GREMLIN Database
Q9HNM2 - Uncharacterized protein
UniProt: Q9HNM2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 506 (471)
Sequences: 6303 (5324)
Seq/√Len: 245.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
328_V342_L4.4671.00
478_V489_I4.2101.00
494_S497_G4.1091.00
292_R296_E3.9841.00
479_R483_T3.9811.00
33_D133_R3.6971.00
490_D502_T3.3531.00
445_A500_R3.0901.00
411_L482_A3.0611.00
148_L152_T2.8661.00
452_G455_D2.7101.00
292_R295_R2.5611.00
456_T491_A2.5401.00
391_S428_T2.4651.00
442_F503_I2.4591.00
160_T163_A2.4321.00
34_A54_V2.4011.00
423_G447_D2.4001.00
332_K340_T2.3891.00
415_L444_V2.3481.00
293_A296_E2.3421.00
432_G443_F2.3311.00
446_D450_G2.3251.00
191_G195_P2.3101.00
430_T445_A2.3041.00
139_K142_A2.2881.00
482_A503_I2.2861.00
36_V130_G2.2771.00
491_A501_F2.2761.00
401_L404_D2.2571.00
433_A442_F2.2481.00
434_L441_G2.2481.00
443_F500_R2.2471.00
168_V286_T2.2411.00
411_L481_I2.2151.00
403_A408_L2.1951.00
441_G504_H2.1761.00
439_S504_H2.1031.00
453_D456_T2.0911.00
217_L221_A2.0661.00
481_I485_H2.0291.00
441_G502_T2.0211.00
492_T500_R2.0101.00
422_H465_T1.9951.00
50_G53_R1.9591.00
357_L360_A1.9481.00
451_F459_L1.9231.00
371_P402_N1.9161.00
400_T404_D1.9071.00
166_D170_G1.9031.00
403_A485_H1.8831.00
456_T493_T1.8831.00
57_Y106_A1.8771.00
373_P376_S1.8771.00
142_A146_E1.8521.00
325_R346_L1.8461.00
407_R410_T1.8261.00
72_P75_F1.8221.00
372_V403_A1.8211.00
434_L443_F1.8071.00
443_F502_T1.7841.00
220_H224_T1.7841.00
31_G35_I1.7681.00
326_A330_L1.7571.00
28_V46_Y1.7531.00
169_V181_A1.7441.00
301_R304_E1.7421.00
428_T447_D1.7251.00
389_T392_L1.6951.00
36_V51_V1.6841.00
393_S430_T1.6761.00
404_D410_T1.6741.00
432_G445_A1.6641.00
412_F442_F1.6541.00
58_R61_D1.6511.00
350_D354_A1.6501.00
255_L287_Q1.6411.00
85_H89_T1.6401.00
370_E405_P1.6391.00
376_S380_D1.6321.00
271_F275_T1.6301.00
328_V332_K1.6281.00
75_F102_P1.6081.00
451_F455_D1.5981.00
332_K343_T1.5971.00
338_A345_A1.5681.00
66_S69_T1.5621.00
84_D88_E1.5441.00
455_D458_Q1.5441.00
451_F456_T1.5331.00
65_D69_T1.5331.00
337_D341_D1.5101.00
36_V44_I1.5061.00
79_H82_A1.5041.00
303_N306_L1.5001.00
404_D407_R1.5001.00
80_F84_D1.4891.00
411_L478_V1.4851.00
461_D464_Y1.4841.00
233_D236_A1.4761.00
216_S219_W1.4681.00
220_H228_A1.4641.00
340_T344_A1.4591.00
339_L345_A1.4571.00
482_A487_W1.4531.00
324_A346_L1.4521.00
61_D106_A1.4481.00
346_L349_M1.4411.00
353_I356_V1.4391.00
105_H109_H1.4351.00
452_G495_D1.4311.00
341_D345_A1.4241.00
349_M352_L1.4221.00
347_D351_A1.4191.00
327_T330_L1.4011.00
348_R352_L1.3971.00
349_M357_L1.3961.00
377_V381_A1.3781.00
357_L361_K1.3711.00
493_T499_A1.3661.00
490_D503_I1.3631.00
89_T92_R1.3481.00
316_D320_P1.3311.00
83_V86_Y1.3301.00
336_D339_L1.3271.00
311_S316_D1.3241.00
299_R303_N1.3201.00
393_S428_T1.3191.00
328_V331_A1.3181.00
314_S319_D1.3171.00
349_M353_I1.3171.00
303_N307_E1.3161.00
470_G473_F1.3041.00
138_Q142_A1.3011.00
57_Y61_D1.2991.00
115_I118_E1.2981.00
141_Y145_L1.2961.00
439_S488_T1.2941.00
218_A222_F1.2941.00
436_G441_G1.2921.00
142_A145_L1.2881.00
352_L357_L1.2851.00
86_Y89_T1.2831.00
395_A398_L1.2771.00
85_H91_D1.2621.00
346_L353_I1.2581.00
105_H111_I1.2561.00
198_Q201_A1.2561.00
493_T497_G1.2551.00
350_D353_I1.2551.00
306_L310_A1.2541.00
351_A355_D1.2501.00
204_A207_A1.2481.00
120_H124_G1.2391.00
149_Q152_T1.2371.00
298_E301_R1.2351.00
51_V55_L1.2331.00
412_F416_F1.2291.00
219_W223_E1.2251.00
47_A51_V1.2241.00
200_D203_A1.2201.00
205_L208_D1.2191.00
377_V382_W1.2191.00
49_Q53_R1.2181.00
52_H59_P1.2131.00
353_I357_L1.2121.00
441_G490_D1.2061.00
86_Y92_R1.1991.00
65_D70_I1.1971.00
180_V264_G1.1961.00
460_F489_I1.1951.00
86_Y90_G1.1941.00
324_A342_L1.1931.00
143_A146_E1.1911.00
332_K336_D1.1901.00
100_E139_K1.1871.00
199_S202_A1.1841.00
39_D45_R1.1811.00
159_R296_E1.1801.00
323_T345_A1.1771.00
328_V339_L1.1741.00
289_A293_A1.1721.00
102_P112_Q1.1611.00
379_A382_W1.1601.00
198_Q202_A1.1551.00
378_A433_A1.1411.00
454_T457_A1.1311.00
299_R302_Q1.1281.00
269_V275_T1.1281.00
148_L151_I1.1241.00
132_M135_V1.1181.00
448_G457_A1.1181.00
336_D345_A1.1151.00
356_V361_K1.1131.00
378_A381_A1.1081.00
112_Q115_I1.1061.00
340_T343_T1.1051.00
216_S222_F1.1021.00
349_M360_A1.0991.00
493_T496_S1.0991.00
219_W222_F1.0911.00
482_A489_I1.0871.00
491_A499_A1.0871.00
73_P76_H1.0851.00
374_V442_F1.0851.00
113_L118_E1.0841.00
415_L503_I1.0761.00
34_A132_M1.0761.00
317_L321_L1.0731.00
483_T488_T1.0721.00
139_K143_A1.0701.00
97_N100_E1.0691.00
458_Q461_D1.0691.00
455_D464_Y1.0621.00
372_V380_D1.0621.00
197_A202_A1.0611.00
39_D43_T1.0611.00
222_F225_N1.0581.00
492_T502_T1.0581.00
372_V376_S1.0581.00
143_A147_S1.0551.00
314_S318_R1.0531.00
172_A282_L1.0521.00
196_V202_A1.0511.00
302_Q307_E1.0501.00
319_D323_T1.0471.00
238_T241_H1.0461.00
135_V139_K1.0461.00
161_P290_L1.0421.00
221_A227_S1.0421.00
112_Q116_T1.0391.00
101_M104_Q1.0391.00
407_R481_I1.0291.00
319_D322_Q1.0281.00
218_A260_V1.0251.00
314_S320_P1.0211.00
346_L352_L1.0181.00
144_T147_S1.0151.00
358_T361_K1.0111.00
315_H320_P1.0021.00
329_A332_K1.0001.00
111_I117_F0.9981.00
372_V377_V0.9961.00
114_S138_Q0.9911.00
385_A420_V0.9881.00
72_P102_P0.9871.00
338_A342_L0.9871.00
71_M74_R0.9861.00
388_P391_S0.9851.00
346_L350_D0.9841.00
85_H88_E0.9831.00
252_A262_L0.9811.00
458_Q464_Y0.9791.00
351_A354_A0.9731.00
44_I62_L0.9721.00
114_S133_R0.9701.00
490_D504_H0.9651.00
310_A322_Q0.9651.00
304_E308_R0.9631.00
382_W392_L0.9601.00
356_V360_A0.9601.00
430_T447_D0.9591.00
343_T347_D0.9591.00
225_N256_G0.9591.00
98_A114_S0.9571.00
395_A399_P0.9561.00
336_D340_T0.9541.00
79_H92_R0.9511.00
101_M115_I0.9491.00
192_V195_P0.9481.00
171_A175_I0.9451.00
342_L346_L0.9441.00
169_V183_L0.9381.00
158_A167_H0.9361.00
448_G452_G0.9341.00
119_E125_V0.9311.00
171_A174_D0.9271.00
369_T485_H0.9271.00
317_L352_L0.9271.00
375_A379_A0.9241.00
373_P378_A0.9221.00
325_R350_D0.9201.00
339_L342_L0.9191.00
98_A103_G0.9181.00
80_F86_Y0.9171.00
127_A130_G0.9161.00
114_S118_E0.9141.00
341_D344_A0.9111.00
259_G287_Q0.9081.00
311_S318_R0.9071.00
79_H86_Y0.9031.00
151_I282_L0.9031.00
357_L363_G0.9011.00
375_A378_A0.8991.00
330_L333_A0.8981.00
316_D319_D0.8971.00
217_L222_F0.8971.00
338_A341_D0.8931.00
342_L345_A0.8931.00
349_M356_V0.8921.00
112_Q139_K0.8921.00
221_A228_A0.8911.00
114_S117_F0.8891.00
449_D468_T0.8871.00
191_G196_V0.8851.00
113_L116_T0.8851.00
398_L404_D0.8831.00
220_H229_V0.8811.00
288_A292_R0.8811.00
459_L501_F0.8780.99
380_D383_S0.8780.99
459_L491_A0.8770.99
49_Q52_H0.8760.99
448_G453_D0.8760.99
221_A230_Y0.8750.99
327_T338_A0.8730.99
34_A51_V0.8730.99
197_A200_D0.8700.99
38_I42_S0.8690.99
196_V203_A0.8680.99
448_G451_F0.8670.99
112_Q117_F0.8650.99
451_F457_A0.8620.99
233_D248_I0.8610.99
193_L197_A0.8590.99
355_D358_T0.8580.99
78_A82_A0.8570.99
195_P199_S0.8520.99
335_D339_L0.8510.99
311_S314_S0.8490.99
216_S221_A0.8460.99
220_H223_E0.8450.99
120_H125_V0.8450.99
354_A357_L0.8450.99
38_I83_V0.8400.99
345_A352_L0.8400.99
217_L220_H0.8380.99
29_E49_Q0.8370.99
327_T341_D0.8360.99
120_H123_N0.8320.99
448_G454_T0.8320.99
329_A343_T0.8310.99
71_M76_H0.8310.99
197_A203_A0.8270.99
134_D138_Q0.8270.99
255_L283_A0.8260.99
113_L117_F0.8250.99
336_D341_D0.8250.99
173_V181_A0.8230.99
100_E104_Q0.8220.99
44_I63_I0.8180.99
353_I358_T0.8180.99
389_T393_S0.8170.99
451_F454_T0.8160.99
158_A164_I0.8130.99
216_S220_H0.8120.99
456_T459_L0.8090.99
374_V381_A0.8080.99
224_T228_A0.8080.99
49_Q59_P0.8070.99
381_A385_A0.8060.99
68_T71_M0.8040.99
385_A413_E0.8040.99
35_I48_N0.8020.99
101_M105_H0.8020.99
453_D457_A0.8020.99
78_A83_V0.8010.99
103_G106_A0.8000.99
79_H83_V0.7990.99
338_A343_T0.7980.99
376_S379_A0.7970.99
358_T365_T0.7970.99
299_R305_Q0.7950.99
115_I119_E0.7950.99
83_V92_R0.7910.99
402_N405_P0.7890.99
37_T40_D0.7880.99
219_W227_S0.7870.99
449_D493_T0.7860.99
384_T409_R0.7850.99
309_F315_H0.7850.99
182_S185_R0.7840.99
47_A62_L0.7840.99
191_G198_Q0.7840.99
82_A85_H0.7810.99
488_T504_H0.7790.99
372_V375_A0.7780.99
165_G171_A0.7740.99
325_R329_A0.7740.99
82_A91_D0.7740.99
112_Q118_E0.7730.99
315_H319_D0.7730.99
74_R79_H0.7700.99
450_G454_T0.7690.99
396_P399_P0.7670.99
368_E371_P0.7650.99
453_D494_S0.7650.99
99_I103_G0.7600.99
129_S132_M0.7580.99
422_H467_D0.7560.98
219_W225_N0.7550.98
27_L31_G0.7550.98
337_D340_T0.7550.98
378_A382_W0.7540.98
154_T167_H0.7530.98
112_Q119_E0.7520.98
346_L357_L0.7500.98
195_P198_Q0.7470.98
369_T402_N0.7460.98
421_A465_T0.7450.98
388_P392_L0.7450.98
183_L255_L0.7440.98
332_K339_L0.7440.98
285_N289_A0.7430.98
335_D341_D0.7390.98
178_F181_A0.7380.98
331_A342_L0.7370.98
354_A360_A0.7370.98
78_A90_G0.7360.98
346_L356_V0.7360.98
136_S139_K0.7340.98
423_G426_D0.7330.98
131_I134_D0.7310.98
465_T468_T0.7310.98
392_L398_L0.7310.98
97_N105_H0.7300.98
199_S203_A0.7300.98
338_A344_A0.7270.98
221_A224_T0.7270.98
309_F314_S0.7260.98
78_A86_Y0.7260.98
82_A86_Y0.7260.98
376_S382_W0.7260.98
348_R354_A0.7250.98
375_A385_A0.7250.98
343_T346_L0.7230.98
374_V378_A0.7230.98
87_L91_D0.7200.98
451_F491_A0.7180.98
455_D466_T0.7180.98
330_L338_A0.7170.98
331_A334_G0.7170.98
327_T332_K0.7160.98
37_T42_S0.7160.98
350_D357_L0.7140.98
299_R307_E0.7140.98
113_L132_M0.7130.98
380_D409_R0.7130.98
310_A315_H0.7100.98
31_G37_T0.7070.98
152_T156_M0.7070.98
372_V385_A0.7060.98
167_H171_A0.7050.98
87_L92_R0.7040.98
348_R353_I0.7030.98
257_E287_Q0.7020.98
134_D139_K0.7020.98
135_V138_Q0.7010.98
115_I132_M0.7000.98
180_V184_Y0.7000.98
164_I168_V0.6980.97
44_I47_A0.6980.97
86_Y91_D0.6970.97
34_A50_G0.6960.97
195_P200_D0.6960.97
349_M354_A0.6960.97
312_I316_D0.6950.97
151_I156_M0.6940.97
113_L119_E0.6930.97
110_E114_S0.6930.97
191_G194_R0.6920.97
172_A263_V0.6910.97
291_E295_R0.6900.97
97_N101_M0.6900.97
331_A339_L0.6860.97
448_G455_D0.6850.97
316_D352_L0.6850.97
81_D84_D0.6780.97
314_S357_L0.6760.97
371_P400_T0.6750.97
80_F83_V0.6740.97
297_A307_E0.6740.97
306_L421_A0.6740.97
379_A386_G0.6730.97
76_H79_H0.6730.97
335_D338_A0.6720.97
411_L485_H0.6720.97
327_T333_A0.6710.97
182_S264_G0.6700.97
390_A394_T0.6700.97
416_F431_V0.6700.97
218_A221_A0.6690.97
197_A201_A0.6680.97
117_F130_G0.6660.97
139_K145_L0.6650.97
400_T405_P0.6610.97
390_A393_S0.6610.97
117_F128_F0.6600.96
263_V279_I0.6600.96
210_P214_A0.6590.96
34_A48_N0.6580.96
134_D137_R0.6580.96
280_E284_A0.6570.96
345_A348_R0.6550.96
265_D269_V0.6550.96
271_F276_S0.6540.96
404_D409_R0.6540.96
36_V47_A0.6530.96
405_P410_T0.6520.96
379_A383_S0.6520.96
330_L334_G0.6520.96
47_A52_H0.6500.96
57_Y105_H0.6490.96
327_T334_G0.6480.96
222_F227_S0.6480.96
173_V271_F0.6470.96
104_Q110_E0.6460.96
465_T469_D0.6460.96
47_A55_L0.6450.96
261_L283_A0.6440.96
367_G404_D0.6430.96
325_R328_V0.6430.96
187_D190_T0.6410.96
352_L360_A0.6400.96
221_A225_N0.6390.96
162_G166_D0.6380.96
150_D153_H0.6380.96
352_L356_V0.6370.96
452_G466_T0.6370.96
418_N450_G0.6350.96
406_E409_R0.6350.96
310_A314_S0.6350.96
189_A192_V0.6340.96
66_S70_I0.6340.96
452_G457_A0.6330.96
313_V319_D0.6320.96
373_P379_A0.6320.96
423_G465_T0.6310.95
75_F78_A0.6300.95
78_A81_D0.6300.95
76_H80_F0.6290.95
262_L265_D0.6290.95
352_L355_D0.6290.95
38_I44_I0.6270.95
38_I117_F0.6230.95
404_D408_L0.6210.95
227_S280_E0.6200.95
374_V380_D0.6190.95
319_D349_M0.6170.95
149_Q153_H0.6160.95
411_L415_L0.6140.95
243_P246_P0.6130.95
366_V369_T0.6130.95
52_H62_L0.6120.95
373_P381_A0.6120.95
55_L62_L0.6100.95
66_S71_M0.6100.95
71_M75_F0.6080.94
52_H55_L0.6080.94
378_A442_F0.6070.94
102_P110_E0.6070.94
236_A240_V0.6030.94
68_T72_P0.6030.94
104_Q107_D0.6020.94
473_F477_I0.6000.94
198_Q204_A0.5990.94
151_I171_A0.5980.94
161_P165_G0.5970.94
300_E303_N0.5970.94
348_R357_L0.5970.94
98_A116_T0.5960.94
331_A335_D0.5960.94
27_L30_H0.5960.94
307_E349_M0.5960.94
105_H108_G0.5950.94
140_A144_T0.5950.94
182_S262_L0.5950.94
318_R350_D0.5940.94
302_Q306_L0.5920.94
315_H318_R0.5910.94
353_I359_L0.5890.93
326_A331_A0.5890.93
128_F132_M0.5890.93
194_R197_A0.5860.93
414_N417_G0.5860.93
141_Y144_T0.5860.93
383_S386_G0.5860.93
78_A85_H0.5850.93
99_I104_Q0.5850.93
417_G421_A0.5830.93
353_I361_K0.5810.93
37_T127_A0.5800.93
415_L501_F0.5790.93
467_D470_G0.5780.93
84_D87_L0.5780.93
255_L258_H0.5780.93
369_T403_A0.5770.93
325_R347_D0.5770.93
79_H87_L0.5760.93
80_F90_G0.5760.93
451_F499_A0.5750.93
79_H91_D0.5750.93
345_A350_D0.5710.92
436_G439_S0.5690.92
312_I319_D0.5690.92
82_A89_T0.5670.92
285_N288_A0.5660.92
339_L343_T0.5660.92
110_E113_L0.5660.92
46_Y49_Q0.5650.92
418_N474_G0.5630.92
101_M132_M0.5620.92
289_A295_R0.5610.92
375_A382_W0.5600.92
164_I167_H0.5600.92
191_G197_A0.5590.92
345_A353_I0.5590.92
417_G422_H0.5590.92
122_H125_V0.5580.92
112_Q136_S0.5560.91
101_M112_Q0.5560.91
154_T170_G0.5550.91
154_T157_Q0.5540.91
37_T45_R0.5530.91
411_L503_I0.5530.91
57_Y70_I0.5530.91
173_V180_V0.5530.91
335_D342_L0.5520.91
109_H116_T0.5520.91
98_A101_M0.5520.91
327_T345_A0.5510.91
43_T47_A0.5510.91
163_A167_H0.5500.91
364_Q367_G0.5500.91
378_A412_F0.5500.91
345_A349_M0.5500.91
214_A217_L0.5490.91
193_L199_S0.5470.91
111_I116_T0.5470.91
67_L72_P0.5460.91
450_G498_G0.5460.91
38_I67_L0.5450.91
104_Q108_G0.5450.91
422_H447_D0.5430.90
312_I317_L0.5430.90
463_G471_T0.5430.90
281_L285_N0.5420.90
317_L353_I0.5410.90
250_E264_G0.5410.90
318_R357_L0.5410.90
356_V359_L0.5380.90
316_D414_N0.5380.90
154_T171_A0.5380.90
401_L407_R0.5360.90
118_E131_I0.5350.90
196_V200_D0.5340.90
111_I118_E0.5340.90
203_A207_A0.5330.90
450_G457_A0.5330.90
169_V182_S0.5330.90
466_T470_G0.5320.90
327_T331_A0.5300.89
398_L433_A0.5300.89
416_F420_V0.5300.89
227_S231_H0.5290.89
126_R130_G0.5290.89
376_S385_A0.5290.89
196_V201_A0.5280.89
324_A328_V0.5280.89
44_I65_D0.5270.89
98_A102_P0.5240.89
446_D498_G0.5240.89
317_L320_P0.5230.89
47_A59_P0.5230.89
374_V385_A0.5220.89
349_M355_D0.5220.89
341_D353_I0.5220.89
358_T407_R0.5220.89
71_M103_G0.5210.89
401_L409_R0.5200.88
76_H86_Y0.5200.88
35_I46_Y0.5190.88
385_A417_G0.5180.88
311_S320_P0.5160.88
322_Q330_L0.5160.88
68_T76_H0.5120.88
247_M252_A0.5110.88
46_Y51_V0.5110.88
78_A91_D0.5080.87
72_P110_E0.5080.87
221_A226_D0.5080.87
43_T64_G0.5070.87
100_E105_H0.5070.87
37_T46_Y0.5070.87
469_D473_F0.5060.87
334_G338_A0.5060.87
37_T48_N0.5060.87
259_G264_G0.5040.87
335_D345_A0.5040.87
28_V48_N0.5030.87
478_V503_I0.5030.87
291_E296_E0.5020.87
114_S119_E0.5020.87
118_E129_S0.5010.87
102_P106_A0.5010.87
255_L259_G0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gczA 2 0.6838 100 0.447 Contact Map
4i5sA 2 0.6502 100 0.474 Contact Map
3a0rA 2 0.6166 100 0.482 Contact Map
4r3aA 1 0.587 100 0.545 Contact Map
4mpcA 2 0.5534 100 0.608 Contact Map
4q20A 2 0.4269 100 0.609 Contact Map
4ctiA 2 0.4368 100 0.61 Contact Map
2q8gA 2 0.5375 100 0.616 Contact Map
3d36A 2 0.4091 100 0.617 Contact Map
3jz3A 2 0.2905 100 0.621 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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