GREMLIN Database
Q9HNK6 - Aaa superfamily atpase
UniProt: Q9HNK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (298)
Sequences: 14631 (7794)
Seq/√Len: 451.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_E294_A5.3851.00
272_A290_A5.1721.00
291_A295_E4.3121.00
276_S289_P4.2331.00
267_D270_M3.4571.00
93_A96_T3.1261.00
245_H248_E2.6031.00
275_I304_L2.5971.00
272_A276_S2.5881.00
273_D276_S2.5091.00
99_L106_D2.4571.00
276_S286_D2.3961.00
97_V100_D2.3511.00
27_R30_A2.3481.00
268_E290_A2.3401.00
95_L99_L2.2491.00
197_F242_A2.2251.00
184_V196_L2.2211.00
101_D155_H2.2001.00
273_D277_L2.1751.00
241_G257_F2.1631.00
285_A288_D2.1171.00
23_W26_D1.9901.00
265_R300_T1.9081.00
307_V311_A1.9031.00
23_W30_A1.8481.00
207_T216_I1.8371.00
100_D155_H1.8091.00
135_K227_I1.8061.00
38_V42_V1.7981.00
71_L74_E1.7801.00
32_R36_N1.7721.00
305_R309_R1.7681.00
35_A38_V1.7651.00
33_I37_P1.7651.00
318_E327_D1.6451.00
33_I36_N1.6451.00
64_D67_W1.6181.00
49_V53_T1.6111.00
26_D30_A1.6061.00
114_K314_D1.6001.00
49_V52_E1.5931.00
291_A294_A1.5911.00
29_A33_I1.5901.00
29_A32_R1.5861.00
30_A34_S1.5801.00
37_P41_F1.5661.00
272_A289_P1.5591.00
279_T308_L1.5561.00
137_L257_F1.5431.00
97_V156_Q1.5381.00
36_N40_A1.5341.00
222_T226_S1.4901.00
138_F263_F1.4881.00
25_V29_A1.4711.00
94_E156_Q1.4611.00
31_D34_S1.4611.00
324_T327_D1.4591.00
32_R35_A1.4391.00
23_W27_R1.4211.00
186_E190_R1.4211.00
150_A240_I1.4201.00
28_A31_D1.4171.00
28_A32_R1.4141.00
33_I40_A1.4121.00
114_K318_E1.4121.00
153_L240_I1.3891.00
205_A253_A1.3861.00
25_V28_A1.3851.00
22_D26_D1.3841.00
35_A39_L1.3831.00
21_I25_V1.3821.00
280_S284_I1.3791.00
24_F27_R1.3751.00
61_V64_D1.3671.00
20_A23_W1.3651.00
29_A36_N1.3441.00
282_V308_L1.3431.00
30_A33_I1.3381.00
320_R327_D1.3331.00
280_S283_D1.3281.00
272_A286_D1.3071.00
254_W260_I1.3061.00
34_S40_A1.3031.00
204_V223_L1.3021.00
25_V31_D1.3021.00
65_P69_D1.2931.00
121_H124_Y1.2911.00
309_R313_L1.2811.00
177_T180_N1.2811.00
36_N43_F1.2641.00
37_P40_A1.2611.00
103_V277_L1.2561.00
278_V281_E1.2541.00
85_D190_R1.2511.00
268_E293_A1.2441.00
36_N39_L1.2401.00
106_D270_M1.2371.00
33_I39_L1.2341.00
68_I72_L1.2321.00
275_I292_L1.2251.00
67_W71_L1.2201.00
160_P191_L1.2141.00
295_E311_A1.2041.00
23_W34_S1.1991.00
63_A71_L1.1941.00
47_F51_Y1.1921.00
40_A43_F1.1771.00
226_S239_L1.1761.00
275_I289_P1.1761.00
28_A35_A1.1681.00
192_S236_D1.1661.00
50_D53_T1.1601.00
60_P64_D1.1581.00
24_F28_A1.1571.00
290_A294_A1.1571.00
109_E149_T1.1531.00
93_A97_V1.1511.00
41_F44_G1.1501.00
53_T57_A1.1491.00
122_R127_T1.1441.00
321_T327_D1.1441.00
201_F241_G1.1381.00
55_R60_P1.1371.00
271_R293_A1.1301.00
95_L110_A1.1241.00
23_W31_D1.1231.00
25_V34_S1.1231.00
311_A315_A1.1231.00
291_A325_Q1.1191.00
46_E50_D1.1141.00
28_A33_I1.1141.00
255_R302_S1.1131.00
31_D36_N1.1131.00
34_S37_P1.1091.00
59_R62_Q1.1061.00
162_V194_C1.1041.00
23_W28_A1.1011.00
58_N61_V1.1011.00
139_V243_T1.0991.00
21_I24_F1.0961.00
30_A40_A1.0951.00
118_A121_H1.0931.00
31_D40_A1.0851.00
162_V196_L1.0821.00
26_D29_A1.0751.00
28_A34_S1.0741.00
29_A34_S1.0721.00
176_E179_K1.0661.00
51_Y54_A1.0631.00
71_L75_Y1.0621.00
51_Y55_R1.0591.00
171_S177_T1.0411.00
99_L109_E1.0331.00
278_V305_R1.0231.00
84_L236_D1.0221.00
20_A28_A1.0181.00
30_A37_P1.0171.00
36_N41_F1.0111.00
264_P270_M1.0071.00
30_A44_G1.0051.00
39_L43_F1.0021.00
25_V32_R0.9971.00
23_W33_I0.9941.00
31_D35_A0.9931.00
25_V30_A0.9921.00
64_D68_I0.9881.00
101_D152_G0.9881.00
54_A58_N0.9841.00
137_L201_F0.9771.00
23_W44_G0.9721.00
54_A57_A0.9711.00
107_D264_P0.9711.00
78_E81_E0.9631.00
20_A34_S0.9531.00
27_R32_R0.9461.00
157_L238_L0.9451.00
68_I71_L0.9421.00
269_G272_A0.9411.00
25_V33_I0.9401.00
139_V260_I0.9381.00
287_F290_A0.9381.00
20_A24_F0.9351.00
171_S178_A0.9341.00
74_E78_E0.9331.00
23_W37_P0.9211.00
103_V273_D0.9171.00
23_W41_F0.9161.00
166_L198_M0.9141.00
27_R34_S0.9111.00
110_A114_K0.9081.00
291_A311_A0.9081.00
285_A322_E0.9061.00
182_E232_L0.9021.00
85_D93_A0.8951.00
288_D325_Q0.8911.00
150_A197_F0.8911.00
70_G77_D0.8891.00
30_A36_N0.8881.00
321_T324_T0.8841.00
173_Y179_K0.8841.00
279_T284_I0.8821.00
288_D291_A0.8821.00
31_D37_P0.8751.00
251_A254_W0.8741.00
106_D110_A0.8651.00
34_S38_V0.8591.00
22_D28_A0.8581.00
59_R63_A0.8581.00
162_V188_A0.8571.00
28_A36_N0.8561.00
21_I28_A0.8491.00
26_D34_S0.8471.00
52_E56_D0.8401.00
111_E261_L0.8391.00
27_R31_D0.8361.00
60_P63_A0.8321.00
284_I288_D0.8301.00
162_V191_L0.8291.00
40_A44_G0.8261.00
320_R324_T0.8241.00
38_V43_F0.8231.00
34_S39_L0.8151.00
20_A32_R0.8151.00
282_V323_L0.8141.00
22_D30_A0.8131.00
25_V36_N0.8111.00
37_P43_F0.8081.00
61_V71_L0.8071.00
303_D307_V0.8071.00
295_E307_V0.8061.00
45_D52_E0.8021.00
45_D48_G0.8011.00
24_F31_D0.8001.00
161_F197_F0.7971.00
32_R38_V0.7961.00
29_A39_L0.7961.00
308_L312_V0.7941.00
72_L75_Y0.7921.00
32_R37_P0.7921.00
200_E244_N0.7911.00
268_E272_A0.7891.00
71_L79_D0.7861.00
34_S43_F0.7811.00
83_M86_L0.7791.00
171_S180_N0.7771.00
29_A40_A0.7771.00
173_Y178_A0.7741.00
25_V40_A0.7711.00
34_S41_F0.7711.00
101_D148_S0.7701.00
21_I33_I0.7701.00
305_R308_L0.7691.00
185_F232_L0.7681.00
29_A37_P0.7681.00
47_F50_D0.7631.00
123_D127_T0.7581.00
26_D31_D0.7581.00
63_A67_W0.7571.00
60_P68_I0.7551.00
64_D74_E0.7491.00
149_T263_F0.7491.00
161_F195_I0.7481.00
58_N63_A0.7481.00
70_G73_E0.7471.00
307_V313_L0.7461.00
24_F29_A0.7461.00
48_G52_E0.7441.00
48_G51_Y0.7421.00
270_M273_D0.7351.00
20_A27_R0.7311.00
200_E256_R0.7281.00
84_L87_V0.7261.00
25_V39_L0.7261.00
259_E310_E0.7231.00
31_D39_L0.7211.00
108_Q261_L0.7201.00
20_A33_I0.7181.00
308_L328_L0.7151.00
164_V184_V0.7151.00
32_R41_F0.7121.00
67_W74_E0.7101.00
21_I30_A0.7081.00
152_G155_H0.7071.00
69_D72_L0.7051.00
296_T304_L0.7051.00
272_A293_A0.7051.00
20_A26_D0.7021.00
46_E49_V0.7011.00
65_P68_I0.7001.00
118_A122_R0.6971.00
32_R40_A0.6971.00
58_N64_D0.6961.00
39_L42_V0.6931.00
25_V41_F0.6921.00
230_I235_D0.6921.00
25_V37_P0.6911.00
303_D306_L0.6871.00
24_F34_S0.6861.00
35_A40_A0.6861.00
74_E81_E0.6841.00
171_S179_K0.6841.00
21_I26_D0.6821.00
97_V155_H0.6811.00
26_D44_G0.6791.00
322_E326_D0.6751.00
107_D110_A0.6751.00
246_P260_I0.6741.00
286_D290_A0.6731.00
313_L317_V0.6691.00
275_I293_A0.6691.00
67_W72_L0.6671.00
169_I183_K0.6641.00
71_L80_D0.6641.00
282_V305_R0.6631.00
64_D71_L0.6621.00
50_D54_A0.6621.00
122_R125_L0.6611.00
26_D41_F0.6591.00
173_Y177_T0.6581.00
279_T289_P0.6581.00
36_N44_G0.6571.00
89_V93_A0.6531.00
269_G290_A0.6501.00
31_D41_F0.6491.00
275_I308_L0.6461.00
105_T108_Q0.6451.00
127_T133_V0.6451.00
28_A41_F0.6451.00
27_R33_I0.6441.00
21_I31_D0.6441.00
54_A61_V0.6420.99
53_T56_D0.6400.99
22_D25_V0.6390.99
24_F30_A0.6380.99
22_D27_R0.6360.99
63_A74_E0.6350.99
98_S102_I0.6340.99
70_G74_E0.6330.99
287_F325_Q0.6290.99
312_V317_V0.6290.99
198_M223_L0.6270.99
54_A60_P0.6260.99
27_R36_N0.6260.99
228_D305_R0.6220.99
86_L90_R0.6220.99
229_E232_L0.6210.99
28_A37_P0.6210.99
314_D318_E0.6180.99
173_Y180_N0.6180.99
111_E259_E0.6180.99
71_L78_E0.6160.99
57_A62_Q0.6150.99
223_L227_I0.6150.99
71_L76_F0.6120.99
30_A38_V0.6100.99
75_Y78_E0.6080.99
62_Q67_W0.6070.99
312_V316_L0.6070.99
29_A35_A0.6070.99
181_V222_T0.6050.99
284_I289_P0.6050.99
30_A35_A0.6030.99
88_D93_A0.6010.99
85_D160_P0.5980.99
53_T58_N0.5970.99
177_T181_V0.5950.99
28_A40_A0.5940.99
172_Q176_E0.5900.99
55_R72_L0.5900.99
309_R314_D0.5880.99
47_F52_E0.5870.99
49_V55_R0.5850.99
23_W29_A0.5840.99
21_I29_A0.5830.99
82_E86_L0.5810.99
150_A161_F0.5760.99
24_F37_P0.5750.99
22_D31_D0.5750.99
26_D32_R0.5730.99
309_R312_V0.5720.99
25_V43_F0.5720.99
110_A317_V0.5700.99
24_F33_I0.5700.99
56_D59_R0.5650.99
55_R64_D0.5640.99
95_L120_E0.5640.99
74_E77_D0.5630.99
21_I27_R0.5620.99
27_R40_A0.5620.99
292_L311_A0.5610.99
162_V187_V0.5610.99
172_Q181_V0.5600.99
32_R39_L0.5590.99
199_D256_R0.5580.99
30_A41_F0.5570.99
68_I74_E0.5560.99
306_L309_R0.5530.98
62_Q66_Q0.5530.98
76_F80_D0.5520.98
55_R58_N0.5490.98
55_R68_I0.5460.98
44_G48_G0.5460.98
38_V41_F0.5450.98
76_F79_D0.5450.98
85_D89_V0.5440.98
65_P70_G0.5410.98
220_V250_D0.5410.98
128_I131_N0.5390.98
23_W43_F0.5390.98
20_A25_V0.5390.98
33_I44_G0.5350.98
45_D49_V0.5350.98
187_V191_L0.5340.98
86_L89_V0.5340.98
55_R63_A0.5300.98
177_T219_A0.5300.98
73_E80_D0.5300.98
21_I37_P0.5290.98
74_E80_D0.5290.98
72_L78_E0.5280.98
63_A68_I0.5280.98
23_W36_N0.5280.98
37_P44_G0.5270.98
284_I311_A0.5270.98
27_R41_F0.5250.98
29_A41_F0.5240.98
182_E185_F0.5210.98
30_A39_L0.5200.98
269_G273_D0.5200.98
63_A78_E0.5160.98
280_S308_L0.5150.98
24_F32_R0.5150.98
102_I148_S0.5150.98
285_A324_T0.5140.98
138_F153_L0.5130.98
22_D34_S0.5110.97
99_L152_G0.5100.97
51_Y58_N0.5100.97
170_T207_T0.5090.97
201_F249_L0.5080.97
51_Y60_P0.5050.97
69_D73_E0.5050.97
110_A113_S0.5030.97
192_S232_L0.5020.97
24_F38_V0.5010.97
23_W32_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cr2J 1 0.9214 100 0.356 Contact Map
2ce7A 3 0.7317 100 0.375 Contact Map
3cf2A 3 0.7724 100 0.378 Contact Map
4ww0A 4 0.7344 100 0.385 Contact Map
4cr2L 1 0.8916 100 0.385 Contact Map
4cr2M 1 0.8889 100 0.397 Contact Map
2zanA 1 0.7019 100 0.399 Contact Map
2qp9X 1 0.6694 100 0.404 Contact Map
1xwiA 1 0.729 100 0.411 Contact Map
4ko8A 3 0.8645 100 0.412 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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