GREMLIN Database
Q9HNL0 - Uncharacterized protein
UniProt: Q9HNL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (119)
Sequences: 132 (105)
Seq/√Len: 9.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_D70_G4.6991.00
24_E27_R3.4030.96
5_A83_L3.1440.94
22_F69_C3.0570.93
95_V106_V2.9460.91
83_L95_V2.6800.87
83_L106_V2.3380.78
13_L21_L2.2300.74
42_D45_V2.1370.71
6_I83_L2.1110.70
52_G57_A2.0980.69
23_E28_L2.0420.67
37_P105_R2.0270.67
45_V67_D1.9550.64
21_L51_A1.8530.59
17_Q20_R1.7450.55
29_L32_Y1.7450.55
25_L52_G1.7100.53
16_T20_R1.6840.52
37_P86_L1.6590.51
13_L17_Q1.5590.46
10_A96_V1.5540.46
79_A86_L1.4890.43
50_G55_A1.4700.42
56_S92_V1.4380.41
23_E47_L1.4320.41
16_T54_T1.4220.40
9_N83_L1.4200.40
72_L115_H1.3990.39
62_V91_D1.3510.37
81_D105_R1.3500.37
17_Q119_R1.3480.37
38_Q73_R1.3190.36
40_V69_C1.3130.36
106_V114_I1.2920.35
104_E110_G1.2870.34
41_H71_T1.2400.33
100_G103_K1.1930.31
5_A106_V1.1840.30
57_A117_R1.1820.30
30_G96_V1.1770.30
7_D11_L1.1580.29
13_L98_N1.1520.29
102_L105_R1.0910.27
57_A68_R1.0840.27
19_L116_L1.0820.27
16_T118_G1.0660.26
33_D108_D1.0650.26
40_V72_L1.0650.26
25_L73_R1.0640.26
25_L37_P1.0420.25
35_V91_D1.0340.25
38_Q41_H1.0310.25
110_G115_H1.0240.25
4_V84_H1.0230.25
13_L16_T1.0160.24
112_P116_L1.0080.24
47_L79_A1.0040.24
19_L57_A0.9960.24
5_A95_V0.9950.24
28_L105_R0.9930.24
34_A114_I0.9880.24
19_L119_R0.9660.23
46_A78_Y0.9560.22
41_H65_A0.9550.22
13_L110_G0.9420.22
27_R57_A0.9340.22
9_N98_N0.9330.22
37_P82_A0.9320.22
11_L85_A0.9200.21
111_T115_H0.9160.21
22_F60_V0.9040.21
24_E52_G0.9020.21
10_A60_V0.8930.21
18_P72_L0.8900.20
12_L16_T0.8870.20
79_A82_A0.8830.20
16_T75_D0.8740.20
19_L52_G0.8690.20
115_H121_Q0.8680.20
13_L103_K0.8590.20
114_I122_L0.8510.19
19_L117_R0.8490.19
41_H100_G0.8300.19
87_A95_V0.8280.19
30_G77_S0.8150.18
51_A89_S0.8120.18
34_A59_S0.8100.18
38_Q111_T0.7970.18
103_K108_D0.7910.18
13_L96_V0.7900.18
30_G94_A0.7820.17
74_T123_T0.7780.17
32_Y115_H0.7730.17
107_L115_H0.7550.17
27_R78_Y0.7540.17
35_V41_H0.7480.17
67_D112_P0.7450.17
5_A92_V0.7380.16
28_L117_R0.7350.16
39_A82_A0.7350.16
24_E118_G0.7340.16
45_V62_V0.7220.16
6_I100_G0.7190.16
4_V115_H0.7190.16
73_R110_G0.7180.16
59_S124_I0.7130.16
41_H49_A0.7110.16
29_L114_I0.7100.16
6_I21_L0.7080.16
18_P34_A0.7060.16
27_R52_G0.7060.16
23_E124_I0.7040.16
58_A65_A0.6970.15
94_A103_K0.6900.15
61_G72_L0.6890.15
29_L112_P0.6880.15
5_A9_N0.6860.15
15_A60_V0.6820.15
9_N106_V0.6800.15
4_V38_Q0.6790.15
36_V112_P0.6750.15
22_F40_V0.6740.15
25_L41_H0.6730.15
62_V118_G0.6720.15
5_A94_A0.6700.15
67_D123_T0.6680.15
72_L87_A0.6670.15
104_E112_P0.6550.14
15_A121_Q0.6430.14
40_V52_G0.6410.14
19_L37_P0.6400.14
105_R117_R0.6340.14
5_A79_A0.6310.14
47_L55_A0.6290.14
4_V41_H0.6230.14
68_R87_A0.6160.14
88_V110_G0.6130.14
110_G124_I0.6110.13
56_S68_R0.6060.13
49_A95_V0.6040.13
76_V95_V0.6030.13
10_A16_T0.6020.13
16_T122_L0.6000.13
84_H105_R0.5990.13
50_G96_V0.5950.13
63_D101_P0.5900.13
114_I119_R0.5880.13
8_T121_Q0.5870.13
45_V48_A0.5830.13
15_A47_L0.5810.13
47_L56_S0.5790.13
14_P113_V0.5780.13
13_L109_A0.5580.12
21_L116_L0.5550.12
41_H70_G0.5530.12
21_L100_G0.5490.12
13_L122_L0.5480.12
83_L96_V0.5430.12
43_E97_T0.5420.12
43_E80_D0.5420.12
43_E99_D0.5420.12
80_D99_D0.5420.12
80_D97_T0.5420.12
25_L96_V0.5390.12
20_R63_D0.5390.12
27_R60_V0.5340.12
55_A81_D0.5320.12
10_A58_A0.5310.12
4_V7_D0.5280.12
47_L78_Y0.5280.12
68_R79_A0.5270.12
4_V95_V0.5260.12
23_E40_V0.5160.12
30_G92_V0.5100.12
101_P108_D0.5060.11
51_A123_T0.5060.11
68_R101_P0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mj7A 2 0.9449 99.9 0.495 Contact Map
1o4wA 2 0.9685 99.7 0.65 Contact Map
2dokA 2 0.8898 99.5 0.688 Contact Map
3i8oA 2 0.9055 99.4 0.706 Contact Map
3ix7A 2 0.937 99.4 0.709 Contact Map
2lcqA 1 0.8425 98.8 0.773 Contact Map
2hwyA 1 0.7717 98.8 0.776 Contact Map
3tndA 3 0.8661 97.9 0.826 Contact Map
4chgA 2 0.8583 97.9 0.828 Contact Map
3zvkA 3 0.8819 97.7 0.834 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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