GREMLIN Database
IF2G - Translation initiation factor 2 subunit gamma
UniProt: Q9HNK9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 414 (344)
Sequences: 17570 (8321)
Seq/√Len: 448.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
287_A293_L4.6071.00
246_E286_S3.9401.00
145_A181_V3.8601.00
244_E286_S3.7601.00
179_V195_A2.9401.00
155_E159_Q2.6201.00
249_D316_P2.5261.00
212_L242_D2.4971.00
80_A84_E2.4471.00
211_P240_L2.4121.00
246_E249_D2.2721.00
47_I52_A2.2031.00
119_N151_L2.1951.00
247_A285_D2.1631.00
194_D198_T2.1161.00
181_V192_V2.1031.00
170_G173_A2.0751.00
348_D353_E1.9961.00
48_R52_A1.9691.00
250_E271_T1.9471.00
161_Y180_P1.9381.00
348_D351_T1.9131.00
206_D209_A1.9121.00
244_E288_S1.8981.00
48_R51_Y1.8901.00
78_D86_T1.8501.00
211_P245_L1.8271.00
154_A158_R1.8261.00
49_L52_A1.8151.00
111_G200_I1.8111.00
13_G109_M1.7921.00
161_Y165_Q1.7901.00
161_Y178_V1.7851.00
32_E190_D1.7851.00
47_I51_Y1.7831.00
348_D357_L1.7781.00
247_A283_D1.7591.00
128_E167_F1.7511.00
354_P358_T1.7321.00
351_T354_P1.7151.00
209_A242_D1.7091.00
118_A146_Q1.7051.00
162_E166_A1.6831.00
288_S291_G1.6831.00
236_I308_A1.6701.00
213_L238_G1.6581.00
113_V145_A1.6531.00
354_P357_L1.6441.00
46_S49_L1.6441.00
211_P251_L1.6421.00
195_A199_E1.6341.00
238_G295_V1.6241.00
348_D352_G1.6231.00
352_G357_L1.6191.00
159_Q163_E1.6101.00
348_D354_P1.5871.00
353_E357_L1.5731.00
12_I87_V1.5721.00
240_L287_A1.5721.00
26_V89_F1.5711.00
47_I50_G1.5711.00
252_E317_P1.5681.00
349_I354_P1.5641.00
346_I352_G1.5521.00
240_L293_L1.5471.00
60_P65_P1.5441.00
355_L358_T1.5351.00
61_D70_V1.5331.00
360_G364_T1.5181.00
235_V294_G1.5131.00
351_T356_M1.5061.00
219_F237_G1.5011.00
351_T357_L1.5011.00
14_L26_V1.4991.00
46_S51_Y1.4951.00
340_A343_G1.4891.00
346_I357_L1.4771.00
348_D356_M1.4651.00
353_E358_T1.4611.00
46_S50_G1.4611.00
78_D84_E1.4581.00
348_D355_L1.4571.00
76_E86_T1.4511.00
46_S52_A1.4441.00
353_E356_M1.4381.00
348_D358_T1.4331.00
215_A236_I1.4331.00
352_G355_L1.4161.00
341_A344_E1.4091.00
56_L75_P1.4071.00
117_G120_E1.4041.00
276_S283_D1.3981.00
25_L115_V1.3951.00
254_R315_G1.3771.00
131_L164_I1.3761.00
349_I358_T1.3751.00
85_R197_Q1.3631.00
342_D345_Q1.3531.00
28_A31_G1.3521.00
351_T358_T1.3431.00
346_I349_I1.3421.00
350_S353_E1.3311.00
158_R162_E1.3231.00
349_I356_M1.3231.00
80_A194_D1.3131.00
349_I357_L1.3091.00
352_G356_M1.3031.00
351_T355_L1.2991.00
116_V127_T1.2941.00
325_E328_E1.2921.00
160_N163_E1.2901.00
8_P85_R1.2711.00
245_L295_V1.2571.00
36_Q55_T1.2521.00
347_D351_T1.2521.00
279_A282_E1.2481.00
28_A186_E1.2461.00
341_A345_Q1.2421.00
360_G363_T1.2371.00
284_V287_A1.2371.00
144_I164_I1.2371.00
368_V374_G1.2341.00
147_N183_A1.2341.00
29_L77_H1.2331.00
349_I352_G1.2321.00
349_I353_E1.2281.00
182_S185_Q1.2231.00
177_P199_E1.2211.00
295_V314_A1.2181.00
120_E124_Q1.2131.00
77_H87_V1.2061.00
207_P288_S1.2051.00
346_I351_T1.2011.00
352_G358_T1.2011.00
347_D354_P1.2011.00
145_A183_A1.1981.00
369_T372_R1.1961.00
80_A197_Q1.1931.00
346_I354_P1.1901.00
349_I355_L1.1801.00
25_L183_A1.1771.00
112_A134_L1.1691.00
149_V180_P1.1691.00
346_I355_L1.1651.00
346_I356_M1.1561.00
79_T194_D1.1541.00
239_S292_L1.1521.00
144_I178_V1.1501.00
103_L133_A1.1501.00
15_V134_L1.1441.00
347_D352_G1.1351.00
346_I358_T1.1341.00
252_E257_R1.1331.00
339_G345_Q1.1331.00
347_D353_E1.1311.00
33_W193_I1.1311.00
338_V341_A1.1241.00
149_V187_I1.1131.00
372_R379_A1.1121.00
213_L240_L1.1081.00
59_C71_A1.0991.00
77_H89_F1.0951.00
346_I353_E1.0901.00
143_V195_A1.0831.00
359_V363_T1.0801.00
25_L192_V1.0791.00
114_L144_I1.0791.00
347_D355_L1.0731.00
324_W327_F1.0731.00
339_G344_E1.0681.00
146_Q180_P1.0631.00
338_V343_G1.0591.00
330_D333_L1.0591.00
334_L337_L1.0591.00
340_A344_E1.0561.00
11_N88_S1.0531.00
252_E320_L1.0531.00
326_S379_A1.0511.00
251_L270_V1.0481.00
130_H133_A1.0461.00
28_A189_V1.0451.00
316_P319_S1.0401.00
122_V127_T1.0381.00
334_L339_G1.0361.00
350_S355_L1.0341.00
336_R339_G1.0341.00
347_D358_T1.0331.00
275_R284_V1.0321.00
15_V112_A1.0321.00
90_V109_M1.0301.00
331_V376_C1.0271.00
334_L338_V1.0261.00
339_G342_D1.0241.00
326_S329_M1.0231.00
181_V188_N1.0201.00
150_D182_S1.0141.00
207_P244_E1.0051.00
251_L314_A1.0011.00
388_A391_K0.9961.00
112_A139_I0.9931.00
325_E329_M0.9931.00
258_E307_D0.9931.00
274_V277_L0.9891.00
309_L312_Q0.9881.00
87_V197_Q0.9871.00
256_G312_Q0.9851.00
359_V364_T0.9831.00
330_D336_R0.9821.00
326_S377_E0.9801.00
340_A345_Q0.9801.00
347_D356_M0.9771.00
177_P195_A0.9701.00
58_R73_T0.9681.00
157_A180_P0.9641.00
146_Q157_A0.9601.00
162_E165_Q0.9601.00
8_P84_E0.9591.00
28_A32_E0.9531.00
190_D194_D0.9521.00
328_E377_E0.9491.00
255_P312_Q0.9471.00
238_G293_L0.9411.00
58_R71_A0.9371.00
207_P289_P0.9361.00
315_G321_P0.9361.00
333_L336_R0.9361.00
338_V345_Q0.9341.00
33_W77_H0.9301.00
143_V200_I0.9271.00
26_V56_L0.9271.00
350_S354_P0.9271.00
328_E375_E0.9271.00
157_A160_N0.9241.00
359_V362_A0.9191.00
350_S358_T0.9151.00
335_E338_V0.9141.00
338_V342_D0.9131.00
245_L274_V0.9111.00
324_W328_E0.9111.00
272_T283_D0.9111.00
56_L69_T0.9071.00
250_E317_P0.9061.00
158_R161_Y0.9041.00
192_V197_Q0.9041.00
192_V196_L0.9031.00
163_E166_A0.9031.00
116_V164_I0.8991.00
350_S357_L0.8951.00
157_A161_Y0.8951.00
337_L340_A0.8951.00
143_V179_V0.8931.00
25_L145_A0.8911.00
37_H48_R0.8911.00
14_L113_V0.8891.00
210_D316_P0.8881.00
362_A365_V0.8861.00
273_D276_S0.8761.00
24_T183_A0.8731.00
63_D67_C0.8721.00
336_R344_E0.8691.00
37_H46_S0.8671.00
114_L127_T0.8621.00
15_V114_L0.8621.00
339_G343_G0.8601.00
361_T364_T0.8571.00
165_Q169_E0.8551.00
72_E90_V0.8531.00
350_S356_M0.8521.00
245_L287_A0.8491.00
61_D66_E0.8491.00
336_R343_G0.8451.00
144_I176_A0.8441.00
172_V175_D0.8431.00
12_I196_L0.8371.00
131_L142_I0.8351.00
29_L189_V0.8351.00
56_L73_T0.8291.00
118_A149_V0.8271.00
242_D321_P0.8231.00
338_V344_E0.8181.00
215_A308_A0.8181.00
13_G92_A0.8161.00
245_L251_L0.8161.00
347_D357_L0.8151.00
330_D375_E0.8131.00
287_A291_G0.8131.00
339_G379_A0.8121.00
194_D197_Q0.8071.00
336_R340_A0.8061.00
113_V143_V0.8051.00
253_L308_A0.8021.00
32_E186_E0.7981.00
331_V334_L0.7971.00
134_L142_I0.7971.00
19_D95_H0.7961.00
274_V278_Q0.7931.00
193_I197_Q0.7921.00
315_G320_L0.7911.00
154_A159_Q0.7901.00
25_L189_V0.7881.00
60_P64_E0.7841.00
346_I350_S0.7841.00
212_L321_P0.7771.00
253_L314_A0.7751.00
339_G381_K0.7721.00
246_E285_D0.7691.00
32_E189_V0.7671.00
334_L343_G0.7611.00
158_R180_P0.7611.00
269_P273_D0.7591.00
207_P210_D0.7581.00
115_V147_N0.7561.00
188_N191_L0.7561.00
29_L193_I0.7541.00
324_W329_M0.7521.00
272_T302_S0.7461.00
347_D350_S0.7451.00
250_E269_P0.7441.00
328_E331_V0.7441.00
369_T374_G0.7431.00
336_R345_Q0.7421.00
195_A198_T0.7401.00
208_S244_E0.7401.00
30_S35_D0.7391.00
205_R209_A0.7341.00
13_G106_A0.7331.00
331_V338_V0.7321.00
13_G112_A0.7281.00
165_Q175_D0.7241.00
284_V291_G0.7181.00
119_N153_D0.7171.00
273_D278_Q0.7151.00
256_G309_L0.7141.00
368_V372_R0.7141.00
145_A192_V0.7131.00
205_R289_P0.7121.00
164_I168_V0.7111.00
331_V336_R0.7101.00
205_R242_D0.7081.00
210_D319_S0.7081.00
316_P320_L0.7061.00
362_A366_G0.7041.00
184_E188_N0.7031.00
122_V160_N0.7021.00
17_H20_H0.7021.00
270_V273_D0.7011.00
9_E88_S0.7001.00
71_A101_T0.6941.00
193_I196_L0.6931.00
113_V196_L0.6921.00
252_E318_G0.6921.00
337_L345_Q0.6911.00
116_V144_I0.6911.00
31_G38_S0.6901.00
272_T276_S0.6831.00
221_I235_V0.6831.00
333_L338_V0.6821.00
114_L130_H0.6811.00
252_E315_G0.6791.00
164_I167_F0.6771.00
244_E289_P0.6691.00
333_L357_L0.6691.00
334_L341_A0.6681.00
155_E158_R0.6671.00
16_G20_H0.6661.00
281_G294_G0.6631.00
18_V95_H0.6631.00
159_Q162_E0.6591.00
30_S55_T0.6551.00
111_G143_V0.6541.00
166_A169_E0.6541.00
18_V68_Y0.6521.00
250_E270_V0.6440.99
213_L295_V0.6400.99
160_N164_I0.6400.99
334_L342_D0.6390.99
245_L270_V0.6390.99
111_G201_A0.6370.99
363_T370_S0.6370.99
180_P187_I0.6350.99
215_A314_A0.6340.99
118_A154_A0.6330.99
128_E132_M0.6300.99
63_D66_E0.6300.99
275_R278_Q0.6290.99
370_S375_E0.6270.99
242_D387_P0.6230.99
218_S310_A0.6210.99
51_Y55_T0.6190.99
221_I232_L0.6190.99
252_E271_T0.6180.99
337_L342_D0.6180.99
66_E70_V0.6150.99
79_T84_E0.6140.99
333_L345_Q0.6130.99
274_V283_D0.6120.99
15_V106_A0.6110.99
329_M333_L0.6110.99
29_L33_W0.6060.99
303_L308_A0.6060.99
334_L340_A0.6050.99
30_S75_P0.6040.99
273_D301_P0.6020.99
149_V157_A0.6020.99
185_Q188_N0.6010.99
337_L343_G0.6010.99
10_V203_P0.5980.99
284_V293_L0.5970.99
72_E105_G0.5960.99
334_L345_Q0.5940.99
110_D239_S0.5930.99
213_L245_L0.5930.99
131_L135_D0.5910.99
253_L256_G0.5910.99
278_Q283_D0.5880.99
327_F380_L0.5850.99
165_Q178_V0.5840.99
336_R342_D0.5830.99
317_P320_L0.5820.99
325_E331_V0.5820.99
277_L282_E0.5810.99
253_L272_T0.5800.99
199_E202_T0.5800.99
113_V192_V0.5780.99
86_T291_G0.5770.99
163_E167_F0.5750.99
79_T197_Q0.5730.99
212_L323_T0.5710.99
79_T193_I0.5710.99
219_F294_G0.5710.99
171_T174_E0.5700.99
154_A157_A0.5690.99
273_D303_L0.5680.99
106_A137_I0.5680.99
240_L245_L0.5670.99
368_V371_A0.5670.99
359_V365_V0.5640.99
254_R321_P0.5640.99
114_L164_I0.5620.99
50_G55_T0.5620.99
251_L272_T0.5600.99
238_G314_A0.5590.99
64_E67_C0.5580.99
63_D70_V0.5550.98
35_D77_H0.5540.98
36_Q52_A0.5530.98
272_T278_Q0.5530.98
38_S49_L0.5530.98
329_M332_D0.5520.98
122_V163_E0.5500.98
103_L130_H0.5500.98
327_F330_D0.5500.98
31_G35_D0.5490.98
102_M130_H0.5480.98
368_V382_R0.5470.98
196_L200_I0.5470.98
356_M367_S0.5470.98
17_H124_Q0.5460.98
107_A241_V0.5450.98
19_D68_Y0.5450.98
121_P163_E0.5440.98
327_F331_V0.5430.98
216_A237_G0.5430.98
335_E341_A0.5420.98
365_V368_V0.5410.98
131_L168_V0.5390.98
36_Q49_L0.5390.98
71_A75_P0.5390.98
327_F332_D0.5370.98
75_P277_L0.5370.98
272_T301_P0.5360.98
327_F378_V0.5360.98
331_V339_G0.5330.98
250_E273_D0.5330.98
7_Q85_R0.5330.98
132_M135_D0.5320.98
10_V202_T0.5320.98
18_V69_T0.5320.98
92_A102_M0.5310.98
333_L340_A0.5310.98
76_E88_S0.5310.98
253_L312_Q0.5270.98
211_P244_E0.5240.98
99_M133_A0.5240.98
52_A55_T0.5230.98
360_G374_G0.5230.98
220_D234_G0.5220.98
135_D168_V0.5220.98
235_V281_G0.5220.98
146_Q161_Y0.5210.98
330_D334_L0.5210.98
366_G370_S0.5210.98
61_D369_T0.5210.98
86_T275_R0.5200.98
254_R320_L0.5200.98
336_R341_A0.5180.98
111_G196_L0.5180.98
36_Q48_R0.5160.98
329_M334_L0.5160.98
96_E125_P0.5160.98
61_D65_P0.5150.98
273_D283_D0.5150.98
273_D277_L0.5130.98
154_A160_N0.5120.97
170_G174_E0.5110.97
60_P374_G0.5100.97
96_E129_E0.5090.97
215_A238_G0.5090.97
335_E344_E0.5080.97
172_V176_A0.5080.97
127_T144_I0.5070.97
360_G366_G0.5060.97
337_L344_E0.5060.97
335_E343_G0.5020.97
120_E151_L0.5010.97
330_D335_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jnyA 1 0.8865 100 0.296 Contact Map
3mcaA 1 0.7947 100 0.305 Contact Map
4d61i 1 0.9082 100 0.309 Contact Map
3wy9A 1 0.9106 100 0.309 Contact Map
1d2eA 3 0.8889 100 0.31 Contact Map
4crnP 1 0.913 100 0.311 Contact Map
1f60A 1 0.9227 100 0.312 Contact Map
2c78A 1 0.8937 100 0.317 Contact Map
1r5bA 1 0.8261 100 0.319 Contact Map
3avxA 1 0.8478 100 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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