GREMLIN Database
Q9HNL8 - HAM1 protein homolog
UniProt: Q9HNL8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (176)
Sequences: 4618 (3263)
Seq/√Len: 246.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_S44_A3.3361.00
128_V154_F3.0951.00
136_R156_E2.9471.00
78_F98_L2.6881.00
92_I146_I2.5871.00
34_Y37_L2.5781.00
38_Q48_H2.5651.00
71_F108_A2.4361.00
158_P161_R2.4281.00
108_A127_A2.3271.00
133_V153_T2.2691.00
46_A114_A2.2631.00
94_R98_L2.2541.00
124_F178_W2.2351.00
152_T161_R2.2341.00
108_A129_Q2.1781.00
73_R106_H2.1681.00
87_E90_L2.1311.00
86_V98_L2.0121.00
73_R108_A2.0001.00
3_T61_T1.9891.00
71_F110_R1.9701.00
12_G15_Q1.9621.00
72_V95_V1.9461.00
43_A125_T1.9251.00
97_E100_S1.9231.00
110_R125_T1.8861.00
73_R104_D1.8591.00
26_R29_Q1.8331.00
93_E135_P1.8031.00
26_R30_L1.7511.00
89_T135_P1.7351.00
89_T93_E1.6891.00
47_T51_R1.6821.00
19_S163_N1.6261.00
51_R121_V1.6251.00
133_V148_E1.5791.00
114_A123_T1.5491.00
169_G173_A1.5281.00
3_T28_E1.5071.00
62_P115_Y1.4951.00
6_F17_A1.4851.00
170_R173_A1.4741.00
47_T121_V1.4541.00
47_T123_T1.4511.00
92_I135_P1.4421.00
133_V136_R1.4301.00
78_F86_V1.4271.00
22_D25_R1.4271.00
51_R55_R1.4201.00
40_D44_A1.4131.00
50_A114_A1.3821.00
42_L71_F1.3771.00
5_R53_A1.3711.00
122_E178_W1.3701.00
148_E151_G1.3361.00
161_R164_A1.3341.00
93_E97_E1.3201.00
115_Y175_F1.2951.00
3_T26_R1.2591.00
43_A123_T1.2571.00
96_W146_I1.2261.00
52_E56_E1.2221.00
54_Y116_T1.2201.00
157_M161_R1.2091.00
57_T61_T1.1691.00
8_T14_V1.1681.00
42_L68_A1.1581.00
57_T63_V1.1371.00
152_T157_M1.1361.00
110_R127_A1.1251.00
88_D91_G1.1081.00
57_T60_D1.1021.00
5_R61_T1.1001.00
54_Y117_D1.0901.00
43_A114_A1.0861.00
107_A132_M1.0811.00
129_Q150_D1.0711.00
91_G94_R1.0711.00
53_A63_V1.0631.00
17_A113_V1.0581.00
47_T114_A1.0461.00
48_H52_E1.0431.00
11_S15_Q1.0421.00
174_T177_D1.0161.00
14_V29_Q1.0121.00
64_I113_V1.0091.00
70_L132_M0.9931.00
23_G176_A0.9901.00
116_T121_V0.9901.00
39_S48_H0.9871.00
124_F175_F0.9761.00
73_R77_G0.9721.00
50_A116_T0.9621.00
95_V146_I0.9521.00
64_I175_F0.9491.00
90_L93_E0.9461.00
139_G158_P0.9451.00
113_V175_F0.9451.00
92_I145_P0.9311.00
47_T116_T0.9301.00
96_W105_R0.9261.00
174_T178_W0.9191.00
51_R116_T0.9111.00
154_F157_M0.9081.00
176_A180_A0.9051.00
5_R63_V0.9001.00
106_H129_Q0.8931.00
173_A176_A0.8841.00
74_G102_L0.8821.00
112_V125_T0.8781.00
37_L52_E0.8760.99
83_S143_Y0.8730.99
68_A111_C0.8720.99
32_Y37_L0.8650.99
41_D81_P0.8640.99
131_T148_E0.8640.99
14_V18_A0.8630.99
33_D37_L0.8570.99
112_V123_T0.8480.99
12_G17_A0.8470.99
131_T150_D0.8460.99
113_V172_L0.8400.99
45_I81_P0.8390.99
137_G155_A0.8350.99
128_V165_L0.8320.99
124_F174_T0.8290.99
133_V146_I0.8260.99
91_G95_V0.8240.99
19_S159_T0.8210.99
128_V170_R0.8040.99
87_E91_G0.8020.99
52_E55_R0.8010.99
96_W133_V0.8010.99
5_R57_T0.7930.99
86_V94_R0.7820.99
173_A177_D0.7790.99
92_I95_V0.7580.99
149_H157_M0.7580.99
81_P85_Y0.7570.99
19_S22_D0.7560.99
17_A172_L0.7540.98
151_G161_R0.7530.98
117_D120_T0.7400.98
144_D162_K0.7360.98
15_Q19_S0.7320.98
27_V30_L0.7320.98
6_F64_I0.7270.98
101_D105_R0.7260.98
102_L105_R0.7250.98
99_A132_M0.7200.98
106_H131_T0.7110.98
92_I96_W0.7100.98
37_L48_H0.7050.98
102_L106_H0.6990.98
31_D37_L0.6980.98
15_Q18_A0.6940.97
17_A21_L0.6920.97
177_D180_A0.6900.97
41_D44_A0.6900.97
131_T151_G0.6890.97
73_R129_Q0.6890.97
40_D82_Y0.6880.97
162_K166_S0.6880.97
88_D95_V0.6840.97
40_D81_P0.6750.97
12_G88_D0.6730.97
138_D156_E0.6730.97
31_D34_Y0.6670.97
94_R97_E0.6670.97
70_L109_F0.6660.97
15_Q159_T0.6640.97
68_A92_I0.6630.97
111_C171_A0.6600.97
126_G170_R0.6590.96
112_V124_F0.6590.96
11_S18_A0.6560.96
154_F165_L0.6550.96
16_E162_K0.6550.96
20_Y159_T0.6530.96
42_L110_R0.6530.96
170_R174_T0.6520.96
153_T156_E0.6480.96
16_E163_N0.6470.96
109_F154_F0.6450.96
35_A56_E0.6420.96
141_F162_K0.6390.96
109_F146_I0.6390.96
64_I115_Y0.6360.96
32_Y35_A0.6310.96
54_Y62_P0.6270.95
38_Q81_P0.6270.95
98_L101_D0.6250.95
99_A105_R0.6250.95
152_T156_E0.6220.95
109_F143_Y0.6210.95
151_G165_L0.6170.95
35_A48_H0.6140.95
34_Y53_A0.6130.95
136_R152_T0.6120.95
24_L180_A0.6090.95
9_T30_L0.6090.95
115_Y122_E0.6060.94
34_Y49_G0.6040.94
20_Y113_V0.6030.94
137_G141_F0.6010.94
141_F144_D0.6010.94
60_D63_V0.5900.94
164_A169_G0.5890.94
54_Y63_V0.5890.94
46_A123_T0.5880.93
55_R60_D0.5860.93
12_G20_Y0.5860.93
175_F179_L0.5860.93
132_M146_I0.5790.93
152_T158_P0.5790.93
4_L115_Y0.5780.93
42_L69_G0.5760.93
96_W99_A0.5760.93
135_P145_P0.5750.93
105_R132_M0.5740.93
20_Y172_L0.5740.93
136_R153_T0.5720.93
19_S160_D0.5610.92
34_Y52_E0.5590.92
18_A22_D0.5560.91
88_D92_I0.5560.91
76_S79_P0.5510.91
89_T92_I0.5480.91
43_A112_V0.5450.91
137_G140_G0.5410.90
90_L94_R0.5390.90
66_D113_V0.5380.90
9_T53_A0.5380.90
35_A52_E0.5350.90
104_D131_T0.5320.90
105_R133_V0.5300.89
114_A121_V0.5300.89
125_T174_T0.5300.89
163_N166_S0.5290.89
71_F77_G0.5290.89
21_L176_A0.5280.89
116_T119_D0.5250.89
42_L81_P0.5240.89
112_V126_G0.5230.89
157_M165_L0.5200.89
16_E168_R0.5190.88
155_A163_N0.5190.88
135_P146_I0.5180.88
150_D170_R0.5180.88
111_C167_H0.5160.88
11_S14_V0.5160.88
151_G157_M0.5140.88
62_P117_D0.5120.88
9_T29_Q0.5090.87
72_V75_L0.5090.87
141_F145_P0.5090.87
103_D131_T0.5070.87
54_Y61_T0.5060.87
20_Y163_N0.5060.87
91_G146_I0.5030.87
68_A83_S0.5020.87
72_V107_A0.5010.87
32_Y53_A0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v7rA 1 0.9837 100 0.073 Contact Map
1b78A 2 0.9674 100 0.079 Contact Map
2carA 2 0.9837 100 0.083 Contact Map
1k7kA 1 0.9783 100 0.101 Contact Map
1vp2A 3 0.9674 100 0.117 Contact Map
3tquA 2 0.9783 100 0.137 Contact Map
4bnqA 2 0.9837 100 0.154 Contact Map
1ex2A 2 0.8207 96.1 0.892 Contact Map
4jhcA 2 0.8261 96 0.893 Contact Map
4p0eA 2 0.8207 95.4 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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