GREMLIN Database
PYRH - Uridylate kinase
UniProt: Q9HNN8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (202)
Sequences: 10253 (5766)
Seq/√Len: 405.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_A153_D4.5281.00
144_G158_H2.6141.00
29_N33_D2.4261.00
26_D87_D2.3841.00
128_A136_L2.3721.00
90_P107_D2.2591.00
29_N89_A2.2511.00
165_G193_E2.1211.00
48_A51_Y2.1071.00
39_G131_T2.0521.00
147_S157_E2.0221.00
137_L202_L1.9861.00
135_L200_I1.9801.00
45_G48_A1.9791.00
29_N87_D1.9701.00
93_A96_Y1.8611.00
11_V204_G1.8521.00
22_D87_D1.8351.00
30_E211_V1.8261.00
81_I91_S1.8151.00
46_G50_D1.7941.00
143_P206_D1.7891.00
32_T89_A1.7831.00
166_E170_I1.7741.00
143_P203_D1.7641.00
147_S153_D1.7501.00
211_V215_R1.7351.00
9_G48_A1.7311.00
89_A108_I1.7171.00
32_T106_G1.7071.00
46_G49_R1.7041.00
129_E197_V1.6961.00
149_D152_E1.6761.00
148_A155_D1.6331.00
167_L189_A1.5941.00
23_A26_D1.5741.00
141_S151_N1.5721.00
64_E67_D1.5561.00
47_V50_D1.5461.00
200_I213_A1.5321.00
22_D86_G1.5281.00
125_A136_L1.5231.00
32_T37_E1.5201.00
125_A192_I1.5161.00
5_V28_I1.5151.00
140_T201_V1.4851.00
102_A107_D1.4831.00
30_E207_P1.4491.00
192_I199_T1.4431.00
168_V190_K1.4291.00
167_L170_I1.4051.00
147_S159_F1.3971.00
45_G49_R1.3941.00
23_A27_A1.3891.00
98_D102_A1.3891.00
25_A83_A1.3871.00
143_P146_F1.3621.00
30_E33_D1.3531.00
27_A208_R1.3521.00
65_L69_G1.3481.00
209_R212_D1.3461.00
4_V133_A1.3431.00
206_D212_D1.3421.00
100_G104_R1.3351.00
83_A87_D1.3331.00
101_E104_R1.3251.00
92_P107_D1.3241.00
39_G42_V1.2921.00
34_A215_R1.2841.00
101_E105_R1.2841.00
84_L91_S1.2831.00
150_P156_A1.2651.00
73_T92_P1.2581.00
26_D29_N1.2541.00
24_H80_L1.2491.00
203_D206_D1.2451.00
22_D83_A1.2371.00
210_I213_A1.2331.00
20_Q23_A1.2121.00
111_M114_V1.2081.00
32_T108_I1.2061.00
28_I40_A1.2051.00
129_E195_S1.2041.00
159_F170_I1.2001.00
202_L213_A1.1971.00
30_E34_A1.1961.00
72_V76_N1.1931.00
22_D26_D1.1611.00
42_V77_A1.1551.00
102_A109_A1.1301.00
206_D209_R1.1251.00
148_A156_A1.1251.00
70_V112_G1.1231.00
92_P102_A1.1111.00
27_A207_P1.1031.00
202_L209_R1.0961.00
10_S13_A1.0901.00
124_S136_L1.0801.00
146_F156_A1.0771.00
145_V162_M1.0751.00
84_L89_A1.0711.00
147_S156_A1.0661.00
71_D75_L1.0421.00
42_V80_L1.0421.00
143_P158_H1.0421.00
190_K194_R1.0421.00
37_E106_G1.0341.00
99_A103_M1.0321.00
39_G103_M1.0231.00
73_T76_N1.0201.00
158_H203_D1.0171.00
26_D30_E1.0091.00
47_V115_V1.0041.00
3_V36_C1.0001.00
21_V83_A0.9971.00
106_G109_A0.9901.00
137_L200_I0.9861.00
165_G168_V0.9831.00
85_G90_P0.9761.00
132_D195_S0.9761.00
122_A191_L0.9751.00
20_Q205_T0.9641.00
165_G169_D0.9561.00
31_L34_A0.9521.00
145_V201_V0.9451.00
107_D110_V0.9431.00
83_A86_G0.9341.00
9_G177_N0.9321.00
148_A154_A0.9241.00
19_D22_D0.9211.00
139_A202_L0.9211.00
18_A22_D0.9191.00
63_I111_M0.9161.00
166_E169_D0.9161.00
122_A187_L0.9151.00
37_E104_R0.9141.00
25_A84_L0.9141.00
29_N32_T0.9121.00
84_L87_D0.9091.00
74_R77_A0.9021.00
164_A189_A0.9011.00
159_F162_M0.8971.00
29_N84_L0.8971.00
128_A197_V0.8901.00
136_L192_I0.8861.00
30_E208_R0.8851.00
7_I40_A0.8801.00
103_M109_A0.8781.00
21_V80_L0.8721.00
46_G51_Y0.8601.00
32_T38_V0.8561.00
31_L137_L0.8531.00
14_P19_D0.8521.00
137_L210_I0.8471.00
23_A204_G0.8461.00
5_V31_L0.8461.00
37_E42_V0.8441.00
180_S193_E0.8441.00
26_D207_P0.8431.00
145_V159_F0.8431.00
211_V214_V0.8421.00
67_D101_E0.8401.00
54_T57_E0.8291.00
31_L214_V0.8251.00
143_P208_R0.8251.00
44_G72_V0.8231.00
45_G50_D0.8171.00
146_F150_P0.8151.00
14_P20_Q0.8141.00
25_A87_D0.8091.00
135_L198_R0.8071.00
31_L36_C0.8061.00
68_I79_L0.8061.00
23_A207_P0.8041.00
77_A80_L0.8031.00
149_D156_A0.7911.00
146_F158_H0.7871.00
5_V137_L0.7821.00
82_A86_G0.7791.00
71_D74_R0.7791.00
27_A30_E0.7751.00
47_V51_Y0.7711.00
125_A191_L0.7701.00
208_R212_D0.7701.00
187_L190_K0.7651.00
28_I84_L0.7621.00
193_E199_T0.7571.00
138_Y141_S0.7441.00
127_L131_T0.7411.00
152_E182_A0.7341.00
76_N80_L0.7301.00
14_P18_A0.7301.00
141_S205_T0.7281.00
98_D101_E0.7221.00
208_R211_V0.7201.00
28_I108_I0.7141.00
34_A211_V0.7131.00
3_V214_V0.7131.00
3_V135_L0.7111.00
188_A192_I0.7101.00
192_I197_V0.7101.00
31_L38_V0.7061.00
51_Y54_T0.7061.00
102_A105_R0.7061.00
25_A29_N0.7051.00
46_G182_A0.7051.00
187_L191_L0.7031.00
36_C134_D0.6901.00
163_T166_E0.6871.00
141_S150_P0.6871.00
36_C42_V0.6871.00
81_I85_G0.6841.00
92_P109_A0.6841.00
191_L195_S0.6801.00
168_V186_L0.6760.99
7_I11_V0.6740.99
69_G72_V0.6700.99
11_V141_S0.6670.99
10_S45_G0.6610.99
39_G133_A0.6610.99
118_Q188_A0.6560.99
69_G76_N0.6550.99
51_Y55_A0.6540.99
7_I12_L0.6520.99
146_F184_V0.6520.99
63_I67_D0.6510.99
82_A85_G0.6460.99
97_E101_E0.6450.99
157_E161_R0.6380.99
178_A186_L0.6330.99
60_A65_L0.6260.99
184_V188_A0.6250.99
184_V199_T0.6240.99
10_S141_S0.6230.99
33_D89_A0.6230.99
212_D215_R0.6200.99
102_A106_G0.6160.99
112_G116_A0.6140.99
24_H28_I0.6120.99
90_P106_G0.6110.99
85_G91_S0.6110.99
28_I38_V0.6100.99
153_D156_A0.6050.99
29_N108_I0.5990.99
129_E191_L0.5970.99
140_T199_T0.5970.99
70_V74_R0.5960.99
20_Q24_H0.5880.99
184_V201_V0.5870.99
47_V72_V0.5840.98
88_A91_S0.5830.98
68_I78_R0.5800.98
69_G73_T0.5800.98
21_V25_A0.5790.98
26_D86_G0.5780.98
68_I75_L0.5770.98
38_V42_V0.5760.98
100_G132_D0.5720.98
99_A102_A0.5690.98
10_S140_T0.5690.98
98_D111_M0.5690.98
138_Y184_V0.5650.98
8_G121_D0.5620.98
81_I97_E0.5590.98
25_A80_L0.5570.98
5_V38_V0.5570.98
113_G116_A0.5540.98
112_G115_V0.5530.98
98_D107_D0.5520.98
23_A208_R0.5490.98
20_Q204_G0.5480.98
114_V119_T0.5440.98
11_V20_Q0.5370.97
96_Y99_A0.5310.97
189_A199_T0.5310.97
3_V38_V0.5290.97
48_A54_T0.5280.97
84_L108_I0.5280.97
160_T210_I0.5270.97
13_A18_A0.5210.97
67_D74_R0.5190.97
85_G92_P0.5190.97
149_D153_D0.5160.97
99_A110_V0.5150.97
185_D191_L0.5130.97
24_H204_G0.5100.96
100_G103_M0.5090.96
207_P211_V0.5080.96
49_R117_G0.5080.96
47_V75_L0.5080.96
26_D33_D0.5070.96
67_D71_D0.5070.96
27_A206_D0.5060.96
12_L76_N0.5050.96
32_T90_P0.5050.96
145_V193_E0.5030.96
19_D26_D0.5020.96
27_A211_V0.5020.96
97_E100_G0.5020.96
55_A58_L0.5020.96
142_V146_F0.5020.96
66_D114_V0.5010.96
113_G126_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q1tA 4 0.9129 100 0.288 Contact Map
2j5vA 2 0.8299 100 0.309 Contact Map
3l76A 2 0.917 100 0.323 Contact Map
2j4jA 5 0.9295 100 0.325 Contact Map
2brxA 5 0.8963 100 0.331 Contact Map
3ab4A 7 0.917 100 0.34 Contact Map
2va1A 5 0.8838 100 0.349 Contact Map
3nwyA 5 0.888 100 0.35 Contact Map
3c1mA 3 0.917 100 0.353 Contact Map
1z9dA 5 0.888 100 0.354 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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