GREMLIN Database
Q9HNJ9 - Uncharacterized protein
UniProt: Q9HNJ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (249)
Sequences: 6663 (5252)
Seq/√Len: 332.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_T171_H4.0821.00
211_E241_E3.5141.00
158_A167_V3.4191.00
214_R238_K3.3931.00
174_D219_E3.3411.00
38_R68_Q3.3041.00
72_L83_A3.0091.00
147_D152_T2.8651.00
145_T152_T2.8371.00
214_R241_E2.7721.00
42_V73_T2.7401.00
232_D235_A2.6191.00
71_L168_F2.6111.00
69_A96_Y2.4911.00
145_T154_T2.4901.00
170_D173_C2.4541.00
142_D212_M2.4421.00
10_S13_P2.4191.00
99_E141_T2.2791.00
165_Q179_A2.1961.00
260_S263_A2.1581.00
94_D138_V2.1361.00
238_K242_H2.0901.00
42_V177_F2.0761.00
151_R173_C2.0711.00
40_A69_A2.0391.00
69_A94_D1.9821.00
155_A166_V1.9041.00
32_Y177_F1.8481.00
98_H157_H1.8471.00
96_Y138_V1.7741.00
155_A168_F1.7701.00
212_M215_R1.7331.00
73_T179_A1.6981.00
202_D205_Q1.6951.00
141_T144_D1.6591.00
174_D217_D1.6491.00
138_V144_D1.6221.00
169_E174_D1.6191.00
39_P67_L1.6061.00
56_A59_E1.5831.00
152_T172_S1.5671.00
52_R56_A1.5591.00
147_D150_S1.5521.00
54_L89_A1.5391.00
241_E245_R1.5221.00
54_L58_E1.5151.00
217_D234_D1.5081.00
102_A106_V1.4941.00
211_E215_R1.4851.00
51_E55_D1.4781.00
262_A266_D1.4681.00
98_H166_V1.4581.00
34_I42_V1.4501.00
211_E245_R1.4481.00
158_A209_D1.4391.00
85_L89_A1.4171.00
175_A222_L1.4091.00
58_E89_A1.3981.00
97_V101_G1.3771.00
207_I241_E1.3741.00
214_R234_D1.3741.00
44_T70_V1.3641.00
40_A71_L1.3611.00
207_I245_R1.3501.00
178_T221_L1.3481.00
140_L166_V1.3361.00
169_E218_P1.3031.00
153_L168_F1.3001.00
176_V216_L1.2981.00
36_A150_S1.2951.00
158_A165_Q1.2931.00
142_D157_H1.2811.00
206_C209_D1.2781.00
169_E176_V1.2631.00
145_T171_H1.2431.00
151_R170_D1.2401.00
32_Y222_L1.2371.00
99_E139_E1.2311.00
16_S60_H1.2221.00
102_A139_E1.2171.00
207_I211_E1.2091.00
50_Y85_L1.2061.00
55_D59_E1.1991.00
152_T171_H1.1981.00
87_A95_V1.1861.00
201_F204_E1.1721.00
14_G151_R1.1631.00
151_R172_S1.1551.00
263_A266_D1.1491.00
153_L170_D1.1451.00
85_L88_E1.1431.00
235_A239_E1.1411.00
143_G154_T1.1401.00
79_H180_D1.1361.00
37_D149_G1.1241.00
42_V168_F1.1241.00
40_A153_L1.1231.00
223_Y226_F1.1201.00
175_A220_T1.1131.00
55_D58_E1.1081.00
245_R249_A1.0971.00
70_V86_L1.0891.00
242_H246_D1.0871.00
211_E214_R1.0841.00
154_T216_L1.0811.00
160_G209_D1.0681.00
10_S14_G1.0621.00
39_P62_I1.0581.00
205_Q208_D1.0571.00
33_V39_P1.0461.00
259_H267_H1.0451.00
70_V83_A1.0361.00
50_Y54_L1.0331.00
73_T168_F1.0301.00
154_T169_E1.0291.00
83_A95_V1.0081.00
99_E103_R0.9991.00
170_D175_A0.9931.00
70_V93_A0.9851.00
157_H166_V0.9831.00
38_R69_A0.9781.00
262_A265_I0.9691.00
156_H169_E0.9621.00
33_V41_V0.9621.00
58_E64_P0.9621.00
15_I170_D0.9611.00
87_A135_D0.9601.00
254_E267_H0.9591.00
181_A213_I0.9581.00
101_G105_V0.9521.00
250_A253_R0.9501.00
96_Y140_L0.9471.00
10_S16_S0.9431.00
11_G222_L0.9391.00
204_E208_D0.9371.00
40_A148_L0.9341.00
182_A237_L0.9311.00
31_V53_I0.9291.00
74_H180_D0.9271.00
44_T83_A0.9261.00
177_F222_L0.9261.00
249_A253_R0.9211.00
218_P221_L0.9211.00
221_L233_T0.9171.00
50_Y53_I0.9071.00
253_R257_E0.9041.00
243_V247_W0.9011.00
236_V239_E0.9001.00
76_H79_H0.8991.00
236_V240_Y0.8971.00
131_P134_E0.8971.00
126_Y130_T0.8941.00
97_V105_V0.8871.00
167_V176_V0.8861.00
263_A267_H0.8791.00
254_E264_A0.8791.00
31_V45_G0.8781.00
14_G173_C0.8771.00
171_H174_D0.8711.00
273_T276_D0.8671.00
205_Q209_D0.8651.00
237_L241_E0.8611.00
118_A122_Q0.8591.00
220_T231_A0.8551.00
52_R55_D0.8541.00
119_V122_Q0.8521.00
34_I153_L0.8481.00
30_S226_F0.8401.00
252_K256_I0.8391.00
208_D211_E0.8371.00
15_I34_I0.8331.00
63_Q66_D0.8301.00
53_I57_L0.8301.00
140_L155_A0.8291.00
34_I170_D0.8281.00
74_H79_H0.8261.00
210_V237_L0.8261.00
100_L103_R0.8241.00
101_G164_H0.8211.00
32_Y224_A0.8201.00
169_E216_L0.8191.00
43_D74_H0.8181.00
144_D155_A0.8151.00
68_Q94_D0.8131.00
203_L206_C0.8131.00
98_H101_G0.8121.00
15_I177_F0.8101.00
208_D212_M0.8061.00
214_R237_L0.8041.00
101_G104_H0.8031.00
167_V213_I0.8011.00
12_C173_C0.7981.00
181_A209_D0.7981.00
187_R240_Y0.7961.00
229_G236_V0.7951.00
12_C15_I0.7951.00
167_V181_A0.7941.00
261_E265_I0.7921.00
41_V86_L0.7901.00
253_R256_I0.7871.00
80_A83_A0.7871.00
41_V67_L0.7821.00
31_V41_V0.7811.00
125_Y129_P0.7791.00
37_D68_Q0.7771.00
103_R106_V0.7751.00
254_E258_R0.7741.00
254_E257_E0.7731.00
206_C210_V0.7721.00
242_H245_R0.7721.00
39_P68_Q0.7671.00
71_L166_V0.7611.00
35_D150_S0.7561.00
72_L80_A0.7531.00
234_D238_K0.7521.00
161_H180_D0.7490.99
257_E267_H0.7470.99
156_H167_V0.7450.99
185_W227_G0.7440.99
179_A224_A0.7430.99
259_H263_A0.7360.99
126_Y129_P0.7340.99
250_A254_E0.7340.99
69_A138_V0.7320.99
53_I56_A0.7320.99
221_L229_G0.7320.99
156_H212_M0.7280.99
51_E54_L0.7280.99
251_V264_A0.7230.99
265_I269_A0.7180.99
102_A105_V0.7160.99
49_N52_R0.7140.99
78_D225_H0.7130.99
240_Y243_V0.7120.99
266_D269_A0.7070.99
31_V44_T0.7070.99
248_V252_K0.7060.99
246_D250_A0.7050.99
200_D203_L0.7020.99
202_D209_D0.7000.99
217_D220_T0.6960.99
203_L207_I0.6950.99
210_V214_R0.6930.99
233_T237_L0.6910.99
42_V153_L0.6900.99
262_A267_H0.6900.99
264_A268_F0.6870.99
56_A60_H0.6860.99
33_V60_H0.6850.99
128_E131_P0.6800.99
148_L151_R0.6800.99
271_T274_V0.6780.99
99_E102_A0.6760.99
79_H225_H0.6750.99
265_I268_F0.6750.99
165_Q224_A0.6750.99
70_V95_V0.6740.99
84_G88_E0.6730.99
240_Y244_L0.6730.99
181_A206_C0.6720.99
50_Y82_G0.6710.99
249_A252_K0.6660.99
125_Y128_E0.6610.99
35_D65_A0.6600.99
244_L247_W0.6580.99
49_N54_L0.6570.99
38_R66_D0.6560.99
51_E85_L0.6560.99
178_T223_Y0.6530.99
239_E242_H0.6520.99
209_D212_M0.6510.99
47_G82_G0.6510.99
40_A68_Q0.6490.99
237_L240_Y0.6490.99
33_V57_L0.6480.99
128_E132_V0.6480.99
62_I66_D0.6430.98
12_C219_E0.6410.98
39_P57_L0.6390.98
73_T79_H0.6350.98
140_L144_D0.6350.98
248_V251_V0.6350.98
106_V133_P0.6340.98
246_D249_A0.6330.98
36_A39_P0.6320.98
241_E244_L0.6290.98
73_T76_H0.6280.98
176_V213_I0.6230.98
238_K241_E0.6220.98
75_V164_H0.6210.98
34_I151_R0.6190.98
39_P63_Q0.6190.98
94_D135_D0.6170.98
35_D39_P0.6160.98
220_T228_P0.6150.98
49_N53_I0.6140.98
254_E259_H0.6130.98
184_I227_G0.6120.98
160_G165_Q0.6100.98
43_D180_D0.6090.98
135_D138_V0.6070.98
30_S223_Y0.6060.98
35_D38_R0.6060.98
54_L85_L0.6050.98
34_I40_A0.6030.98
213_I216_L0.6010.98
44_T72_L0.6000.98
140_L143_G0.5920.97
245_R248_V0.5920.97
200_D206_C0.5910.97
49_N56_A0.5900.97
118_A121_D0.5880.97
18_V56_A0.5860.97
21_G52_R0.5850.97
125_Y130_T0.5840.97
272_T275_E0.5810.97
25_T28_Y0.5810.97
75_V80_A0.5790.97
42_V170_D0.5790.97
57_L62_I0.5780.97
129_P132_V0.5780.97
41_V53_I0.5770.97
9_V17_F0.5730.97
22_M26_A0.5710.97
210_V241_E0.5680.97
75_V101_G0.5670.97
76_H162_T0.5670.97
270_A273_T0.5640.96
127_V130_T0.5630.96
176_V221_L0.5620.96
87_A93_A0.5620.96
178_T182_A0.5610.96
262_A269_A0.5600.96
30_S224_A0.5570.96
247_W250_A0.5570.96
210_V240_Y0.5560.96
87_A92_N0.5550.96
140_L168_F0.5540.96
184_I229_G0.5500.96
180_D225_H0.5490.96
82_G85_L0.5490.96
223_Y229_G0.5450.96
42_V71_L0.5420.96
126_Y132_V0.5400.95
203_L248_V0.5390.95
222_L228_P0.5370.95
83_A87_A0.5360.95
58_E63_Q0.5360.95
18_V33_V0.5360.95
255_V258_R0.5360.95
170_D177_F0.5360.95
103_R107_D0.5350.95
162_T165_Q0.5340.95
17_F32_Y0.5330.95
71_L96_Y0.5310.95
254_E268_F0.5300.95
267_H271_T0.5300.95
67_L93_A0.5270.95
50_Y89_A0.5250.95
39_P66_D0.5250.95
104_H107_D0.5230.95
12_C220_T0.5220.95
120_G123_W0.5180.94
183_G188_A0.5130.94
98_H105_V0.5120.94
54_L57_L0.5100.94
183_G186_V0.5100.94
266_D270_A0.5090.94
215_R218_P0.5060.94
14_G35_D0.5040.94
119_V123_W0.5030.93
264_A267_H0.5020.93
239_E243_V0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9305 100 0.299 Contact Map
4ad9A 4 0.8808 100 0.37 Contact Map
2yheA 3 0.9603 100 0.39 Contact Map
2cfuA 2 0.9503 100 0.401 Contact Map
4nurA 2 0.957 100 0.409 Contact Map
4pdxA 2 0.9536 100 0.416 Contact Map
2vw8A 2 0.9404 100 0.416 Contact Map
2fhxA 2 0.7748 100 0.459 Contact Map
4fekA 1 0.7483 100 0.468 Contact Map
1k07A 1 0.7947 100 0.47 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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