GREMLIN Database
SYH - Histidine--tRNA ligase
UniProt: Q9HNP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 432 (407)
Sequences: 7918 (5245)
Seq/√Len: 260.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
400_N413_T3.6821.00
28_D148_S3.2591.00
412_T422_A3.2431.00
300_E306_P3.1081.00
159_R261_S3.0561.00
250_E256_Q2.9631.00
405_N408_S2.9281.00
403_I422_A2.9221.00
101_S123_N2.8801.00
147_T156_F2.7891.00
65_T69_G2.6021.00
352_D356_A2.5961.00
349_E352_D2.5061.00
415_P418_A2.4611.00
186_V189_R2.4511.00
398_D413_T2.4441.00
418_A421_G2.3991.00
268_L271_Y2.3901.00
400_N415_P2.3361.00
304_G308_P2.2951.00
227_V243_R2.2551.00
29_A148_S2.2221.00
65_T71_D2.2091.00
25_A148_S2.2061.00
402_T411_Q2.1661.00
30_A122_T2.1641.00
388_V406_M2.1531.00
394_Q398_D2.1291.00
354_A364_V2.1291.00
329_L332_D2.1171.00
267_G271_Y2.0881.00
337_D363_R2.0871.00
20_R23_I2.0751.00
27_E37_E2.0341.00
26_I145_G2.0281.00
340_V354_A2.0041.00
393_E397_A1.9791.00
271_Y274_V1.9661.00
24_D28_D1.9351.00
338_Y362_N1.9191.00
46_T50_V1.9161.00
418_A422_A1.8911.00
8_F43_M1.8901.00
372_S375_A1.8741.00
15_E324_E1.8441.00
187_D190_E1.8411.00
349_E396_L1.8361.00
224_D228_S1.8191.00
128_G134_A1.7961.00
267_G270_Y1.7951.00
168_G231_G1.7951.00
63_S71_D1.7581.00
387_T403_I1.7451.00
66_D70_R1.7291.00
32_S144_D1.7291.00
128_G133_R1.7101.00
20_R37_E1.7101.00
33_Y144_D1.7061.00
124_L138_V1.6951.00
21_A25_A1.6821.00
250_E255_R1.6801.00
38_V85_M1.6791.00
142_A278_C1.6771.00
242_L260_V1.6691.00
337_D362_N1.6611.00
136_A248_A1.6541.00
140_A144_D1.6521.00
31_A100_Y1.6071.00
206_L211_A1.6051.00
32_S148_S1.6001.00
377_M390_I1.5921.00
18_P324_E1.5701.00
354_A366_T1.5691.00
183_I191_K1.5681.00
144_D355_S1.5611.00
22_A320_N1.5461.00
26_I316_H1.5421.00
38_V82_V1.5321.00
394_Q397_A1.5161.00
28_D32_S1.5131.00
387_T423_H1.5071.00
243_R247_D1.4931.00
284_D287_R1.4911.00
42_A103_R1.4891.00
348_A352_D1.4801.00
356_A416_I1.4751.00
389_V401_V1.4661.00
293_G297_D1.4661.00
175_A229_F1.4601.00
120_Y317_A1.4551.00
157_E259_D1.4451.00
224_D227_V1.4441.00
174_D178_D1.4351.00
136_A140_A1.4351.00
35_F98_K1.4341.00
213_Q216_D1.4331.00
126_I134_A1.4101.00
246_L250_E1.4081.00
209_D213_Q1.4081.00
392_G395_D1.4031.00
247_D251_T1.4001.00
143_A147_T1.3991.00
272_T277_E1.3871.00
75_T103_R1.3861.00
240_A244_N1.3771.00
46_T73_A1.3751.00
237_D240_A1.3711.00
403_I414_A1.3701.00
373_F377_M1.3651.00
244_N248_A1.3621.00
356_A359_E1.3611.00
104_P118_E1.3601.00
51_D87_V1.3591.00
324_E333_E1.3591.00
78_L101_S1.3531.00
271_Y275_V1.3501.00
168_G238_A1.3451.00
46_T71_D1.3311.00
304_G307_T1.3251.00
354_A358_R1.3251.00
344_G347_D1.3241.00
42_A106_W1.3201.00
339_Y380_A1.3151.00
283_G286_G1.3131.00
78_L123_N1.2961.00
20_R27_E1.2951.00
402_T413_T1.2901.00
387_T405_N1.2901.00
157_E281_S1.2891.00
124_L141_V1.2851.00
342_Q350_A1.2781.00
140_A252_L1.2771.00
419_F423_H1.2771.00
293_G309_A1.2721.00
188_K191_K1.2711.00
83_A299_I1.2691.00
5_L43_M1.2601.00
5_L8_F1.2441.00
142_A290_F1.2441.00
193_E196_A1.2141.00
98_K365_D1.2121.00
20_R31_A1.2071.00
266_R271_Y1.2051.00
268_L275_V1.2041.00
271_Y277_E1.2041.00
18_P320_N1.2031.00
212_E216_D1.2021.00
20_R24_D1.1971.00
206_L210_Q1.1951.00
272_T276_F1.1811.00
247_D250_E1.1811.00
203_A206_L1.1811.00
159_R259_D1.1801.00
205_G210_Q1.1801.00
355_S359_E1.1791.00
5_L72_V1.1731.00
274_V277_E1.1711.00
401_V416_I1.1691.00
231_G238_A1.1571.00
222_D227_V1.1541.00
165_I231_G1.1531.00
371_R375_A1.1531.00
46_T63_S1.1421.00
143_A158_F1.1411.00
211_A215_D1.1391.00
14_A17_G1.1381.00
207_S210_Q1.1381.00
206_L215_D1.1371.00
271_Y276_F1.1321.00
349_E416_I1.1311.00
19_R317_A1.1271.00
346_T393_E1.1261.00
244_N247_D1.1211.00
205_G211_A1.1191.00
208_Y211_A1.1181.00
23_I39_G1.1081.00
270_Y277_E1.1081.00
192_I198_L1.1031.00
338_Y357_L1.1031.00
338_Y364_V1.1021.00
67_Q108_Y1.1001.00
78_L105_F1.0991.00
191_K194_R1.0971.00
225_A228_S1.0921.00
342_Q376_Q1.0911.00
16_M20_R1.0881.00
265_A268_L1.0841.00
246_L260_V1.0751.00
33_Y141_V1.0641.00
394_Q413_T1.0611.00
266_R270_Y1.0611.00
70_R108_Y1.0551.00
404_K411_Q1.0551.00
176_T179_T1.0551.00
331_D378_N1.0541.00
356_A360_R1.0451.00
266_R269_D1.0451.00
165_I168_G1.0451.00
19_R120_Y1.0441.00
403_I419_F1.0441.00
360_R420_P1.0431.00
338_Y389_V1.0411.00
25_A149_L1.0401.00
26_I122_T1.0391.00
263_T268_L1.0381.00
356_A420_P1.0331.00
281_S284_D1.0331.00
340_V350_A1.0321.00
240_A243_R1.0301.00
17_G31_A1.0301.00
239_V242_L1.0291.00
83_A127_F1.0281.00
270_Y275_V1.0281.00
35_F126_I1.0281.00
42_A118_E1.0261.00
43_M74_L1.0241.00
37_E100_Y1.0211.00
223_L227_V1.0181.00
131_D309_A1.0171.00
386_D405_N1.0141.00
190_E193_E1.0111.00
251_T348_A1.0091.00
190_E206_L1.0081.00
242_L245_V0.9951.00
134_A137_E0.9951.00
399_G417_A0.9941.00
116_F317_A0.9931.00
23_I27_E0.9891.00
344_G393_E0.9851.00
6_K110_E0.9821.00
207_S211_A0.9771.00
273_G276_F0.9771.00
86_V99_W0.9731.00
341_L373_F0.9721.00
246_L256_Q0.9711.00
351_A355_S0.9701.00
248_A255_R0.9681.00
239_V243_R0.9681.00
27_E102_S0.9671.00
12_Y85_M0.9641.00
122_T316_H0.9641.00
247_D348_A0.9631.00
377_M381_D0.9621.00
263_T266_R0.9611.00
263_T271_Y0.9581.00
305_Q308_P0.9521.00
42_A104_P0.9511.00
212_E215_D0.9501.00
26_I30_A0.9481.00
405_N410_E0.9451.00
129_T303_G0.9431.00
404_K409_G0.9411.00
11_F19_R0.9411.00
33_Y98_K0.9391.00
144_D147_T0.9321.00
199_D203_A0.9241.00
251_T254_V0.9241.00
342_Q366_T0.9211.00
139_L158_F0.9211.00
50_V71_D0.9191.00
75_T78_L0.9181.00
263_T270_Y0.9181.00
159_R279_F0.9171.00
223_L226_L0.9141.00
341_L388_V0.9121.00
273_G277_E0.9101.00
265_A277_E0.9101.00
349_E391_V0.9041.00
40_T81_T0.9001.00
98_K124_L0.8991.00
119_F313_A0.8981.00
33_Y137_E0.8971.00
241_N245_V0.8931.00
414_A419_F0.8921.00
66_D69_G0.8911.00
340_V353_V0.8901.00
167_G171_A0.8891.00
248_A252_L0.8881.00
43_M72_V0.8771.00
211_A214_F0.8771.00
144_D359_E0.8761.00
401_V414_A0.8741.00
264_T275_V0.8731.00
294_R298_L0.8691.00
24_D27_E0.8681.00
143_A255_R0.8671.00
143_A156_F0.8661.00
5_L45_R0.8651.00
127_F299_I0.8621.00
17_G36_R0.8611.00
260_V263_T0.8601.00
138_V310_V0.8591.00
416_I420_P0.8571.00
63_S73_A0.8551.00
274_V278_C0.8541.00
249_A255_R0.8520.99
261_S268_L0.8500.99
283_G287_R0.8490.99
9_R317_A0.8480.99
191_K196_A0.8430.99
261_S267_G0.8400.99
202_A205_G0.8400.99
82_V123_N0.8380.99
165_I238_A0.8370.99
268_L274_V0.8360.99
367_D371_R0.8350.99
343_V373_F0.8340.99
9_R15_E0.8340.99
40_T82_V0.8330.99
388_V411_Q0.8330.99
261_S264_T0.8300.99
25_A29_A0.8290.99
281_S287_R0.8280.99
401_V419_F0.8270.99
25_A28_D0.8270.99
24_D31_A0.8240.99
187_D206_L0.8230.99
186_V190_E0.8190.99
297_D300_E0.8190.99
270_Y274_V0.8180.99
208_Y214_F0.8170.99
381_D406_M0.8160.99
210_Q213_Q0.8150.99
264_T271_Y0.8150.99
47_E50_V0.8140.99
275_V278_C0.8130.99
389_V403_I0.8110.99
204_A207_S0.8110.99
27_E100_Y0.8100.99
222_D225_A0.8080.99
78_L103_R0.8060.99
375_A378_N0.8060.99
243_R246_L0.8060.99
180_E195_A0.8060.99
381_D404_K0.8040.99
145_G314_P0.8030.99
206_L209_D0.7910.99
113_Q116_F0.7900.99
365_D385_A0.7880.99
265_A271_Y0.7870.99
415_P419_F0.7860.99
261_S271_Y0.7850.99
21_A363_R0.7840.99
264_T268_L0.7830.99
272_T275_V0.7780.99
64_F72_V0.7780.99
315_G318_T0.7730.99
362_N423_H0.7720.99
203_A207_S0.7670.99
43_M62_Y0.7650.99
202_A251_T0.7630.99
414_A422_A0.7630.99
260_V264_T0.7630.99
339_Y385_A0.7630.99
180_E183_I0.7620.99
68_G108_Y0.7620.99
209_D215_D0.7600.99
205_G209_D0.7600.99
263_T267_G0.7590.99
251_T255_R0.7580.99
386_D407_A0.7570.99
27_E31_A0.7550.99
162_H168_G0.7550.99
29_A144_D0.7540.99
250_E254_V0.7510.99
321_L324_E0.7490.99
271_Y278_C0.7490.99
202_A207_S0.7460.99
381_D388_V0.7460.99
265_A270_Y0.7410.99
32_S362_N0.7360.99
205_G215_D0.7340.98
389_V419_F0.7290.98
345_D351_A0.7290.98
86_V90_Q0.7280.98
268_L277_E0.7280.98
352_D416_I0.7280.98
247_D255_R0.7240.98
16_M19_R0.7240.98
202_A208_Y0.7220.98
391_V401_V0.7220.98
342_Q345_D0.7210.98
43_M64_F0.7200.98
249_A256_Q0.7200.98
203_A211_A0.7200.98
98_K137_E0.7200.98
241_N244_N0.7190.98
29_A145_G0.7180.98
248_A251_T0.7150.98
243_R250_E0.7140.98
102_S122_T0.7120.98
200_D203_A0.7120.98
11_F15_E0.7090.98
8_F40_T0.7060.98
353_V356_A0.7060.98
177_V180_E0.7040.98
261_S266_R0.7020.98
412_T418_A0.7010.98
203_A214_F0.7000.98
16_M39_G0.6990.98
210_Q215_D0.6970.98
265_A275_V0.6960.98
261_S265_A0.6950.98
267_G277_E0.6940.98
42_A74_L0.6930.98
144_D148_S0.6900.98
161_S166_L0.6880.98
23_I37_E0.6870.98
205_G212_E0.6850.98
265_A269_D0.6840.98
82_V99_W0.6830.98
358_R364_V0.6820.98
263_T275_V0.6810.98
106_W118_E0.6800.98
262_L266_R0.6790.98
194_R198_L0.6790.98
156_F278_C0.6780.97
273_G278_C0.6760.97
249_A254_V0.6760.97
327_G330_P0.6740.97
55_A73_A0.6740.97
208_Y212_E0.6730.97
4_R88_A0.6730.97
158_F278_C0.6730.97
245_V248_A0.6700.97
189_R192_I0.6660.97
208_Y213_Q0.6660.97
9_R116_F0.6650.97
115_R315_G0.6650.97
139_L143_A0.6610.97
209_D212_E0.6600.97
303_G307_T0.6590.97
23_I316_H0.6570.97
272_T278_C0.6560.97
205_G214_F0.6550.97
269_D277_E0.6550.97
264_T270_Y0.6540.97
374_G378_N0.6540.97
90_Q97_I0.6520.97
340_V389_V0.6510.97
146_L319_L0.6510.97
267_G275_V0.6490.97
159_R162_H0.6480.97
137_E358_R0.6470.97
136_A252_L0.6450.97
205_G208_Y0.6450.97
180_E194_R0.6430.97
347_D393_E0.6410.96
264_T277_E0.6410.96
261_S270_Y0.6400.96
183_I194_R0.6400.96
57_I60_E0.6390.96
262_L268_L0.6390.96
130_S308_P0.6370.96
373_F390_I0.6340.96
23_I102_S0.6340.96
203_A208_Y0.6330.96
299_I307_T0.6330.96
33_Y358_R0.6320.96
32_S358_R0.6310.96
152_T326_A0.6290.96
187_D211_A0.6290.96
356_A417_A0.6280.96
290_F314_P0.6270.96
340_V364_V0.6270.96
242_L246_L0.6260.96
246_L249_A0.6240.96
244_N250_E0.6200.96
84_R88_A0.6190.96
223_L228_S0.6190.96
270_Y273_G0.6160.96
280_D283_G0.6140.96
182_A185_T0.6130.95
146_L156_F0.6130.95
203_A215_D0.6130.95
339_Y342_Q0.6120.95
151_L322_L0.6100.95
38_V99_W0.6090.95
196_A199_D0.6080.95
265_A274_V0.6070.95
21_A24_D0.6060.95
146_L290_F0.6060.95
338_Y419_F0.6060.95
31_A363_R0.6050.95
156_F161_S0.6040.95
87_V302_F0.6040.95
270_Y278_C0.6030.95
378_N382_N0.6030.95
104_P120_Y0.6010.95
328_V331_D0.6000.95
19_R39_G0.5990.95
119_F318_T0.5980.95
181_A194_R0.5970.95
408_S412_T0.5960.95
261_S273_G0.5950.95
340_V366_T0.5940.95
157_E161_S0.5940.95
131_D293_G0.5940.95
183_I186_V0.5930.95
33_Y138_V0.5930.95
161_S165_I0.5920.95
107_R119_F0.5910.95
270_Y276_F0.5910.95
397_A400_N0.5890.94
341_L376_Q0.5890.94
86_V127_F0.5870.94
199_D202_A0.5860.94
135_D138_V0.5860.94
269_D275_V0.5850.94
350_A366_T0.5840.94
203_A210_Q0.5840.94
164_D241_N0.5830.94
302_F305_Q0.5820.94
86_V95_K0.5800.94
39_G103_R0.5800.94
35_F137_E0.5800.94
378_N381_D0.5800.94
162_H166_L0.5790.94
109_E318_T0.5790.94
237_D241_N0.5780.94
237_D244_N0.5760.94
248_A256_Q0.5760.94
260_V271_Y0.5750.94
109_E315_G0.5740.94
173_F177_V0.5740.94
139_L288_A0.5720.94
210_Q214_F0.5710.93
260_V268_L0.5700.93
239_V246_L0.5700.93
17_G363_R0.5680.93
190_E195_A0.5680.93
161_S164_D0.5680.93
281_S286_G0.5670.93
60_E63_S0.5630.93
337_D386_D0.5620.93
21_A331_D0.5600.93
266_R275_V0.5590.93
260_V267_G0.5590.93
268_L272_T0.5590.93
168_G171_A0.5580.93
280_D284_D0.5580.93
124_L312_V0.5570.93
194_R203_A0.5570.93
183_I195_A0.5560.93
191_K195_A0.5560.93
336_P363_R0.5560.93
77_E80_P0.5560.93
29_A33_Y0.5550.92
262_L271_Y0.5540.92
352_D355_S0.5520.92
207_S215_D0.5500.92
179_T182_A0.5480.92
29_A32_S0.5480.92
136_A139_L0.5470.92
405_N409_G0.5460.92
208_Y215_D0.5430.92
163_R166_L0.5420.92
323_L327_G0.5410.92
261_S275_V0.5400.91
266_R273_G0.5400.91
232_T240_A0.5380.91
262_L270_Y0.5370.91
245_V249_A0.5370.91
193_E197_Y0.5370.91
263_T277_E0.5360.91
57_I61_L0.5360.91
28_D361_G0.5340.91
84_R87_V0.5340.91
337_D385_A0.5320.91
282_T286_G0.5320.91
159_R163_R0.5320.91
25_A145_G0.5310.91
278_C290_F0.5310.91
109_E115_R0.5300.91
241_N273_G0.5300.91
10_D41_P0.5300.91
250_E253_G0.5280.91
268_L278_C0.5260.90
83_A301_R0.5260.90
156_F162_H0.5250.90
140_A143_A0.5220.90
189_R193_E0.5210.90
177_V195_A0.5210.90
190_E194_R0.5210.90
156_F168_G0.5210.90
353_V391_V0.5200.90
147_T152_T0.5190.90
249_A253_G0.5180.90
377_M406_M0.5150.89
149_L319_L0.5150.89
338_Y387_T0.5120.89
269_D272_T0.5120.89
216_D222_D0.5120.89
268_L273_G0.5100.89
162_H241_N0.5080.89
198_L212_E0.5080.89
161_S168_G0.5080.89
126_I138_V0.5070.89
377_M388_V0.5060.89
204_A208_Y0.5060.89
117_R315_G0.5050.89
142_A312_V0.5040.88
130_S296_D0.5040.88
16_M37_E0.5030.88
86_V307_T0.5030.88
146_L314_P0.5030.88
203_A209_D0.5020.88
222_D226_L0.5020.88
263_T273_G0.5010.88
82_V101_S0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lc0A 2 0.9468 100 0.193 Contact Map
3netA 2 0.9514 100 0.199 Contact Map
1wu7A 2 0.9583 100 0.202 Contact Map
4phcA 2 0.9769 100 0.203 Contact Map
4g84A 2 0.9653 100 0.213 Contact Map
1httA 2 0.831 100 0.243 Contact Map
1h4vB 2 0.9167 100 0.253 Contact Map
3od1A 2 0.8634 100 0.26 Contact Map
1qe0A 2 0.8773 100 0.261 Contact Map
4e51A 2 0.9213 100 0.277 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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