GREMLIN Database
Q9HNK2 - Uncharacterized protein
UniProt: Q9HNK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (125)
Sequences: 1605 (1188)
Seq/√Len: 106.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_E151_T3.4181.00
35_G69_M2.9581.00
67_L90_L2.8361.00
34_V68_V2.5871.00
135_A139_A2.4531.00
42_T64_A2.4141.00
68_V72_V2.4061.00
24_R148_S2.3631.00
43_L61_S2.3581.00
39_D58_N2.2721.00
58_N132_K2.2521.00
27_K76_W2.2351.00
74_D89_R2.2301.00
39_D61_S2.0041.00
74_D152_W1.9891.00
63_E94_H1.8811.00
46_L60_A1.8751.00
110_G114_G1.7211.00
23_A27_K1.6871.00
69_M97_R1.6481.00
58_N108_F1.6471.00
73_N77_T1.6101.00
43_L128_L1.5911.00
40_V132_K1.5841.00
70_F89_R1.5701.00
103_L142_V1.5641.00
98_A102_T1.5511.00
62_I66_I1.5351.00
111_V131_V1.5081.00
24_R144_Y1.4781.00
35_G68_V1.4771.00
103_L139_A1.4281.00
44_L129_I1.4061.00
39_D104_Q1.4031.00
59_V105_Y1.3911.00
100_G142_V1.3891.00
39_D132_K1.3751.00
38_V68_V1.3681.00
92_R150_F1.3471.00
43_L132_K1.3330.99
54_A112_F1.3000.99
46_L57_A1.2960.99
48_E128_L1.2750.99
96_V146_F1.2740.99
62_I101_S1.2690.99
41_T45_V1.2070.99
107_L135_A1.2030.99
144_Y148_S1.1690.99
33_A37_V1.1690.99
31_V72_V1.1570.98
44_L128_L1.1560.98
66_I94_H1.1500.98
132_K136_I1.0990.98
141_L145_V1.0950.98
42_T46_L1.0930.98
58_N105_Y1.0870.98
43_L108_F1.0710.97
133_G137_A1.0620.97
88_R92_R1.0490.97
104_Q139_A1.0470.97
25_F143_N1.0300.97
40_V136_I1.0260.97
21_S24_R1.0220.97
66_I97_R1.0060.96
104_Q131_V1.0010.96
28_F143_N0.9920.96
137_A141_L0.9920.96
90_L94_H0.9890.96
35_G97_R0.9890.96
104_Q136_I0.9790.96
69_M93_S0.9770.96
43_L47_T0.9730.96
29_V33_A0.9730.96
30_S34_V0.9690.95
26_G30_S0.9610.95
78_F93_S0.9560.95
47_T128_L0.9480.95
111_V134_G0.9480.95
107_L139_A0.9330.94
44_L48_E0.9160.94
61_S132_K0.9160.94
91_V95_V0.9110.94
111_V130_A0.9110.94
93_S97_R0.8890.93
54_A108_F0.8870.93
70_F86_V0.8680.92
71_A75_R0.8640.92
97_R147_E0.8610.92
24_R80_D0.8540.91
78_F149_L0.8470.91
102_T106_A0.8440.91
55_A105_Y0.8270.90
36_A69_M0.8250.90
29_V140_M0.8100.89
126_C130_A0.8070.89
145_V149_L0.8000.88
146_F151_T0.7970.88
22_R26_G0.7960.88
70_F151_T0.7870.88
54_A113_Y0.7860.88
108_F132_K0.7830.87
39_D43_L0.7810.87
100_G103_L0.7780.87
39_D65_A0.7730.87
45_V50_A0.7600.86
36_A39_D0.7580.86
62_I65_A0.7520.85
53_W57_A0.7390.84
36_A40_V0.7300.83
28_F65_A0.7040.81
45_V49_A0.7030.81
98_A109_V0.7020.81
102_T107_L0.6990.81
63_E67_L0.6890.80
126_C129_I0.6870.79
67_L94_H0.6870.79
105_Y108_F0.6830.79
36_A70_F0.6800.79
142_V152_W0.6750.78
56_A91_V0.6740.78
35_G136_I0.6730.78
70_F74_D0.6710.78
107_L138_V0.6710.78
107_L111_V0.6700.78
150_F153_H0.6630.77
30_S64_A0.6580.77
146_F150_F0.6540.76
34_V72_V0.6520.76
94_H152_W0.6440.75
30_S76_W0.6430.75
142_V146_F0.6310.73
146_F149_L0.6290.73
78_F144_Y0.6270.73
89_R152_W0.6230.73
35_G77_T0.6220.72
35_G147_E0.6210.72
58_N69_M0.6130.71
62_I144_Y0.6100.71
34_V37_V0.6070.71
35_G72_V0.6070.71
52_V60_A0.6000.70
85_S88_R0.5980.69
41_T49_A0.5970.69
62_I97_R0.5970.69
92_R147_E0.5930.69
97_R151_T0.5820.67
43_L104_Q0.5780.67
55_A113_Y0.5750.66
63_E152_W0.5720.66
108_F112_F0.5710.66
46_L50_A0.5640.65
30_S87_G0.5590.64
132_K135_A0.5560.64
129_I134_G0.5540.64
47_T54_A0.5520.63
74_D94_H0.5490.63
35_G38_V0.5470.63
31_V34_V0.5460.63
55_A59_V0.5450.62
71_A91_V0.5420.62
62_I143_N0.5380.61
140_M145_V0.5380.61
101_S104_Q0.5380.61
66_I90_L0.5330.61
45_V48_E0.5320.61
44_L106_A0.5310.60
102_T105_Y0.5300.60
93_S101_S0.5290.60
70_F96_V0.5270.60
60_A64_A0.5260.60
72_V147_E0.5240.59
47_T61_S0.5240.59
57_A114_G0.5230.59
78_F148_S0.5220.59
86_V90_L0.5200.59
22_R29_V0.5200.59
124_V134_G0.5190.59
50_A56_A0.5190.59
51_G125_D0.5170.58
23_A99_G0.5150.58
127_W130_A0.5110.57
70_F83_S0.5100.57
104_Q143_N0.5090.57
35_G73_N0.5050.57
45_V63_E0.5010.56
37_V137_A0.5010.56
92_R96_V0.5000.56
34_V38_V0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rh5B 1 0.25 11.5 0.937 Contact Map
4lz6A 1 0.8718 8.7 0.94 Contact Map
3mp7B 1 0.2628 8 0.941 Contact Map
2b2hA 3 0.7628 6.8 0.943 Contact Map
1u7gA 3 0.7372 6.2 0.944 Contact Map
4il3A 1 0.9295 5.9 0.944 Contact Map
3v2yA 1 0.5385 4.8 0.947 Contact Map
4humA 1 0.891 4.5 0.948 Contact Map
3ogkQ 1 0.0321 4.2 0.948 Contact Map
1m56D 1 0.2564 3.7 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0065 seconds.