNPDARERILEIHAGEMNVADSVDFSDLAADTAEFSGAQLASLATEAGMFAIRDDRDEVHRQDFDDAYEKLVAEGDTESSGPRYPSYIQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	411 (329)
Sequences:	7753 (5024)
Seq/√Len:	277.0

ECOLI - FTSH
BACSU - FTSH YJOB SP5K
HALSA - PAN2 CDCH Q9HPU1 Q9HHW2 PAN1 Q9HPV0 Q9HPG1 Q9HNK6
SULSO - Q980U9 Q97ZZ9 PAN Q97W25 Q97V06 Q97ZJ7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
329_E	348_S	5.519	1.00
325_P	352_A	4.261	1.00
333_E	347_F	3.893	1.00
332_L	362_L	3.459	1.00
145_E	148_S	3.112	1.00
337_G	340_N	3.063	1.00
382_H	385_D	3.027	1.00
349_D	353_D	2.974	1.00
117_R	120_I	2.834	1.00
343_D	346_D	2.783	1.00
91_I	94_H	2.768	1.00
329_E	333_E	2.655	1.00
296_A	314_F	2.653	1.00
152_A	208_N	2.599	1.00
153_D	208_N	2.542	1.00
330_R	333_E	2.484	1.00
149_V	152_A	2.457	1.00
147_P	151_Y	2.456	1.00
324_N	327_A	2.440	1.00
151_Y	158_D	2.434	1.00
117_R	121_N	2.426	1.00
190_L	314_F	2.351	1.00
356_E	359_G	2.349	1.00
123_S	126_V	2.328	1.00
250_F	297_A	2.323	1.00
98_Q	101_L	2.309	1.00
330_R	334_I	2.276	1.00
118_V	121_N	2.209	1.00
278_Q	282_E	2.092	1.00
92_K	95_G	2.080	1.00
44_A	47_D	2.066	1.00
237_L	249_I	2.058	1.00
44_A	48_D	2.053	1.00
129_V	133_E	2.049	1.00
86_D	90_V	2.013	1.00
92_K	96_N	1.975	1.00
99_E	102_T	1.971	1.00
92_K	97_N	1.970	1.00
51_A	55_E	1.966	1.00
91_I	97_N	1.957	1.00
122_D	126_V	1.944	1.00
101_L	105_S	1.898	1.00
98_Q	104_L	1.873	1.00
137_R	243_Q	1.869	1.00
333_E	344_S	1.837	1.00
116_D	120_I	1.793	1.00
363_A	367_T	1.789	1.00
94_H	97_N	1.728	1.00
91_I	95_G	1.679	1.00
93_Q	96_N	1.679	1.00
93_Q	97_N	1.651	1.00
116_D	119_A	1.650	1.00
349_D	352_A	1.641	1.00
61_N	65_R	1.636	1.00
177_K	180_A	1.636	1.00
206_V	295_I	1.633	1.00
60_V	63_L	1.623	1.00
126_V	134_T	1.608	1.00
258_A	308_I	1.551	1.00
101_L	108_L	1.546	1.00
114_V	121_N	1.501	1.00
136_A	291_D	1.490	1.00
174_N	177_K	1.489	1.00
366_A	370_G	1.489	1.00
48_D	52_R	1.472	1.00
101_L	104_L	1.465	1.00
127_Q	131_D	1.463	1.00
105_S	108_L	1.439	1.00
376_D	385_D	1.437	1.00
67_N	70_L	1.431	1.00
104_L	108_L	1.412	1.00
127_Q	130_L	1.412	1.00
113_E	121_N	1.407	1.00
174_N	179_D	1.400	1.00
371_M	375_R	1.399	1.00
80_V	84_P	1.386	1.00
122_D	130_L	1.372	1.00
123_S	133_E	1.363	1.00
253_E	299_N	1.346	1.00
116_D	121_N	1.344	1.00
114_V	117_R	1.334	1.00
53_R	57_R	1.330	1.00
354_T	357_F	1.303	1.00
190_L	254_I	1.300	1.00
122_D	125_S	1.299	1.00
359_G	363_A	1.295	1.00
68_E	71_K	1.294	1.00
358_S	364_S	1.292	1.00
151_Y	161_L	1.289	1.00
361_Q	364_S	1.289	1.00
282_E	294_I	1.288	1.00
175_P	178_F	1.283	1.00
51_A	54_E	1.283	1.00
91_I	96_N	1.281	1.00
257_V	279_L	1.281	1.00
192_H	317_L	1.274	1.00
332_L	350_L	1.273	1.00
356_E	360_A	1.270	1.00
79_T	83_L	1.264	1.00
58_E	62_R	1.261	1.00
332_L	347_F	1.259	1.00
127_Q	133_E	1.255	1.00
63_L	67_N	1.244	1.00
47_D	51_A	1.243	1.00
348_S	352_A	1.239	1.00
80_V	83_L	1.234	1.00
300_R	303_M	1.224	1.00
380_E	384_Q	1.220	1.00
48_D	51_A	1.211	1.00
102_T	106_P	1.205	1.00
111_T	115_G	1.205	1.00
322_N	358_S	1.202	1.00
72_T	76_Y	1.199	1.00
55_E	59_E	1.192	1.00
95_G	98_Q	1.192	1.00
98_Q	108_L	1.188	1.00
99_E	103_E	1.183	1.00
98_Q	102_T	1.182	1.00
60_V	64_Q	1.176	1.00
75_L	79_T	1.174	1.00
345_V	348_S	1.167	1.00
58_E	61_N	1.154	1.00
203_A	295_I	1.154	1.00
81_E	85_E	1.151	1.00
100_V	103_E	1.150	1.00
329_E	347_F	1.150	1.00
76_Y	80_V	1.148	1.00
309_L	317_L	1.143	1.00
191_L	320_V	1.129	1.00
346_D	350_L	1.126	1.00
77_L	81_E	1.116	1.00
76_Y	79_T	1.116	1.00
361_Q	365_L	1.114	1.00
55_E	58_E	1.113	1.00
42_L	45_Q	1.107	1.00
72_T	75_L	1.104	1.00
68_E	72_T	1.104	1.00
326_D	329_E	1.104	1.00
215_I	247_A	1.093	1.00
124_F	127_Q	1.084	1.00
42_L	67_N	1.083	1.00
113_E	116_D	1.079	1.00
325_P	348_S	1.079	1.00
127_Q	134_T	1.059	1.00
100_V	104_L	1.057	1.00
354_T	362_L	1.053	1.00
358_S	362_L	1.053	1.00
109_A	112_L	1.050	1.00
63_L	66_E	1.050	1.00
344_S	348_S	1.047	1.00
62_R	66_E	1.041	1.00
222_L	236_D	1.036	1.00
85_E	89_A	1.035	1.00
73_A	76_Y	1.034	1.00
131_D	134_T	1.034	1.00
355_A	358_S	1.033	1.00
113_E	117_R	1.032	1.00
77_L	80_V	1.027	1.00
43_Q	47_D	1.025	1.00
65_R	68_E	1.025	1.00
115_G	119_A	1.025	1.00
188_G	283_M	1.020	1.00
102_T	105_S	1.014	1.00
97_N	100_V	1.009	1.00
113_E	120_I	1.004	1.00
225_K	274_R	1.001	1.00
124_F	128_R	0.995	1.00
126_V	129_V	0.993	1.00
355_A	359_G	0.990	1.00
123_S	127_Q	0.983	1.00
215_I	249_I	0.982	1.00
203_A	250_F	0.973	1.00
122_D	127_Q	0.969	1.00
158_D	162_R	0.964	1.00
54_E	58_E	0.962	1.00
88_S	93_Q	0.962	1.00
219_G	251_I	0.959	1.00
78_A	82_D	0.957	1.00
51_A	58_E	0.957	1.00
161_L	202_L	0.949	1.00
112_L	120_I	0.948	1.00
74_S	78_A	0.943	1.00
64_Q	67_N	0.943	1.00
60_V	67_N	0.942	1.00
346_D	349_D	0.940	1.00
56_L	67_N	0.940	1.00
381_V	385_D	0.938	1.00
239_E	243_Q	0.936	1.00
122_D	134_T	0.934	1.00
306_S	309_L	0.930	1.00
56_L	60_V	0.927	1.00
92_K	101_L	0.926	1.00
214_F	218_A	0.926	1.00
74_S	77_L	0.920	1.00
122_D	133_E	0.919	1.00
356_E	361_Q	0.917	1.00
370_G	374_I	0.917	1.00
52_R	55_E	0.908	1.00
86_D	89_A	0.906	1.00
50_E	54_E	0.906	1.00
145_E	149_V	0.905	1.00
254_I	296_A	0.902	1.00
58_E	65_R	0.900	1.00
109_A	116_D	0.898	1.00
146_S	209_Q	0.894	1.00
74_S	81_E	0.894	1.00
354_T	359_G	0.893	1.00
363_A	366_A	0.893	1.00
112_L	117_R	0.891	1.00
369_A	374_I	0.890	1.00
358_S	361_Q	0.886	1.00
310_R	360_A	0.884	1.00
136_A	244_K	0.883	1.00
253_E	313_R	0.882	1.00
126_V	133_E	0.880	1.00
71_K	74_S	0.879	1.00
356_E	363_A	0.877	1.00
78_A	81_E	0.874	1.00
217_M	249_I	0.874	1.00
365_L	371_M	0.873	1.00
108_L	112_L	0.871	1.00
100_V	108_L	0.870	1.00
108_L	111_T	0.870	1.00
100_V	105_S	0.865	1.00
114_V	119_A	0.862	1.00
49_V	52_R	0.862	1.00
52_R	56_L	0.860	1.00
158_D	327_A	0.857	1.00
213_S	244_K	0.851	1.00
112_L	116_D	0.850	1.00
358_S	363_A	0.847	1.00
357_F	365_L	0.846	1.00
48_D	58_E	0.845	1.00
325_P	329_E	0.840	1.00
47_D	58_E	0.838	1.00
336_A	366_A	0.838	1.00
130_L	134_T	0.838	1.00
215_I	244_K	0.837	1.00
56_L	63_L	0.836	1.00
111_T	114_V	0.835	1.00
159_D	162_R	0.834	1.00
217_M	237_L	0.827	1.00
213_S	247_A	0.826	1.00
354_T	358_S	0.822	0.99
97_N	104_L	0.820	0.99
301_F	317_L	0.819	0.99
122_D	131_D	0.817	0.99
82_D	86_D	0.817	0.99
67_N	74_S	0.811	0.99
362_L	365_L	0.809	0.99
215_I	241_A	0.805	0.99
89_A	93_Q	0.803	0.99
365_L	368_E	0.803	0.99
61_N	64_Q	0.796	0.99
372_F	378_R	0.790	0.99
47_D	50_E	0.789	0.99
73_A	77_L	0.788	0.99
361_Q	366_A	0.786	0.99
96_N	99_E	0.782	0.99
336_A	347_F	0.781	0.99
51_A	61_N	0.778	0.99
98_Q	103_E	0.777	0.99
54_E	57_R	0.777	0.99
57_R	61_N	0.775	0.99
106_P	109_A	0.771	0.99
53_R	60_V	0.768	0.99
42_L	47_D	0.765	0.99
56_L	62_R	0.763	0.99
299_N	313_R	0.763	0.99
149_V	208_N	0.762	0.99
41_E	44_A	0.760	0.99
84_P	87_G	0.758	0.99
158_D	330_R	0.755	0.99
43_Q	46_L	0.755	0.99
77_L	84_P	0.754	0.99
103_E	106_P	0.753	0.99
60_V	65_R	0.751	0.99
97_N	101_L	0.746	0.99
46_L	50_E	0.744	0.99
182_G	212_A	0.743	0.99
325_P	351_A	0.743	0.99
369_A	373_A	0.742	0.99
252_D	313_R	0.742	0.99
59_E	62_R	0.741	0.99
44_A	51_A	0.737	0.99
107_R	110_D	0.736	0.99
125_S	133_E	0.734	0.99
147_P	169_E	0.734	0.99
72_T	77_L	0.732	0.99
93_Q	100_V	0.732	0.99
370_G	373_A	0.731	0.99
245_D	291_D	0.731	0.99
214_F	250_F	0.731	0.99
157_L	320_V	0.729	0.99
57_R	60_V	0.728	0.99
244_K	291_D	0.725	0.99
99_E	106_P	0.716	0.99
96_N	100_V	0.715	0.99
114_V	120_I	0.713	0.99
52_R	59_E	0.713	0.99
141_M	145_E	0.713	0.99
321_P	327_A	0.708	0.98
85_E	88_S	0.706	0.98
60_V	66_E	0.700	0.98
105_S	112_L	0.698	0.98
49_V	54_E	0.698	0.98
214_F	248_I	0.695	0.98
368_E	373_A	0.694	0.98
67_N	71_K	0.694	0.98
68_E	82_D	0.694	0.98
380_E	383_R	0.693	0.98
178_F	181_V	0.692	0.98
45_Q	48_D	0.692	0.98
279_L	282_E	0.686	0.98
155_G	334_I	0.685	0.98
88_S	91_I	0.681	0.98
103_E	107_R	0.680	0.98
252_D	299_N	0.678	0.98
347_F	351_A	0.678	0.98
99_E	104_L	0.677	0.98
45_Q	53_R	0.677	0.98
101_L	107_R	0.675	0.98
368_E	371_M	0.672	0.98
137_R	145_E	0.671	0.98
235_R	238_F	0.671	0.98
42_L	60_V	0.671	0.98
346_D	352_A	0.671	0.98
299_N	307_A	0.669	0.98
99_E	105_S	0.669	0.98
373_A	376_D	0.669	0.98
70_L	74_S	0.668	0.98
336_A	341_V	0.664	0.98
53_R	56_L	0.664	0.98
124_F	133_E	0.663	0.98
84_P	91_I	0.662	0.98
66_E	73_A	0.662	0.98
349_D	383_R	0.661	0.98
359_G	362_L	0.660	0.98
48_D	59_E	0.660	0.98
71_K	84_P	0.660	0.98
103_E	108_L	0.659	0.98
253_E	280_L	0.658	0.98
100_V	106_P	0.658	0.98
164_V	362_L	0.655	0.97
350_L	362_L	0.651	0.97
124_F	130_L	0.651	0.97
251_I	279_L	0.650	0.97
159_D	321_P	0.650	0.97
53_R	63_L	0.650	0.97
270_A	273_Q	0.648	0.97
380_E	385_D	0.647	0.97
328_R	351_A	0.647	0.97
346_D	351_A	0.643	0.97
47_D	55_E	0.642	0.97
76_Y	89_A	0.642	0.97
350_L	353_D	0.640	0.97
130_L	133_E	0.638	0.97
114_V	118_V	0.635	0.97
369_A	376_D	0.634	0.97
191_L	206_V	0.633	0.97
375_R	379_D	0.632	0.97
345_V	351_A	0.631	0.97
84_P	88_S	0.630	0.97
55_E	62_R	0.628	0.97
48_D	54_E	0.626	0.97
94_H	98_Q	0.625	0.97
202_L	320_V	0.625	0.97
107_R	111_T	0.624	0.97
339_M	381_V	0.624	0.97
111_T	116_D	0.624	0.97
73_A	89_A	0.623	0.97
215_I	237_L	0.622	0.97
361_Q	378_R	0.622	0.97
177_K	181_V	0.622	0.97
370_G	376_D	0.621	0.97
367_T	371_M	0.620	0.96
111_T	117_R	0.615	0.96
92_K	98_Q	0.614	0.96
112_L	115_G	0.611	0.96
140_A	145_E	0.610	0.96
66_E	69_T	0.609	0.96
41_E	45_Q	0.608	0.96
137_R	213_S	0.606	0.96
367_T	372_F	0.605	0.96
105_S	114_V	0.605	0.96
357_F	361_Q	0.604	0.96
363_A	368_E	0.603	0.96
79_T	82_D	0.603	0.96
355_A	360_A	0.602	0.96
112_L	118_V	0.600	0.96
113_E	118_V	0.600	0.96
301_F	309_L	0.598	0.96
96_N	101_L	0.597	0.96
112_L	119_A	0.594	0.96
124_F	129_V	0.592	0.95
75_L	85_E	0.591	0.95
153_D	205_A	0.591	0.95
44_A	55_E	0.589	0.95
51_A	65_R	0.588	0.95
361_Q	371_M	0.588	0.95
104_L	109_A	0.587	0.95
57_R	62_R	0.587	0.95
238_F	241_A	0.587	0.95
329_E	344_S	0.587	0.95
359_G	365_L	0.586	0.95
55_E	60_V	0.584	0.95
95_G	99_E	0.584	0.95
53_R	59_E	0.584	0.95
50_E	58_E	0.583	0.95
365_L	369_A	0.583	0.95
84_P	89_A	0.582	0.95
174_N	178_F	0.576	0.95
113_E	119_A	0.575	0.95
359_G	364_S	0.573	0.95
371_M	374_I	0.572	0.95
359_G	367_T	0.571	0.94
104_L	107_R	0.568	0.94
126_V	130_L	0.567	0.94
110_D	121_N	0.567	0.94
365_L	370_G	0.566	0.94
50_E	53_R	0.566	0.94
69_T	74_S	0.566	0.94
44_A	58_E	0.564	0.94
190_L	317_L	0.563	0.94
122_D	129_V	0.562	0.94
280_L	299_N	0.561	0.94
45_Q	67_N	0.560	0.94
102_T	107_R	0.559	0.94
76_Y	83_L	0.559	0.94
83_L	95_G	0.558	0.94
238_F	244_K	0.557	0.94
128_R	131_D	0.556	0.94
71_K	88_S	0.555	0.94
360_A	364_S	0.553	0.93
309_L	319_E	0.551	0.93
43_Q	48_D	0.551	0.93
360_A	366_A	0.549	0.93
223_V	275_T	0.546	0.93
110_D	114_V	0.546	0.93
93_Q	105_S	0.544	0.93
360_A	368_E	0.544	0.93
50_E	55_E	0.544	0.93
155_G	330_R	0.544	0.93
69_T	72_T	0.543	0.93
94_H	102_T	0.543	0.93
94_H	101_L	0.543	0.93
95_G	104_L	0.542	0.93
368_E	375_R	0.541	0.93
58_E	70_L	0.541	0.93
54_E	61_N	0.540	0.93
149_V	209_Q	0.540	0.93
361_Q	373_A	0.537	0.92
366_A	376_D	0.537	0.92
329_E	351_A	0.536	0.92
93_Q	98_Q	0.536	0.92
94_H	99_E	0.536	0.92
345_V	352_A	0.535	0.92
370_G	378_R	0.532	0.92
376_D	379_D	0.532	0.92
73_A	79_T	0.532	0.92
74_S	82_D	0.531	0.92
98_Q	105_S	0.531	0.92
182_G	338_E	0.530	0.92
95_G	100_V	0.530	0.92
91_I	101_L	0.529	0.92
129_V	134_T	0.528	0.92
360_A	370_G	0.528	0.92
347_F	353_D	0.526	0.92
87_G	90_V	0.523	0.91
157_L	160_Q	0.522	0.91
56_L	61_N	0.521	0.91
200_T	313_R	0.521	0.91
111_T	119_A	0.521	0.91
274_R	277_M	0.519	0.91
98_Q	106_P	0.519	0.91
68_E	73_A	0.517	0.91
341_V	345_V	0.516	0.91
46_L	49_V	0.515	0.91
205_A	208_N	0.515	0.91
41_E	59_E	0.515	0.91
65_R	69_T	0.511	0.91
75_L	87_G	0.511	0.91
45_Q	49_V	0.511	0.91
47_D	63_L	0.511	0.91
191_L	295_I	0.511	0.91
63_L	74_S	0.510	0.90
50_E	66_E	0.509	0.90
373_A	378_R	0.509	0.90
343_D	384_Q	0.508	0.90
81_E	84_P	0.507	0.90
125_S	131_D	0.506	0.90
213_S	242_E	0.504	0.90
339_M	366_A	0.501	0.90
101_L	106_P	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cr2J	1	0.9051	100	0.331	Contact Map
4cr2L	1	0.8759	100	0.361	Contact Map
3cf2A	3	0.7251	100	0.381	Contact Map
4cr2M	1	0.8759	100	0.388	Contact Map
2ce7A	3	0.6253	100	0.395	Contact Map
4cr2K	1	0.9027	100	0.401	Contact Map
4cr2I	1	0.8321	100	0.408	Contact Map
2x8aA	1	0.5645	100	0.41	Contact Map
4ww0A	4	0.6277	100	0.412	Contact Map
4cr2H	1	0.8102	100	0.422	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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