GREMLIN Database
THIL - Thiamine-monophosphate kinase
UniProt: Q9HNP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (255)
Sequences: 14656 (9151)
Seq/√Len: 573.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_S263_V3.6891.00
209_A266_R3.0541.00
209_A268_T2.9801.00
135_P269_A2.5781.00
137_D184_T2.5421.00
182_H249_R2.4851.00
211_D214_R2.4711.00
138_S266_R2.4641.00
47_Y87_A2.4391.00
140_V263_V2.3871.00
201_A208_M2.3781.00
138_S250_V2.3341.00
245_V253_A2.3181.00
47_Y94_D2.3101.00
139_V244_A2.2971.00
184_T246_P2.2941.00
249_R252_A2.2821.00
87_A90_T2.2801.00
206_C267_V2.2571.00
93_R97_T2.2031.00
28_A66_A2.1771.00
197_L208_M2.0911.00
207_G268_T2.0841.00
138_S247_P2.0761.00
246_P249_R2.0241.00
250_V254_R1.9791.00
140_V245_V1.9751.00
47_Y90_T1.9681.00
140_V261_L1.9581.00
140_V254_R1.9081.00
250_V263_V1.8801.00
139_V208_M1.8421.00
51_W95_V1.8401.00
207_G270_A1.8151.00
69_T123_D1.8091.00
197_L210_V1.8041.00
61_V66_A1.7991.00
184_T244_A1.7921.00
46_R114_F1.7501.00
135_P206_C1.7361.00
247_P266_R1.6991.00
30_T120_A1.6851.00
200_L244_A1.6711.00
29_L72_V1.6511.00
254_R261_L1.6211.00
140_V250_V1.5491.00
90_T94_D1.5461.00
263_V266_R1.5331.00
186_M243_A1.5311.00
94_D97_T1.5211.00
23_V28_A1.5131.00
208_M267_V1.5071.00
73_A92_A1.4981.00
133_A267_V1.4711.00
197_L242_V1.4711.00
48_T168_Q1.4571.00
94_D98_A1.4561.00
133_A185_A1.4491.00
185_A200_L1.4331.00
172_R240_E1.4291.00
95_V98_A1.4261.00
134_R246_P1.4171.00
133_A244_A1.4171.00
31_I74_A1.4071.00
48_T51_W1.4071.00
137_D267_V1.4041.00
134_R184_T1.4031.00
137_D246_P1.3941.00
14_V26_D1.3921.00
75_Y85_L1.3891.00
21_A64_T1.3791.00
72_V105_G1.3741.00
48_T91_G1.3681.00
63_A186_M1.3661.00
207_G271_A1.3541.00
46_R84_E1.3421.00
70_A104_V1.3391.00
25_G123_D1.3341.00
147_R155_F1.3311.00
67_T177_R1.3291.00
244_A267_V1.3191.00
239_F264_V1.3171.00
189_A242_V1.3141.00
128_V186_M1.3121.00
165_D168_Q1.3111.00
186_M241_L1.3101.00
165_D169_F1.2691.00
54_V71_A1.2681.00
175_A178_V1.2671.00
147_R218_A1.2651.00
54_V92_A1.2591.00
251_E254_R1.2541.00
22_A104_V1.2501.00
189_A196_S1.2171.00
31_I119_A1.2121.00
57_S118_T1.2101.00
254_R263_V1.2061.00
53_S116_V1.1991.00
61_V120_A1.1871.00
29_L119_A1.1711.00
138_S245_V1.1631.00
211_D266_R1.1531.00
51_W98_A1.1521.00
139_V242_V1.1461.00
12_G24_V1.1451.00
21_A28_A1.1371.00
29_L121_I1.1351.00
137_D244_A1.1231.00
185_A244_A1.1221.00
26_D127_R1.1201.00
144_S147_R1.1141.00
42_S113_E1.1131.00
55_G95_V1.1011.00
96_C103_Y1.0921.00
187_M199_Q1.0741.00
77_A85_L1.0721.00
58_L101_A1.0671.00
126_H180_G1.0631.00
57_S120_A1.0591.00
33_M117_A1.0581.00
142_T175_A1.0511.00
81_D84_E1.0391.00
67_T123_D1.0351.00
140_V253_A1.0331.00
33_M74_A1.0331.00
129_T133_A1.0241.00
251_E255_A1.0201.00
124_A127_R1.0151.00
111_H115_T1.0131.00
45_T48_T1.0121.00
207_G273_G0.9981.00
181_A253_A0.9961.00
76_G111_H0.9961.00
30_T61_V0.9931.00
71_A120_A0.9921.00
129_T132_G0.9851.00
50_G91_G0.9811.00
23_V127_R0.9741.00
19_D64_T0.9721.00
149_A235_F0.9651.00
62_A173_V0.9611.00
252_A256_A0.9571.00
230_E235_F0.9511.00
166_L169_F0.9501.00
133_A200_L0.9481.00
175_A179_L0.9471.00
54_V96_C0.9451.00
70_A102_E0.9411.00
142_T243_A0.9401.00
209_A212_S0.9371.00
144_S260_S0.9361.00
193_L242_V0.9311.00
51_W94_D0.9301.00
136_G266_R0.9221.00
43_G163_A0.9221.00
217_V222_A0.9181.00
170_M174_A0.9181.00
15_S129_T0.9081.00
187_M242_V0.9041.00
96_C101_A0.8991.00
83_D87_A0.8971.00
71_A118_T0.8921.00
132_G184_T0.8861.00
126_H181_A0.8811.00
26_D124_A0.8801.00
135_P268_T0.8791.00
181_A249_R0.8781.00
153_A156_D0.8771.00
50_G88_F0.8771.00
54_V58_L0.8751.00
133_A204_S0.8731.00
13_L102_E0.8641.00
197_L201_A0.8641.00
84_E88_F0.8631.00
77_A88_F0.8631.00
51_W55_G0.8571.00
67_T174_A0.8551.00
160_T168_Q0.8551.00
71_A96_C0.8501.00
216_P262_S0.8481.00
71_A92_A0.8351.00
173_V177_R0.8341.00
160_T164_N0.8311.00
135_P138_S0.8281.00
58_L95_V0.8281.00
142_T241_L0.8271.00
92_A116_V0.8261.00
62_A177_R0.8251.00
160_T165_D0.8231.00
228_P231_R0.8221.00
134_R137_D0.8201.00
245_V250_V0.8201.00
169_F173_V0.8161.00
171_P174_A0.8151.00
152_M155_F0.8141.00
28_A61_V0.8121.00
171_P259_G0.8071.00
182_H252_A0.8061.00
149_A152_M0.8031.00
201_A267_V0.8011.00
164_N167_F0.8001.00
88_F116_V0.7971.00
67_T180_G0.7921.00
207_G272_D0.7921.00
163_A167_F0.7881.00
63_A241_L0.7871.00
178_V256_A0.7861.00
228_P232_A0.7861.00
74_A117_A0.7841.00
243_A253_A0.7811.00
179_L253_A0.7741.00
33_M76_G0.7731.00
45_T164_N0.7681.00
162_R166_L0.7671.00
24_V70_A0.7671.00
20_D187_M0.7661.00
98_A170_M0.7621.00
195_R199_Q0.7601.00
76_G109_D0.7591.00
70_A121_I0.7531.00
161_E164_N0.7531.00
13_L16_R0.7531.00
99_V172_R0.7511.00
270_A273_G0.7501.00
128_V183_A0.7471.00
189_A193_L0.7461.00
196_S242_V0.7461.00
37_A113_E0.7431.00
170_M173_V0.7421.00
34_L56_A0.7411.00
82_D86_A0.7341.00
205_D270_A0.7311.00
86_A90_T0.7311.00
67_T100_G0.7281.00
23_V64_T0.7281.00
147_R152_M0.7241.00
176_G179_L0.7211.00
168_Q171_P0.7131.00
139_V267_V0.7121.00
50_G92_A0.7121.00
132_G139_V0.7121.00
227_D230_E0.7091.00
80_F84_E0.7081.00
110_G113_E0.7061.00
47_Y91_G0.7051.00
250_V253_A0.7011.00
229_V232_A0.7001.00
140_V243_A0.7001.00
167_F171_P0.6991.00
139_V143_G0.6991.00
193_L197_L0.6971.00
145_L168_Q0.6971.00
58_L99_V0.6951.00
42_S84_E0.6941.00
177_R180_G0.6941.00
201_A204_S0.6911.00
54_V95_V0.6911.00
51_W168_Q0.6911.00
45_T87_A0.6901.00
80_F85_L0.6871.00
148_S166_L0.6841.00
162_R165_D0.6821.00
84_E87_A0.6821.00
232_A235_F0.6801.00
76_G115_T0.6781.00
172_R241_L0.6771.00
19_D130_R0.6731.00
72_V104_V0.6721.00
141_V239_F0.6721.00
13_L104_V0.6711.00
189_A240_E0.6701.00
34_L53_S0.6681.00
164_N168_Q0.6661.00
75_Y116_V0.6661.00
23_V26_D0.6641.00
152_M156_D0.6631.00
176_G241_L0.6631.00
88_F92_A0.6621.00
150_A221_L0.6611.00
174_A178_V0.6561.00
73_A89_V0.6501.00
235_F238_D0.6491.00
149_A153_A0.6481.00
26_D125_D0.6441.00
187_M200_L0.6441.00
33_M115_T0.6411.00
55_G239_F0.6311.00
181_A256_A0.6301.00
269_A272_D0.6301.00
247_P250_V0.6271.00
60_D188_D0.6251.00
72_V119_A0.6241.00
29_L70_A0.6231.00
252_A255_A0.6221.00
173_V176_G0.6211.00
214_R262_S0.6191.00
31_I72_V0.6141.00
90_T93_R0.6131.00
143_G262_S0.6091.00
232_A236_G0.6091.00
188_D199_Q0.6071.00
71_A103_Y0.6071.00
160_T163_A0.6071.00
143_G260_S0.6061.00
145_L148_S0.6051.00
181_A252_A0.6051.00
58_L120_A0.6041.00
138_S248_E0.6001.00
195_R234_S0.5991.00
216_P222_A0.5971.00
36_D42_S0.5961.00
136_G247_P0.5931.00
53_S118_T0.5911.00
130_R203_A0.5901.00
31_I117_A0.5891.00
15_S23_V0.5861.00
198_H202_A0.5861.00
91_G95_V0.5851.00
257_V261_L0.5831.00
119_A122_G0.5831.00
12_G67_T0.5801.00
83_D86_A0.5801.00
162_R169_F0.5781.00
77_A84_E0.5771.00
128_V132_G0.5771.00
193_L264_V0.5751.00
68_A101_A0.5690.99
164_N169_F0.5690.99
141_V145_L0.5670.99
149_A231_R0.5670.99
141_V189_A0.5660.99
133_A206_C0.5630.99
268_T271_A0.5600.99
141_V216_P0.5600.99
251_E263_V0.5590.99
71_A101_A0.5580.99
169_F172_R0.5560.99
182_H246_P0.5550.99
148_S236_G0.5530.99
260_S263_V0.5510.99
163_A166_L0.5500.99
139_V210_V0.5490.99
201_A207_G0.5450.99
51_W166_L0.5450.99
195_R198_H0.5430.99
72_V117_A0.5420.99
28_A124_A0.5410.99
196_S199_Q0.5400.99
24_V104_V0.5390.99
127_R130_R0.5370.99
184_T249_R0.5370.99
21_A63_A0.5350.99
212_S230_E0.5340.99
38_T88_F0.5340.99
49_A88_F0.5330.99
206_C209_A0.5320.99
139_V200_L0.5290.99
176_G243_A0.5280.99
44_T49_A0.5250.99
24_V29_L0.5240.99
30_T57_S0.5230.99
32_D60_D0.5220.99
206_C269_A0.5210.99
131_S203_A0.5190.99
59_S239_F0.5190.99
133_A184_T0.5180.99
231_R235_F0.5170.99
229_V233_V0.5160.99
92_A95_V0.5160.99
79_G110_G0.5160.99
92_A118_T0.5160.99
233_V236_G0.5140.99
46_R87_A0.5120.99
72_V121_I0.5110.99
219_D222_A0.5100.99
151_A154_L0.5080.99
60_D190_S0.5080.99
92_A103_Y0.5080.99
73_A103_Y0.5050.99
227_D231_R0.5040.99
139_V197_L0.5010.99
214_R263_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcqA 2 0.9722 100 0.217 Contact Map
3c9uA 2 0.9688 100 0.223 Contact Map
2yxzA 2 0.9618 100 0.234 Contact Map
3m84A 2 0.9479 100 0.307 Contact Map
2z01A 2 0.9201 100 0.307 Contact Map
3vtiC 2 0.9722 100 0.312 Contact Map
2btuA 2 0.9479 100 0.319 Contact Map
2zodA 2 0.9306 100 0.328 Contact Map
2z1uA 2 0.9861 100 0.332 Contact Map
3p4eA 2 0.9306 100 0.337 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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