Q9HNP8 - HALSA - GREMLIN Contacts

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Q9HNP8 - Oligopeptidase

UniProt:	Q9HNP8	Sequences: MPPATSGTGLISGAVAGNHPVVCERLTGRTRTLGHMSSVPDRADVADEYKWALASIYETDDEWEAAFEDVQAELDALNDYEGRLTEDGETLLAALELRDAVYRDAKTVSAYASMRSDEDTRDQEYQALQARGASLMTDVSSATSFFDPELQACTREQLQSMIEETPELAAYEHYFDDVLRMKPHTRSAEVEGLLSELGEVFGAPSDAYNMLTDADLEFPTVEDPAGDAVEISQSNFTNLLKTPDRAFRQTVHEQFYDTISGVRNTIGSTMKTQMKRDVKLAEARNYDTARQAALDSGNIPVEVYDTLVDTVDDNLDTLQRHADLKRRALGVDDLEMWDLYMPIVDSEGPDIEYADAREHVIEAVAPLGEDYQQRVADGLDSNWVDVYENRGKRSGAYSGGTYDTQPFILMNYQDDISSMFTLAHELGHSLHSQYTSEHQPYVYSNYEIFVAEVASTVNEALLVNHLLDTVEDDHFRRHILNEYLERFRSTLYRQTLFADVEQRLHELTRAGEALTPDRIDEVYGDRKRAYYANATIDDHIEREWMRIPHFYYNFYVFQYATGISAAVALVEDILDDDQPDAAARYREFLTRGSSAYPIELLQDAGVDMSTSAPIERAIGVYDHYLDEADDLV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	632 (545)
Sequences:	6827 (4722)
Seq/√Len:	202.3

ECOLI - DCP OPDA
BACSU - PEPF
HALSA - Q9HNP8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
249_Q	253_E	6.974	1.00
199_E	272_T	5.363	1.00
287_D	291_Q	5.324	1.00
602_Q	607_D	5.246	1.00
193_L	279_K	4.841	1.00
187_S	190_V	4.683	1.00
595_A	599_E	3.903	1.00
595_A	603_D	3.760	1.00
288_T	291_Q	3.597	1.00
572_D	584_R	3.405	1.00
243_P	341_M	3.300	1.00
246_A	249_Q	3.266	1.00
518_R	521_E	3.165	1.00
57_Y	66_A	2.988	1.00
521_E	525_D	2.978	1.00
312_D	529_A	2.859	1.00
278_V	282_E	2.856	1.00
584_R	587_E	2.717	1.00
587_E	603_D	2.614	1.00
525_D	529_A	2.540	1.00
268_S	272_T	2.536	1.00
291_Q	301_V	2.505	1.00
64_E	131_R	2.500	1.00
65_A	69_D	2.481	1.00
172_E	176_D	2.432	1.00
65_A	68_E	2.426	1.00
169_A	172_E	2.387	1.00
376_A	433_Q	2.299	1.00
64_E	68_E	2.230	1.00
246_A	250_T	2.216	1.00
73_E	104_D	2.192	1.00
524_G	528_R	2.176	1.00
69_D	73_E	2.148	1.00
361_I	376_A	2.135	1.00
71_Q	138_D	2.108	1.00
358_E	362_E	2.106	1.00
595_A	600_L	2.104	1.00
571_E	575_D	2.096	1.00
92_L	96_E	2.071	1.00
522_V	525_D	2.066	1.00
193_L	196_E	2.055	1.00
68_E	72_A	2.051	1.00
58_E	62_E	2.042	1.00
286_Y	295_D	2.036	1.00
507_L	518_R	2.033	1.00
572_D	576_D	2.027	1.00
168_L	172_E	1.991	1.00
243_P	345_D	1.991	1.00
200_V	273_Q	1.968	1.00
62_E	65_A	1.960	1.00
190_V	193_L	1.892	1.00
591_R	600_L	1.875	1.00
71_Q	75_D	1.873	1.00
192_G	196_E	1.870	1.00
197_L	276_R	1.870	1.00
222_E	228_A	1.867	1.00
503_R	525_D	1.861	1.00
477_R	481_N	1.853	1.00
302_E	306_T	1.842	1.00
576_D	580_D	1.839	1.00
503_R	507_L	1.839	1.00
408_I	429_S	1.817	1.00
577_D	580_D	1.799	1.00
117_D	397_Y	1.794	1.00
156_E	159_Q	1.790	1.00
352_E	355_D	1.789	1.00
66_A	69_D	1.786	1.00
61_D	65_A	1.775	1.00
309_D	313_D	1.775	1.00
503_R	522_V	1.759	1.00
270_M	504_L	1.757	1.00
599_E	603_D	1.755	1.00
242_T	247_F	1.740	1.00
123_Q	127_A	1.734	1.00
188_A	192_G	1.731	1.00
68_E	71_Q	1.729	1.00
154_T	157_Q	1.729	1.00
591_R	595_A	1.728	1.00
305_D	502_Q	1.708	1.00
467_L	473_D	1.702	1.00
166_P	170_A	1.669	1.00
352_E	412_Y	1.668	1.00
52_A	55_S	1.665	1.00
166_P	169_A	1.660	1.00
220_T	228_A	1.656	1.00
368_G	371_Y	1.648	1.00
467_L	472_D	1.645	1.00
181_M	295_D	1.645	1.00
263_R	520_D	1.643	1.00
184_H	285_N	1.639	1.00
260_S	263_R	1.638	1.00
314_N	615_E	1.638	1.00
249_Q	337_W	1.636	1.00
60_D	131_R	1.605	1.00
466_L	472_D	1.594	1.00
305_D	309_D	1.590	1.00
580_D	583_A	1.589	1.00
356_A	361_I	1.588	1.00
66_A	104_D	1.555	1.00
525_D	528_R	1.554	1.00
294_L	297_G	1.550	1.00
493_R	497_F	1.548	1.00
398_S	432_S	1.547	1.00
173_H	177_D	1.540	1.00
87_D	90_T	1.533	1.00
73_E	76_A	1.525	1.00
503_R	506_E	1.522	1.00
416_I	463_V	1.513	1.00
357_R	361_I	1.500	1.00
310_T	314_N	1.490	1.00
240_L	251_V	1.484	1.00
323_D	350_D	1.481	1.00
236_F	251_V	1.474	1.00
520_D	544_W	1.473	1.00
197_L	200_V	1.463	1.00
323_D	326_R	1.463	1.00
300_P	303_V	1.460	1.00
170_A	173_H	1.459	1.00
59_T	62_E	1.453	1.00
210_M	266_I	1.449	1.00
158_L	162_I	1.443	1.00
580_D	584_R	1.442	1.00
103_R	403_D	1.439	1.00
315_L	491_L	1.436	1.00
326_R	329_L	1.433	1.00
272_T	275_K	1.427	1.00
306_T	310_T	1.424	1.00
199_E	202_G	1.417	1.00
576_D	581_A	1.417	1.00
127_A	131_R	1.412	1.00
222_E	226_G	1.408	1.00
90_T	93_A	1.406	1.00
245_R	331_V	1.400	1.00
82_G	149_E	1.399	1.00
55_S	405_Q	1.398	1.00
211_L	548_P	1.394	1.00
360_V	423_A	1.389	1.00
60_D	64_E	1.382	1.00
69_D	104_D	1.374	1.00
571_E	616_R	1.362	1.00
293_A	297_G	1.359	1.00
325_K	333_D	1.357	1.00
193_L	283_A	1.357	1.00
370_D	373_Q	1.351	1.00
223_D	227_D	1.344	1.00
245_R	335_E	1.341	1.00
358_E	361_I	1.336	1.00
203_A	269_T	1.330	1.00
196_E	199_E	1.329	1.00
596_Y	599_E	1.327	1.00
578_Q	583_A	1.322	1.00
159_Q	163_E	1.319	1.00
170_A	176_D	1.318	1.00
147_D	151_Q	1.318	1.00
67_F	135_L	1.317	1.00
250_T	254_Q	1.316	1.00
167_E	172_E	1.310	1.00
72_A	75_D	1.305	1.00
223_D	226_G	1.301	1.00
369_E	373_Q	1.301	1.00
599_E	602_Q	1.296	1.00
362_E	469_T	1.296	1.00
612_A	616_R	1.295	1.00
578_Q	581_A	1.293	1.00
50_K	53_L	1.291	1.00
309_D	529_A	1.287	1.00
245_R	337_W	1.284	1.00
72_A	76_A	1.283	1.00
453_V	569_L	1.280	1.00
524_G	541_E	1.278	1.00
193_L	197_L	1.275	1.00
71_Q	74_L	1.267	1.00
169_A	173_H	1.265	1.00
571_E	574_L	1.264	1.00
288_T	506_E	1.263	1.00
280_L	289_A	1.258	1.00
254_Q	257_D	1.256	1.00
197_L	280_L	1.233	1.00
180_R	295_D	1.230	1.00
413_Q	418_S	1.224	1.00
180_R	185_T	1.224	1.00
362_E	365_A	1.222	1.00
297_G	558_Q	1.217	1.00
51_W	54_A	1.216	1.00
469_T	473_D	1.215	1.00
610_T	613_P	1.208	1.00
586_R	590_T	1.201	1.00
131_R	135_L	1.194	1.00
496_L	526_R	1.194	1.00
288_T	301_V	1.186	1.00
467_L	471_E	1.185	1.00
311_V	495_T	1.181	1.00
270_M	519_I	1.180	1.00
400_G	403_D	1.179	1.00
368_G	373_Q	1.177	1.00
583_A	587_E	1.174	1.00
415_D	418_S	1.173	1.00
271_K	275_K	1.166	1.00
229_V	251_V	1.164	1.00
146_F	150_L	1.162	1.00
167_E	170_A	1.160	1.00
155_R	159_Q	1.159	1.00
64_E	135_L	1.159	1.00
374_R	377_D	1.157	1.00
355_D	358_E	1.156	1.00
55_S	58_E	1.148	1.00
231_I	254_Q	1.146	1.00
116_S	129_Q	1.144	1.00
99_D	441_Y	1.143	1.00
497_F	550_F	1.134	1.00
328_A	349_P	1.132	1.00
538_D	541_E	1.130	1.00
474_H	477_R	1.115	1.00
305_D	506_E	1.114	1.00
206_D	210_M	1.111	1.00
77_L	94_A	1.107	1.00
158_L	161_M	1.106	1.00
253_E	539_H	1.102	1.00
75_D	142_A	1.100	1.00
499_D	530_Y	1.094	1.00
587_E	590_T	1.090	1.00
274_M	504_L	1.088	1.00
186_R	190_V	1.086	1.00
470_V	473_D	1.076	1.00
321_H	325_K	1.074	1.00
119_D	122_D	1.073	1.00
365_A	372_Q	1.071	1.00
180_R	298_N	1.070	1.00
239_L	251_V	1.062	1.00
138_D	142_A	1.054	1.00
236_F	255_F	1.054	1.00
75_D	138_D	1.052	1.00
363_A	377_D	1.051	1.00
476_R	480_L	1.049	1.00
114_M	399_G	1.048	1.00
398_S	429_S	1.047	1.00
203_A	207_A	1.047	1.00
466_L	473_D	1.046	1.00
61_D	64_E	1.045	1.00
528_R	533_N	1.044	1.00
131_R	134_S	1.040	1.00
236_F	240_L	1.039	1.00
503_R	526_R	1.037	1.00
66_A	108_V	1.035	1.00
322_A	325_K	1.033	1.00
157_Q	160_S	1.032	1.00
233_Q	237_T	1.032	1.00
502_Q	506_E	1.029	1.00
368_G	586_R	1.029	1.00
170_A	174_Y	1.028	1.00
75_D	82_G	1.026	1.00
192_G	195_S	1.026	1.00
457_V	569_L	1.025	1.00
507_L	512_E	1.021	1.00
262_V	265_T	1.021	1.00
310_T	615_E	1.019	1.00
252_H	256_Y	1.017	1.00
520_D	524_G	1.017	1.00
361_I	383_W	1.014	1.00
591_R	603_D	1.014	1.00
326_R	331_V	1.013	1.00
204_P	273_Q	1.010	1.00
503_R	529_A	1.009	1.00
313_D	615_E	1.008	1.00
173_H	176_D	1.006	1.00
346_S	350_D	1.002	1.00
134_S	138_D	1.001	1.00
466_L	471_E	0.996	1.00
598_I	602_Q	0.995	1.00
270_M	544_W	0.994	1.00
313_D	316_D	0.992	1.00
221_V	224_P	0.990	1.00
494_Q	497_F	0.989	1.00
76_A	97_L	0.988	1.00
329_L	342_P	0.988	1.00
129_Q	133_A	0.988	1.00
279_K	282_E	0.987	1.00
229_V	235_N	0.987	1.00
460_A	570_V	0.986	1.00
273_Q	277_D	0.985	1.00
159_Q	172_E	0.982	1.00
217_E	220_T	0.980	1.00
303_V	306_T	0.978	1.00
119_D	391_G	0.976	1.00
313_D	611_S	0.975	1.00
591_R	594_S	0.973	1.00
470_V	475_F	0.972	1.00
197_L	279_K	0.969	0.99
365_A	376_A	0.968	0.99
245_R	338_D	0.966	0.99
96_E	99_D	0.965	0.99
598_I	608_M	0.964	0.99
194_L	198_G	0.959	0.99
502_Q	554_F	0.958	0.99
568_A	606_V	0.958	0.99
62_E	66_A	0.955	0.99
132_G	135_L	0.951	0.99
150_L	154_T	0.950	0.99
576_D	584_R	0.949	0.99
223_D	228_A	0.948	0.99
309_D	499_D	0.948	0.99
270_M	274_M	0.945	0.99
96_E	100_A	0.943	0.99
70_V	101_V	0.942	0.99
70_V	139_V	0.942	0.99
253_E	257_D	0.938	0.99
54_A	58_E	0.937	0.99
466_L	469_T	0.936	0.99
245_R	249_Q	0.936	0.99
424_H	452_E	0.936	0.99
247_F	250_T	0.935	0.99
301_V	305_D	0.935	0.99
92_L	167_E	0.935	0.99
425_E	428_H	0.933	0.99
184_H	191_E	0.932	0.99
128_L	131_R	0.931	0.99
378_G	384_V	0.930	0.99
114_M	401_T	0.928	0.99
89_E	93_A	0.927	0.99
399_G	407_F	0.925	0.99
600_L	603_D	0.925	0.99
308_V	499_D	0.925	0.99
294_L	304_Y	0.924	0.99
466_L	470_V	0.923	0.99
447_E	597_P	0.923	0.99
94_A	146_F	0.922	0.99
204_P	207_A	0.922	0.99
257_D	261_G	0.922	0.99
51_W	56_I	0.910	0.99
202_G	206_D	0.909	0.99
189_E	192_G	0.907	0.99
504_L	544_W	0.907	0.99
318_L	492_Y	0.903	0.99
239_L	242_T	0.902	0.99
115_R	118_E	0.901	0.99
469_T	472_D	0.898	0.99
598_I	607_D	0.898	0.99
55_S	407_F	0.898	0.99
585_Y	589_L	0.895	0.99
71_Q	142_A	0.894	0.99
490_T	494_Q	0.893	0.99
206_D	209_N	0.893	0.99
384_V	426_L	0.892	0.99
83_R	87_D	0.889	0.99
188_A	191_E	0.889	0.99
408_I	414_D	0.888	0.99
220_T	225_A	0.886	0.99
159_Q	162_I	0.885	0.99
244_D	247_F	0.884	0.99
271_K	519_I	0.883	0.99
526_R	530_Y	0.881	0.99
504_L	519_I	0.878	0.99
217_E	221_V	0.877	0.99
54_A	59_T	0.876	0.99
110_A	399_G	0.876	0.99
447_E	450_V	0.876	0.99
165_T	168_L	0.874	0.99
198_G	280_L	0.872	0.99
517_D	521_E	0.872	0.99
405_Q	436_S	0.871	0.99
457_V	585_Y	0.870	0.99
89_E	165_T	0.868	0.99
203_A	272_T	0.867	0.99
572_D	575_D	0.867	0.99
194_L	280_L	0.866	0.99
81_E	84_L	0.864	0.99
53_L	56_I	0.862	0.99
147_D	191_E	0.860	0.99
326_R	332_D	0.859	0.99
165_T	172_E	0.858	0.99
163_E	167_E	0.858	0.99
221_V	226_G	0.857	0.99
96_E	167_E	0.854	0.99
233_Q	255_F	0.854	0.99
129_Q	205_S	0.853	0.99
174_Y	177_D	0.849	0.99
375_V	426_L	0.847	0.99
460_A	566_A	0.847	0.99
277_D	505_H	0.847	0.99
114_M	397_Y	0.846	0.99
135_L	138_D	0.846	0.99
350_D	414_D	0.842	0.99
545_M	551_Y	0.838	0.99
534_A	537_D	0.838	0.99
424_H	559_Y	0.838	0.99
302_E	305_D	0.837	0.99
448_I	451_A	0.834	0.98
496_L	531_Y	0.834	0.98
113_S	117_D	0.832	0.98
464_N	574_L	0.831	0.98
157_Q	161_M	0.831	0.98
396_A	421_T	0.831	0.98
97_L	100_A	0.830	0.98
105_A	136_M	0.829	0.98
356_A	363_A	0.826	0.98
63_W	132_G	0.825	0.98
386_V	410_M	0.821	0.98
276_R	280_L	0.818	0.98
372_Q	376_A	0.815	0.98
465_H	469_T	0.814	0.98
150_L	180_R	0.814	0.98
225_A	250_T	0.813	0.98
389_N	392_K	0.813	0.98
574_L	577_D	0.813	0.98
59_T	115_R	0.813	0.98
363_A	423_A	0.810	0.98
147_D	188_A	0.810	0.98
421_T	549_H	0.809	0.98
143_T	147_D	0.809	0.98
60_D	128_L	0.808	0.98
121_R	391_G	0.807	0.98
515_T	518_R	0.805	0.98
70_V	108_V	0.805	0.98
156_E	160_S	0.804	0.98
170_A	177_D	0.803	0.98
378_G	426_L	0.803	0.98
611_S	615_E	0.803	0.98
424_H	428_H	0.797	0.98
84_L	149_E	0.797	0.98
71_Q	135_L	0.792	0.98
467_L	470_V	0.791	0.98
63_W	109_S	0.790	0.98
252_H	336_M	0.786	0.98
139_V	143_T	0.786	0.98
208_Y	211_L	0.785	0.98
56_I	404_T	0.784	0.98
436_S	590_T	0.781	0.98
63_W	67_F	0.780	0.98
371_Y	375_V	0.780	0.98
549_H	556_V	0.779	0.98
408_I	413_Q	0.776	0.98
69_D	72_A	0.775	0.98
66_A	70_V	0.775	0.98
306_T	309_D	0.773	0.98
67_F	71_Q	0.771	0.97
93_A	97_L	0.770	0.97
151_Q	155_R	0.769	0.97
255_F	258_T	0.768	0.97
56_I	123_Q	0.768	0.97
273_Q	553_N	0.768	0.97
405_Q	438_H	0.767	0.97
359_H	362_E	0.766	0.97
93_A	96_E	0.765	0.97
109_S	113_S	0.765	0.97
172_E	175_F	0.763	0.97
357_R	360_V	0.762	0.97
372_Q	375_V	0.759	0.97
170_A	442_V	0.755	0.97
67_F	108_V	0.755	0.97
507_L	522_V	0.754	0.97
494_Q	560_A	0.752	0.97
267_G	545_M	0.751	0.97
73_E	100_A	0.749	0.97
472_D	475_F	0.749	0.97
57_Y	104_D	0.747	0.97
361_I	372_Q	0.746	0.97
435_T	593_S	0.746	0.97
414_D	418_S	0.745	0.97
359_H	419_M	0.743	0.97
170_A	175_F	0.743	0.97
142_A	146_F	0.742	0.97
304_Y	308_V	0.742	0.97
464_N	468_D	0.741	0.97
321_H	334_L	0.741	0.97
277_D	289_A	0.741	0.97
425_E	452_E	0.739	0.97
114_M	407_F	0.738	0.97
173_H	596_Y	0.738	0.97
362_E	465_H	0.737	0.97
549_H	559_Y	0.735	0.97
229_V	247_F	0.734	0.97
499_D	503_R	0.734	0.97
319_Q	323_D	0.733	0.97
356_A	383_W	0.732	0.97
207_A	210_M	0.731	0.97
417_S	420_F	0.730	0.97
207_A	211_L	0.727	0.96
565_A	601_L	0.726	0.96
142_A	145_F	0.726	0.96
523_Y	543_E	0.725	0.96
268_S	271_K	0.725	0.96
463_V	479_I	0.725	0.96
171_Y	175_F	0.725	0.96
146_F	149_E	0.725	0.96
165_T	170_A	0.724	0.96
491_L	560_A	0.723	0.96
52_A	355_D	0.722	0.96
137_T	141_S	0.722	0.96
312_D	499_D	0.722	0.96
479_I	482_E	0.722	0.96
454_A	589_L	0.721	0.96
70_V	74_L	0.718	0.96
62_E	74_L	0.718	0.96
267_G	516_P	0.717	0.96
373_Q	376_A	0.716	0.96
235_N	388_E	0.715	0.96
275_K	279_K	0.714	0.96
166_P	172_E	0.713	0.96
133_A	137_T	0.712	0.96
279_K	283_A	0.711	0.96
200_V	204_P	0.711	0.96
113_S	399_G	0.710	0.96
92_L	165_T	0.709	0.96
319_Q	322_A	0.709	0.96
396_A	408_I	0.708	0.96
428_H	452_E	0.708	0.96
547_I	550_F	0.706	0.96
587_E	591_R	0.706	0.96
58_E	61_D	0.704	0.96
65_A	74_L	0.702	0.96
349_P	475_F	0.702	0.96
374_R	430_L	0.701	0.96
56_I	60_D	0.701	0.96
148_P	151_Q	0.701	0.96
214_A	259_I	0.700	0.96
583_A	586_R	0.700	0.96
200_V	203_A	0.699	0.96
353_Y	386_V	0.699	0.96
565_A	608_M	0.699	0.96
520_D	541_E	0.697	0.95
60_D	63_W	0.695	0.95
155_R	158_L	0.694	0.95
457_V	570_V	0.693	0.95
220_T	223_D	0.691	0.95
370_D	586_R	0.689	0.95
134_S	137_T	0.688	0.95
122_D	127_A	0.688	0.95
307_L	560_A	0.686	0.95
124_E	128_L	0.685	0.95
450_V	600_L	0.683	0.95
496_L	527_K	0.682	0.95
301_V	506_E	0.682	0.95
168_L	176_D	0.681	0.95
276_R	279_K	0.680	0.95
60_D	74_L	0.680	0.95
451_A	454_A	0.680	0.95
257_D	260_S	0.678	0.95
331_V	334_L	0.678	0.95
82_G	148_P	0.678	0.95
172_E	177_D	0.677	0.95
356_A	412_Y	0.676	0.95
271_K	516_P	0.674	0.95
349_P	352_E	0.674	0.95
118_E	409_L	0.673	0.95
374_R	433_Q	0.672	0.94
420_F	462_L	0.671	0.94
70_V	73_E	0.671	0.94
349_P	355_D	0.670	0.94
378_G	383_W	0.669	0.94
210_M	269_T	0.668	0.94
181_M	296_S	0.664	0.94
457_V	573_I	0.663	0.94
452_E	559_Y	0.663	0.94
208_Y	212_T	0.663	0.94
351_I	412_Y	0.662	0.94
310_T	313_D	0.662	0.94
222_E	225_A	0.661	0.94
528_R	534_A	0.659	0.94
435_T	444_S	0.659	0.94
171_Y	174_Y	0.659	0.94
291_Q	295_D	0.658	0.94
467_L	476_R	0.656	0.94
401_T	407_F	0.656	0.94
177_D	298_N	0.656	0.94
121_R	390_R	0.653	0.94
239_L	247_F	0.652	0.94
167_E	176_D	0.652	0.94
166_P	176_D	0.652	0.94
115_R	119_D	0.651	0.94
249_Q	335_E	0.650	0.93
304_Y	502_Q	0.650	0.93
521_E	524_G	0.646	0.93
184_H	187_S	0.646	0.93
207_A	268_S	0.645	0.93
224_P	247_F	0.645	0.93
142_A	195_S	0.644	0.93
260_S	542_R	0.643	0.93
127_A	130_A	0.643	0.93
289_A	293_A	0.642	0.93
83_R	90_T	0.641	0.93
425_E	459_E	0.641	0.93
367_L	374_R	0.638	0.93
364_V	372_Q	0.636	0.93
500_V	523_Y	0.636	0.93
385_D	389_N	0.633	0.93
95_L	153_C	0.633	0.93
107_T	403_D	0.633	0.93
495_T	560_A	0.629	0.92
248_R	338_D	0.629	0.92
416_I	420_F	0.629	0.92
463_V	483_Y	0.629	0.92
442_V	593_S	0.628	0.92
56_I	59_T	0.628	0.92
209_N	213_D	0.627	0.92
360_V	414_D	0.627	0.92
231_I	239_L	0.626	0.92
323_D	534_A	0.626	0.92
258_T	262_V	0.626	0.92
290_R	502_Q	0.625	0.92
547_I	556_V	0.625	0.92
62_E	71_Q	0.623	0.92
154_T	185_T	0.622	0.92
117_D	393_R	0.621	0.92
439_Q	442_V	0.621	0.92
94_A	97_L	0.621	0.92
50_K	389_N	0.621	0.92
408_I	412_Y	0.620	0.92
258_T	261_G	0.619	0.92
169_A	176_D	0.618	0.92
453_V	601_L	0.618	0.92
100_A	103_R	0.618	0.92
468_D	473_D	0.618	0.92
341_M	345_D	0.617	0.92
181_M	292_A	0.616	0.92
73_E	97_L	0.616	0.92
133_A	136_M	0.615	0.91
290_R	305_D	0.613	0.91
126_Q	129_Q	0.613	0.91
240_L	255_F	0.611	0.91
368_G	375_V	0.610	0.91
212_T	266_I	0.608	0.91
229_V	239_L	0.607	0.91
485_E	488_R	0.607	0.91
334_L	339_L	0.606	0.91
543_E	546_R	0.605	0.91
84_L	87_D	0.605	0.91
396_A	451_A	0.604	0.91
335_E	537_D	0.604	0.91
165_T	169_A	0.604	0.91
548_P	552_Y	0.603	0.91
254_Q	258_T	0.603	0.91
334_L	342_P	0.602	0.91
460_A	567_V	0.602	0.91
370_D	590_T	0.601	0.91
447_E	596_Y	0.601	0.91
331_V	335_E	0.600	0.90
183_P	186_R	0.599	0.90
140_S	144_S	0.596	0.90
602_Q	609_S	0.596	0.90
77_L	101_V	0.596	0.90
410_M	421_T	0.595	0.90
117_D	409_L	0.595	0.90
290_R	301_V	0.594	0.90
429_S	432_S	0.593	0.90
196_E	283_A	0.593	0.90
217_E	222_E	0.592	0.90
156_E	162_I	0.591	0.90
343_I	486_R	0.591	0.90
329_L	332_D	0.590	0.90
232_S	235_N	0.589	0.90
355_D	359_H	0.589	0.90
299_I	304_Y	0.589	0.90
134_S	141_S	0.588	0.90
216_L	232_S	0.587	0.89
116_S	126_Q	0.587	0.89
90_T	97_L	0.587	0.89
310_T	610_T	0.585	0.89
363_A	368_G	0.584	0.89
424_H	549_H	0.583	0.89
291_Q	302_E	0.583	0.89
60_D	65_A	0.583	0.89
345_D	474_H	0.582	0.89
373_Q	377_D	0.581	0.89
425_E	559_Y	0.580	0.89
139_V	142_A	0.580	0.89
298_N	596_Y	0.579	0.89
468_D	472_D	0.578	0.89
361_I	366_P	0.578	0.89
74_L	139_V	0.576	0.89
60_D	71_Q	0.576	0.89
446_Y	451_A	0.575	0.89
520_D	542_R	0.574	0.88
400_G	432_S	0.574	0.88
572_D	581_A	0.574	0.88
207_A	212_T	0.572	0.88
194_L	197_L	0.572	0.88
208_Y	548_P	0.572	0.88
73_E	102_Y	0.572	0.88
393_R	397_Y	0.570	0.88
84_L	94_A	0.570	0.88
440_P	443_Y	0.570	0.88
108_V	132_G	0.570	0.88
207_A	213_D	0.568	0.88
100_A	104_D	0.568	0.88
87_D	161_M	0.568	0.88
434_Y	590_T	0.568	0.88
351_I	482_E	0.567	0.88
139_V	145_F	0.567	0.88
210_M	264_N	0.566	0.88
103_R	107_T	0.565	0.88
500_V	504_L	0.565	0.88
588_F	600_L	0.565	0.88
571_E	615_E	0.565	0.88
124_E	127_A	0.564	0.88
211_L	266_I	0.564	0.88
431_H	446_Y	0.564	0.88
237_T	340_Y	0.563	0.87
495_T	499_D	0.563	0.87
438_H	590_T	0.562	0.87
197_L	201_F	0.562	0.87
282_E	287_D	0.561	0.87
126_Q	209_N	0.561	0.87
77_L	143_T	0.560	0.87
475_F	479_I	0.559	0.87
252_H	335_E	0.559	0.87
587_E	595_A	0.557	0.87
384_V	429_S	0.557	0.87
210_M	213_D	0.556	0.87
88_G	92_L	0.555	0.87
106_K	400_G	0.555	0.87
55_S	59_T	0.555	0.87
104_D	403_D	0.552	0.86
274_M	519_I	0.551	0.86
362_E	366_P	0.551	0.86
252_H	337_W	0.551	0.86
524_G	539_H	0.551	0.86
64_E	67_F	0.551	0.86
310_T	611_S	0.550	0.86
166_P	174_Y	0.550	0.86
385_D	392_K	0.550	0.86
370_D	374_R	0.550	0.86
353_Y	479_I	0.549	0.86
54_A	61_D	0.549	0.86
65_A	71_Q	0.547	0.86
58_E	65_A	0.547	0.86
500_V	544_W	0.547	0.86
118_E	389_N	0.547	0.86
479_I	483_Y	0.547	0.86
601_L	608_M	0.545	0.86
61_D	74_L	0.545	0.86
160_S	163_E	0.544	0.86
266_I	545_M	0.543	0.86
245_R	332_D	0.543	0.86
364_V	367_L	0.542	0.85
292_A	296_S	0.542	0.85
578_Q	582_A	0.542	0.85
499_D	529_A	0.542	0.85
207_A	269_T	0.541	0.85
581_A	604_A	0.541	0.85
455_S	549_H	0.540	0.85
326_R	335_E	0.538	0.85
212_T	233_Q	0.538	0.85
177_D	180_R	0.537	0.85
221_V	225_A	0.536	0.85
243_P	348_G	0.536	0.85
102_Y	139_V	0.536	0.85
110_A	445_N	0.535	0.85
357_R	386_V	0.535	0.85
136_M	140_S	0.535	0.85
481_N	485_E	0.535	0.85
103_R	106_K	0.534	0.85
66_A	77_L	0.533	0.85
97_L	101_V	0.533	0.85
273_Q	551_Y	0.533	0.85
83_R	93_A	0.533	0.85
527_K	540_I	0.532	0.84
260_S	267_G	0.532	0.84
432_S	435_T	0.531	0.84
428_H	559_Y	0.530	0.84
110_A	113_S	0.529	0.84
126_Q	130_A	0.529	0.84
352_E	478_H	0.529	0.84
244_D	250_T	0.528	0.84
339_L	489_S	0.527	0.84
98_R	102_Y	0.526	0.84
120_T	393_R	0.526	0.84
420_F	463_V	0.526	0.84
474_H	478_H	0.526	0.84
523_Y	527_K	0.526	0.84
77_L	97_L	0.526	0.84
128_L	132_G	0.525	0.84
130_A	133_A	0.525	0.84
280_L	292_A	0.524	0.84
360_V	426_L	0.523	0.83
305_D	499_D	0.523	0.83
91_L	168_L	0.521	0.83
238_N	241_K	0.521	0.83
336_M	538_D	0.521	0.83
437_E	440_P	0.520	0.83
388_E	411_N	0.520	0.83
410_M	413_Q	0.520	0.83
130_A	209_N	0.519	0.83
563_I	566_A	0.519	0.83
346_S	485_E	0.519	0.83
89_E	152_A	0.516	0.83
300_P	609_S	0.515	0.82
224_P	228_A	0.515	0.82
496_L	543_E	0.513	0.82
308_V	495_T	0.513	0.82
573_I	577_D	0.513	0.82
315_L	492_Y	0.513	0.82
251_V	255_F	0.512	0.82
54_A	62_E	0.512	0.82
384_V	410_M	0.512	0.82
252_H	539_H	0.511	0.82
428_H	459_E	0.511	0.82
66_A	107_T	0.511	0.82
216_L	391_G	0.510	0.82
171_Y	176_D	0.508	0.82
455_S	459_E	0.507	0.81
395_G	421_T	0.507	0.81
374_R	378_G	0.506	0.81
452_E	459_E	0.505	0.81
424_H	459_E	0.505	0.81
453_V	565_A	0.505	0.81
145_F	149_E	0.503	0.81
354_A	357_R	0.502	0.81
56_I	74_L	0.502	0.81
386_V	422_L	0.502	0.81
186_R	191_E	0.502	0.81
366_P	369_E	0.502	0.81
117_D	399_G	0.502	0.81
378_G	429_S	0.501	0.81
74_L	77_L	0.501	0.81
448_I	558_Q	0.501	0.81
326_R	333_D	0.501	0.81
492_Y	495_T	0.500	0.81
416_I	479_I	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ce2A	1	0.9304	100	0.207	Contact Map
2qr4A	2	0.818	100	0.248	Contact Map
4ka7A	1	0.9003	100	0.333	Contact Map
1y791	1	0.9051	100	0.335	Contact Map
2o3eA	1	0.8829	100	0.346	Contact Map
2o36A	1	0.8655	100	0.354	Contact Map
3sksA	1	0.8449	100	0.363	Contact Map
3ahnA	1	0.8703	100	0.37	Contact Map
1r42A	1	0.807	100	0.486	Contact Map
4ca6A	1	0.8212	100	0.491	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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