GREMLIN Database
Q9HNK7 - ATP-binding protein
UniProt: Q9HNK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (216)
Sequences: 8081 (6004)
Seq/√Len: 408.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_A190_P5.1331.00
191_D243_D3.5341.00
184_R239_D3.1881.00
161_V168_K3.0011.00
98_P130_R2.7521.00
146_T163_E2.7211.00
144_D163_E2.7081.00
194_V248_V2.5071.00
192_L246_R2.4521.00
237_G245_T2.4271.00
52_I162_V2.3441.00
139_A144_D2.2901.00
98_P128_A2.2631.00
106_D110_G2.2421.00
40_H49_A2.1961.00
150_V157_C2.1941.00
150_V159_G2.1591.00
48_D72_D2.0721.00
185_D188_R2.0261.00
170_A187_M2.0041.00
201_A231_E1.9871.00
75_V145_V1.9861.00
148_V186_A1.9751.00
195_A228_M1.9381.00
61_Q64_R1.9031.00
57_D60_A1.8711.00
169_L194_V1.8591.00
189_D241_D1.8571.00
235_A239_D1.7671.00
73_A98_P1.7651.00
44_E49_A1.7441.00
50_L73_A1.7051.00
75_V160_V1.7011.00
232_G235_A1.6831.00
163_E168_K1.6561.00
150_V172_S1.5971.00
54_F76_V1.5841.00
75_V138_F1.5521.00
103_T131_G1.5481.00
101_A106_D1.5341.00
187_M190_P1.5261.00
137_S140_A1.5051.00
52_I75_V1.5011.00
83_H249_H1.4951.00
133_A136_R1.4911.00
137_S146_T1.4781.00
151_D176_T1.4531.00
161_V190_P1.4451.00
237_G242_A1.4311.00
181_E184_R1.4301.00
197_G247_V1.3981.00
188_R241_D1.3911.00
45_A48_D1.3871.00
37_F171_V1.3821.00
48_D141_A1.3531.00
229_T232_G1.3431.00
38_S58_F1.3431.00
76_V87_L1.3401.00
102_A158_Y1.3381.00
168_K191_D1.3281.00
176_T232_G1.3201.00
51_L58_F1.3161.00
50_L143_F1.3101.00
58_F62_F1.2771.00
137_S144_D1.2711.00
172_S195_A1.2601.00
148_V183_S1.2541.00
181_E239_D1.2541.00
73_A100_Y1.2471.00
161_V170_A1.2431.00
24_C30_R1.2411.00
96_D128_A1.2371.00
103_T107_P1.2261.00
57_D61_Q1.2121.00
149_P156_L1.2101.00
157_C173_G1.2071.00
230_R234_L1.2021.00
56_P59_R1.2001.00
172_S175_T1.1971.00
50_L145_V1.1961.00
224_G227_H1.1631.00
100_Y130_R1.1591.00
167_A191_D1.1591.00
184_R236_L1.1561.00
106_D131_G1.1551.00
187_M240_L1.1541.00
231_E235_A1.1541.00
108_T112_S1.1451.00
81_F85_D1.1421.00
197_G233_A1.1381.00
40_H51_L1.1171.00
242_A245_T1.1071.00
134_P149_P1.1051.00
39_V248_V1.1041.00
132_V160_V1.0901.00
49_A72_D1.0791.00
192_L244_R1.0781.00
146_T186_A1.0721.00
74_G87_L1.0711.00
184_R188_R1.0701.00
145_V162_V1.0681.00
56_P61_Q1.0621.00
49_A70_L1.0601.00
180_P183_S1.0441.00
24_C28_R1.0391.00
35_T60_A1.0381.00
168_K190_P1.0361.00
175_T183_S1.0341.00
107_P114_A1.0301.00
235_A238_D1.0201.00
182_A185_D1.0181.00
91_Y94_F1.0011.00
195_A233_A0.9951.00
153_P226_K0.9911.00
169_L192_L0.9901.00
67_A70_L0.9901.00
68_L90_A0.9881.00
59_R63_L0.9871.00
147_L160_V0.9841.00
60_A64_R0.9801.00
54_F58_F0.9761.00
181_E185_D0.9701.00
41_V162_V0.9691.00
188_R239_D0.9671.00
52_I160_V0.9671.00
227_H230_R0.9661.00
35_T64_R0.9631.00
79_V104_D0.9611.00
200_P203_L0.9551.00
120_K123_Y0.9541.00
77_T160_V0.9501.00
132_V138_F0.9491.00
159_G172_S0.9461.00
193_L237_G0.9391.00
39_V194_V0.9291.00
24_C29_E0.9211.00
104_D156_L0.9171.00
195_A236_L0.9151.00
96_D126_S0.9061.00
117_V120_K0.9021.00
148_V159_G0.8981.00
183_S186_A0.8931.00
200_P230_R0.8911.00
102_A105_T0.8861.00
184_R240_L0.8841.00
52_I171_V0.8831.00
35_T61_Q0.8811.00
190_P242_A0.8791.00
234_L237_G0.8781.00
101_A105_T0.8731.00
237_G247_V0.8721.00
176_T228_M0.8711.00
79_V105_T0.8691.00
107_P110_G0.8621.00
27_A30_R0.8301.00
80_H152_H0.8231.00
139_A142_G0.8211.00
119_G122_D0.8191.00
48_D143_F0.8191.00
223_F227_H0.8181.00
50_L162_V0.8181.00
39_V52_I0.8061.00
179_I235_A0.8031.00
136_R139_A0.8001.00
229_T233_A0.8001.00
179_I184_R0.7971.00
172_S193_L0.7911.00
40_H44_E0.7891.00
164_R168_K0.7891.00
150_V173_G0.7811.00
250_A254_Y0.7781.00
111_E114_A0.7781.00
107_P111_E0.7781.00
48_D73_A0.7761.00
258_E262_D0.7761.00
132_V147_L0.7731.00
103_T133_A0.7731.00
151_D180_P0.7701.00
119_G123_Y0.7681.00
104_D131_G0.7671.00
88_G112_S0.7651.00
36_R56_P0.7641.00
172_S183_S0.7641.00
161_V186_A0.7631.00
39_V171_V0.7601.00
164_R167_A0.7601.00
197_G230_R0.7601.00
198_I251_A0.7591.00
199_V225_T0.7591.00
50_L75_V0.7531.00
233_A237_G0.7441.00
196_D228_M0.7431.00
234_L238_D0.7401.00
148_V161_V0.7391.00
106_D129_L0.7301.00
48_D140_A0.7291.00
257_E260_F0.7251.00
41_V52_I0.7251.00
226_K230_R0.7221.00
65_T68_L0.7201.00
151_D175_T0.7191.00
132_V158_Y0.7171.00
32_V255_P0.7141.00
136_R147_L0.7121.00
136_R140_A0.7061.00
78_H174_D0.7051.00
163_E166_G0.7051.00
137_S147_L0.7051.00
62_F71_P0.6991.00
75_V100_Y0.6971.00
228_M236_L0.6971.00
179_I236_L0.6941.00
51_L54_F0.6921.00
80_H174_D0.6871.00
56_P60_A0.6871.00
221_R225_T0.6831.00
48_D142_G0.6770.99
60_A63_L0.6730.99
59_R89_N0.6720.99
72_D95_D0.6700.99
203_L254_Y0.6640.99
78_H152_H0.6620.99
258_E261_A0.6590.99
45_A142_G0.6560.99
87_L99_V0.6560.99
176_T226_K0.6530.99
53_D78_H0.6480.99
173_G249_H0.6480.99
187_M193_L0.6480.99
54_F74_G0.6480.99
38_S55_S0.6470.99
159_G170_A0.6370.99
52_I77_T0.6370.99
41_V169_L0.6350.99
62_F68_L0.6340.99
26_A30_R0.6330.99
26_A32_V0.6330.99
189_D243_D0.6300.99
74_G97_L0.6280.99
110_G114_A0.6260.99
255_P258_E0.6240.99
230_R254_Y0.6240.99
34_R38_S0.6230.99
220_P224_G0.6230.99
79_V108_T0.6190.99
33_E60_A0.6150.99
227_H234_L0.6150.99
204_T232_G0.6140.99
256_V259_A0.6120.99
74_G90_A0.6090.99
190_P193_L0.6080.99
38_S51_L0.6080.99
44_E47_G0.6080.99
259_A262_D0.6050.99
56_P249_H0.6010.99
175_T195_A0.6000.99
196_D227_H0.5980.99
72_D141_A0.5960.99
53_D80_H0.5940.99
150_V175_T0.5920.99
79_V84_L0.5900.99
79_V102_A0.5900.99
152_H227_H0.5890.99
145_V160_V0.5860.99
24_C27_A0.5840.99
50_L140_A0.5830.99
56_P86_G0.5830.99
35_T38_S0.5810.98
28_R257_E0.5790.98
223_F226_K0.5790.98
170_A193_L0.5760.98
136_R146_T0.5720.98
182_A186_A0.5720.98
135_R182_A0.5720.98
25_Q28_R0.5710.98
146_T161_V0.5680.98
227_H236_L0.5620.98
175_T196_D0.5580.98
175_T180_P0.5570.98
51_L71_P0.5560.98
53_D171_V0.5560.98
152_H174_D0.5540.98
147_L158_Y0.5530.98
86_G251_A0.5530.98
75_V140_A0.5520.98
197_G229_T0.5510.98
260_F263_E0.5510.98
45_A164_R0.5510.98
76_V105_T0.5500.98
45_A143_F0.5480.98
193_L242_A0.5480.98
237_G241_D0.5460.98
180_P184_R0.5440.98
227_H240_L0.5430.98
79_V101_A0.5390.98
138_F147_L0.5390.98
228_M233_A0.5370.97
201_A204_T0.5360.97
230_R233_A0.5360.97
234_L245_T0.5330.97
189_D242_A0.5320.97
84_L109_T0.5310.97
102_A149_P0.5310.97
172_S196_D0.5290.97
148_V187_M0.5240.97
143_F162_V0.5240.97
247_V250_A0.5240.97
171_V194_V0.5210.97
109_T113_V0.5200.97
37_F248_V0.5190.97
77_T171_V0.5180.97
53_D174_D0.5130.97
56_P89_N0.5130.97
193_L233_A0.5080.96
38_S54_F0.5080.96
228_M234_L0.5070.96
135_R149_P0.5060.96
56_P83_H0.5050.96
57_D62_F0.5050.96
191_D241_D0.5030.96
172_S187_M0.5030.96
171_V248_V0.5000.96
80_H227_H0.5000.96
88_G93_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jxpA 2 0.9487 100 0.356 Contact Map
3zwfA 2 0.7949 100 0.368 Contact Map
1y44A 2 0.8535 100 0.383 Contact Map
2cbnA 2 0.8535 100 0.384 Contact Map
3md7A 2 0.8755 100 0.405 Contact Map
3g1pA 2 0.8608 100 0.406 Contact Map
1zkpA 2 0.8242 100 0.455 Contact Map
4ojvA 2 0.8535 100 0.489 Contact Map
2e7yA 2 0.7985 100 0.494 Contact Map
3bk2A 2 0.8242 100 0.54 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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