GREMLIN Database
PAN2 - Proteasome-activating nucleotidase 2
UniProt: Q9HNP9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 411 (329)
Sequences: 7753 (5024)
Seq/√Len: 277.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_E348_S5.5191.00
325_P352_A4.2611.00
333_E347_F3.8931.00
332_L362_L3.4591.00
145_E148_S3.1121.00
337_G340_N3.0631.00
382_H385_D3.0271.00
349_D353_D2.9741.00
117_R120_I2.8341.00
343_D346_D2.7831.00
91_I94_H2.7681.00
329_E333_E2.6551.00
296_A314_F2.6531.00
152_A208_N2.5991.00
153_D208_N2.5421.00
330_R333_E2.4841.00
149_V152_A2.4571.00
147_P151_Y2.4561.00
324_N327_A2.4401.00
151_Y158_D2.4341.00
117_R121_N2.4261.00
190_L314_F2.3511.00
356_E359_G2.3491.00
123_S126_V2.3281.00
250_F297_A2.3231.00
98_Q101_L2.3091.00
330_R334_I2.2761.00
118_V121_N2.2091.00
278_Q282_E2.0921.00
92_K95_G2.0801.00
44_A47_D2.0661.00
237_L249_I2.0581.00
44_A48_D2.0531.00
129_V133_E2.0491.00
86_D90_V2.0131.00
92_K96_N1.9751.00
99_E102_T1.9711.00
92_K97_N1.9701.00
51_A55_E1.9661.00
91_I97_N1.9571.00
122_D126_V1.9441.00
101_L105_S1.8981.00
98_Q104_L1.8731.00
137_R243_Q1.8691.00
333_E344_S1.8371.00
116_D120_I1.7931.00
363_A367_T1.7891.00
94_H97_N1.7281.00
91_I95_G1.6791.00
93_Q96_N1.6791.00
93_Q97_N1.6511.00
116_D119_A1.6501.00
349_D352_A1.6411.00
61_N65_R1.6361.00
177_K180_A1.6361.00
206_V295_I1.6331.00
60_V63_L1.6231.00
126_V134_T1.6081.00
258_A308_I1.5511.00
101_L108_L1.5461.00
114_V121_N1.5011.00
136_A291_D1.4901.00
174_N177_K1.4891.00
366_A370_G1.4891.00
48_D52_R1.4721.00
101_L104_L1.4651.00
127_Q131_D1.4631.00
105_S108_L1.4391.00
376_D385_D1.4371.00
67_N70_L1.4311.00
104_L108_L1.4121.00
127_Q130_L1.4121.00
113_E121_N1.4071.00
174_N179_D1.4001.00
371_M375_R1.3991.00
80_V84_P1.3861.00
122_D130_L1.3721.00
123_S133_E1.3631.00
253_E299_N1.3461.00
116_D121_N1.3441.00
114_V117_R1.3341.00
53_R57_R1.3301.00
354_T357_F1.3031.00
190_L254_I1.3001.00
122_D125_S1.2991.00
359_G363_A1.2951.00
68_E71_K1.2941.00
358_S364_S1.2921.00
151_Y161_L1.2891.00
361_Q364_S1.2891.00
282_E294_I1.2881.00
175_P178_F1.2831.00
51_A54_E1.2831.00
91_I96_N1.2811.00
257_V279_L1.2811.00
192_H317_L1.2741.00
332_L350_L1.2731.00
356_E360_A1.2701.00
79_T83_L1.2641.00
58_E62_R1.2611.00
332_L347_F1.2591.00
127_Q133_E1.2551.00
63_L67_N1.2441.00
47_D51_A1.2431.00
348_S352_A1.2391.00
80_V83_L1.2341.00
300_R303_M1.2241.00
380_E384_Q1.2201.00
48_D51_A1.2111.00
102_T106_P1.2051.00
111_T115_G1.2051.00
322_N358_S1.2021.00
72_T76_Y1.1991.00
55_E59_E1.1921.00
95_G98_Q1.1921.00
98_Q108_L1.1881.00
99_E103_E1.1831.00
98_Q102_T1.1821.00
60_V64_Q1.1761.00
75_L79_T1.1741.00
345_V348_S1.1671.00
58_E61_N1.1541.00
203_A295_I1.1541.00
81_E85_E1.1511.00
100_V103_E1.1501.00
329_E347_F1.1501.00
76_Y80_V1.1481.00
309_L317_L1.1431.00
191_L320_V1.1291.00
346_D350_L1.1261.00
77_L81_E1.1161.00
76_Y79_T1.1161.00
361_Q365_L1.1141.00
55_E58_E1.1131.00
42_L45_Q1.1071.00
72_T75_L1.1041.00
68_E72_T1.1041.00
326_D329_E1.1041.00
215_I247_A1.0931.00
124_F127_Q1.0841.00
42_L67_N1.0831.00
113_E116_D1.0791.00
325_P348_S1.0791.00
127_Q134_T1.0591.00
100_V104_L1.0571.00
354_T362_L1.0531.00
358_S362_L1.0531.00
109_A112_L1.0501.00
63_L66_E1.0501.00
344_S348_S1.0471.00
62_R66_E1.0411.00
222_L236_D1.0361.00
85_E89_A1.0351.00
73_A76_Y1.0341.00
131_D134_T1.0341.00
355_A358_S1.0331.00
113_E117_R1.0321.00
77_L80_V1.0271.00
43_Q47_D1.0251.00
65_R68_E1.0251.00
115_G119_A1.0251.00
188_G283_M1.0201.00
102_T105_S1.0141.00
97_N100_V1.0091.00
113_E120_I1.0041.00
225_K274_R1.0011.00
124_F128_R0.9951.00
126_V129_V0.9931.00
355_A359_G0.9901.00
123_S127_Q0.9831.00
215_I249_I0.9821.00
203_A250_F0.9731.00
122_D127_Q0.9691.00
158_D162_R0.9641.00
54_E58_E0.9621.00
88_S93_Q0.9621.00
219_G251_I0.9591.00
78_A82_D0.9571.00
51_A58_E0.9571.00
161_L202_L0.9491.00
112_L120_I0.9481.00
74_S78_A0.9431.00
64_Q67_N0.9431.00
60_V67_N0.9421.00
346_D349_D0.9401.00
56_L67_N0.9401.00
381_V385_D0.9381.00
239_E243_Q0.9361.00
122_D134_T0.9341.00
306_S309_L0.9301.00
56_L60_V0.9271.00
92_K101_L0.9261.00
214_F218_A0.9261.00
74_S77_L0.9201.00
122_D133_E0.9191.00
356_E361_Q0.9171.00
370_G374_I0.9171.00
52_R55_E0.9081.00
86_D89_A0.9061.00
50_E54_E0.9061.00
145_E149_V0.9051.00
254_I296_A0.9021.00
58_E65_R0.9001.00
109_A116_D0.8981.00
146_S209_Q0.8941.00
74_S81_E0.8941.00
354_T359_G0.8931.00
363_A366_A0.8931.00
112_L117_R0.8911.00
369_A374_I0.8901.00
358_S361_Q0.8861.00
310_R360_A0.8841.00
136_A244_K0.8831.00
253_E313_R0.8821.00
126_V133_E0.8801.00
71_K74_S0.8791.00
356_E363_A0.8771.00
78_A81_E0.8741.00
217_M249_I0.8741.00
365_L371_M0.8731.00
108_L112_L0.8711.00
100_V108_L0.8701.00
108_L111_T0.8701.00
100_V105_S0.8651.00
114_V119_A0.8621.00
49_V52_R0.8621.00
52_R56_L0.8601.00
158_D327_A0.8571.00
213_S244_K0.8511.00
112_L116_D0.8501.00
358_S363_A0.8471.00
357_F365_L0.8461.00
48_D58_E0.8451.00
325_P329_E0.8401.00
47_D58_E0.8381.00
336_A366_A0.8381.00
130_L134_T0.8381.00
215_I244_K0.8371.00
56_L63_L0.8361.00
111_T114_V0.8351.00
159_D162_R0.8341.00
217_M237_L0.8271.00
213_S247_A0.8261.00
354_T358_S0.8220.99
97_N104_L0.8200.99
301_F317_L0.8190.99
122_D131_D0.8170.99
82_D86_D0.8170.99
67_N74_S0.8110.99
362_L365_L0.8090.99
215_I241_A0.8050.99
89_A93_Q0.8030.99
365_L368_E0.8030.99
61_N64_Q0.7960.99
372_F378_R0.7900.99
47_D50_E0.7890.99
73_A77_L0.7880.99
361_Q366_A0.7860.99
96_N99_E0.7820.99
336_A347_F0.7810.99
51_A61_N0.7780.99
98_Q103_E0.7770.99
54_E57_R0.7770.99
57_R61_N0.7750.99
106_P109_A0.7710.99
53_R60_V0.7680.99
42_L47_D0.7650.99
56_L62_R0.7630.99
299_N313_R0.7630.99
149_V208_N0.7620.99
41_E44_A0.7600.99
84_P87_G0.7580.99
158_D330_R0.7550.99
43_Q46_L0.7550.99
77_L84_P0.7540.99
103_E106_P0.7530.99
60_V65_R0.7510.99
97_N101_L0.7460.99
46_L50_E0.7440.99
182_G212_A0.7430.99
325_P351_A0.7430.99
369_A373_A0.7420.99
252_D313_R0.7420.99
59_E62_R0.7410.99
44_A51_A0.7370.99
107_R110_D0.7360.99
125_S133_E0.7340.99
147_P169_E0.7340.99
72_T77_L0.7320.99
93_Q100_V0.7320.99
370_G373_A0.7310.99
245_D291_D0.7310.99
214_F250_F0.7310.99
157_L320_V0.7290.99
57_R60_V0.7280.99
244_K291_D0.7250.99
99_E106_P0.7160.99
96_N100_V0.7150.99
114_V120_I0.7130.99
52_R59_E0.7130.99
141_M145_E0.7130.99
321_P327_A0.7080.98
85_E88_S0.7060.98
60_V66_E0.7000.98
105_S112_L0.6980.98
49_V54_E0.6980.98
214_F248_I0.6950.98
368_E373_A0.6940.98
67_N71_K0.6940.98
68_E82_D0.6940.98
380_E383_R0.6930.98
178_F181_V0.6920.98
45_Q48_D0.6920.98
279_L282_E0.6860.98
155_G334_I0.6850.98
88_S91_I0.6810.98
103_E107_R0.6800.98
252_D299_N0.6780.98
347_F351_A0.6780.98
99_E104_L0.6770.98
45_Q53_R0.6770.98
101_L107_R0.6750.98
368_E371_M0.6720.98
137_R145_E0.6710.98
235_R238_F0.6710.98
42_L60_V0.6710.98
346_D352_A0.6710.98
299_N307_A0.6690.98
99_E105_S0.6690.98
373_A376_D0.6690.98
70_L74_S0.6680.98
336_A341_V0.6640.98
53_R56_L0.6640.98
124_F133_E0.6630.98
84_P91_I0.6620.98
66_E73_A0.6620.98
349_D383_R0.6610.98
359_G362_L0.6600.98
48_D59_E0.6600.98
71_K84_P0.6600.98
103_E108_L0.6590.98
253_E280_L0.6580.98
100_V106_P0.6580.98
164_V362_L0.6550.97
350_L362_L0.6510.97
124_F130_L0.6510.97
251_I279_L0.6500.97
159_D321_P0.6500.97
53_R63_L0.6500.97
270_A273_Q0.6480.97
380_E385_D0.6470.97
328_R351_A0.6470.97
346_D351_A0.6430.97
47_D55_E0.6420.97
76_Y89_A0.6420.97
350_L353_D0.6400.97
130_L133_E0.6380.97
114_V118_V0.6350.97
369_A376_D0.6340.97
191_L206_V0.6330.97
375_R379_D0.6320.97
345_V351_A0.6310.97
84_P88_S0.6300.97
55_E62_R0.6280.97
48_D54_E0.6260.97
94_H98_Q0.6250.97
202_L320_V0.6250.97
107_R111_T0.6240.97
339_M381_V0.6240.97
111_T116_D0.6240.97
73_A89_A0.6230.97
215_I237_L0.6220.97
361_Q378_R0.6220.97
177_K181_V0.6220.97
370_G376_D0.6210.97
367_T371_M0.6200.96
111_T117_R0.6150.96
92_K98_Q0.6140.96
112_L115_G0.6110.96
140_A145_E0.6100.96
66_E69_T0.6090.96
41_E45_Q0.6080.96
137_R213_S0.6060.96
367_T372_F0.6050.96
105_S114_V0.6050.96
357_F361_Q0.6040.96
363_A368_E0.6030.96
79_T82_D0.6030.96
355_A360_A0.6020.96
112_L118_V0.6000.96
113_E118_V0.6000.96
301_F309_L0.5980.96
96_N101_L0.5970.96
112_L119_A0.5940.96
124_F129_V0.5920.95
75_L85_E0.5910.95
153_D205_A0.5910.95
44_A55_E0.5890.95
51_A65_R0.5880.95
361_Q371_M0.5880.95
104_L109_A0.5870.95
57_R62_R0.5870.95
238_F241_A0.5870.95
329_E344_S0.5870.95
359_G365_L0.5860.95
55_E60_V0.5840.95
95_G99_E0.5840.95
53_R59_E0.5840.95
50_E58_E0.5830.95
365_L369_A0.5830.95
84_P89_A0.5820.95
174_N178_F0.5760.95
113_E119_A0.5750.95
359_G364_S0.5730.95
371_M374_I0.5720.95
359_G367_T0.5710.94
104_L107_R0.5680.94
126_V130_L0.5670.94
110_D121_N0.5670.94
365_L370_G0.5660.94
50_E53_R0.5660.94
69_T74_S0.5660.94
44_A58_E0.5640.94
190_L317_L0.5630.94
122_D129_V0.5620.94
280_L299_N0.5610.94
45_Q67_N0.5600.94
102_T107_R0.5590.94
76_Y83_L0.5590.94
83_L95_G0.5580.94
238_F244_K0.5570.94
128_R131_D0.5560.94
71_K88_S0.5550.94
360_A364_S0.5530.93
309_L319_E0.5510.93
43_Q48_D0.5510.93
360_A366_A0.5490.93
223_V275_T0.5460.93
110_D114_V0.5460.93
93_Q105_S0.5440.93
360_A368_E0.5440.93
50_E55_E0.5440.93
155_G330_R0.5440.93
69_T72_T0.5430.93
94_H102_T0.5430.93
94_H101_L0.5430.93
95_G104_L0.5420.93
368_E375_R0.5410.93
58_E70_L0.5410.93
54_E61_N0.5400.93
149_V209_Q0.5400.93
361_Q373_A0.5370.92
366_A376_D0.5370.92
329_E351_A0.5360.92
93_Q98_Q0.5360.92
94_H99_E0.5360.92
345_V352_A0.5350.92
370_G378_R0.5320.92
376_D379_D0.5320.92
73_A79_T0.5320.92
74_S82_D0.5310.92
98_Q105_S0.5310.92
182_G338_E0.5300.92
95_G100_V0.5300.92
91_I101_L0.5290.92
129_V134_T0.5280.92
360_A370_G0.5280.92
347_F353_D0.5260.92
87_G90_V0.5230.91
157_L160_Q0.5220.91
56_L61_N0.5210.91
200_T313_R0.5210.91
111_T119_A0.5210.91
274_R277_M0.5190.91
98_Q106_P0.5190.91
68_E73_A0.5170.91
341_V345_V0.5160.91
46_L49_V0.5150.91
205_A208_N0.5150.91
41_E59_E0.5150.91
65_R69_T0.5110.91
75_L87_G0.5110.91
45_Q49_V0.5110.91
47_D63_L0.5110.91
191_L295_I0.5110.91
63_L74_S0.5100.90
50_E66_E0.5090.90
373_A378_R0.5090.90
343_D384_Q0.5080.90
81_E84_P0.5070.90
125_S131_D0.5060.90
213_S242_E0.5040.90
339_M366_A0.5010.90
101_L106_P0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cr2J 1 0.9051 100 0.331 Contact Map
4cr2L 1 0.8759 100 0.361 Contact Map
3cf2A 3 0.7251 100 0.381 Contact Map
4cr2M 1 0.8759 100 0.388 Contact Map
2ce7A 3 0.6253 100 0.395 Contact Map
4cr2K 1 0.9027 100 0.401 Contact Map
4cr2I 1 0.8321 100 0.408 Contact Map
2x8aA 1 0.5645 100 0.41 Contact Map
4ww0A 4 0.6277 100 0.412 Contact Map
4cr2H 1 0.8102 100 0.422 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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