GREMLIN Database
Q9HNP4 - Uncharacterized protein
UniProt: Q9HNP4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (192)
Sequences: 113 (78)
Seq/√Len: 5.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_V83_V4.1420.94
91_V98_V4.1390.94
24_Y67_V3.1070.78
88_L119_L2.9610.74
14_T49_T2.7140.67
154_S166_L2.5410.62
47_A64_D2.4060.57
73_D78_N2.3890.57
80_I188_Q2.1930.50
56_L91_V2.1600.49
2_E27_T2.1310.48
66_A121_D2.1180.47
117_Q128_V2.1090.47
5_L18_L1.9970.43
78_N107_R1.9920.43
89_E122_R1.9330.41
104_R120_E1.9080.40
113_R117_Q1.8470.38
71_V79_G1.8400.38
80_I162_Y1.8190.38
162_Y188_Q1.8190.38
80_I165_E1.7870.36
165_E188_Q1.7870.36
89_E105_D1.7020.34
174_R177_T1.6810.33
176_D180_S1.6770.33
70_M79_G1.6710.33
154_S159_R1.6680.33
112_S126_D1.6480.32
120_E135_G1.6450.32
122_R191_V1.6300.32
49_T95_F1.6000.31
148_D189_T1.5770.30
164_A189_T1.5710.30
65_D82_H1.5270.29
124_G189_T1.5240.29
128_V169_L1.5120.28
24_Y134_F1.5090.28
104_R135_G1.4710.27
3_L139_I1.4580.27
115_H190_Y1.4470.26
49_T148_D1.4460.26
47_A60_R1.4240.26
32_H160_A1.4130.26
14_T147_L1.4070.25
62_V111_V1.3720.25
34_G37_D1.3700.24
147_L166_L1.3680.24
162_Y165_E1.3670.24
99_A128_V1.3650.24
35_I50_D1.3640.24
102_T129_S1.3510.24
110_T116_A1.3420.24
35_I169_L1.3250.23
23_F138_A1.3250.23
5_L27_T1.3010.23
42_A105_D1.2910.23
146_E151_T1.2730.22
136_R160_A1.2620.22
24_Y108_V1.2440.21
26_I146_E1.2380.21
3_L141_R1.2380.21
85_E115_H1.2380.21
54_E81_Q1.2300.21
68_A72_E1.2280.21
136_R152_G1.2150.21
67_V71_V1.2140.21
56_L160_A1.2070.21
51_F128_V1.1740.20
29_V91_V1.1720.20
4_G128_V1.1700.20
96_D128_V1.1640.20
7_Y14_T1.1630.20
172_A181_D1.1580.19
47_A65_D1.1580.19
111_V162_Y1.1580.19
72_E189_T1.1580.19
25_D148_D1.1510.19
159_R189_T1.1400.19
67_V194_L1.1360.19
144_A151_T1.1340.19
151_T194_L1.1270.19
115_H166_L1.1180.19
3_L97_A1.1150.19
126_D182_V1.1070.18
79_G99_A1.1050.18
168_A171_A1.0960.18
121_D166_L1.0900.18
27_T52_D1.0700.18
37_D154_S1.0650.18
27_T116_A1.0600.17
7_Y146_E1.0530.17
16_A129_S1.0510.17
69_L194_L1.0440.17
19_V23_F1.0420.17
48_E68_A1.0380.17
105_D122_R1.0310.17
38_E160_A1.0120.17
24_Y81_Q1.0110.17
128_V147_L1.0050.16
5_L70_M1.0020.16
53_F138_A1.0010.16
108_V132_S0.9950.16
95_F117_Q0.9920.16
91_V148_D0.9920.16
49_T145_A0.9880.16
70_M99_A0.9860.16
51_F75_Y0.9820.16
18_L152_G0.9810.16
96_D181_D0.9800.16
93_E128_V0.9800.16
58_L150_E0.9760.16
81_Q155_E0.9690.16
34_G139_I0.9680.16
22_R49_T0.9630.16
25_D112_S0.9520.15
61_G128_V0.9490.15
48_E56_L0.9430.15
3_L190_Y0.9330.15
2_E25_D0.9330.15
17_A92_A0.9290.15
81_Q140_D0.9210.15
68_A173_D0.9170.15
30_T49_T0.9130.15
128_V187_D0.9090.15
45_A158_P0.9070.15
41_H155_E0.9030.15
91_V125_V0.9010.15
64_D171_A0.8790.14
14_T71_V0.8780.14
19_V194_L0.8770.14
88_L143_V0.8750.14
153_P174_R0.8690.14
118_S122_R0.8690.14
171_A190_Y0.8670.14
24_Y149_V0.8610.14
17_A133_G0.8600.14
25_D189_T0.8570.14
132_S174_R0.8560.14
36_T45_A0.8540.14
70_M87_A0.8500.14
64_D144_A0.8490.14
149_V159_R0.8470.14
67_V107_R0.8450.14
56_L87_A0.8440.14
70_M182_V0.8440.14
64_D148_D0.8400.14
32_H139_I0.8380.14
22_R40_A0.8380.14
139_I160_A0.8330.13
136_R140_D0.8320.13
139_I173_D0.8290.13
69_L79_G0.8290.13
81_Q116_A0.8280.13
6_L52_D0.8260.13
23_F175_D0.8260.13
63_A140_D0.8070.13
132_S153_P0.8070.13
61_G157_I0.8010.13
77_R140_D0.8000.13
18_L27_T0.7990.13
96_D170_L0.7990.13
36_T155_E0.7990.13
89_E191_V0.7810.13
66_A135_G0.7740.13
43_R168_A0.7730.12
98_V157_I0.7690.12
34_G88_L0.7690.12
27_T54_E0.7660.12
48_E194_L0.7550.12
99_A189_T0.7510.12
143_V173_D0.7470.12
45_A70_M0.7430.12
52_D194_L0.7420.12
56_L125_V0.7400.12
147_L194_L0.7350.12
19_V147_L0.7340.12
128_V142_L0.7330.12
152_G157_I0.7300.12
126_D137_G0.7270.12
139_I156_E0.7220.12
14_T43_R0.7220.12
32_H159_R0.7200.12
36_T83_V0.7170.12
28_L147_L0.7110.12
68_A166_L0.7100.12
80_I149_V0.7090.12
149_V188_Q0.7090.12
47_A57_Q0.7000.11
155_E185_E0.6930.11
153_P176_D0.6930.11
58_L154_S0.6930.11
45_A128_V0.6920.11
18_L147_L0.6910.11
27_T75_Y0.6890.11
93_E117_Q0.6890.11
41_H88_L0.6860.11
61_G82_H0.6850.11
114_A189_T0.6830.11
38_E126_D0.6820.11
43_R176_D0.6780.11
68_A150_E0.6730.11
47_A137_G0.6710.11
6_L61_G0.6710.11
162_Y193_G0.6710.11
134_F143_V0.6680.11
96_D145_A0.6670.11
58_L104_R0.6660.11
40_A124_G0.6650.11
63_A83_V0.6640.11
52_D69_L0.6600.11
85_E182_V0.6590.11
75_Y181_D0.6590.11
34_G79_G0.6590.11
66_A104_R0.6590.11
16_A130_P0.6580.11
119_L143_V0.6580.11
41_H159_R0.6570.11
48_E124_G0.6520.11
42_A89_E0.6510.11
59_D175_D0.6500.11
44_A98_V0.6460.11
42_A191_V0.6420.11
43_R54_E0.6390.11
44_A57_Q0.6380.11
41_H119_L0.6380.11
95_F166_L0.6370.11
14_T27_T0.6360.11
24_Y117_Q0.6310.11
9_G46_A0.6270.10
66_A166_L0.6240.10
64_D191_V0.6230.10
124_G152_G0.6200.10
30_T53_F0.6120.10
47_A54_E0.6090.10
85_E110_T0.6090.10
58_L159_R0.6050.10
39_H119_L0.6030.10
57_Q61_G0.6030.10
62_V98_V0.6000.10
36_T171_A0.5950.10
27_T63_A0.5920.10
44_A75_Y0.5910.10
25_D123_H0.5810.10
143_V155_E0.5770.10
3_L112_S0.5750.10
30_T127_Y0.5750.10
77_R116_A0.5740.10
160_A181_D0.5740.10
38_E137_G0.5720.10
29_V105_D0.5700.10
53_F114_A0.5680.10
5_L99_A0.5670.10
66_A150_E0.5660.10
45_A112_S0.5640.10
79_G110_T0.5630.10
51_F124_G0.5630.10
98_V132_S0.5630.10
3_L111_V0.5600.10
7_Y67_V0.5570.10
128_V174_R0.5550.10
35_I176_D0.5520.10
75_Y83_V0.5490.10
144_A185_E0.5470.09
50_D141_R0.5460.09
44_A173_D0.5450.09
9_G137_G0.5450.09
67_V193_G0.5440.09
7_Y78_N0.5420.09
39_H114_A0.5380.09
129_S134_F0.5370.09
51_F57_Q0.5360.09
38_E93_E0.5340.09
108_V177_T0.5280.09
5_L164_A0.5260.09
21_D72_E0.5260.09
52_D57_Q0.5240.09
16_A143_V0.5220.09
24_Y193_G0.5200.09
40_A45_A0.5200.09
150_E155_E0.5170.09
153_P185_E0.5110.09
51_F69_L0.5100.09
25_D88_L0.5090.09
79_G132_S0.5080.09
23_F136_R0.5070.09
55_A124_G0.5040.09
85_E116_A0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k32A 2 0.9898 100 0.712 Contact Map
2derA 1 0.9388 99.8 0.793 Contact Map
2hmaA 2 1 99.7 0.812 Contact Map
2dplA 2 0.898 99.5 0.837 Contact Map
1ni5A 2 0.9235 99.5 0.837 Contact Map
3bl5A 3 0.801 99.5 0.841 Contact Map
2ywbA 4 0.9286 99.5 0.841 Contact Map
2vxoA 2 0.9643 99.5 0.841 Contact Map
4xfjA 4 0.9541 99.5 0.842 Contact Map
3vrhA 2 0.9388 99.5 0.842 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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