GREMLIN Database
Q9HNK3 - Dolichol-P-glucose transferase
UniProt: Q9HNK3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (214)
Sequences: 47118 (39398)
Seq/√Len: 2693.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_P86_A3.4161.00
160_A164_E2.9911.00
14_D44_G2.7331.00
46_A58_E2.6451.00
38_L58_E2.5701.00
5_G78_T2.5471.00
59_S71_A2.5281.00
80_V102_V2.4281.00
71_A75_A2.4071.00
180_E184_V2.3721.00
46_A50_R2.3281.00
10_A45_V2.1871.00
33_A55_T2.1591.00
37_E72_G2.1271.00
7_V72_G2.0841.00
63_R67_A2.0201.00
107_A193_A1.9951.00
101_R193_A1.9921.00
8_V34_L1.9461.00
3_S79_D1.9341.00
44_G47_D1.9001.00
12_D42_G1.8971.00
19_T23_D1.8941.00
5_G33_A1.8851.00
14_D48_R1.8831.00
19_T48_R1.8791.00
162_A190_C1.8771.00
69_I85_D1.8741.00
20_A89_A1.7981.00
57_A75_A1.7911.00
82_A157_A1.7821.00
65_K69_I1.7531.00
108_D159_T1.7531.00
98_V157_A1.7391.00
46_A56_V1.7121.00
90_T94_S1.7081.00
28_T96_A1.7051.00
38_L41_A1.7021.00
101_R195_V1.6991.00
8_V21_Y1.6471.00
4_V99_V1.6361.00
94_S98_V1.6161.00
50_R58_E1.5971.00
102_V157_A1.5931.00
36_V49_I1.5541.00
71_A74_E1.5481.00
10_A36_V1.5021.00
80_V157_A1.5021.00
11_Y62_R1.4971.00
55_T75_A1.4941.00
82_A94_S1.4851.00
82_A95_L1.4731.00
84_A90_T1.4511.00
33_A78_T1.4481.00
69_I83_F1.4471.00
203_P206_T1.4221.00
5_G76_L1.3911.00
74_E168_E1.3891.00
199_W202_Q1.3881.00
165_R190_C1.3631.00
66_G177_W1.3561.00
81_V160_A1.3561.00
10_A13_P1.3541.00
59_S63_R1.3531.00
23_D27_E1.3511.00
48_R51_D1.3511.00
57_A71_A1.3471.00
73_F163_W1.3401.00
19_T51_D1.3221.00
101_R104_D1.3221.00
3_S31_P1.3151.00
13_P17_R1.3081.00
49_I56_V1.2851.00
93_G97_E1.2761.00
97_E100_A1.2741.00
165_R188_L1.2631.00
39_D62_R1.2581.00
29_F99_V1.2561.00
99_V103_T1.2511.00
5_G35_R1.2351.00
96_A100_A1.2271.00
29_F32_A1.2201.00
156_K182_V1.2061.00
10_A86_A1.1951.00
38_L46_A1.1901.00
76_L160_A1.1821.00
37_E68_A1.1811.00
162_A185_G1.1661.00
73_F83_F1.1601.00
161_A165_R1.1541.00
60_T63_R1.1511.00
79_D159_T1.1501.00
59_S68_A1.1411.00
159_T162_A1.1261.00
197_I200_E1.1251.00
60_T71_A1.1211.00
12_D41_A1.1201.00
44_G48_R1.0971.00
65_K177_W1.0961.00
108_D190_C1.0961.00
22_L34_L1.0921.00
4_V95_L1.0821.00
98_V112_G1.0811.00
100_A104_D1.0541.00
97_E195_V1.0461.00
161_A164_E1.0381.00
197_I201_D1.0351.00
26_R53_G1.0351.00
33_A77_D1.0311.00
97_E101_R1.0101.00
97_E197_I1.0091.00
4_V157_A1.0061.00
34_L54_V1.0031.00
67_A71_A1.0031.00
9_P68_A1.0031.00
47_D50_R1.0001.00
21_Y84_A0.9911.00
198_T201_D0.9871.00
82_A90_T0.9791.00
24_A90_T0.9761.00
101_R105_G0.9731.00
102_V110_A0.9711.00
27_E92_A0.9641.00
109_L185_G0.9631.00
22_L36_V0.9591.00
47_D51_D0.9531.00
67_A171_Y0.9481.00
23_D26_R0.9441.00
169_H172_E0.9421.00
89_A117_P0.9361.00
25_L84_A0.9331.00
73_F81_V0.9291.00
163_W181_L0.9281.00
6_I25_L0.9211.00
3_S78_T0.9191.00
109_L192_V0.9181.00
113_S194_E0.9171.00
91_P94_S0.9071.00
170_L180_E0.9021.00
24_A89_A0.9001.00
80_V99_V0.8991.00
102_V159_T0.8981.00
108_D191_R0.8971.00
115_R198_T0.8961.00
69_I177_W0.8861.00
70_T74_E0.8851.00
39_D68_A0.8831.00
98_V102_V0.8821.00
204_G207_V0.8811.00
94_S112_G0.8811.00
91_P200_E0.8741.00
65_K85_D0.8721.00
25_L34_L0.8681.00
55_T77_D0.8671.00
94_S97_E0.8651.00
170_L173_A0.8561.00
6_I82_A0.8551.00
117_P121_V0.8511.00
65_K153_C0.8481.00
3_S77_D0.8451.00
20_A23_D0.8401.00
26_R54_V0.8391.00
105_G108_D0.8341.00
126_T129_R0.8281.00
93_G96_A0.8241.00
101_R110_A0.8151.00
114_R154_G0.8131.00
10_A18_L0.7991.00
166_V188_L0.7981.00
212_A216_L0.7981.00
3_S103_T0.7961.00
29_F96_A0.7871.00
125_Q128_V0.7821.00
39_D59_S0.7801.00
210_V213_P0.7771.00
39_D63_R0.7771.00
37_E71_A0.7711.00
167_R170_L0.7711.00
91_P198_T0.7631.00
60_T67_A0.7591.00
39_D64_G0.7551.00
10_A49_I0.7531.00
107_A111_V0.7521.00
76_L81_V0.7471.00
63_R68_A0.7431.00
20_A24_A0.7411.00
91_P115_R0.7401.00
66_G70_T0.7391.00
205_S208_S0.7381.00
18_L86_A0.7351.00
14_D19_T0.7331.00
127_V131_L0.7301.00
6_I95_L0.7301.00
80_V159_T0.7161.00
99_V157_A0.7151.00
105_G193_A0.7141.00
153_C156_K0.7131.00
203_P207_V0.7121.00
98_V110_A0.7101.00
32_A95_L0.7091.00
22_L26_R0.7071.00
25_L90_T0.7061.00
107_A191_R0.7031.00
35_R75_A0.7021.00
135_G138_W0.7021.00
162_A165_R0.7001.00
113_S196_P0.6961.00
9_P69_I0.6951.00
24_A93_G0.6941.00
89_A200_E0.6911.00
185_G190_C0.6871.00
50_R56_V0.6851.00
55_T58_E0.6771.00
4_V82_A0.6721.00
65_K68_A0.6711.00
46_A49_I0.6701.00
9_P86_A0.6671.00
8_V36_V0.6651.00
21_Y24_A0.6641.00
158_L163_W0.6631.00
137_A140_A0.6621.00
35_R55_T0.6601.00
158_L181_L0.6601.00
74_E169_H0.6591.00
162_A166_V0.6571.00
197_I202_Q0.6491.00
59_S67_A0.6481.00
18_L49_I0.6481.00
217_L220_L0.6471.00
81_V163_W0.6461.00
176_A179_V0.6381.00
36_V54_V0.6381.00
8_V86_A0.6371.00
11_Y39_D0.6351.00
181_L185_G0.6241.00
82_A155_A0.6241.00
214_V218_G0.6201.00
35_R72_G0.6191.00
68_A71_A0.6191.00
108_D161_A0.6171.00
65_K206_T0.6141.00
215_G219_A0.6131.00
111_V114_R0.6121.00
136_F140_A0.6101.00
213_P217_L0.6091.00
18_L48_R0.6091.00
198_T202_Q0.6081.00
21_Y25_L0.6061.00
100_A103_T0.6031.00
32_A53_G0.5991.00
203_P208_S0.5981.00
7_V37_E0.5981.00
118_D121_V0.5961.00
130_R134_D0.5941.00
111_V194_E0.5911.00
20_A202_Q0.5901.00
90_T95_L0.5901.00
73_F76_L0.5901.00
106_D191_R0.5891.00
121_V124_H0.5871.00
68_A85_D0.5841.00
98_V101_R0.5841.00
213_P216_L0.5791.00
83_F158_L0.5761.00
101_R107_A0.5751.00
134_D138_W0.5751.00
80_V103_T0.5691.00
63_R71_A0.5651.00
79_D161_A0.5641.00
136_F139_L0.5641.00
9_P39_D0.5621.00
166_V185_G0.5601.00
28_T93_G0.5591.00
21_Y88_G0.5561.00
158_L182_V0.5541.00
17_R20_A0.5541.00
94_S155_A0.5521.00
17_R21_Y0.5521.00
215_G218_G0.5521.00
14_D47_D0.5521.00
3_S29_F0.5501.00
7_V76_L0.5481.00
216_L220_L0.5471.00
212_A215_G0.5471.00
99_V102_V0.5471.00
28_T32_A0.5441.00
14_D18_L0.5441.00
125_Q129_R0.5421.00
158_L185_G0.5411.00
115_R200_E0.5411.00
40_A62_R0.5391.00
24_A200_E0.5381.00
8_V25_L0.5331.00
108_D162_A0.5321.00
168_E181_L0.5311.00
11_Y40_A0.5311.00
135_G139_L0.5301.00
14_D43_P0.5301.00
193_A196_P0.5291.00
28_T31_P0.5271.00
173_A176_A0.5271.00
113_S116_H0.5251.00
85_D177_W0.5251.00
3_S99_V0.5231.00
214_V217_L0.5221.00
65_K178_D0.5211.00
179_V183_A0.5191.00
40_A59_S0.5191.00
65_K83_F0.5161.00
131_L134_D0.5151.00
59_S62_R0.5141.00
14_D45_V0.5131.00
183_A187_A0.5131.00
5_G77_D0.5091.00
138_W142_T0.5081.00
13_P45_V0.5071.00
129_R132_L0.5061.00
70_T168_E0.5051.00
6_I32_A0.5031.00
98_V155_A0.5021.00
39_D85_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l7iA 4 0 100 0.315 Contact Map
3bcvA 2 0.677 100 0.329 Contact Map
1xhbA 1 0.9689 100 0.337 Contact Map
2d7iA 1 1 100 0.339 Contact Map
5ajoA 1 0.9961 100 0.339 Contact Map
2z86A 2 0.9339 100 0.354 Contact Map
1qg8A 1 0.8444 100 0.354 Contact Map
4fixA 3 0.9883 100 0.387 Contact Map
3ckjA 2 0.93 100 0.395 Contact Map
2bo4A 4 0.9339 100 0.403 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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