GREMLIN Database
Q9HNM6 - Enoyl-CoA hydratase
UniProt: Q9HNM6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 144 (132)
Sequences: 23242 (14310)
Seq/√Len: 1245.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_S78_T3.3411.00
35_C90_V3.2891.00
37_P95_E2.8781.00
13_A30_C2.7741.00
38_A96_D2.3791.00
68_H87_M2.2601.00
77_R103_E2.1991.00
83_D86_A2.1511.00
47_T107_N2.1021.00
66_T70_A2.0381.00
70_A120_G2.0271.00
71_D77_R2.0271.00
33_R67_T1.9851.00
126_A129_D1.9671.00
80_D83_D1.9281.00
73_S115_L1.9211.00
20_R42_A1.8691.00
34_V94_V1.8531.00
35_C41_F1.8301.00
83_D87_M1.7931.00
34_V100_V1.7181.00
70_A74_L1.7121.00
71_D91_S1.7081.00
37_P82_A1.6951.00
71_D92_R1.6891.00
18_P40_S1.6231.00
5_A59_R1.5871.00
24_V43_E1.5861.00
15_V27_A1.5831.00
16_D36_T1.5781.00
85_R93_I1.5371.00
37_P96_D1.5291.00
67_T91_S1.5191.00
16_D38_A1.5171.00
36_T96_D1.5001.00
33_R63_A1.4821.00
72_L79_V1.4771.00
82_A86_A1.4751.00
107_N112_L1.4611.00
4_I11_V1.4411.00
31_D116_Q1.4371.00
125_Q129_D1.3781.00
27_A33_R1.3571.00
70_A119_L1.3441.00
68_H83_D1.3361.00
42_A78_T1.3251.00
68_H71_D1.2891.00
15_V19_A1.2821.00
66_T123_G1.2311.00
81_A93_I1.2291.00
25_E56_G1.2241.00
117_A121_Q1.1721.00
79_V87_M1.1681.00
36_T97_P1.1611.00
11_V30_C1.1401.00
101_A105_A1.1271.00
121_Q125_Q1.1141.00
77_R83_D1.0861.00
20_R78_T1.0841.00
72_L87_M1.0521.00
65_G68_H1.0341.00
109_P113_R1.0321.00
114_E117_A1.0321.00
40_S80_D1.0271.00
46_V76_G1.0261.00
130_E133_A1.0061.00
8_D113_R1.0051.00
64_V68_H1.0011.00
24_V41_F0.9951.00
82_A85_R0.9931.00
63_A67_T0.9901.00
6_D128_T0.9841.00
95_E98_R0.9841.00
130_E134_A0.9821.00
66_T120_G0.9731.00
85_R92_R0.9481.00
15_V41_F0.9411.00
37_P93_I0.9341.00
73_S119_L0.9331.00
34_V92_R0.9281.00
7_A11_V0.9211.00
92_R100_V0.9161.00
47_T78_T0.9151.00
71_D75_S0.8891.00
103_E107_N0.8821.00
46_V115_L0.8801.00
25_E45_G0.8791.00
71_D100_V0.8701.00
60_L64_V0.8561.00
85_R90_V0.8251.00
100_V103_E0.8251.00
32_V100_V0.8241.00
68_H85_R0.8201.00
58_R61_R0.8191.00
18_P78_T0.8111.00
32_V91_S0.8111.00
75_S103_E0.8101.00
81_A90_V0.8001.00
15_V33_R0.7861.00
84_A89_L0.7811.00
58_R62_Q0.7761.00
43_E56_G0.7721.00
28_L89_L0.7701.00
14_G101_A0.7691.00
75_S100_V0.7571.00
51_F118_L0.7551.00
16_D96_D0.7531.00
52_G115_L0.7461.00
46_V112_L0.7421.00
41_F90_V0.7381.00
16_D97_P0.7311.00
99_A102_D0.7301.00
15_V39_A0.7211.00
115_L118_L0.7191.00
8_D117_A0.7161.00
79_V84_A0.7081.00
104_I112_L0.7061.00
3_A7_A0.7051.00
103_E106_A0.7041.00
99_A103_E0.7041.00
71_D83_D0.7001.00
109_P112_L0.6991.00
20_R44_T0.6971.00
45_G52_G0.6871.00
64_V72_L0.6871.00
84_A90_V0.6821.00
13_A33_R0.6801.00
102_D106_A0.6781.00
94_V97_P0.6721.00
45_G53_A0.6681.00
25_E53_A0.6601.00
43_E73_S0.6581.00
24_V28_L0.6571.00
121_Q133_A0.6561.00
46_V107_N0.6541.00
20_R40_S0.6521.00
25_E43_E0.6491.00
65_G69_A0.6471.00
22_G54_W0.6361.00
24_V89_L0.6341.00
35_C39_A0.6341.00
44_T48_L0.6311.00
7_A10_V0.6301.00
68_H91_S0.6241.00
22_G25_E0.6241.00
90_V93_I0.6221.00
64_V69_A0.6211.00
125_Q133_A0.6051.00
5_A120_G0.6031.00
21_G44_T0.6011.00
108_D111_A0.6011.00
45_G51_F0.5981.00
42_A76_G0.5971.00
74_L112_L0.5961.00
12_V101_A0.5961.00
82_A93_I0.5901.00
42_A47_T0.5871.00
63_A91_S0.5841.00
33_R90_V0.5821.00
27_A30_C0.5811.00
62_Q123_G0.5801.00
61_R64_V0.5791.00
129_D132_E0.5771.00
110_D114_E0.5751.00
75_S104_I0.5701.00
79_V89_L0.5701.00
68_H86_A0.5671.00
66_T119_L0.5671.00
38_A81_A0.5611.00
116_Q120_G0.5601.00
122_N125_Q0.5581.00
11_V31_D0.5571.00
57_T118_L0.5561.00
5_A127_A0.5531.00
62_Q126_A0.5531.00
43_E60_L0.5511.00
37_P94_V0.5501.00
43_E52_G0.5401.00
70_A116_Q0.5391.00
64_V87_M0.5391.00
61_R119_L0.5381.00
131_R134_A0.5381.00
32_V104_I0.5371.00
13_A27_A0.5351.00
94_V98_R0.5331.00
29_A59_R0.5291.00
102_D105_A0.5281.00
16_D39_A0.5251.00
61_R122_N0.5231.00
53_A56_G0.5211.00
56_G59_R0.5201.00
41_F84_A0.5181.00
47_T103_E0.5171.00
35_C81_A0.5101.00
20_R45_G0.5051.00
47_T77_R0.5021.00
125_Q131_R0.5011.00
47_T106_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fbmA 3 1 100 0.13 Contact Map
1hzdA 5 1 100 0.13 Contact Map
3bptA 1 0.9931 100 0.136 Contact Map
4jfcA 3 1 100 0.137 Contact Map
3hinA 5 1 100 0.14 Contact Map
4u19A 3 1 100 0.14 Contact Map
3laoA 3 0.9444 100 0.14 Contact Map
4lk5A 3 1 100 0.141 Contact Map
4mouA 3 0.9931 100 0.141 Contact Map
4q1kA 3 1 100 0.142 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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