Q9HNK3 - HALSA - GREMLIN Contacts

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Q9HNK3 - Dolichol-P-glucose transferase

UniProt:	Q9HNK3	Sequences: MTSVGIVVPAYDPDIDRLTAYLDALRETFDPAALRVELDAAGPGVADRIRDAGVTVAESTGRRGKGAAITAGFEALDTDVVAFADADGATPAGSLAEVVARVTDGDADLAVGSRRHPDATVESHQTVVRRLLGDGFAWLAGTLLAVDLHDYQCGAKALTAAAWERVREHLYEAGFAWDVELVAVGGALGCRVAEVPITWEDQPGSTVSTVRAPVGLLGALVRARHRAKRLGDSRLHAALAARGSDDRALIDRPGSHE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	257 (214)
Sequences:	47118 (39398)
Seq/√Len:	2693.2

ECOLI - YIBD WBBL WCAA ARNC WCAE GTRB PGAC YAIP
BACSU - GGAA CGED EPSJ SPSA EPSH EPSE YKCC GGAB TUAG YKOT YWDF YFNE CSBB YDAM TAGF SUNS
HALSA - Q9HNK3 Q9HQP4 Q9HQP8 Q9HQQ6 Q9HR08 Q9HSB1 Q9HSC8 Q9HQP3
SULSO - Q7LXF7 Q97TZ0 Q97X05 Q97YG5 Q97TY0 Q97YM4 Q7LXY2 Q97UK7 Q7LXG6 Q97WK7 Q97W52 Q97YN4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
13_P	86_A	3.416	1.00
160_A	164_E	2.991	1.00
14_D	44_G	2.733	1.00
46_A	58_E	2.645	1.00
38_L	58_E	2.570	1.00
5_G	78_T	2.547	1.00
59_S	71_A	2.528	1.00
80_V	102_V	2.428	1.00
71_A	75_A	2.407	1.00
180_E	184_V	2.372	1.00
46_A	50_R	2.328	1.00
10_A	45_V	2.187	1.00
33_A	55_T	2.159	1.00
37_E	72_G	2.127	1.00
7_V	72_G	2.084	1.00
63_R	67_A	2.020	1.00
107_A	193_A	1.995	1.00
101_R	193_A	1.992	1.00
8_V	34_L	1.946	1.00
3_S	79_D	1.934	1.00
44_G	47_D	1.900	1.00
12_D	42_G	1.897	1.00
19_T	23_D	1.894	1.00
5_G	33_A	1.885	1.00
14_D	48_R	1.883	1.00
19_T	48_R	1.879	1.00
162_A	190_C	1.877	1.00
69_I	85_D	1.874	1.00
20_A	89_A	1.798	1.00
57_A	75_A	1.791	1.00
82_A	157_A	1.782	1.00
65_K	69_I	1.753	1.00
108_D	159_T	1.753	1.00
98_V	157_A	1.739	1.00
46_A	56_V	1.712	1.00
90_T	94_S	1.708	1.00
28_T	96_A	1.705	1.00
38_L	41_A	1.702	1.00
101_R	195_V	1.699	1.00
8_V	21_Y	1.647	1.00
4_V	99_V	1.636	1.00
94_S	98_V	1.616	1.00
50_R	58_E	1.597	1.00
102_V	157_A	1.593	1.00
36_V	49_I	1.554	1.00
71_A	74_E	1.548	1.00
10_A	36_V	1.502	1.00
80_V	157_A	1.502	1.00
11_Y	62_R	1.497	1.00
55_T	75_A	1.494	1.00
82_A	94_S	1.485	1.00
82_A	95_L	1.473	1.00
84_A	90_T	1.451	1.00
33_A	78_T	1.448	1.00
69_I	83_F	1.447	1.00
203_P	206_T	1.422	1.00
5_G	76_L	1.391	1.00
74_E	168_E	1.389	1.00
199_W	202_Q	1.388	1.00
165_R	190_C	1.363	1.00
66_G	177_W	1.356	1.00
81_V	160_A	1.356	1.00
10_A	13_P	1.354	1.00
59_S	63_R	1.353	1.00
23_D	27_E	1.351	1.00
48_R	51_D	1.351	1.00
57_A	71_A	1.347	1.00
73_F	163_W	1.340	1.00
19_T	51_D	1.322	1.00
101_R	104_D	1.322	1.00
3_S	31_P	1.315	1.00
13_P	17_R	1.308	1.00
49_I	56_V	1.285	1.00
93_G	97_E	1.276	1.00
97_E	100_A	1.274	1.00
165_R	188_L	1.263	1.00
39_D	62_R	1.258	1.00
29_F	99_V	1.256	1.00
99_V	103_T	1.251	1.00
5_G	35_R	1.235	1.00
96_A	100_A	1.227	1.00
29_F	32_A	1.220	1.00
156_K	182_V	1.206	1.00
10_A	86_A	1.195	1.00
38_L	46_A	1.190	1.00
76_L	160_A	1.182	1.00
37_E	68_A	1.181	1.00
162_A	185_G	1.166	1.00
73_F	83_F	1.160	1.00
161_A	165_R	1.154	1.00
60_T	63_R	1.151	1.00
79_D	159_T	1.150	1.00
59_S	68_A	1.141	1.00
159_T	162_A	1.126	1.00
197_I	200_E	1.125	1.00
60_T	71_A	1.121	1.00
12_D	41_A	1.120	1.00
44_G	48_R	1.097	1.00
65_K	177_W	1.096	1.00
108_D	190_C	1.096	1.00
22_L	34_L	1.092	1.00
4_V	95_L	1.082	1.00
98_V	112_G	1.081	1.00
100_A	104_D	1.054	1.00
97_E	195_V	1.046	1.00
161_A	164_E	1.038	1.00
197_I	201_D	1.035	1.00
26_R	53_G	1.035	1.00
33_A	77_D	1.031	1.00
97_E	101_R	1.010	1.00
97_E	197_I	1.009	1.00
4_V	157_A	1.006	1.00
34_L	54_V	1.003	1.00
67_A	71_A	1.003	1.00
9_P	68_A	1.003	1.00
47_D	50_R	1.000	1.00
21_Y	84_A	0.991	1.00
198_T	201_D	0.987	1.00
82_A	90_T	0.979	1.00
24_A	90_T	0.976	1.00
101_R	105_G	0.973	1.00
102_V	110_A	0.971	1.00
27_E	92_A	0.964	1.00
109_L	185_G	0.963	1.00
22_L	36_V	0.959	1.00
47_D	51_D	0.953	1.00
67_A	171_Y	0.948	1.00
23_D	26_R	0.944	1.00
169_H	172_E	0.942	1.00
89_A	117_P	0.936	1.00
25_L	84_A	0.933	1.00
73_F	81_V	0.929	1.00
163_W	181_L	0.928	1.00
6_I	25_L	0.921	1.00
3_S	78_T	0.919	1.00
109_L	192_V	0.918	1.00
113_S	194_E	0.917	1.00
91_P	94_S	0.907	1.00
170_L	180_E	0.902	1.00
24_A	89_A	0.900	1.00
80_V	99_V	0.899	1.00
102_V	159_T	0.898	1.00
108_D	191_R	0.897	1.00
115_R	198_T	0.896	1.00
69_I	177_W	0.886	1.00
70_T	74_E	0.885	1.00
39_D	68_A	0.883	1.00
98_V	102_V	0.882	1.00
204_G	207_V	0.881	1.00
94_S	112_G	0.881	1.00
91_P	200_E	0.874	1.00
65_K	85_D	0.872	1.00
25_L	34_L	0.868	1.00
55_T	77_D	0.867	1.00
94_S	97_E	0.865	1.00
170_L	173_A	0.856	1.00
6_I	82_A	0.855	1.00
117_P	121_V	0.851	1.00
65_K	153_C	0.848	1.00
3_S	77_D	0.845	1.00
20_A	23_D	0.840	1.00
26_R	54_V	0.839	1.00
105_G	108_D	0.834	1.00
126_T	129_R	0.828	1.00
93_G	96_A	0.824	1.00
101_R	110_A	0.815	1.00
114_R	154_G	0.813	1.00
10_A	18_L	0.799	1.00
166_V	188_L	0.798	1.00
212_A	216_L	0.798	1.00
3_S	103_T	0.796	1.00
29_F	96_A	0.787	1.00
125_Q	128_V	0.782	1.00
39_D	59_S	0.780	1.00
210_V	213_P	0.777	1.00
39_D	63_R	0.777	1.00
37_E	71_A	0.771	1.00
167_R	170_L	0.771	1.00
91_P	198_T	0.763	1.00
60_T	67_A	0.759	1.00
39_D	64_G	0.755	1.00
10_A	49_I	0.753	1.00
107_A	111_V	0.752	1.00
76_L	81_V	0.747	1.00
63_R	68_A	0.743	1.00
20_A	24_A	0.741	1.00
91_P	115_R	0.740	1.00
66_G	70_T	0.739	1.00
205_S	208_S	0.738	1.00
18_L	86_A	0.735	1.00
14_D	19_T	0.733	1.00
127_V	131_L	0.730	1.00
6_I	95_L	0.730	1.00
80_V	159_T	0.716	1.00
99_V	157_A	0.715	1.00
105_G	193_A	0.714	1.00
153_C	156_K	0.713	1.00
203_P	207_V	0.712	1.00
98_V	110_A	0.710	1.00
32_A	95_L	0.709	1.00
22_L	26_R	0.707	1.00
25_L	90_T	0.706	1.00
107_A	191_R	0.703	1.00
35_R	75_A	0.702	1.00
135_G	138_W	0.702	1.00
162_A	165_R	0.700	1.00
113_S	196_P	0.696	1.00
9_P	69_I	0.695	1.00
24_A	93_G	0.694	1.00
89_A	200_E	0.691	1.00
185_G	190_C	0.687	1.00
50_R	56_V	0.685	1.00
55_T	58_E	0.677	1.00
4_V	82_A	0.672	1.00
65_K	68_A	0.671	1.00
46_A	49_I	0.670	1.00
9_P	86_A	0.667	1.00
8_V	36_V	0.665	1.00
21_Y	24_A	0.664	1.00
158_L	163_W	0.663	1.00
137_A	140_A	0.662	1.00
35_R	55_T	0.660	1.00
158_L	181_L	0.660	1.00
74_E	169_H	0.659	1.00
162_A	166_V	0.657	1.00
197_I	202_Q	0.649	1.00
59_S	67_A	0.648	1.00
18_L	49_I	0.648	1.00
217_L	220_L	0.647	1.00
81_V	163_W	0.646	1.00
176_A	179_V	0.638	1.00
36_V	54_V	0.638	1.00
8_V	86_A	0.637	1.00
11_Y	39_D	0.635	1.00
181_L	185_G	0.624	1.00
82_A	155_A	0.624	1.00
214_V	218_G	0.620	1.00
35_R	72_G	0.619	1.00
68_A	71_A	0.619	1.00
108_D	161_A	0.617	1.00
65_K	206_T	0.614	1.00
215_G	219_A	0.613	1.00
111_V	114_R	0.612	1.00
136_F	140_A	0.610	1.00
213_P	217_L	0.609	1.00
18_L	48_R	0.609	1.00
198_T	202_Q	0.608	1.00
21_Y	25_L	0.606	1.00
100_A	103_T	0.603	1.00
32_A	53_G	0.599	1.00
203_P	208_S	0.598	1.00
7_V	37_E	0.598	1.00
118_D	121_V	0.596	1.00
130_R	134_D	0.594	1.00
111_V	194_E	0.591	1.00
20_A	202_Q	0.590	1.00
90_T	95_L	0.590	1.00
73_F	76_L	0.590	1.00
106_D	191_R	0.589	1.00
121_V	124_H	0.587	1.00
68_A	85_D	0.584	1.00
98_V	101_R	0.584	1.00
213_P	216_L	0.579	1.00
83_F	158_L	0.576	1.00
101_R	107_A	0.575	1.00
134_D	138_W	0.575	1.00
80_V	103_T	0.569	1.00
63_R	71_A	0.565	1.00
79_D	161_A	0.564	1.00
136_F	139_L	0.564	1.00
9_P	39_D	0.562	1.00
166_V	185_G	0.560	1.00
28_T	93_G	0.559	1.00
21_Y	88_G	0.556	1.00
158_L	182_V	0.554	1.00
17_R	20_A	0.554	1.00
94_S	155_A	0.552	1.00
17_R	21_Y	0.552	1.00
215_G	218_G	0.552	1.00
14_D	47_D	0.552	1.00
3_S	29_F	0.550	1.00
7_V	76_L	0.548	1.00
216_L	220_L	0.547	1.00
212_A	215_G	0.547	1.00
99_V	102_V	0.547	1.00
28_T	32_A	0.544	1.00
14_D	18_L	0.544	1.00
125_Q	129_R	0.542	1.00
158_L	185_G	0.541	1.00
115_R	200_E	0.541	1.00
40_A	62_R	0.539	1.00
24_A	200_E	0.538	1.00
8_V	25_L	0.533	1.00
108_D	162_A	0.532	1.00
168_E	181_L	0.531	1.00
11_Y	40_A	0.531	1.00
135_G	139_L	0.530	1.00
14_D	43_P	0.530	1.00
193_A	196_P	0.529	1.00
28_T	31_P	0.527	1.00
173_A	176_A	0.527	1.00
113_S	116_H	0.525	1.00
85_D	177_W	0.525	1.00
3_S	99_V	0.523	1.00
214_V	217_L	0.522	1.00
65_K	178_D	0.521	1.00
179_V	183_A	0.519	1.00
40_A	59_S	0.519	1.00
65_K	83_F	0.516	1.00
131_L	134_D	0.515	1.00
59_S	62_R	0.514	1.00
14_D	45_V	0.513	1.00
183_A	187_A	0.513	1.00
5_G	77_D	0.509	1.00
138_W	142_T	0.508	1.00
13_P	45_V	0.507	1.00
129_R	132_L	0.506	1.00
70_T	168_E	0.505	1.00
6_I	32_A	0.503	1.00
98_V	155_A	0.502	1.00
39_D	85_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l7iA	4	0	100	0.315	Contact Map
3bcvA	2	0.677	100	0.329	Contact Map
1xhbA	1	0.9689	100	0.337	Contact Map
2d7iA	1	1	100	0.339	Contact Map
5ajoA	1	0.9961	100	0.339	Contact Map
2z86A	2	0.9339	100	0.354	Contact Map
1qg8A	1	0.8444	100	0.354	Contact Map
4fixA	3	0.9883	100	0.387	Contact Map
3ckjA	2	0.93	100	0.395	Contact Map
2bo4A	4	0.9339	100	0.403	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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