GREMLIN Database
Q9HNP7 - Uncharacterized protein
UniProt: Q9HNP7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 441 (395)
Sequences: 4047 (3024)
Seq/√Len: 152.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A50_E3.9891.00
45_V49_G3.8771.00
372_W377_A3.7241.00
45_V58_T3.6261.00
221_D266_E3.6001.00
116_V121_V3.5581.00
123_A151_F3.3051.00
48_L273_T3.2851.00
228_V399_V3.0941.00
97_T199_E3.0731.00
99_R119_A3.0291.00
253_A256_R2.8841.00
58_T212_V2.8521.00
60_P210_T2.7781.00
103_A123_A2.7131.00
20_V43_H2.6461.00
298_A402_L2.5821.00
120_V150_G2.5611.00
217_V270_R2.4641.00
59_E291_L2.4481.00
222_T225_E2.4291.00
229_I299_V2.4251.00
41_A214_T2.3351.00
286_A290_S2.3171.00
61_F275_S2.3061.00
98_G149_A2.3031.00
118_G149_A2.2951.00
35_A39_R2.2871.00
389_R393_M2.2701.00
37_D275_S2.2471.00
42_E45_V2.1621.00
95_T201_T2.1141.00
38_R42_E2.1101.00
44_V232_H2.0971.00
121_V148_A2.0941.00
251_L273_T2.0791.00
99_R197_A2.0591.00
141_G145_A2.0231.00
224_T295_A2.0121.00
142_R146_G1.9511.00
220_P266_E1.9341.00
100_L122_V1.9321.00
248_V273_T1.9261.00
37_D232_H1.9221.00
284_A350_P1.8441.00
21_L245_G1.8401.00
215_H272_G1.8381.00
293_T356_V1.8381.00
95_T199_E1.8231.00
152_V180_V1.8181.00
250_T305_A1.8131.00
44_V273_T1.8041.00
22_T380_R1.7981.00
42_E46_D1.7971.00
62_P210_T1.7641.00
13_T16_T1.7451.00
101_V116_V1.7441.00
142_R145_A1.7311.00
225_E267_T1.7281.00
23_A27_L1.7111.00
229_I274_V1.7081.00
48_L216_G1.7051.00
250_T392_G1.6901.00
182_G186_S1.6841.00
32_A276_G1.6831.00
111_F142_R1.6791.00
274_V299_V1.6581.00
92_P95_T1.6511.00
62_P208_P1.6441.00
69_G203_D1.6261.00
74_R199_E1.5971.00
111_F143_A1.5911.00
211_G275_S1.5871.00
288_A350_P1.5551.00
14_D389_R1.5291.00
152_V178_A1.5161.00
287_L296_V1.4991.00
18_W385_A1.4981.00
277_E374_H1.4971.00
41_A232_H1.4911.00
186_S190_A1.4891.00
107_A110_G1.4861.00
23_A26_A1.4821.00
106_G111_F1.4761.00
217_V268_R1.4761.00
16_T253_A1.4741.00
126_G139_K1.4631.00
97_T197_A1.4601.00
180_V184_V1.4591.00
60_P212_V1.4591.00
221_D225_E1.4431.00
243_D277_E1.4401.00
302_L395_A1.4251.00
277_E373_G1.4211.00
230_A248_V1.4191.00
41_A58_T1.4121.00
327_A401_E1.4081.00
48_L255_A1.4061.00
46_D50_E1.4031.00
230_A251_L1.4021.00
232_H273_T1.3981.00
400_R404_R1.3881.00
51_A216_G1.3871.00
278_E374_H1.3821.00
258_L269_V1.3761.00
51_A252_V1.3331.00
256_R260_A1.3291.00
20_V47_A1.3221.00
59_E286_A1.3211.00
243_D374_H1.3211.00
98_G120_V1.3151.00
227_V272_G1.3101.00
111_F146_G1.3081.00
270_R287_L1.3071.00
261_M400_R1.3071.00
46_D49_G1.3051.00
116_V148_A1.3051.00
48_L252_V1.3041.00
88_L91_A1.3041.00
239_E379_T1.3011.00
24_L248_V1.3001.00
18_W22_T1.2981.00
115_D119_A1.2971.00
219_G267_T1.2901.00
47_A256_R1.2861.00
231_H243_D1.2771.00
285_S289_D1.2741.00
69_G205_H1.2651.00
219_G225_E1.2611.00
18_W380_R1.2571.00
234_A240_G1.2551.00
276_G282_V1.2491.00
17_P392_G1.2461.00
45_V56_A1.2451.00
100_L198_A1.2311.00
38_R212_V1.2281.00
16_T256_R1.2281.00
323_D326_A1.2241.00
109_A112_D1.2201.00
288_A354_A1.2141.00
58_T214_T1.2131.00
220_P223_P1.2121.00
329_E394_L1.2121.00
219_G222_T1.2111.00
244_N301_N1.2041.00
57_T217_V1.1951.00
265_L269_V1.1941.00
184_V187_W1.1931.00
103_A121_V1.1901.00
31_M34_H1.1891.00
187_W191_Y1.1831.00
231_H277_E1.1761.00
73_L200_L1.1721.00
219_G268_R1.1611.00
40_A232_H1.1591.00
324_V402_L1.1581.00
222_T266_E1.1521.00
340_D343_H1.1401.00
47_A51_A1.1401.00
326_A330_D1.1361.00
21_L249_A1.1261.00
59_E213_N1.1231.00
143_A148_A1.1170.99
53_V216_G1.1170.99
300_V399_V1.1080.99
53_V271_L1.1060.99
152_V198_A1.1000.99
28_D35_A1.0990.99
82_A85_A1.0980.99
299_V358_A1.0910.99
93_A203_D1.0870.99
379_T382_K1.0820.99
339_V342_L1.0820.99
278_E373_G1.0810.99
20_V252_V1.0780.99
258_L271_L1.0770.99
41_A212_V1.0750.99
70_D203_D1.0720.99
87_A91_A1.0680.99
144_V174_E1.0570.99
265_L268_R1.0540.99
120_V198_A1.0530.99
25_T241_A1.0510.99
293_T354_A1.0490.99
255_A271_L1.0470.99
327_A330_D1.0390.99
229_I272_G1.0360.99
31_M279_V1.0360.99
286_A289_D1.0280.99
36_G39_R1.0150.99
59_E290_S1.0110.99
269_V403_A1.0080.99
20_V51_A0.9980.99
254_A399_V0.9980.99
103_A151_F0.9940.99
221_D224_T0.9930.99
140_Y151_F0.9920.99
80_E84_D0.9910.99
228_V251_L0.9870.99
20_V253_A0.9850.99
323_D327_A0.9830.99
231_H303_D0.9830.99
51_A259_A0.9820.99
218_L265_L0.9780.99
100_L152_V0.9780.99
124_S189_E0.9730.99
299_V351_F0.9720.99
87_A90_Y0.9670.99
102_S124_S0.9640.98
72_A201_T0.9620.98
53_V255_A0.9610.98
235_H238_G0.9600.98
187_W190_A0.9550.98
231_H278_E0.9550.98
143_A147_G0.9550.98
317_A322_A0.9540.98
103_A114_V0.9510.98
53_V218_L0.9500.98
274_V351_F0.9490.98
82_A87_A0.9450.98
285_S350_P0.9400.98
150_G200_L0.9380.98
102_S192_A0.9350.98
185_G189_E0.9330.98
12_W257_V0.9280.98
215_H270_R0.9270.98
242_L372_W0.9230.98
296_V356_V0.9170.98
339_V343_H0.9150.98
108_P146_G0.9140.98
76_T79_D0.9130.98
100_L188_L0.9120.98
231_H374_H0.9110.98
106_G110_G0.9110.98
213_N283_G0.9090.98
277_E346_S0.9070.98
228_V271_L0.9070.98
218_L259_A0.9070.98
180_V185_G0.9030.98
254_A396_A0.9000.98
168_R171_R0.8990.98
282_V286_A0.8980.98
372_W375_T0.8950.98
25_T380_R0.8920.97
277_E281_L0.8900.97
281_L346_S0.8900.97
19_D22_T0.8890.97
104_G110_G0.8870.97
226_V402_L0.8830.97
42_E58_T0.8810.97
35_A38_R0.8800.97
80_E83_F0.8770.97
372_W382_K0.8750.97
139_K143_A0.8720.97
380_R385_A0.8700.97
48_L53_V0.8700.97
181_S184_V0.8680.97
218_L271_L0.8680.97
363_S391_H0.8670.97
18_W384_D0.8660.97
116_V146_G0.8650.97
253_A257_V0.8630.97
140_Y177_A0.8620.97
288_A351_F0.8610.97
292_D295_A0.8610.97
242_L304_G0.8590.97
48_L271_L0.8590.97
163_Q168_R0.8490.97
324_V328_V0.8490.97
65_V207_E0.8490.97
111_F116_V0.8480.97
140_Y167_L0.8480.97
14_D18_W0.8470.97
105_Y124_S0.8460.97
67_T205_H0.8460.97
243_D373_G0.8450.97
200_L204_A0.8420.96
231_H373_G0.8400.96
258_L396_A0.8400.96
37_D44_V0.8350.96
54_R259_A0.8340.96
328_V398_L0.8340.96
277_E303_D0.8310.96
322_A326_A0.8300.96
102_S189_E0.8260.96
73_L85_A0.8260.96
247_G303_D0.8260.96
84_D87_A0.8250.96
88_L177_A0.8240.96
30_R245_G0.8190.96
23_A39_R0.8140.96
124_S154_H0.8130.96
242_L307_R0.8130.96
111_F121_V0.8130.96
234_A238_G0.8120.96
19_D23_A0.8110.96
65_V209_G0.8090.96
348_H360_Q0.8030.95
227_V299_V0.7960.95
100_L150_G0.7960.95
243_D347_D0.7950.95
28_D36_G0.7900.95
161_L164_T0.7860.95
332_A335_P0.7850.95
222_T406_D0.7850.95
240_G378_D0.7800.95
284_A347_D0.7770.94
231_H347_D0.7760.94
81_R84_D0.7750.94
130_G153_F0.7730.94
21_L25_T0.7730.94
304_G373_G0.7730.94
125_T136_R0.7730.94
277_E301_N0.7710.94
352_L358_A0.7700.94
125_T155_N0.7690.94
85_A88_L0.7680.94
334_H337_D0.7650.94
233_D280_G0.7640.94
73_L178_A0.7620.94
258_L399_V0.7610.94
243_D301_N0.7540.94
150_G176_P0.7510.93
221_D268_R0.7500.93
180_V188_L0.7490.93
331_A397_L0.7480.93
75_V198_A0.7470.93
106_G143_A0.7440.93
231_H244_N0.7440.93
59_E287_L0.7430.93
278_E281_L0.7410.93
322_A325_L0.7410.93
289_D354_A0.7410.93
243_D303_D0.7400.93
106_G139_K0.7390.93
32_A279_V0.7390.93
274_V284_A0.7360.93
16_T19_D0.7350.93
156_Q159_G0.7340.93
346_S373_G0.7330.93
241_A378_D0.7320.93
323_D411_R0.7320.93
23_A43_H0.7300.92
287_L291_L0.7280.92
278_E284_A0.7280.92
327_A331_A0.7270.92
402_L405_E0.7270.92
85_A89_P0.7260.92
45_V214_T0.7240.92
20_V256_R0.7230.92
329_E333_G0.7190.92
144_V175_R0.7170.92
80_E87_A0.7170.92
231_H301_N0.7110.91
258_L265_L0.7110.91
246_C383_V0.7090.91
345_Y349_W0.7090.91
227_V296_V0.7080.91
304_G346_S0.7080.91
117_E147_G0.7070.91
220_P225_E0.7060.91
303_D346_S0.7050.91
31_M36_G0.7040.91
223_P268_R0.7020.91
112_D146_G0.7020.91
300_V395_A0.7010.91
9_G397_L0.6980.91
361_L395_A0.6960.91
301_N347_D0.6950.90
218_L258_L0.6930.90
10_Q14_D0.6930.90
54_R217_V0.6930.90
255_A259_A0.6890.90
44_V248_V0.6880.90
83_F87_A0.6880.90
110_G113_G0.6840.90
76_T97_T0.6810.90
276_G279_V0.6790.89
230_A244_N0.6790.89
305_A308_Y0.6790.89
374_H378_D0.6780.89
76_T199_E0.6780.89
396_A400_R0.6770.89
57_T215_H0.6760.89
236_D239_E0.6750.89
332_A397_L0.6740.89
257_V396_A0.6720.89
383_V388_L0.6710.89
14_D386_R0.6690.89
106_G123_A0.6680.89
317_A321_F0.6680.89
191_Y196_G0.6680.89
75_V78_P0.6660.89
386_R389_R0.6650.88
325_L329_E0.6630.88
40_A44_V0.6610.88
216_G271_L0.6600.88
24_L245_G0.6600.88
228_V395_A0.6600.88
232_H248_V0.6580.88
43_H47_A0.6560.88
107_A111_F0.6560.88
108_P112_D0.6550.88
347_D373_G0.6550.88
61_F290_S0.6540.88
345_Y373_G0.6540.88
297_R408_T0.6500.87
164_T167_L0.6500.87
23_A50_E0.6500.87
350_P353_R0.6490.87
29_S36_G0.6480.87
245_G249_A0.6480.87
143_A175_R0.6470.87
239_E242_L0.6450.87
15_D19_D0.6450.87
277_E347_D0.6440.87
82_A89_P0.6440.87
328_V331_A0.6430.87
30_R244_N0.6420.87
59_E215_H0.6420.87
332_A390_E0.6390.86
401_E405_E0.6370.86
20_V23_A0.6360.86
178_A204_A0.6320.86
292_D296_V0.6310.86
163_Q166_A0.6310.86
10_Q15_D0.6310.86
301_N346_S0.6290.86
37_D212_V0.6290.86
122_V189_E0.6280.85
321_F325_L0.6280.85
355_G358_A0.6270.85
17_P250_T0.6270.85
320_A323_D0.6240.85
259_A264_V0.6220.85
319_P322_A0.6220.85
158_D183_E0.6220.85
68_R87_A0.6220.85
218_L269_V0.6210.85
344_P349_W0.6200.85
240_G243_D0.6200.85
122_V152_V0.6180.85
329_E336_I0.6170.84
272_G287_L0.6160.84
304_G307_R0.6160.84
191_Y195_G0.6150.84
238_G376_Q0.6150.84
211_G276_G0.6150.84
226_V298_A0.6140.84
30_R40_A0.6140.84
349_W353_R0.6120.84
165_G171_R0.6120.84
167_L170_G0.6120.84
311_L314_F0.6080.84
15_D386_R0.6070.83
32_A37_D0.6070.83
29_S237_I0.6070.83
163_Q167_L0.6070.83
226_V297_R0.6070.83
387_T391_H0.6060.83
16_T20_V0.6050.83
30_R234_A0.6030.83
38_R58_T0.6020.83
216_G273_T0.6000.83
219_G223_P0.5990.83
317_A325_L0.5980.83
281_L284_A0.5970.82
20_V249_A0.5960.82
254_A258_L0.5930.82
219_G224_T0.5910.82
120_V200_L0.5900.82
64_P208_P0.5900.82
359_V398_L0.5890.82
243_D278_E0.5880.82
24_L44_V0.5860.81
122_V192_A0.5860.81
285_S353_R0.5850.81
53_V56_A0.5850.81
242_L366_P0.5840.81
311_L315_L0.5840.81
98_G119_A0.5810.81
164_T169_G0.5810.81
160_Q163_Q0.5810.81
123_A153_F0.5790.81
226_V403_A0.5790.81
189_E192_A0.5780.80
71_C74_R0.5770.80
226_V399_V0.5760.80
330_D336_I0.5760.80
278_E347_D0.5760.80
139_K155_N0.5760.80
242_L306_G0.5760.80
261_M396_A0.5730.80
338_V341_T0.5730.80
37_D41_A0.5720.80
306_G388_L0.5710.80
228_V269_V0.5710.80
250_T254_A0.5710.80
158_D182_G0.5700.79
74_R79_D0.5690.79
266_E406_D0.5680.79
112_D115_D0.5670.79
37_D211_G0.5670.79
66_W177_A0.5660.79
178_A202_V0.5650.79
88_L121_V0.5650.79
242_L246_C0.5640.79
338_V342_L0.5630.79
347_D374_H0.5620.79
29_S34_H0.5620.79
261_M265_L0.5600.78
74_R77_A0.5600.78
84_D89_P0.5590.78
83_F86_I0.5590.78
68_R236_D0.5590.78
174_E177_A0.5580.78
17_P249_A0.5580.78
405_E408_T0.5570.78
11_A261_M0.5570.78
83_F88_L0.5570.78
220_P265_L0.5550.78
53_V259_A0.5550.78
320_A410_P0.5540.78
14_D17_P0.5530.77
293_T296_V0.5520.77
381_D385_A0.5520.77
54_R264_V0.5510.77
107_A128_P0.5510.77
37_D40_A0.5510.77
307_R366_P0.5500.77
298_A359_V0.5500.77
165_G169_G0.5500.77
164_T168_R0.5500.77
76_T197_A0.5490.77
121_V146_G0.5480.77
235_H278_E0.5480.77
83_F90_Y0.5470.77
167_L171_R0.5470.77
9_G12_W0.5450.76
34_H65_V0.5440.76
178_A200_L0.5430.76
122_V154_H0.5400.76
183_E186_S0.5400.76
107_A127_S0.5390.76
117_E145_A0.5380.75
188_L196_G0.5370.75
110_G126_G0.5360.75
156_Q182_G0.5350.75
118_G148_A0.5340.75
344_P352_L0.5340.75
80_E90_Y0.5330.75
114_V121_V0.5330.75
218_L268_R0.5320.75
318_T321_F0.5310.75
234_A245_G0.5310.75
362_H365_T0.5300.74
300_V402_L0.5290.74
321_F328_V0.5290.74
38_R41_A0.5270.74
12_W393_M0.5270.74
97_T200_L0.5260.74
23_A47_A0.5250.74
324_V401_E0.5250.74
117_E197_A0.5240.74
24_L40_A0.5240.74
278_E301_N0.5240.74
227_V270_R0.5240.74
86_I89_P0.5240.74
328_V332_A0.5230.73
138_E141_G0.5230.73
118_G121_V0.5230.73
174_E178_A0.5220.73
250_T306_G0.5210.73
299_V350_P0.5170.73
301_N374_H0.5150.72
405_E409_I0.5140.72
130_G136_R0.5120.72
105_Y139_K0.5120.72
259_A262_E0.5100.72
284_A348_H0.5100.72
72_A203_D0.5090.71
303_D374_H0.5080.71
246_C304_G0.5080.71
254_A257_V0.5070.71
32_A209_G0.5050.71
159_G377_A0.5040.71
320_A324_V0.5040.71
331_A401_E0.5030.71
160_Q164_T0.5020.70
21_L385_A0.5000.70
85_A90_Y0.5000.70
225_E268_R0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kasA 2 0.9773 100 0.284 Contact Map
4tweA 2 0.9773 100 0.289 Contact Map
3fedA 2 0.9728 100 0.295 Contact Map
2ek8A 2 0.8957 100 0.305 Contact Map
3iibA 2 0.9342 100 0.333 Contact Map
4r12A 1 0.8118 100 0.523 Contact Map
3k9tA 3 0.8209 100 0.56 Contact Map
1tkjA 1 0.5714 100 0.598 Contact Map
5a63A 1 0.8413 100 0.621 Contact Map
4mhpA 1 0.5896 100 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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