GREMLIN Database
Q9HNN9 - Uncharacterized protein
UniProt: Q9HNN9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 83 (74)
Sequences: 144 (88)
Seq/√Len: 10.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_V73_T2.3670.81
53_A75_A2.2450.77
14_Q22_S2.0820.71
9_S58_L1.7370.57
15_D81_Q1.7100.55
66_T81_Q1.6990.55
60_K66_T1.5880.50
36_K72_Y1.5650.49
64_D80_V1.5520.48
18_T81_Q1.5460.48
38_K79_R1.5450.48
14_Q23_Y1.5210.47
55_M74_S1.4910.45
51_I54_L1.4830.45
8_S11_A1.4230.42
38_K71_S1.4050.41
22_S60_K1.4040.41
46_L60_K1.4040.41
16_K50_E1.3990.41
25_R65_I1.3590.39
50_E74_S1.3530.39
54_L73_T1.3430.39
22_S66_T1.3320.38
55_M67_V1.3130.37
11_A45_D1.3030.37
20_L51_I1.2620.35
25_R64_D1.2610.35
41_A75_A1.2500.35
47_S64_D1.2430.34
31_G38_K1.2380.34
51_I73_T1.2300.34
35_F40_I1.2130.33
37_S43_D1.2100.33
19_R42_D1.2030.33
58_L67_V1.1900.32
69_K74_S1.1750.32
19_R69_K1.1560.31
10_E29_D1.1510.31
8_S22_S1.1090.29
10_E22_S1.0970.28
17_E61_S1.0900.28
36_K50_E1.0590.27
36_K54_L1.0500.27
8_S29_D1.0420.26
17_E57_K1.0310.26
17_E54_L1.0200.26
55_M60_K1.0090.25
62_A67_V0.9780.24
34_Y70_W0.9750.24
44_V51_I0.9750.24
41_A53_A0.9360.23
12_E42_D0.9340.23
39_F71_S0.9290.23
50_E54_L0.9210.22
35_F45_D0.9200.22
51_I75_A0.8980.22
33_L74_S0.8970.22
36_K43_D0.8940.21
44_V61_S0.8870.21
22_S29_D0.8780.21
23_Y80_V0.8740.21
8_S26_E0.8660.21
71_S79_R0.8630.21
44_V54_L0.8350.20
12_E69_K0.8320.20
16_K64_D0.8280.19
10_E18_T0.8270.19
25_R80_V0.8150.19
59_S64_D0.8080.19
17_E50_E0.7940.19
65_I79_R0.7930.18
42_D62_A0.7870.18
42_D67_V0.7810.18
13_S33_L0.7720.18
11_A65_I0.7400.17
28_A64_D0.7310.17
39_F54_L0.7220.17
24_L35_F0.7220.17
29_D80_V0.7090.16
19_R61_S0.7090.16
18_T69_K0.7070.16
43_D72_Y0.6940.16
20_L75_A0.6930.16
10_E15_D0.6830.16
16_K36_K0.6740.15
54_L72_Y0.6740.15
19_R46_L0.6560.15
40_I49_K0.6510.15
50_E72_Y0.6480.15
39_F73_T0.6420.15
45_D75_A0.6420.15
8_S12_E0.6400.15
39_F51_I0.6340.14
23_Y66_T0.6290.14
20_L54_L0.6260.14
16_K72_Y0.6250.14
43_D79_R0.6020.14
15_D18_T0.5910.13
30_D42_D0.5850.13
22_S69_K0.5760.13
37_S65_I0.5710.13
43_D81_Q0.5520.13
13_S51_I0.5520.13
9_S45_D0.5430.12
11_A22_S0.5430.12
13_S38_K0.5290.12
12_E65_I0.5250.12
39_F74_S0.5130.12
15_D66_T0.5100.12
36_K55_M0.5000.12
19_R68_E0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qgpA 1 0.9036 90.9 0.858 Contact Map
3eyiA 1 0.747 89.6 0.862 Contact Map
1qbjA 1 0.7831 87.7 0.866 Contact Map
1xmkA 1 0.8434 77.2 0.882 Contact Map
1oyiA 1 0.747 76.2 0.883 Contact Map
4un1A 1 0.8434 76.1 0.883 Contact Map
3lmmA 1 0.8916 75.5 0.883 Contact Map
4ou0A 1 0.7831 74.2 0.884 Contact Map
4ch7A 1 0.8193 72.6 0.886 Contact Map
2ia0A 2 0.7952 71.9 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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