GREMLIN Database
Q9HNN1 - Acetyltransferase homolog
UniProt: Q9HNN1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (228)
Sequences: 349 (294)
Seq/√Len: 19.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_P54_Y7.1541.00
40_V51_R4.4041.00
75_D97_S4.1541.00
44_L52_D3.3861.00
152_I166_L3.3221.00
189_H201_N3.2971.00
133_G154_L3.1650.99
25_E44_L2.8150.99
188_T203_R2.6850.98
133_G136_E2.6830.98
27_L44_L2.5990.98
155_G158_A2.5640.98
116_V135_G2.4830.97
155_G175_G2.3820.96
125_M144_I2.3640.96
160_V174_V2.2980.95
158_A178_A2.2530.95
9_P17_R2.1920.94
58_R62_D2.1750.94
149_G152_I2.1590.93
186_L191_H2.1220.93
72_A93_A2.1140.93
154_L158_A2.1000.92
154_L160_V2.0910.92
59_D134_V2.0600.92
28_S44_L2.0110.90
126_L129_H1.9960.90
68_A94_F1.9920.90
155_G178_A1.8020.85
22_G55_E1.7760.84
18_A59_D1.7580.83
158_A175_G1.7110.82
154_L174_V1.7090.81
78_N85_Y1.6980.81
34_D56_A1.6920.81
227_N230_V1.6470.79
16_R94_F1.6390.79
217_L232_S1.6120.77
49_G52_D1.6090.77
204_T222_V1.5980.77
186_L189_H1.5930.77
133_G158_A1.5840.76
208_A226_E1.5800.76
192_D208_A1.5440.74
148_Y160_V1.5430.74
46_D82_E1.5120.73
117_D139_R1.5100.72
166_L172_L1.4990.72
47_L116_V1.4970.72
214_Q219_R1.4780.71
7_S11_D1.4630.70
71_L97_S1.4560.70
155_G177_R1.4540.70
124_R128_G1.4530.69
48_R51_R1.4130.67
175_G193_V1.3950.66
118_V135_G1.3700.65
14_D102_W1.3620.64
76_P90_D1.3600.64
176_A193_V1.3570.64
204_T220_A1.3520.64
76_P88_E1.3510.64
133_G138_V1.3350.63
5_H17_R1.3330.63
76_P121_P1.3290.62
66_A70_R1.3210.62
190_D205_E1.2870.60
129_H172_L1.2680.59
210_A225_G1.2580.58
127_A131_F1.2570.58
131_F148_Y1.2530.58
33_P40_V1.2460.57
111_P123_R1.2430.57
197_T200_T1.2390.57
212_V224_V1.2350.57
33_P51_R1.2220.56
186_L212_V1.2050.55
149_G167_D1.1840.53
72_A90_D1.1830.53
24_D55_E1.1700.52
207_G226_E1.1680.52
11_D179_S1.1660.52
167_D187_Y1.1620.52
147_T186_L1.1570.52
204_T221_G1.1500.51
71_L75_D1.1440.51
194_V209_D1.1320.50
129_H144_I1.1310.50
115_N120_L1.1150.49
133_G155_G1.1080.48
190_D203_R1.1040.48
155_G193_V1.0730.46
69_A121_P1.0710.46
35_E39_A1.0530.45
228_A232_S1.0440.44
157_N162_D1.0430.44
164_V218_V1.0420.44
154_L159_V1.0400.44
79_A96_R1.0280.43
121_P130_L1.0280.43
158_A177_R1.0260.43
155_G176_A1.0250.43
31_E86_Y1.0060.42
210_A226_E1.0010.42
28_S82_E0.9990.42
192_D196_Q0.9980.42
162_D181_S0.9940.41
121_P143_G0.9940.41
15_V99_P0.9900.41
23_V102_W0.9860.41
206_I216_A0.9830.41
156_D176_A0.9760.40
20_V56_A0.9730.40
185_H199_V0.9700.40
86_Y115_N0.9700.40
122_F125_M0.9690.40
175_G208_A0.9670.40
161_H179_S0.9500.39
154_L175_G0.9490.39
40_V95_A0.9380.38
151_N160_V0.9360.38
218_V224_V0.9360.38
217_L221_G0.9360.38
222_V228_A0.9350.38
152_I172_L0.9320.38
4_R77_R0.9250.37
7_S125_M0.9090.36
131_F216_A0.8980.35
117_D157_N0.8940.35
132_A136_E0.8850.35
158_A193_V0.8790.34
173_V176_A0.8750.34
80_S86_Y0.8720.34
57_W61_D0.8700.34
29_A91_E0.8670.34
57_W68_A0.8670.34
125_M160_V0.8660.34
26_R55_E0.8620.33
133_G148_Y0.8600.33
62_D111_P0.8590.33
184_A212_V0.8500.33
197_T220_A0.8470.33
195_D198_D0.8450.32
153_E173_V0.8450.32
122_F176_A0.8420.32
37_A68_A0.8400.32
140_L148_Y0.8370.32
90_D110_T0.8310.32
46_D80_S0.8310.32
31_E120_L0.8270.31
20_V87_A0.8240.31
175_G180_V0.8230.31
68_A99_P0.8200.31
105_R108_D0.8190.31
45_A81_L0.8180.31
36_L39_A0.8180.31
184_A229_L0.8150.31
3_K7_S0.8150.31
26_R57_W0.8140.31
4_R7_S0.8140.31
63_V124_R0.8130.31
94_F112_L0.8110.31
103_L230_V0.8090.30
189_H197_T0.8080.30
178_A195_D0.8080.30
214_Q220_A0.8060.30
18_A21_S0.8040.30
91_E166_L0.7990.30
164_V182_N0.7970.30
23_V59_D0.7950.30
47_L224_V0.7830.29
73_T103_L0.7830.29
21_S111_P0.7830.29
18_A91_E0.7820.29
7_S132_A0.7810.29
26_R44_L0.7780.29
8_L77_R0.7760.29
104_W108_D0.7700.28
13_K37_A0.7700.28
222_V232_S0.7690.28
86_Y120_L0.7660.28
112_L123_R0.7590.28
90_D93_A0.7540.28
149_G212_V0.7520.27
184_A223_R0.7420.27
33_P95_A0.7410.27
142_K157_N0.7400.27
85_Y124_R0.7370.27
3_K176_A0.7310.26
196_Q211_R0.7300.26
76_P85_Y0.7280.26
130_L143_G0.7270.26
15_V63_V0.7230.26
39_A95_A0.7220.26
6_V10_A0.7170.26
4_R92_A0.7140.26
8_L25_E0.7130.26
20_V178_A0.7060.25
43_T46_D0.7060.25
193_V196_Q0.7060.25
46_D86_Y0.7040.25
49_G77_R0.7020.25
7_S96_R0.7010.25
14_D100_L0.6990.25
31_E137_D0.6980.25
64_R82_E0.6950.25
31_E43_T0.6940.25
67_A153_E0.6940.25
41_T91_E0.6940.25
205_E223_R0.6920.25
195_D207_G0.6890.24
3_K210_A0.6860.24
11_D71_L0.6860.24
114_D123_R0.6840.24
130_L134_V0.6770.24
7_S171_E0.6770.24
48_R192_D0.6750.24
59_D111_P0.6710.24
137_D147_T0.6680.23
40_V174_V0.6660.23
83_S114_D0.6650.23
117_D182_N0.6620.23
185_H211_R0.6610.23
121_P125_M0.6610.23
4_R76_P0.6600.23
197_T214_Q0.6590.23
15_V65_P0.6580.23
86_Y219_R0.6560.23
6_V224_V0.6540.23
97_S119_A0.6540.23
171_E203_R0.6530.23
183_G199_V0.6520.23
3_K52_D0.6490.23
8_L184_A0.6470.22
12_A100_L0.6460.22
6_V95_A0.6460.22
3_K75_D0.6420.22
31_E115_N0.6370.22
197_T204_T0.6370.22
164_V181_S0.6330.22
161_H164_V0.6320.22
42_G61_D0.6300.22
7_S50_E0.6290.22
97_S104_W0.6290.22
68_A112_L0.6280.22
134_V137_D0.6280.22
54_Y197_T0.6270.22
11_D97_S0.6240.21
22_G75_D0.6230.21
87_A90_D0.6180.21
97_S228_A0.6170.21
112_L126_L0.6160.21
31_E80_S0.6130.21
96_R160_V0.6120.21
28_S31_E0.6120.21
151_N171_E0.6100.21
22_G36_L0.6080.21
146_M163_G0.6070.21
20_V34_D0.6040.21
177_R196_Q0.6020.20
59_D119_A0.6010.20
149_G163_G0.6000.20
71_L211_R0.5980.20
178_A217_L0.5980.20
137_D143_G0.5880.20
65_P90_D0.5870.20
72_A188_T0.5860.20
204_T218_V0.5820.20
63_V165_H0.5800.20
108_D114_D0.5780.20
206_I209_D0.5750.19
30_A60_G0.5750.19
164_V206_I0.5730.19
6_V48_R0.5710.19
155_G159_V0.5700.19
49_G190_D0.5700.19
21_S160_V0.5680.19
33_P42_G0.5670.19
6_V14_D0.5660.19
24_D98_K0.5630.19
37_A92_A0.5620.19
35_E205_E0.5600.19
20_V59_D0.5600.19
31_E46_D0.5590.19
36_L67_A0.5580.19
16_R101_Q0.5570.19
103_L131_F0.5560.19
72_A166_L0.5560.19
73_T230_V0.5550.19
83_S172_L0.5540.19
131_F138_V0.5540.19
36_L97_S0.5520.18
73_T77_R0.5470.18
116_V185_H0.5440.18
198_D211_R0.5420.18
220_A229_L0.5400.18
180_V203_R0.5380.18
59_D63_V0.5380.18
36_L206_I0.5380.18
197_T224_V0.5380.18
198_D221_G0.5370.18
24_D50_E0.5360.18
214_Q221_G0.5350.18
211_R226_E0.5350.18
214_Q229_L0.5340.18
15_V186_L0.5340.18
92_A100_L0.5340.18
127_A139_R0.5330.18
160_V223_R0.5330.18
8_L12_A0.5320.18
6_V71_L0.5300.18
56_A103_L0.5270.18
38_T44_L0.5270.18
116_V184_A0.5260.18
109_T124_R0.5260.18
46_D117_D0.5250.17
52_D76_P0.5250.17
11_D144_I0.5240.17
126_L183_G0.5210.17
87_A91_E0.5200.17
53_A230_V0.5170.17
135_G181_S0.5160.17
181_S210_A0.5160.17
33_P98_K0.5140.17
4_R36_L0.5140.17
24_D96_R0.5130.17
58_R217_L0.5130.17
185_H198_D0.5130.17
54_Y87_A0.5110.17
153_E156_D0.5110.17
104_W175_G0.5070.17
201_N214_Q0.5070.17
88_E199_V0.5060.17
28_S46_D0.5060.17
104_W122_F0.5050.17
43_T86_Y0.5050.17
180_V217_L0.5040.17
6_V104_W0.5030.17
201_N211_R0.5030.17
132_A209_D0.5020.17
215_G220_A0.5000.17
58_R88_E0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g3qA 3 0.9079 100 0.59 Contact Map
1hm9A 3 0.8783 100 0.606 Contact Map
2v0hA 3 0.8487 100 0.612 Contact Map
4fceA 3 0.8355 100 0.622 Contact Map
2i5kA 5 0.6217 100 0.682 Contact Map
4r7pA 4 0.6217 100 0.688 Contact Map
2ggoA 3 0.773 100 0.692 Contact Map
3brkX 2 0.7467 100 0.7 Contact Map
2icyA 1 0.6842 100 0.702 Contact Map
3gueA 1 0.6809 100 0.708 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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