GREMLIN Database
Q9HNP0 - Uncharacterized protein
UniProt: Q9HNP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 370 (335)
Sequences: 505 (363)
Seq/√Len: 19.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_D347_R6.1361.00
133_H187_P4.9111.00
146_V182_I4.8511.00
133_H137_H4.7391.00
180_F347_R4.3121.00
137_H187_P4.2991.00
133_H186_G3.7131.00
137_H186_G3.6941.00
283_L351_G3.4791.00
337_P340_D3.4421.00
250_V254_V3.1500.99
232_G236_V2.9380.99
174_P178_A2.9200.99
125_A253_V2.8350.99
135_L139_V2.8140.99
93_L97_A2.7290.98
131_G153_F2.6670.98
199_V233_I2.6650.98
167_I278_H2.5770.98
192_V359_A2.5130.97
175_S178_A2.4890.97
349_A353_V2.4450.97
132_T189_A2.2160.94
228_L328_V2.2100.94
165_A273_Q2.2040.94
237_L359_A2.1510.93
141_S148_A2.1430.93
39_A44_I2.0830.92
173_M185_A2.0060.91
41_R62_T1.9740.90
185_A250_V1.9720.90
258_W319_W1.8990.88
128_G193_A1.8910.88
283_L348_V1.8350.86
184_A354_T1.8020.85
147_D353_V1.8010.85
39_A43_T1.7860.85
165_A267_N1.7650.84
138_Y142_K1.7620.84
202_L205_P1.7590.84
252_P257_G1.7390.83
121_P322_W1.7200.82
227_P239_E1.7030.82
103_G154_I1.6970.82
133_H167_I1.6860.81
35_G121_P1.6840.81
136_G189_A1.6720.81
280_L284_V1.6700.80
133_H136_G1.6470.80
91_L264_T1.6420.79
264_T267_N1.6350.79
94_A98_S1.6300.79
103_G122_F1.6290.79
32_L36_Q1.6240.79
198_S261_M1.6040.78
280_L355_F1.5600.76
153_F165_A1.5400.75
128_G189_A1.5350.74
205_P251_N1.5230.74
99_T123_T1.5190.74
187_P190_G1.5120.73
160_F299_L1.5040.73
144_H178_A1.4870.72
201_G257_G1.4800.72
144_H181_D1.4720.71
184_A350_L1.4570.70
251_N254_V1.4560.70
44_I175_S1.4540.70
304_A366_P1.4480.70
183_G264_T1.4390.69
146_V174_P1.4360.69
287_T352_V1.4270.69
121_P344_D1.4140.68
150_L351_G1.4110.68
258_W322_W1.4080.68
167_I264_T1.3960.67
120_I323_G1.3940.67
271_V296_P1.3740.66
271_V322_W1.3730.66
279_I350_L1.3550.65
203_V236_V1.3330.63
187_P278_H1.3270.63
297_T363_M1.3250.63
99_T102_V1.3220.63
165_A186_G1.3180.62
33_Y72_A1.3170.62
180_F184_A1.3160.62
37_P44_I1.3060.62
295_V354_T1.3050.62
192_V195_V1.2870.61
198_S257_G1.2870.61
134_E187_P1.2830.60
112_F284_V1.2690.59
133_H275_D1.2630.59
182_I185_A1.2620.59
42_A92_F1.2530.58
25_Q366_P1.2500.58
47_E269_L1.2470.58
119_A351_G1.2290.57
294_L342_P1.2220.56
165_A187_P1.2110.56
18_R21_V1.2040.55
104_A153_F1.1960.55
140_M197_V1.1860.54
199_V357_L1.1850.54
31_L49_W1.1760.54
300_L329_V1.1730.53
133_H190_G1.1640.53
154_I332_S1.1620.53
218_S353_V1.1610.53
179_L282_S1.1590.52
288_A292_A1.1570.52
299_L302_L1.1530.52
181_D257_G1.1480.52
167_I187_P1.1480.52
100_L123_T1.1430.51
128_G192_V1.1310.51
266_L342_P1.1300.51
169_M193_A1.1290.50
182_I269_L1.1260.50
135_L359_A1.1140.50
260_G322_W1.1110.49
149_T152_Y1.1110.49
122_F269_L1.1090.49
156_F263_V1.1070.49
183_G267_N1.1070.49
95_T267_N1.1010.49
185_A189_A1.0980.48
14_A17_D1.0970.48
137_H167_I1.0930.48
93_L123_T1.0890.48
269_L290_R1.0820.47
125_A322_W1.0810.47
114_P324_V1.0790.47
151_P275_D1.0760.47
154_I278_H1.0710.47
17_D36_Q1.0670.46
138_Y150_L1.0620.46
134_E272_G1.0600.46
132_T193_A1.0560.46
270_P276_G1.0520.46
161_G272_G1.0480.45
129_V185_A1.0470.45
121_P125_A1.0440.45
31_L55_H1.0400.45
265_F336_T1.0300.44
134_E277_G1.0250.44
108_Y255_M1.0240.44
100_L132_T1.0200.43
68_R73_T1.0200.43
290_R318_I1.0120.43
104_A283_L1.0110.43
87_T359_A1.0110.43
21_V48_L1.0090.43
137_H165_A1.0070.43
127_M360_L1.0030.42
220_V226_Y1.0020.42
185_A254_V0.9860.41
176_R236_V0.9850.41
96_L172_R0.9850.41
245_D341_R0.9800.41
125_A341_R0.9780.41
148_A166_V0.9770.41
48_L163_M0.9770.41
90_A128_G0.9740.41
198_S265_F0.9700.40
86_W89_V0.9690.40
123_T139_V0.9670.40
148_A167_I0.9660.40
134_E267_N0.9630.40
146_V295_V0.9620.40
354_T359_A0.9590.40
279_I351_G0.9560.39
232_G255_M0.9500.39
233_I236_V0.9460.39
265_F364_P0.9440.39
48_L52_F0.9390.38
32_L63_D0.9330.38
246_P359_A0.9310.38
123_T156_F0.9280.38
19_F43_T0.9180.37
50_P53_R0.9170.37
14_A18_R0.9170.37
202_L237_L0.9120.37
232_G329_V0.9100.37
320_L325_L0.9090.37
52_F295_V0.9020.36
130_L273_Q0.8990.36
165_A278_H0.8980.36
95_T274_L0.8940.36
288_A295_V0.8930.36
188_L350_L0.8900.35
272_G285_G0.8900.35
180_F344_D0.8890.35
254_V257_G0.8860.35
151_P165_A0.8850.35
147_D326_A0.8850.35
263_V302_L0.8840.35
102_V160_F0.8830.35
140_M144_H0.8810.35
128_G292_A0.8800.35
135_L222_V0.8800.35
22_Y34_F0.8790.35
191_L358_G0.8780.35
194_A335_V0.8760.35
93_L139_V0.8650.34
202_L251_N0.8620.34
17_D225_G0.8600.34
204_L257_G0.8600.34
118_R295_V0.8590.34
160_F325_L0.8580.34
176_R274_L0.8580.34
90_A353_V0.8560.34
200_I204_L0.8480.33
41_R44_I0.8440.33
280_L292_A0.8430.33
204_L237_L0.8410.33
69_V76_D0.8410.33
25_Q123_T0.8400.33
154_I187_P0.8400.33
112_F216_S0.8390.33
295_V360_L0.8390.33
192_V302_L0.8390.33
269_L332_S0.8360.32
227_P238_G0.8320.32
97_A360_L0.8310.32
154_I167_I0.8310.32
201_G205_P0.8300.32
280_L295_V0.8290.32
103_G366_P0.8280.32
150_L183_G0.8270.32
205_P238_G0.8250.32
140_M365_V0.8230.32
184_A188_L0.8220.32
129_V172_R0.8210.32
85_P117_V0.8190.31
14_A20_D0.8190.31
180_F351_G0.8190.31
122_F183_G0.8170.31
155_P276_G0.8170.31
155_P270_P0.8170.31
19_F24_V0.8170.31
16_G61_L0.8110.31
91_L126_V0.8090.31
141_S251_N0.8090.31
147_D328_V0.8090.31
344_D347_R0.8070.31
227_P231_R0.8030.31
132_T353_V0.8000.30
238_G305_Y0.7940.30
14_A21_V0.7940.30
115_A118_R0.7850.30
87_T97_A0.7840.30
117_V184_A0.7830.29
168_R340_D0.7810.29
88_N150_L0.7810.29
195_V301_S0.7800.29
84_V163_M0.7800.29
139_V199_V0.7760.29
148_A278_H0.7710.29
52_F291_F0.7700.29
148_A173_M0.7700.29
48_L353_V0.7680.29
327_S331_L0.7670.29
55_H342_P0.7670.29
237_L325_L0.7660.29
205_P248_T0.7600.28
283_L342_P0.7600.28
99_T162_T0.7590.28
47_E55_H0.7580.28
94_A259_I0.7580.28
267_N278_H0.7570.28
136_G275_D0.7560.28
127_M138_Y0.7560.28
336_T340_D0.7560.28
139_V346_R0.7560.28
205_P239_E0.7550.28
194_A279_I0.7550.28
116_V192_V0.7550.28
349_A356_V0.7540.28
127_M368_Q0.7530.28
107_Y305_Y0.7530.28
319_W365_V0.7510.28
158_S261_M0.7480.28
200_I295_V0.7470.28
155_P164_G0.7450.27
105_N258_W0.7440.27
93_L287_T0.7430.27
281_R337_P0.7400.27
141_S169_M0.7370.27
130_L278_H0.7330.27
60_R233_I0.7310.27
41_R329_V0.7300.27
25_Q42_A0.7290.27
128_G305_Y0.7290.27
126_V200_I0.7270.27
167_I186_G0.7260.26
119_A281_R0.7220.26
113_S325_L0.7170.26
130_L174_P0.7160.26
177_N344_D0.7160.26
93_L129_V0.7150.26
181_D344_D0.7120.26
100_L206_P0.7090.26
156_F163_M0.7090.26
290_R355_F0.7090.26
171_G302_L0.7080.26
215_N236_V0.7080.26
204_L252_P0.7070.26
129_V206_P0.7040.25
318_I366_P0.7020.25
292_A303_G0.7020.25
48_L263_V0.7010.25
128_G248_T0.6970.25
135_L305_Y0.6960.25
111_P359_A0.6920.25
228_L234_A0.6900.25
167_I267_N0.6900.25
244_A301_S0.6880.25
196_V256_G0.6870.25
204_L251_N0.6840.24
183_G192_V0.6840.24
154_I273_Q0.6820.24
201_G251_N0.6810.24
227_P363_M0.6800.24
172_R250_V0.6780.24
96_L124_L0.6760.24
126_V259_I0.6750.24
155_P275_D0.6750.24
144_H190_G0.6740.24
128_G240_Q0.6740.24
163_M237_L0.6730.24
116_V228_L0.6730.24
70_L73_T0.6700.24
50_P240_Q0.6700.24
321_L325_L0.6700.24
123_T230_L0.6690.24
22_Y67_E0.6660.24
196_V358_G0.6660.24
96_L232_G0.6650.24
98_S102_V0.6650.24
129_V260_G0.6650.24
184_A235_A0.6630.23
223_D286_E0.6620.23
47_E51_L0.6610.23
263_V271_V0.6590.23
191_L319_W0.6580.23
14_A36_Q0.6560.23
83_G325_L0.6560.23
19_F49_W0.6550.23
199_V237_L0.6520.23
263_V306_L0.6520.23
189_A253_V0.6520.23
140_M178_A0.6510.23
128_G246_P0.6510.23
204_L253_V0.6480.23
83_G86_W0.6470.23
206_P249_A0.6450.23
236_V324_V0.6450.23
116_V170_R0.6440.23
136_G186_G0.6430.23
255_M317_G0.6420.22
145_D216_S0.6410.22
186_G275_D0.6400.22
43_T295_V0.6390.22
191_L346_R0.6380.22
257_G347_R0.6370.22
108_Y148_A0.6360.22
219_A280_L0.6350.22
103_G190_G0.6340.22
51_L65_T0.6330.22
196_V205_P0.6320.22
28_D71_V0.6310.22
262_F362_F0.6300.22
179_L268_L0.6280.22
194_A334_T0.6270.22
94_A258_W0.6270.22
126_V135_L0.6270.22
37_P88_N0.6260.22
105_N113_S0.6220.22
301_S328_V0.6190.21
92_F199_V0.6170.21
137_H275_D0.6160.21
146_V240_Q0.6140.21
137_H266_L0.6140.21
196_V318_I0.6130.21
351_G358_G0.6090.21
182_I186_G0.6090.21
82_T132_T0.6080.21
89_V353_V0.6080.21
96_L189_A0.6060.21
92_F96_L0.6050.21
319_W363_M0.6030.21
137_H162_T0.6020.21
52_F126_V0.6020.21
191_L305_Y0.6020.21
90_A94_A0.6010.21
268_L273_Q0.6000.21
68_R342_P0.5990.21
119_A127_M0.5980.21
246_P354_T0.5980.21
85_P152_Y0.5980.21
35_G44_I0.5970.21
50_P136_G0.5960.20
168_R204_L0.5940.20
328_V351_G0.5930.20
81_D353_V0.5920.20
230_L362_F0.5900.20
32_L58_D0.5900.20
233_I356_V0.5880.20
35_G285_G0.5870.20
92_F153_F0.5870.20
25_Q30_E0.5850.20
38_G54_E0.5850.20
22_Y298_A0.5850.20
172_R338_V0.5840.20
52_F72_A0.5840.20
62_T65_T0.5830.20
163_M291_F0.5800.20
34_F67_E0.5800.20
36_Q63_D0.5780.20
291_F295_V0.5780.20
132_T292_A0.5740.20
24_V324_V0.5720.19
122_F256_G0.5700.19
40_D154_I0.5690.19
48_L59_V0.5680.19
134_E137_H0.5680.19
284_V345_R0.5670.19
74_P250_V0.5660.19
151_P267_N0.5660.19
189_A306_L0.5660.19
283_L329_V0.5650.19
165_A263_V0.5630.19
162_T324_V0.5630.19
137_H190_G0.5610.19
299_L305_Y0.5600.19
202_L239_E0.5600.19
87_T147_D0.5600.19
121_P239_E0.5600.19
233_I291_F0.5580.19
250_V306_L0.5580.19
96_L140_M0.5570.19
43_T50_P0.5570.19
47_E61_L0.5560.19
235_A239_E0.5560.19
91_L269_L0.5540.19
90_A359_A0.5530.19
81_D359_A0.5500.19
17_D367_I0.5490.19
284_V292_A0.5490.19
138_Y148_A0.5470.18
283_L356_V0.5470.18
131_G363_M0.5450.18
318_I337_P0.5450.18
179_L233_I0.5440.18
135_L153_F0.5420.18
215_N235_A0.5390.18
32_L61_L0.5370.18
326_A343_L0.5370.18
47_E54_E0.5360.18
296_P355_F0.5360.18
70_L263_V0.5360.18
46_R58_D0.5360.18
231_R241_F0.5360.18
42_A240_Q0.5360.18
162_T273_Q0.5350.18
134_E165_A0.5340.18
83_G175_S0.5340.18
356_V360_L0.5330.18
113_S193_A0.5320.18
359_A368_Q0.5310.18
19_F240_Q0.5310.18
126_V268_L0.5310.18
328_V357_L0.5290.18
233_I257_G0.5270.18
93_L232_G0.5240.18
51_L189_A0.5230.18
229_L261_M0.5230.18
50_P140_M0.5220.18
136_G266_L0.5190.17
58_D234_A0.5190.17
330_S343_L0.5180.17
133_H278_H0.5180.17
173_M361_C0.5140.17
21_V163_M0.5140.17
187_P266_L0.5120.17
267_N274_L0.5110.17
56_G70_L0.5110.17
88_N319_W0.5110.17
174_P333_G0.5100.17
69_V74_P0.5080.17
167_I343_L0.5070.17
103_G267_N0.5060.17
345_R353_V0.5050.17
240_Q298_A0.5050.17
180_F257_G0.5040.17
25_Q31_L0.5030.17
83_G156_F0.5020.17
144_H180_F0.5020.17
31_L48_L0.5010.17
52_F59_V0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.5676 99.9 0.785 Contact Map
4qq0A 1 0.1838 12.4 0.975 Contact Map
4alzA 1 0.1811 8.7 0.977 Contact Map
1ug8A 1 0.2216 8 0.977 Contact Map
4p7xA 1 0.2189 6.7 0.978 Contact Map
3l7hA 2 0.1973 6.6 0.978 Contact Map
3vr4D 1 0.1568 6.4 0.978 Contact Map
1e5rA 2 0.227 6.2 0.978 Contact Map
2nn4A 1 0.1676 5.9 0.978 Contact Map
3h90A 3 0.1919 5.5 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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