Q9HNN1 - HALSA - GREMLIN Contacts

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Q9HNN1 - Acetyltransferase homolog

UniProt:	Q9HNN1	Sequences: MTKRHVSLPADAKDVRRAFVSGVDERLSAAETPDELATAVTGTLADLRGERDAYEAWRDGDDVRPAAAARLATLDPRNASLESEYYAEKDEAAFARSKPLQWLWRQFDTTPLADNVDVALPFRRMLAGHLFAGVGEDVRLFKGITMTYGHNIELGDNAVVHDGVHLDDRGELVVGARASVSNGAHLYTHDHDVVDQTDVTNYRTEIGADARVTQGALVRAGVRVGENALVGSRSVVQGDVPAHHIAVGSPAESVRVKPGWEAVAAPLDAGGERRQAERRLDDAVPADAAVYDEFQRDRSPPGER	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	304 (228)
Sequences:	349 (294)
Seq/√Len:	19.5

ECOLI - GLMU
BACSU - GLMU
HALSA - Q9HNN1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_P	54_Y	7.154	1.00
40_V	51_R	4.404	1.00
75_D	97_S	4.154	1.00
44_L	52_D	3.386	1.00
152_I	166_L	3.322	1.00
189_H	201_N	3.297	1.00
133_G	154_L	3.165	0.99
25_E	44_L	2.815	0.99
188_T	203_R	2.685	0.98
133_G	136_E	2.683	0.98
27_L	44_L	2.599	0.98
155_G	158_A	2.564	0.98
116_V	135_G	2.483	0.97
155_G	175_G	2.382	0.96
125_M	144_I	2.364	0.96
160_V	174_V	2.298	0.95
158_A	178_A	2.253	0.95
9_P	17_R	2.192	0.94
58_R	62_D	2.175	0.94
149_G	152_I	2.159	0.93
186_L	191_H	2.122	0.93
72_A	93_A	2.114	0.93
154_L	158_A	2.100	0.92
154_L	160_V	2.091	0.92
59_D	134_V	2.060	0.92
28_S	44_L	2.011	0.90
126_L	129_H	1.996	0.90
68_A	94_F	1.992	0.90
155_G	178_A	1.802	0.85
22_G	55_E	1.776	0.84
18_A	59_D	1.758	0.83
158_A	175_G	1.711	0.82
154_L	174_V	1.709	0.81
78_N	85_Y	1.698	0.81
34_D	56_A	1.692	0.81
227_N	230_V	1.647	0.79
16_R	94_F	1.639	0.79
217_L	232_S	1.612	0.77
49_G	52_D	1.609	0.77
204_T	222_V	1.598	0.77
186_L	189_H	1.593	0.77
133_G	158_A	1.584	0.76
208_A	226_E	1.580	0.76
192_D	208_A	1.544	0.74
148_Y	160_V	1.543	0.74
46_D	82_E	1.512	0.73
117_D	139_R	1.510	0.72
166_L	172_L	1.499	0.72
47_L	116_V	1.497	0.72
214_Q	219_R	1.478	0.71
7_S	11_D	1.463	0.70
71_L	97_S	1.456	0.70
155_G	177_R	1.454	0.70
124_R	128_G	1.453	0.69
48_R	51_R	1.413	0.67
175_G	193_V	1.395	0.66
118_V	135_G	1.370	0.65
14_D	102_W	1.362	0.64
76_P	90_D	1.360	0.64
176_A	193_V	1.357	0.64
204_T	220_A	1.352	0.64
76_P	88_E	1.351	0.64
133_G	138_V	1.335	0.63
5_H	17_R	1.333	0.63
76_P	121_P	1.329	0.62
66_A	70_R	1.321	0.62
190_D	205_E	1.287	0.60
129_H	172_L	1.268	0.59
210_A	225_G	1.258	0.58
127_A	131_F	1.257	0.58
131_F	148_Y	1.253	0.58
33_P	40_V	1.246	0.57
111_P	123_R	1.243	0.57
197_T	200_T	1.239	0.57
212_V	224_V	1.235	0.57
33_P	51_R	1.222	0.56
186_L	212_V	1.205	0.55
149_G	167_D	1.184	0.53
72_A	90_D	1.183	0.53
24_D	55_E	1.170	0.52
207_G	226_E	1.168	0.52
11_D	179_S	1.166	0.52
167_D	187_Y	1.162	0.52
147_T	186_L	1.157	0.52
204_T	221_G	1.150	0.51
71_L	75_D	1.144	0.51
194_V	209_D	1.132	0.50
129_H	144_I	1.131	0.50
115_N	120_L	1.115	0.49
133_G	155_G	1.108	0.48
190_D	203_R	1.104	0.48
155_G	193_V	1.073	0.46
69_A	121_P	1.071	0.46
35_E	39_A	1.053	0.45
228_A	232_S	1.044	0.44
157_N	162_D	1.043	0.44
164_V	218_V	1.042	0.44
154_L	159_V	1.040	0.44
79_A	96_R	1.028	0.43
121_P	130_L	1.028	0.43
158_A	177_R	1.026	0.43
155_G	176_A	1.025	0.43
31_E	86_Y	1.006	0.42
210_A	226_E	1.001	0.42
28_S	82_E	0.999	0.42
192_D	196_Q	0.998	0.42
162_D	181_S	0.994	0.41
121_P	143_G	0.994	0.41
15_V	99_P	0.990	0.41
23_V	102_W	0.986	0.41
206_I	216_A	0.983	0.41
156_D	176_A	0.976	0.40
20_V	56_A	0.973	0.40
185_H	199_V	0.970	0.40
86_Y	115_N	0.970	0.40
122_F	125_M	0.969	0.40
175_G	208_A	0.967	0.40
161_H	179_S	0.950	0.39
154_L	175_G	0.949	0.39
40_V	95_A	0.938	0.38
151_N	160_V	0.936	0.38
218_V	224_V	0.936	0.38
217_L	221_G	0.936	0.38
222_V	228_A	0.935	0.38
152_I	172_L	0.932	0.38
4_R	77_R	0.925	0.37
7_S	125_M	0.909	0.36
131_F	216_A	0.898	0.35
117_D	157_N	0.894	0.35
132_A	136_E	0.885	0.35
158_A	193_V	0.879	0.34
173_V	176_A	0.875	0.34
80_S	86_Y	0.872	0.34
57_W	61_D	0.870	0.34
29_A	91_E	0.867	0.34
57_W	68_A	0.867	0.34
125_M	160_V	0.866	0.34
26_R	55_E	0.862	0.33
133_G	148_Y	0.860	0.33
62_D	111_P	0.859	0.33
184_A	212_V	0.850	0.33
197_T	220_A	0.847	0.33
195_D	198_D	0.845	0.32
153_E	173_V	0.845	0.32
122_F	176_A	0.842	0.32
37_A	68_A	0.840	0.32
140_L	148_Y	0.837	0.32
90_D	110_T	0.831	0.32
46_D	80_S	0.831	0.32
31_E	120_L	0.827	0.31
20_V	87_A	0.824	0.31
175_G	180_V	0.823	0.31
68_A	99_P	0.820	0.31
105_R	108_D	0.819	0.31
45_A	81_L	0.818	0.31
36_L	39_A	0.818	0.31
184_A	229_L	0.815	0.31
3_K	7_S	0.815	0.31
26_R	57_W	0.814	0.31
4_R	7_S	0.814	0.31
63_V	124_R	0.813	0.31
94_F	112_L	0.811	0.31
103_L	230_V	0.809	0.30
189_H	197_T	0.808	0.30
178_A	195_D	0.808	0.30
214_Q	220_A	0.806	0.30
18_A	21_S	0.804	0.30
91_E	166_L	0.799	0.30
164_V	182_N	0.797	0.30
23_V	59_D	0.795	0.30
47_L	224_V	0.783	0.29
73_T	103_L	0.783	0.29
21_S	111_P	0.783	0.29
18_A	91_E	0.782	0.29
7_S	132_A	0.781	0.29
26_R	44_L	0.778	0.29
8_L	77_R	0.776	0.29
104_W	108_D	0.770	0.28
13_K	37_A	0.770	0.28
222_V	232_S	0.769	0.28
86_Y	120_L	0.766	0.28
112_L	123_R	0.759	0.28
90_D	93_A	0.754	0.28
149_G	212_V	0.752	0.27
184_A	223_R	0.742	0.27
33_P	95_A	0.741	0.27
142_K	157_N	0.740	0.27
85_Y	124_R	0.737	0.27
3_K	176_A	0.731	0.26
196_Q	211_R	0.730	0.26
76_P	85_Y	0.728	0.26
130_L	143_G	0.727	0.26
15_V	63_V	0.723	0.26
39_A	95_A	0.722	0.26
6_V	10_A	0.717	0.26
4_R	92_A	0.714	0.26
8_L	25_E	0.713	0.26
20_V	178_A	0.706	0.25
43_T	46_D	0.706	0.25
193_V	196_Q	0.706	0.25
46_D	86_Y	0.704	0.25
49_G	77_R	0.702	0.25
7_S	96_R	0.701	0.25
14_D	100_L	0.699	0.25
31_E	137_D	0.698	0.25
64_R	82_E	0.695	0.25
31_E	43_T	0.694	0.25
67_A	153_E	0.694	0.25
41_T	91_E	0.694	0.25
205_E	223_R	0.692	0.25
195_D	207_G	0.689	0.24
3_K	210_A	0.686	0.24
11_D	71_L	0.686	0.24
114_D	123_R	0.684	0.24
130_L	134_V	0.677	0.24
7_S	171_E	0.677	0.24
48_R	192_D	0.675	0.24
59_D	111_P	0.671	0.24
137_D	147_T	0.668	0.23
40_V	174_V	0.666	0.23
83_S	114_D	0.665	0.23
117_D	182_N	0.662	0.23
185_H	211_R	0.661	0.23
121_P	125_M	0.661	0.23
4_R	76_P	0.660	0.23
197_T	214_Q	0.659	0.23
15_V	65_P	0.658	0.23
86_Y	219_R	0.656	0.23
6_V	224_V	0.654	0.23
97_S	119_A	0.654	0.23
171_E	203_R	0.653	0.23
183_G	199_V	0.652	0.23
3_K	52_D	0.649	0.23
8_L	184_A	0.647	0.22
12_A	100_L	0.646	0.22
6_V	95_A	0.646	0.22
3_K	75_D	0.642	0.22
31_E	115_N	0.637	0.22
197_T	204_T	0.637	0.22
164_V	181_S	0.633	0.22
161_H	164_V	0.632	0.22
42_G	61_D	0.630	0.22
7_S	50_E	0.629	0.22
97_S	104_W	0.629	0.22
68_A	112_L	0.628	0.22
134_V	137_D	0.628	0.22
54_Y	197_T	0.627	0.22
11_D	97_S	0.624	0.21
22_G	75_D	0.623	0.21
87_A	90_D	0.618	0.21
97_S	228_A	0.617	0.21
112_L	126_L	0.616	0.21
31_E	80_S	0.613	0.21
96_R	160_V	0.612	0.21
28_S	31_E	0.612	0.21
151_N	171_E	0.610	0.21
22_G	36_L	0.608	0.21
146_M	163_G	0.607	0.21
20_V	34_D	0.604	0.21
177_R	196_Q	0.602	0.20
59_D	119_A	0.601	0.20
149_G	163_G	0.600	0.20
71_L	211_R	0.598	0.20
178_A	217_L	0.598	0.20
137_D	143_G	0.588	0.20
65_P	90_D	0.587	0.20
72_A	188_T	0.586	0.20
204_T	218_V	0.582	0.20
63_V	165_H	0.580	0.20
108_D	114_D	0.578	0.20
206_I	209_D	0.575	0.19
30_A	60_G	0.575	0.19
164_V	206_I	0.573	0.19
6_V	48_R	0.571	0.19
155_G	159_V	0.570	0.19
49_G	190_D	0.570	0.19
21_S	160_V	0.568	0.19
33_P	42_G	0.567	0.19
6_V	14_D	0.566	0.19
24_D	98_K	0.563	0.19
37_A	92_A	0.562	0.19
35_E	205_E	0.560	0.19
20_V	59_D	0.560	0.19
31_E	46_D	0.559	0.19
36_L	67_A	0.558	0.19
16_R	101_Q	0.557	0.19
103_L	131_F	0.556	0.19
72_A	166_L	0.556	0.19
73_T	230_V	0.555	0.19
83_S	172_L	0.554	0.19
131_F	138_V	0.554	0.19
36_L	97_S	0.552	0.18
73_T	77_R	0.547	0.18
116_V	185_H	0.544	0.18
198_D	211_R	0.542	0.18
220_A	229_L	0.540	0.18
180_V	203_R	0.538	0.18
59_D	63_V	0.538	0.18
36_L	206_I	0.538	0.18
197_T	224_V	0.538	0.18
198_D	221_G	0.537	0.18
24_D	50_E	0.536	0.18
214_Q	221_G	0.535	0.18
211_R	226_E	0.535	0.18
214_Q	229_L	0.534	0.18
15_V	186_L	0.534	0.18
92_A	100_L	0.534	0.18
127_A	139_R	0.533	0.18
160_V	223_R	0.533	0.18
8_L	12_A	0.532	0.18
6_V	71_L	0.530	0.18
56_A	103_L	0.527	0.18
38_T	44_L	0.527	0.18
116_V	184_A	0.526	0.18
109_T	124_R	0.526	0.18
46_D	117_D	0.525	0.17
52_D	76_P	0.525	0.17
11_D	144_I	0.524	0.17
126_L	183_G	0.521	0.17
87_A	91_E	0.520	0.17
53_A	230_V	0.517	0.17
135_G	181_S	0.516	0.17
181_S	210_A	0.516	0.17
33_P	98_K	0.514	0.17
4_R	36_L	0.514	0.17
24_D	96_R	0.513	0.17
58_R	217_L	0.513	0.17
185_H	198_D	0.513	0.17
54_Y	87_A	0.511	0.17
153_E	156_D	0.511	0.17
104_W	175_G	0.507	0.17
201_N	214_Q	0.507	0.17
88_E	199_V	0.506	0.17
28_S	46_D	0.506	0.17
104_W	122_F	0.505	0.17
43_T	86_Y	0.505	0.17
180_V	217_L	0.504	0.17
6_V	104_W	0.503	0.17
201_N	211_R	0.503	0.17
132_A	209_D	0.502	0.17
215_G	220_A	0.500	0.17
58_R	88_E	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g3qA	3	0.9079	100	0.59	Contact Map
1hm9A	3	0.8783	100	0.606	Contact Map
2v0hA	3	0.8487	100	0.612	Contact Map
4fceA	3	0.8355	100	0.622	Contact Map
2i5kA	5	0.6217	100	0.682	Contact Map
4r7pA	4	0.6217	100	0.688	Contact Map
2ggoA	3	0.773	100	0.692	Contact Map
3brkX	2	0.7467	100	0.7	Contact Map
2icyA	1	0.6842	100	0.702	Contact Map
3gueA	1	0.6809	100	0.708	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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