Q9HNJ9 - HALSA - GREMLIN Contacts

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Q9HNJ9 - Uncharacterized protein

UniProt:	Q9HNJ9	Sequences: MSAGDVFDVSGCPGISFVDTGMYDTAEYGSVYVIDADRPAVVDTGTGTNYERILDALEEHGIQPADLQAVLLTHVHLDHAGGAGLLAEACPNADVYVHELGARHVVDPERLVEGTKQAVGDQWQYYVEPTPVPEDRVVELTDGDTVDLGSRTLTAHHAPGHTPHQVVFEDHSCDAVFTADAAGIWVRAQDRVRETSPPTDFDLEQCIDDVEMIRRLDPETLLYAHFGPGPADTDAVLKEYEHVLRDWVAAVKREVIERHSEAAAIDHFAATTTVEDVWGEHKARAETKMNVRGVLRYLNTRA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	302 (249)
Sequences:	6663 (5252)
Seq/√Len:	332.9

ECOLI - YCBL GLO2 YJCS
BACSU - YQJP YFLN YOBT YYBB PKSB YQGX
HALSA - Q9HNJ9 Q9HRG5 Q9HSD1 Q9HSH2 Q9HQ50 Q9HNJ2
SULSO - Q97VU0 Q97VU4 Q97UV2 Q97WC2 Q97YZ2 Q7LYK3 Q97XZ1 Q97U88 Q97UR2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
154_T	171_H	4.082	1.00
211_E	241_E	3.514	1.00
158_A	167_V	3.419	1.00
214_R	238_K	3.393	1.00
174_D	219_E	3.341	1.00
38_R	68_Q	3.304	1.00
72_L	83_A	3.009	1.00
147_D	152_T	2.865	1.00
145_T	152_T	2.837	1.00
214_R	241_E	2.772	1.00
42_V	73_T	2.740	1.00
232_D	235_A	2.619	1.00
71_L	168_F	2.611	1.00
69_A	96_Y	2.491	1.00
145_T	154_T	2.490	1.00
170_D	173_C	2.454	1.00
142_D	212_M	2.442	1.00
10_S	13_P	2.419	1.00
99_E	141_T	2.279	1.00
165_Q	179_A	2.196	1.00
260_S	263_A	2.158	1.00
94_D	138_V	2.136	1.00
238_K	242_H	2.090	1.00
42_V	177_F	2.076	1.00
151_R	173_C	2.071	1.00
40_A	69_A	2.039	1.00
69_A	94_D	1.982	1.00
155_A	166_V	1.904	1.00
32_Y	177_F	1.848	1.00
98_H	157_H	1.847	1.00
96_Y	138_V	1.774	1.00
155_A	168_F	1.770	1.00
212_M	215_R	1.733	1.00
73_T	179_A	1.698	1.00
202_D	205_Q	1.695	1.00
141_T	144_D	1.659	1.00
174_D	217_D	1.649	1.00
138_V	144_D	1.622	1.00
169_E	174_D	1.619	1.00
39_P	67_L	1.606	1.00
56_A	59_E	1.583	1.00
152_T	172_S	1.567	1.00
52_R	56_A	1.559	1.00
147_D	150_S	1.552	1.00
54_L	89_A	1.539	1.00
241_E	245_R	1.522	1.00
54_L	58_E	1.515	1.00
217_D	234_D	1.508	1.00
102_A	106_V	1.494	1.00
211_E	215_R	1.485	1.00
51_E	55_D	1.478	1.00
262_A	266_D	1.468	1.00
98_H	166_V	1.458	1.00
34_I	42_V	1.450	1.00
211_E	245_R	1.448	1.00
158_A	209_D	1.439	1.00
85_L	89_A	1.417	1.00
175_A	222_L	1.409	1.00
58_E	89_A	1.398	1.00
97_V	101_G	1.377	1.00
207_I	241_E	1.374	1.00
214_R	234_D	1.374	1.00
44_T	70_V	1.364	1.00
40_A	71_L	1.361	1.00
207_I	245_R	1.350	1.00
178_T	221_L	1.348	1.00
140_L	166_V	1.336	1.00
169_E	218_P	1.303	1.00
153_L	168_F	1.300	1.00
176_V	216_L	1.298	1.00
36_A	150_S	1.295	1.00
158_A	165_Q	1.293	1.00
142_D	157_H	1.281	1.00
206_C	209_D	1.278	1.00
169_E	176_V	1.263	1.00
145_T	171_H	1.243	1.00
151_R	170_D	1.240	1.00
32_Y	222_L	1.237	1.00
99_E	139_E	1.231	1.00
16_S	60_H	1.222	1.00
102_A	139_E	1.217	1.00
207_I	211_E	1.209	1.00
50_Y	85_L	1.206	1.00
55_D	59_E	1.199	1.00
152_T	171_H	1.198	1.00
87_A	95_V	1.186	1.00
201_F	204_E	1.172	1.00
14_G	151_R	1.163	1.00
151_R	172_S	1.155	1.00
263_A	266_D	1.149	1.00
153_L	170_D	1.145	1.00
85_L	88_E	1.143	1.00
235_A	239_E	1.141	1.00
143_G	154_T	1.140	1.00
79_H	180_D	1.136	1.00
37_D	149_G	1.124	1.00
42_V	168_F	1.124	1.00
40_A	153_L	1.123	1.00
223_Y	226_F	1.120	1.00
175_A	220_T	1.113	1.00
55_D	58_E	1.108	1.00
245_R	249_A	1.097	1.00
70_V	86_L	1.089	1.00
242_H	246_D	1.087	1.00
211_E	214_R	1.084	1.00
154_T	216_L	1.081	1.00
160_G	209_D	1.068	1.00
10_S	14_G	1.062	1.00
39_P	62_I	1.058	1.00
205_Q	208_D	1.057	1.00
33_V	39_P	1.046	1.00
259_H	267_H	1.045	1.00
70_V	83_A	1.036	1.00
50_Y	54_L	1.033	1.00
73_T	168_F	1.030	1.00
154_T	169_E	1.029	1.00
83_A	95_V	1.008	1.00
99_E	103_R	0.999	1.00
170_D	175_A	0.993	1.00
70_V	93_A	0.985	1.00
157_H	166_V	0.983	1.00
38_R	69_A	0.978	1.00
262_A	265_I	0.969	1.00
156_H	169_E	0.962	1.00
33_V	41_V	0.962	1.00
58_E	64_P	0.962	1.00
15_I	170_D	0.961	1.00
87_A	135_D	0.960	1.00
254_E	267_H	0.959	1.00
181_A	213_I	0.958	1.00
101_G	105_V	0.952	1.00
250_A	253_R	0.950	1.00
96_Y	140_L	0.947	1.00
10_S	16_S	0.943	1.00
11_G	222_L	0.939	1.00
204_E	208_D	0.937	1.00
40_A	148_L	0.934	1.00
182_A	237_L	0.931	1.00
31_V	53_I	0.929	1.00
74_H	180_D	0.927	1.00
44_T	83_A	0.926	1.00
177_F	222_L	0.926	1.00
249_A	253_R	0.921	1.00
218_P	221_L	0.921	1.00
221_L	233_T	0.917	1.00
50_Y	53_I	0.907	1.00
253_R	257_E	0.904	1.00
243_V	247_W	0.901	1.00
236_V	239_E	0.900	1.00
76_H	79_H	0.899	1.00
236_V	240_Y	0.897	1.00
131_P	134_E	0.897	1.00
126_Y	130_T	0.894	1.00
97_V	105_V	0.887	1.00
167_V	176_V	0.886	1.00
263_A	267_H	0.879	1.00
254_E	264_A	0.879	1.00
31_V	45_G	0.878	1.00
14_G	173_C	0.877	1.00
171_H	174_D	0.871	1.00
273_T	276_D	0.867	1.00
205_Q	209_D	0.865	1.00
237_L	241_E	0.861	1.00
118_A	122_Q	0.859	1.00
220_T	231_A	0.855	1.00
52_R	55_D	0.854	1.00
119_V	122_Q	0.852	1.00
34_I	153_L	0.848	1.00
30_S	226_F	0.840	1.00
252_K	256_I	0.839	1.00
208_D	211_E	0.837	1.00
15_I	34_I	0.833	1.00
63_Q	66_D	0.830	1.00
53_I	57_L	0.830	1.00
140_L	155_A	0.829	1.00
34_I	170_D	0.828	1.00
74_H	79_H	0.826	1.00
210_V	237_L	0.826	1.00
100_L	103_R	0.824	1.00
101_G	164_H	0.821	1.00
32_Y	224_A	0.820	1.00
169_E	216_L	0.819	1.00
43_D	74_H	0.818	1.00
144_D	155_A	0.815	1.00
68_Q	94_D	0.813	1.00
203_L	206_C	0.813	1.00
98_H	101_G	0.812	1.00
15_I	177_F	0.810	1.00
208_D	212_M	0.806	1.00
214_R	237_L	0.804	1.00
101_G	104_H	0.803	1.00
167_V	213_I	0.801	1.00
12_C	173_C	0.798	1.00
181_A	209_D	0.798	1.00
187_R	240_Y	0.796	1.00
229_G	236_V	0.795	1.00
12_C	15_I	0.795	1.00
167_V	181_A	0.794	1.00
261_E	265_I	0.792	1.00
41_V	86_L	0.790	1.00
253_R	256_I	0.787	1.00
80_A	83_A	0.787	1.00
41_V	67_L	0.782	1.00
31_V	41_V	0.781	1.00
125_Y	129_P	0.779	1.00
37_D	68_Q	0.777	1.00
103_R	106_V	0.775	1.00
254_E	258_R	0.774	1.00
254_E	257_E	0.773	1.00
206_C	210_V	0.772	1.00
242_H	245_R	0.772	1.00
39_P	68_Q	0.767	1.00
71_L	166_V	0.761	1.00
35_D	150_S	0.756	1.00
72_L	80_A	0.753	1.00
234_D	238_K	0.752	1.00
161_H	180_D	0.749	0.99
257_E	267_H	0.747	0.99
156_H	167_V	0.745	0.99
185_W	227_G	0.744	0.99
179_A	224_A	0.743	0.99
259_H	263_A	0.736	0.99
126_Y	129_P	0.734	0.99
250_A	254_E	0.734	0.99
69_A	138_V	0.732	0.99
53_I	56_A	0.732	0.99
221_L	229_G	0.732	0.99
156_H	212_M	0.728	0.99
51_E	54_L	0.728	0.99
251_V	264_A	0.723	0.99
265_I	269_A	0.718	0.99
102_A	105_V	0.716	0.99
49_N	52_R	0.714	0.99
78_D	225_H	0.713	0.99
240_Y	243_V	0.712	0.99
266_D	269_A	0.707	0.99
31_V	44_T	0.707	0.99
248_V	252_K	0.706	0.99
246_D	250_A	0.705	0.99
200_D	203_L	0.702	0.99
202_D	209_D	0.700	0.99
217_D	220_T	0.696	0.99
203_L	207_I	0.695	0.99
210_V	214_R	0.693	0.99
233_T	237_L	0.691	0.99
42_V	153_L	0.690	0.99
262_A	267_H	0.690	0.99
264_A	268_F	0.687	0.99
56_A	60_H	0.686	0.99
33_V	60_H	0.685	0.99
128_E	131_P	0.680	0.99
148_L	151_R	0.680	0.99
271_T	274_V	0.678	0.99
99_E	102_A	0.676	0.99
79_H	225_H	0.675	0.99
265_I	268_F	0.675	0.99
165_Q	224_A	0.675	0.99
70_V	95_V	0.674	0.99
84_G	88_E	0.673	0.99
240_Y	244_L	0.673	0.99
181_A	206_C	0.672	0.99
50_Y	82_G	0.671	0.99
249_A	252_K	0.666	0.99
125_Y	128_E	0.661	0.99
35_D	65_A	0.660	0.99
244_L	247_W	0.658	0.99
49_N	54_L	0.657	0.99
38_R	66_D	0.656	0.99
51_E	85_L	0.656	0.99
178_T	223_Y	0.653	0.99
239_E	242_H	0.652	0.99
209_D	212_M	0.651	0.99
47_G	82_G	0.651	0.99
40_A	68_Q	0.649	0.99
237_L	240_Y	0.649	0.99
33_V	57_L	0.648	0.99
128_E	132_V	0.648	0.99
62_I	66_D	0.643	0.98
12_C	219_E	0.641	0.98
39_P	57_L	0.639	0.98
73_T	79_H	0.635	0.98
140_L	144_D	0.635	0.98
248_V	251_V	0.635	0.98
106_V	133_P	0.634	0.98
246_D	249_A	0.633	0.98
36_A	39_P	0.632	0.98
241_E	244_L	0.629	0.98
73_T	76_H	0.628	0.98
176_V	213_I	0.623	0.98
238_K	241_E	0.622	0.98
75_V	164_H	0.621	0.98
34_I	151_R	0.619	0.98
39_P	63_Q	0.619	0.98
94_D	135_D	0.617	0.98
35_D	39_P	0.616	0.98
220_T	228_P	0.615	0.98
49_N	53_I	0.614	0.98
254_E	259_H	0.613	0.98
184_I	227_G	0.612	0.98
160_G	165_Q	0.610	0.98
43_D	180_D	0.609	0.98
135_D	138_V	0.607	0.98
30_S	223_Y	0.606	0.98
35_D	38_R	0.606	0.98
54_L	85_L	0.605	0.98
34_I	40_A	0.603	0.98
213_I	216_L	0.601	0.98
44_T	72_L	0.600	0.98
140_L	143_G	0.592	0.97
245_R	248_V	0.592	0.97
200_D	206_C	0.591	0.97
49_N	56_A	0.590	0.97
118_A	121_D	0.588	0.97
18_V	56_A	0.586	0.97
21_G	52_R	0.585	0.97
125_Y	130_T	0.584	0.97
272_T	275_E	0.581	0.97
25_T	28_Y	0.581	0.97
75_V	80_A	0.579	0.97
42_V	170_D	0.579	0.97
57_L	62_I	0.578	0.97
129_P	132_V	0.578	0.97
41_V	53_I	0.577	0.97
9_V	17_F	0.573	0.97
22_M	26_A	0.571	0.97
210_V	241_E	0.568	0.97
75_V	101_G	0.567	0.97
76_H	162_T	0.567	0.97
270_A	273_T	0.564	0.96
127_V	130_T	0.563	0.96
176_V	221_L	0.562	0.96
87_A	93_A	0.562	0.96
178_T	182_A	0.561	0.96
262_A	269_A	0.560	0.96
30_S	224_A	0.557	0.96
247_W	250_A	0.557	0.96
210_V	240_Y	0.556	0.96
87_A	92_N	0.555	0.96
140_L	168_F	0.554	0.96
184_I	229_G	0.550	0.96
180_D	225_H	0.549	0.96
82_G	85_L	0.549	0.96
223_Y	229_G	0.545	0.96
42_V	71_L	0.542	0.96
126_Y	132_V	0.540	0.95
203_L	248_V	0.539	0.95
222_L	228_P	0.537	0.95
83_A	87_A	0.536	0.95
58_E	63_Q	0.536	0.95
18_V	33_V	0.536	0.95
255_V	258_R	0.536	0.95
170_D	177_F	0.536	0.95
103_R	107_D	0.535	0.95
162_T	165_Q	0.534	0.95
17_F	32_Y	0.533	0.95
71_L	96_Y	0.531	0.95
254_E	268_F	0.530	0.95
267_H	271_T	0.530	0.95
67_L	93_A	0.527	0.95
50_Y	89_A	0.525	0.95
39_P	66_D	0.525	0.95
104_H	107_D	0.523	0.95
12_C	220_T	0.522	0.95
120_G	123_W	0.518	0.94
183_G	188_A	0.513	0.94
98_H	105_V	0.512	0.94
54_L	57_L	0.510	0.94
183_G	186_V	0.510	0.94
266_D	270_A	0.509	0.94
215_R	218_P	0.506	0.94
14_G	35_D	0.504	0.94
119_V	123_W	0.503	0.93
264_A	267_H	0.502	0.93
239_E	243_V	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zo4A	1	0.9305	100	0.299	Contact Map
4ad9A	4	0.8808	100	0.37	Contact Map
2yheA	3	0.9603	100	0.39	Contact Map
2cfuA	2	0.9503	100	0.401	Contact Map
4nurA	2	0.957	100	0.409	Contact Map
4pdxA	2	0.9536	100	0.416	Contact Map
2vw8A	2	0.9404	100	0.416	Contact Map
2fhxA	2	0.7748	100	0.459	Contact Map
4fekA	1	0.7483	100	0.468	Contact Map
1k07A	1	0.7947	100	0.47	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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