GREMLIN Database
Q9HNK4 - Probable acetyl-coa acetyltransferase
UniProt: Q9HNK4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (371)
Sequences: 15087 (8072)
Seq/√Len: 419.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_Q208_R3.4491.00
197_E347_D3.3581.00
36_T280_E3.2891.00
282_F286_H3.2621.00
141_R144_V2.9711.00
203_L244_L2.8691.00
129_I377_P2.8391.00
35_T281_A2.8311.00
69_H72_A2.7941.00
211_E215_A2.6881.00
204_Q207_R2.6431.00
280_E284_R2.6261.00
282_F285_D2.6071.00
214_D240_P2.5841.00
380_L392_A2.5771.00
189_E255_K2.5081.00
198_Q259_S2.4441.00
38_V283_A2.4131.00
42_A378_V2.3951.00
318_L322_T2.3701.00
318_L407_S2.3651.00
136_V277_V2.3441.00
67_I145_I2.3211.00
43_Y73_E2.2761.00
70_I276_L2.1771.00
219_D233_E2.1191.00
292_A381_I2.0971.00
143_A278_T2.0851.00
132_A144_V2.0781.00
213_T238_I2.0171.00
384_M389_A2.0061.00
296_D322_T2.0061.00
194_T197_E1.9951.00
331_L358_V1.9921.00
237_G267_Q1.9651.00
63_S86_W1.9551.00
77_T80_H1.9471.00
40_A278_T1.9421.00
136_V279_S1.9381.00
65_T225_V1.9101.00
226_Q231_L1.9041.00
291_L385_N1.9011.00
324_E391_K1.8991.00
36_T293_R1.8981.00
210_A214_D1.8201.00
196_T200_E1.8131.00
187_V193_I1.8041.00
210_A238_I1.8001.00
293_R409_E1.7831.00
273_A374_A1.7761.00
247_L263_G1.7721.00
80_H286_H1.7491.00
296_D318_L1.7381.00
53_V232_V1.7071.00
330_D389_A1.7031.00
142_D279_S1.6971.00
213_T222_I1.6911.00
219_D234_E1.6781.00
346_R353_N1.6661.00
346_R356_F1.6561.00
316_R320_D1.6561.00
359_N383_E1.6491.00
278_T283_A1.6471.00
278_T282_F1.6381.00
315_T395_T1.6281.00
190_R306_V1.6201.00
326_I332_V1.6071.00
217_R359_N1.5961.00
329_F407_S1.5811.00
70_I74_T1.5801.00
324_E329_F1.5641.00
65_T223_V1.5591.00
181_G254_F1.5561.00
279_S282_F1.5541.00
246_A249_E1.5531.00
213_T234_E1.5531.00
204_Q353_N1.5511.00
383_E387_R1.5461.00
86_W147_G1.5461.00
134_D140_Q1.5441.00
203_L207_R1.5431.00
135_A141_R1.5421.00
142_D282_F1.5391.00
220_D385_N1.5351.00
329_F332_V1.5251.00
275_T374_A1.5231.00
41_A74_T1.5231.00
38_V293_R1.5181.00
116_A131_R1.5081.00
61_D106_L1.5081.00
69_H223_V1.4991.00
132_A277_V1.4961.00
151_N154_R1.4871.00
63_S103_I1.4801.00
67_I103_I1.4751.00
313_P316_R1.4711.00
200_E244_L1.4661.00
331_L383_E1.4621.00
383_E386_K1.4471.00
200_E204_Q1.4431.00
217_R383_E1.4341.00
324_E407_S1.4291.00
68_D72_A1.4271.00
207_R241_D1.4131.00
54_Y232_V1.4031.00
66_V274_A1.3901.00
377_P408_F1.3881.00
207_R211_E1.3741.00
143_A282_F1.3691.00
295_G409_E1.3691.00
35_T279_S1.3681.00
66_V272_A1.3611.00
69_H73_E1.3551.00
352_D355_R1.3441.00
130_M406_I1.3241.00
332_V393_L1.3141.00
319_L326_I1.3111.00
390_G409_E1.3061.00
298_N317_G1.3031.00
99_V149_V1.3011.00
111_E303_N1.2981.00
227_T230_G1.2981.00
41_A70_I1.2951.00
298_N318_L1.2891.00
47_Q371_A1.2811.00
210_A241_D1.2791.00
317_G320_D1.2661.00
197_E200_E1.2551.00
217_R386_K1.2381.00
123_A404_A1.2291.00
389_A392_A1.2261.00
82_D141_R1.2211.00
329_F391_K1.2151.00
281_A285_D1.2131.00
57_T65_T1.2091.00
358_V383_E1.2031.00
393_L407_S1.2021.00
381_I385_N1.1951.00
64_V106_L1.1951.00
81_I143_A1.1951.00
316_R348_E1.1891.00
130_M297_H1.1881.00
314_A405_A1.1871.00
86_W274_A1.1861.00
129_I275_T1.1771.00
378_V382_H1.1721.00
193_I198_Q1.1711.00
43_Y223_V1.1661.00
88_V91_Q1.1651.00
300_A313_P1.1581.00
145_I276_L1.1421.00
123_A398_V1.1391.00
47_Q365_V1.1391.00
37_P277_V1.1381.00
195_R261_T1.1361.00
220_D386_K1.1271.00
221_E379_T1.1221.00
38_V280_E1.1211.00
312_V316_R1.1141.00
315_T393_L1.1021.00
185_E255_K1.0991.00
201_Y342_T1.0991.00
42_A382_H1.0971.00
388_D392_A1.0961.00
322_T407_S1.0931.00
302_V309_I1.0901.00
82_D142_D1.0881.00
85_Q144_V1.0841.00
126_M377_P1.0781.00
38_V278_T1.0771.00
132_A146_A1.0741.00
140_Q321_R1.0731.00
325_D328_E1.0721.00
306_V309_I1.0691.00
330_D355_R1.0591.00
80_H282_F1.0561.00
182_M255_K1.0531.00
201_Y343_L1.0441.00
309_I312_V1.0391.00
210_A240_P1.0371.00
65_T69_H1.0361.00
220_D382_H1.0321.00
193_I343_L1.0291.00
296_D321_R1.0241.00
186_E190_R1.0231.00
294_V406_I1.0231.00
67_I109_L1.0201.00
46_P232_V1.0201.00
35_T142_D1.0171.00
127_E131_R1.0141.00
137_R140_Q1.0121.00
244_L248_G1.0101.00
87_G124_S1.0071.00
39_I408_F1.0051.00
242_T247_L1.0051.00
295_G391_K0.9971.00
181_G253_V0.9931.00
358_V387_R0.9841.00
300_A317_G0.9831.00
380_L394_A0.9801.00
330_D384_M0.9801.00
191_H309_I0.9771.00
213_T219_D0.9751.00
134_D138_A0.9741.00
227_T232_V0.9721.00
80_H285_D0.9691.00
326_I329_F0.9661.00
203_L247_L0.9621.00
84_L104_A0.9601.00
250_L263_G0.9571.00
42_A381_I0.9571.00
129_I277_V0.9551.00
375_R379_T0.9541.00
331_L387_R0.9461.00
43_Y69_H0.9451.00
291_L381_I0.9361.00
296_D407_S0.9351.00
71_L109_L0.9341.00
273_A371_A0.9321.00
165_L170_S0.9291.00
190_R305_E0.9281.00
351_I356_F0.9281.00
204_Q354_D0.9261.00
280_E293_R0.9241.00
66_V69_H0.9211.00
41_A73_E0.9211.00
395_T398_V0.9211.00
64_V68_D0.9201.00
329_F393_L0.9101.00
359_N386_K0.9101.00
185_E189_E0.9071.00
174_N178_L0.9051.00
332_V351_I0.8961.00
207_R210_A0.8941.00
51_G164_H0.8921.00
40_A288_L0.8921.00
109_L113_V0.8901.00
376_L394_A0.8881.00
391_K409_E0.8861.00
191_H348_E0.8851.00
71_L76_L0.8811.00
48_G236_E0.8801.00
133_A294_V0.8801.00
45_T66_V0.8801.00
58_R61_D0.8781.00
331_L380_L0.8711.00
377_P406_I0.8701.00
47_Q269_S0.8701.00
203_L241_D0.8691.00
309_I344_Y0.8691.00
188_A340_S0.8681.00
317_G321_R0.8671.00
391_K407_S0.8671.00
398_V402_Q0.8661.00
250_L261_T0.8601.00
88_V95_Q0.8581.00
196_T248_G0.8581.00
278_T288_L0.8541.00
85_Q128_A0.8541.00
243_T246_A0.8511.00
120_R127_E0.8501.00
209_A238_I0.8471.00
168_G172_Q0.8471.00
214_D234_E0.8441.00
85_Q116_A0.8421.00
46_P65_T0.8421.00
187_V309_I0.8411.00
70_I145_I0.8411.00
187_V344_Y0.8391.00
36_T137_R0.8371.00
45_T62_L0.8371.00
273_A378_V0.8361.00
398_V404_A0.8351.00
309_I348_E0.8291.00
146_A275_T0.8281.00
362_A372_S0.8271.00
315_T349_L0.8271.00
381_I408_F0.8261.00
294_V297_H0.8261.00
215_A386_K0.8241.00
85_Q132_A0.8221.00
37_P279_S0.8211.00
45_T65_T0.8171.00
199_D264_N0.8151.00
252_T255_K0.8121.00
213_T240_P0.8091.00
346_R351_I0.8061.00
133_A137_R0.8051.00
105_L111_E0.8011.00
47_Q375_R0.7991.00
186_E189_E0.7991.00
128_A374_A0.7981.00
280_E283_A0.7961.00
42_A275_T0.7951.00
80_H143_A0.7941.00
339_A363_I0.7921.00
82_D317_G0.7921.00
334_L395_T0.7881.00
140_Q297_H0.7791.00
342_T346_R0.7791.00
251_P262_P0.7771.00
49_K237_G0.7761.00
211_E217_R0.7761.00
37_P133_A0.7741.00
281_A284_R0.7711.00
167_P171_E0.7691.00
312_V348_E0.7681.00
71_L81_I0.7651.00
289_D385_N0.7641.00
59_S149_V0.7621.00
81_I145_I0.7611.00
388_D391_K0.7601.00
211_E214_D0.7591.00
302_V313_P0.7591.00
153_S270_D0.7591.00
315_T405_A0.7571.00
57_T61_D0.7551.00
66_V70_I0.7541.00
184_A340_S0.7521.00
398_V403_G0.7501.00
45_T225_V0.7501.00
255_K258_G0.7481.00
359_N387_R0.7471.00
84_L113_V0.7381.00
208_R211_E0.7351.00
170_S174_N0.7331.00
209_A213_T0.7331.00
302_V310_G0.7311.00
197_E343_L0.7281.00
37_P137_R0.7281.00
264_N339_A0.7271.00
70_I274_A0.7191.00
130_M404_A0.7181.00
126_M406_I0.7131.00
63_S147_G0.7121.00
88_V99_V0.7111.00
131_R134_D0.7091.00
242_T263_G0.7081.00
242_T246_A0.7081.00
203_L243_T0.7041.00
212_A216_G0.7011.00
316_R349_L0.7001.00
131_R135_A0.6991.00
334_L345_S0.6991.00
135_A140_Q0.6991.00
196_T244_L0.6971.00
327_D355_R0.6961.00
83_D135_A0.6961.00
58_R154_R0.6881.00
384_M392_A0.6871.00
315_T334_L0.6871.00
168_G171_E0.6871.00
203_L246_A0.6851.00
179_E182_M0.6851.00
86_W100_A0.6851.00
324_E328_E0.6841.00
206_Q237_G0.6841.00
83_D299_V0.6841.00
134_D137_R0.6831.00
167_P170_S0.6821.00
145_I274_A0.6811.00
206_Q238_I0.6801.00
203_L242_T0.6791.00
216_G219_D0.6791.00
126_M394_A0.6751.00
170_S173_Y0.6741.00
82_D144_V0.6731.00
326_I351_I0.6721.00
68_D78_G0.6701.00
245_E249_E0.6691.00
53_V236_E0.6691.00
120_R299_V0.6670.99
291_L382_H0.6670.99
57_T154_R0.6670.99
327_D350_G0.6670.99
295_G322_T0.6650.99
319_L324_E0.6620.99
71_L78_G0.6580.99
65_T68_D0.6560.99
85_Q131_R0.6510.99
344_Y348_E0.6500.99
109_L145_I0.6480.99
142_D321_R0.6470.99
37_P136_V0.6460.99
169_L172_Q0.6450.99
143_A286_H0.6400.99
237_G269_S0.6390.99
299_V404_A0.6390.99
397_C401_G0.6380.99
318_L393_L0.6380.99
71_L75_G0.6380.99
43_Y66_V0.6380.99
74_T276_L0.6350.99
193_I347_D0.6350.99
135_A144_V0.6330.99
89_A369_L0.6290.99
43_Y70_I0.6280.99
78_G110_G0.6280.99
315_T326_I0.6260.99
178_L182_M0.6250.99
182_M186_E0.6240.99
183_T307_M0.6230.99
193_I197_E0.6220.99
169_L174_N0.6220.99
330_D391_K0.6210.99
206_Q210_A0.6210.99
118_I131_R0.6170.99
330_D390_G0.6160.99
209_A364_A0.6150.99
62_L225_V0.6120.99
114_P299_V0.6110.99
61_D64_V0.6100.99
206_Q241_D0.6090.99
39_I277_V0.6070.99
116_A127_E0.6070.99
81_I109_L0.6070.99
38_V282_F0.6060.99
103_I107_S0.6060.99
68_D108_E0.6050.99
275_T378_V0.6040.99
41_A291_L0.6010.99
304_P307_M0.6010.99
60_E106_L0.6000.99
67_I71_L0.5990.99
103_I149_V0.5980.99
63_S149_V0.5980.99
303_N306_V0.5980.99
83_D120_R0.5980.99
208_R353_N0.5980.99
397_C400_F0.5970.99
396_L399_G0.5960.99
397_C403_G0.5950.99
39_I381_I0.5940.99
342_T356_F0.5930.99
290_V293_R0.5920.99
38_V279_S0.5900.99
167_P172_Q0.5900.99
67_I274_A0.5900.99
132_A141_R0.5900.99
60_E95_Q0.5890.99
337_A367_H0.5860.99
142_D285_D0.5860.99
71_L74_T0.5860.99
372_S376_L0.5860.99
217_R387_R0.5850.99
40_A283_A0.5850.99
40_A282_F0.5850.99
332_V395_T0.5850.99
206_Q363_I0.5840.99
64_V107_S0.5840.99
210_A239_R0.5840.99
320_D325_D0.5830.99
67_I107_S0.5830.99
185_E258_G0.5830.99
104_A115_A0.5820.99
377_P394_A0.5820.99
57_T151_N0.5810.99
395_T401_G0.5780.99
253_V262_P0.5770.99
199_D244_L0.5770.99
294_V408_F0.5770.99
277_V294_V0.5770.99
298_N321_R0.5770.99
98_N402_Q0.5750.99
316_R350_G0.5740.98
304_P308_G0.5730.98
295_G324_E0.5730.98
129_I146_A0.5720.98
152_M369_L0.5720.98
395_T399_G0.5710.98
55_A164_H0.5710.98
184_A260_V0.5700.98
187_V191_H0.5700.98
35_T137_R0.5700.98
224_P231_L0.5700.98
191_H306_V0.5700.98
86_W103_I0.5680.98
319_L322_T0.5670.98
79_D112_N0.5670.98
365_V375_R0.5670.98
127_E299_V0.5660.98
129_I374_A0.5660.98
241_D246_A0.5650.98
371_A374_A0.5640.98
394_A398_V0.5640.98
184_A188_A0.5630.98
209_A365_V0.5630.98
157_M162_Y0.5610.98
159_G162_Y0.5590.98
278_T286_H0.5580.98
161_S164_H0.5580.98
343_L347_D0.5580.98
127_E130_M0.5560.98
104_A109_L0.5560.98
46_P222_I0.5550.98
68_D107_S0.5540.98
395_T400_F0.5540.98
56_D154_R0.5530.98
91_Q117_S0.5520.98
227_T231_L0.5520.98
89_A121_W0.5520.98
167_P174_N0.5500.98
260_V265_A0.5500.98
137_R297_H0.5480.98
394_A397_C0.5470.98
221_E382_H0.5460.98
191_H344_Y0.5430.98
199_D248_G0.5430.98
318_L329_F0.5400.98
128_A146_A0.5400.98
67_I84_L0.5400.98
295_G407_S0.5380.98
287_G290_V0.5370.98
76_L276_L0.5370.98
189_E257_D0.5370.98
392_A408_F0.5360.98
166_H173_Y0.5350.98
202_A247_L0.5350.98
147_G274_A0.5330.98
170_S177_E0.5320.98
90_Q155_V0.5320.98
340_S344_Y0.5310.97
200_E353_N0.5300.97
84_L145_I0.5300.97
166_H171_E0.5290.97
399_G402_Q0.5290.97
38_V286_H0.5290.97
126_M404_A0.5270.97
178_L305_E0.5260.97
384_M408_F0.5260.97
43_Y74_T0.5250.97
224_P233_E0.5240.97
51_G153_S0.5220.97
244_L247_L0.5210.97
165_L179_E0.5210.97
82_D113_V0.5200.97
201_Y361_G0.5200.97
374_A378_V0.5190.97
85_Q118_I0.5190.97
361_G364_A0.5170.97
168_G174_N0.5160.97
341_Q345_S0.5160.97
315_T345_S0.5160.97
346_R352_D0.5150.97
328_E391_K0.5150.97
101_R105_L0.5130.97
313_P317_G0.5110.97
180_M337_A0.5100.97
178_L186_E0.5090.97
127_E135_A0.5080.97
305_E308_G0.5050.97
218_F365_V0.5050.97
334_L342_T0.5040.97
202_A206_Q0.5020.97
385_N388_D0.5010.96
315_T319_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wu9A 2 0.922 100 0.292 Contact Map
1ulqA 4 0.9122 100 0.293 Contact Map
2vu1A 4 0.9122 100 0.296 Contact Map
3ss6A 4 0.9195 100 0.299 Contact Map
4n46A 4 0.9122 100 0.303 Contact Map
4e1lA 4 0.9146 100 0.307 Contact Map
1wdkC 2 0.922 100 0.307 Contact Map
4o9aA 4 0.9098 100 0.309 Contact Map
4nzsA 4 0.9122 100 0.309 Contact Map
3svkA 2 0.839 100 0.31 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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