GREMLIN Database
Q9HNM3 - HoxA-like transcriptional regulator
UniProt: Q9HNM3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (174)
Sequences: 71644 (53111)
Seq/√Len: 4026.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_A33_T3.8841.00
18_A35_T3.4991.00
22_A33_T3.4331.00
11_V40_A2.8671.00
41_L68_A2.7691.00
38_A59_T2.6411.00
32_R48_V2.5161.00
60_M68_A2.4741.00
37_G60_M2.3751.00
36_S59_T2.3571.00
45_D72_R2.3211.00
24_W105_G2.2451.00
7_V32_R2.2321.00
34_A43_A2.1181.00
22_A26_E2.0421.00
56_Q84_I2.0271.00
7_V30_E2.0051.00
53_L65_V1.9531.00
35_T39_A1.9041.00
165_E168_D1.8851.00
87_D107_T1.8381.00
32_R43_A1.8241.00
36_S39_A1.7971.00
66_L78_V1.7791.00
9_L34_A1.7791.00
80_M95_F1.7431.00
68_A72_R1.7211.00
80_M90_I1.7201.00
70_R96_D1.7041.00
67_A93_M1.6891.00
37_G65_V1.6141.00
6_P116_R1.5551.00
60_M64_E1.5511.00
97_E111_V1.5311.00
61_T64_E1.4921.00
44_A69_L1.4821.00
25_L112_V1.4741.00
38_A60_M1.4631.00
141_Q144_E1.4471.00
43_A46_D1.4431.00
51_A76_I1.4301.00
68_A71_E1.4121.00
170_A173_A1.3941.00
15_P35_T1.3931.00
55_R63_D1.3741.00
43_A48_V1.3121.00
66_L80_M1.2951.00
50_V112_V1.2641.00
79_A115_L1.2631.00
129_Y133_Q1.2491.00
63_D90_I1.2461.00
41_L65_V1.2441.00
64_E67_A1.2261.00
89_D93_M1.2161.00
29_Y113_A1.2111.00
151_D159_R1.2041.00
13_D54_D1.1981.00
109_H113_A1.1971.00
41_L60_M1.1951.00
96_D115_L1.1881.00
11_V57_M1.1691.00
9_L48_V1.1681.00
34_A40_A1.1601.00
12_D18_A1.1541.00
39_A43_A1.1481.00
42_E46_D1.1471.00
53_L66_L1.1251.00
73_A76_I1.1201.00
38_A42_E1.1141.00
96_D118_L1.1031.00
9_L40_A1.0951.00
55_R80_M1.0931.00
9_L43_A1.0931.00
63_D89_D1.0921.00
39_A42_E1.0911.00
165_E169_A1.0771.00
8_V29_Y1.0751.00
28_D113_A1.0681.00
88_F92_E1.0441.00
41_L45_D1.0311.00
169_A172_D1.0301.00
139_E142_L1.0141.00
87_D100_Q1.0141.00
147_L151_D1.0131.00
153_Y156_L1.0021.00
110_D114_R0.9981.00
131_V134_K0.9821.00
50_V116_R0.9771.00
34_A39_A0.9701.00
7_V49_S0.9691.00
22_A31_V0.9611.00
40_A65_V0.9581.00
130_R133_Q0.9571.00
55_R61_T0.9501.00
10_V21_F0.9491.00
151_D155_R0.9471.00
129_Y132_T0.9471.00
21_F81_V0.9331.00
136_A139_E0.9331.00
51_A69_L0.9311.00
152_E155_R0.9271.00
107_T110_D0.9241.00
19_E33_T0.9231.00
123_D126_D0.9221.00
77_R96_D0.9171.00
92_E113_A0.9131.00
40_A44_A0.9101.00
67_A89_D0.9011.00
130_R134_K0.8981.00
15_P19_E0.8951.00
139_E143_S0.8901.00
9_L44_A0.8891.00
63_D93_M0.8841.00
53_L78_V0.8821.00
11_V34_A0.8801.00
66_L95_F0.8741.00
16_R20_A0.8701.00
29_Y109_H0.8621.00
11_V51_A0.8611.00
6_P29_Y0.8581.00
42_E45_D0.8571.00
168_D171_L0.8531.00
171_L175_G0.8521.00
6_P120_Q0.8511.00
127_E131_V0.8441.00
146_A151_D0.8431.00
107_T111_V0.8401.00
66_L93_M0.8331.00
145_R148_A0.8261.00
128_L132_T0.8241.00
166_A170_A0.8231.00
19_E22_A0.8191.00
135_L139_E0.8161.00
173_A176_T0.8101.00
164_S168_D0.8091.00
64_E68_A0.8081.00
105_G109_H0.8041.00
85_D100_Q0.7891.00
55_R84_I0.7871.00
15_P18_A0.7781.00
89_D92_E0.7751.00
52_L108_L0.7731.00
7_V48_V0.7711.00
169_A173_A0.7711.00
142_L177_S0.7631.00
23_L27_D0.7621.00
51_A78_V0.7591.00
129_Y134_K0.7571.00
115_L118_L0.7541.00
146_A149_D0.7531.00
53_L80_M0.7511.00
158_E161_A0.7491.00
165_E172_D0.7401.00
79_A111_V0.7391.00
10_V31_V0.7341.00
44_A48_V0.7331.00
119_N123_D0.7321.00
149_D168_D0.7301.00
65_V69_L0.7301.00
147_L153_Y0.7291.00
52_L81_V0.7221.00
122_D127_E0.7181.00
114_R117_T0.7171.00
114_R119_N0.7141.00
44_A73_A0.7101.00
17_V103_V0.7091.00
57_M65_V0.7091.00
140_A144_E0.7071.00
60_M65_V0.7051.00
149_D159_R0.7041.00
163_L166_A0.7021.00
148_A151_D0.7021.00
56_Q83_G0.6941.00
81_V103_V0.6941.00
157_R160_K0.6901.00
87_D104_D0.6871.00
11_V65_V0.6871.00
19_E23_L0.6821.00
67_A71_E0.6821.00
20_A24_W0.6811.00
123_D127_E0.6811.00
21_F108_L0.6761.00
44_A76_I0.6761.00
14_E17_V0.6691.00
150_N153_Y0.6651.00
127_E130_R0.6651.00
91_V111_V0.6601.00
172_D176_T0.6541.00
37_G59_T0.6501.00
37_G41_L0.6451.00
146_A159_R0.6441.00
136_A143_S0.6421.00
146_A152_E0.6401.00
44_A51_A0.6371.00
135_L143_S0.6371.00
69_L78_V0.6341.00
122_D126_D0.6331.00
52_L112_V0.6321.00
153_Y168_D0.6311.00
24_W109_H0.6301.00
41_L72_R0.6301.00
145_R151_D0.6281.00
128_L131_V0.6271.00
97_E114_R0.6271.00
116_R119_N0.6261.00
104_D107_T0.6251.00
127_E134_K0.6221.00
90_I95_F0.6201.00
136_A140_A0.6191.00
70_R77_R0.6141.00
12_D57_M0.6121.00
17_V20_A0.6121.00
152_E156_L0.6111.00
77_R116_R0.6081.00
103_V108_L0.6081.00
47_D73_A0.6071.00
140_A143_S0.6071.00
149_D153_Y0.6061.00
146_A150_N0.6061.00
128_L133_Q0.6051.00
41_L44_A0.6031.00
151_D156_L0.6021.00
18_A22_A0.6021.00
26_E31_V0.6011.00
162_T167_A0.5991.00
88_F106_D0.5981.00
152_E157_R0.5951.00
106_D110_D0.5941.00
39_A59_T0.5931.00
8_V50_V0.5921.00
8_V25_L0.5911.00
122_D129_Y0.5791.00
55_R90_I0.5791.00
45_D73_A0.5781.00
10_V22_A0.5771.00
136_A142_L0.5761.00
111_V115_L0.5731.00
135_L142_L0.5711.00
14_E83_G0.5711.00
88_F91_V0.5701.00
124_S127_E0.5691.00
37_G57_M0.5681.00
154_Q164_S0.5641.00
126_D129_Y0.5631.00
45_D68_A0.5501.00
155_R159_R0.5491.00
79_A97_E0.5471.00
92_E110_D0.5441.00
10_V33_T0.5411.00
153_Y157_R0.5411.00
126_D130_R0.5401.00
147_L150_N0.5401.00
6_P49_S0.5331.00
77_R118_L0.5301.00
125_I129_Y0.5211.00
149_D156_L0.5181.00
25_L29_Y0.5161.00
75_D121_Y0.5161.00
66_L70_R0.5071.00
69_L74_L0.5061.00
20_A23_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yioA 1 0.9841 100 0.267 Contact Map
3c3wA 2 0.9788 100 0.277 Contact Map
4gvpA 1 0.9788 100 0.281 Contact Map
3kloA 2 0.9894 100 0.295 Contact Map
4b09A 2 0.9048 100 0.297 Contact Map
1a04A 1 0.9683 100 0.298 Contact Map
4ldzA 2 0.9735 100 0.303 Contact Map
4hyeA 2 0.9735 100 0.309 Contact Map
1ys7A 2 0.9735 100 0.328 Contact Map
2gwrA 1 0.9894 100 0.332 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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