SYS - HALSA - GREMLIN Contacts

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SYS - Serine--tRNA ligase

UniProt:	Q9HNJ8	Sequences: MLSRQFVREHPEKVRDALDAKGVDADLDRILEVDEEWRELKARGDELRHDRNEVSSKIGELKQAGDEDAAQEAIERSQALKDELADVEARADDLEAELERLLLTLPMVPDEDAPVGDSEAENVERRREGFDDRRDLPESVVPHYDLGEELDILDFERGAKVSGGGFYFSKGAGARLEHALVQFMLDVHREQGYEDVFPPMPVSARSMEGTGQFPKFVEDAYRIGGENDADYDDDDLWLLPTAEVPVTNMYRDEILLDDDLPVKHQAYSPNFRREAGEHGTETRGIVRVHQFNKVELVNFVRPEDSAERFHGLLDEAEAVLRRLDLPYRVLEMCTGDMGFTQAKKYDIEVWAPGDDMDGGPEMGGRWLEVSSVSNFKDFQARRADIQYRPERHESAEHLHTLNGSGVAVPRVLVAILEYYQNDDGTVTVPEALQPYMNGQTRIEGSRKVGESALGDGDREA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	460 (420)
Sequences:	4328 (2348)
Seq/√Len:	114.6

ECOLI - SYS
BACSU - SYS
HALSA - SYS
SULSO - SYS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
421_N	427_T	4.415	1.00
250_Y	264_H	3.944	1.00
187_V	319_V	3.735	1.00
124_E	127_R	3.643	1.00
324_D	430_E	3.251	1.00
301_R	304_D	3.229	1.00
36_E	90_R	3.154	1.00
67_E	71_Q	3.154	1.00
50_D	76_R	3.126	1.00
306_A	376_K	3.068	1.00
43_R	83_E	2.922	1.00
427_T	433_Q	2.816	1.00
141_V	149_E	2.793	1.00
433_Q	440_T	2.722	1.00
183_F	322_R	2.701	1.00
168_F	249_M	2.660	1.00
304_D	307_E	2.607	1.00
342_A	376_K	2.574	1.00
389_P	396_E	2.524	1.00
146_L	426_V	2.518	1.00
131_D	134_R	2.509	1.00
151_D	170_K	2.492	1.00
103_L	208_E	2.481	1.00
318_A	322_R	2.382	1.00
115_V	334_T	2.372	1.00
137_P	422_D	2.356	1.00
20_A	115_V	2.341	1.00
187_V	322_R	2.330	1.00
126_R	317_E	2.319	1.00
15_R	28_D	2.313	1.00
29_R	97_E	2.304	1.00
263_K	311_G	2.295	1.00
126_R	329_V	2.290	1.00
430_E	433_Q	2.280	1.00
62_K	74_I	2.168	1.00
416_L	426_V	2.144	1.00
10_H	13_K	2.126	1.00
61_L	66_D	2.113	1.00
186_D	435_Y	2.086	1.00
308_R	311_G	2.057	1.00
93_D	97_E	2.045	1.00
317_E	321_R	2.043	1.00
157_R	253_E	2.013	1.00
110_D	306_A	1.990	1.00
421_N	425_T	1.956	1.00
161_V	168_F	1.942	1.00
191_Q	318_A	1.926	1.00
388_R	395_A	1.913	1.00
325_L	349_V	1.867	1.00
16_D	20_A	1.866	1.00
201_P	223_I	1.858	1.00
298_N	308_R	1.857	1.00
204_A	237_W	1.835	1.00
206_S	251_R	1.822	1.00
190_E	322_R	1.817	1.00
326_P	418_Y	1.804	1.00
152_I	173_G	1.794	1.00
128_E	321_R	1.792	1.00
332_M	344_K	1.781	1.00
240_P	244_V	1.767	1.00
196_V	249_M	1.761	1.00
112_D	343_K	1.735	1.00
57_K	60_E	1.722	1.00
49_H	53_E	1.711	1.00
331_E	343_K	1.691	1.00
110_D	376_K	1.682	1.00
200_M	271_F	1.675	1.00
16_D	19_D	1.672	1.00
96_A	100_R	1.663	1.00
147_G	153_L	1.662	1.00
32_E	36_E	1.653	1.00
8_R	34_D	1.642	1.00
256_L	259_D	1.633	1.00
17_A	111_E	1.631	1.00
71_Q	75_E	1.619	1.00
79_A	83_E	1.616	1.00
109_P	337_M	1.605	1.00
95_E	99_E	1.604	1.00
438_G	442_I	1.584	1.00
341_Q	344_K	1.583	1.00
198_P	245_P	1.583	1.00
29_R	32_E	1.582	1.00
160_K	253_E	1.562	1.00
224_G	233_D	1.556	1.00
318_A	321_R	1.552	1.00
53_E	57_K	1.544	1.00
305_S	399_H	1.541	1.00
339_F	378_F	1.519	1.00
257_D	301_R	1.515	1.00
6_F	10_H	1.509	1.00
109_P	334_T	1.508	1.00
41_K	45_D	1.497	1.00
263_K	298_N	1.487	1.00
17_A	20_A	1.485	1.00
201_P	236_L	1.474	1.00
47_L	80_L	1.468	1.00
39_E	43_R	1.460	1.00
83_E	86_D	1.453	1.00
117_D	121_E	1.451	1.00
130_F	135_D	1.448	1.00
205_R	251_R	1.447	1.00
167_Y	288_V	1.444	1.00
35_E	39_E	1.440	1.00
142_P	145_D	1.433	1.00
234_D	273_R	1.429	1.00
406_V	411_V	1.424	1.00
301_R	387_Y	1.424	1.00
177_E	292_N	1.420	1.00
157_R	249_M	1.401	1.00
40_L	91_A	1.401	1.00
48_R	88_E	1.398	1.00
204_A	235_D	1.385	1.00
50_D	53_E	1.375	1.00
43_R	46_E	1.366	1.00
148_E	156_E	1.356	1.00
263_K	308_R	1.354	1.00
158_G	167_Y	1.353	1.00
204_A	217_V	1.351	1.00
246_V	266_A	1.350	1.00
170_K	194_E	1.335	1.00
299_F	398_L	1.332	1.00
20_A	334_T	1.332	1.00
71_Q	74_I	1.329	1.00
11_P	31_L	1.321	1.00
6_F	13_K	1.316	1.00
54_V	77_S	1.315	1.00
121_E	333_C	1.306	1.00
89_A	93_D	1.305	1.00
300_V	308_R	1.304	1.00
40_L	94_L	1.299	1.00
257_D	390_E	1.296	1.00
217_V	237_W	1.286	0.99
305_S	374_N	1.286	0.99
162_S	236_L	1.284	0.99
62_K	67_E	1.275	0.99
36_E	39_E	1.273	0.99
250_Y	299_F	1.270	0.99
310_H	345_Y	1.269	0.99
70_A	74_I	1.267	0.99
75_E	79_A	1.257	0.99
324_D	419_Y	1.254	0.99
82_D	86_D	1.247	0.99
118_S	121_E	1.246	0.99
37_W	41_K	1.243	0.99
126_R	313_L	1.240	0.99
34_D	38_R	1.239	0.99
60_E	64_A	1.236	0.99
314_D	321_R	1.222	0.99
187_V	190_E	1.220	0.99
354_D	367_L	1.217	0.99
46_E	50_D	1.216	0.99
187_V	318_A	1.209	0.99
306_A	342_A	1.207	0.99
12_E	16_D	1.203	0.99
86_D	90_R	1.198	0.99
81_K	85_A	1.193	0.99
142_P	353_G	1.191	0.99
419_Y	428_V	1.190	0.99
131_D	326_P	1.181	0.99
89_A	92_D	1.177	0.99
17_A	109_P	1.170	0.99
127_R	131_D	1.168	0.99
286_V	413_V	1.160	0.99
6_F	14_V	1.160	0.99
76_R	79_A	1.159	0.99
203_S	206_S	1.155	0.99
329_V	347_I	1.151	0.99
181_V	267_Y	1.145	0.99
321_R	329_V	1.139	0.99
302_P	387_Y	1.138	0.99
321_R	327_Y	1.134	0.99
439_Q	442_I	1.133	0.99
126_R	321_R	1.132	0.99
298_N	311_G	1.130	0.99
246_V	375_F	1.130	0.99
372_V	403_G	1.127	0.99
312_L	372_V	1.126	0.99
172_A	439_Q	1.121	0.99
100_R	104_T	1.119	0.99
90_R	93_D	1.119	0.99
112_D	306_A	1.110	0.98
78_Q	81_K	1.109	0.98
187_V	191_Q	1.100	0.98
312_L	375_F	1.097	0.98
40_L	87_V	1.091	0.98
385_I	398_L	1.089	0.98
72_E	76_R	1.081	0.98
85_A	88_E	1.081	0.98
57_K	61_L	1.074	0.98
183_F	431_A	1.068	0.98
341_Q	375_F	1.067	0.98
421_N	441_R	1.066	0.98
259_D	262_V	1.055	0.98
196_V	246_V	1.055	0.98
425_T	441_R	1.054	0.98
209_G	383_A	1.054	0.98
145_D	148_E	1.052	0.98
60_E	63_Q	1.051	0.98
184_M	319_V	1.049	0.98
254_I	386_Q	1.046	0.98
389_P	393_E	1.046	0.98
61_L	73_A	1.044	0.98
8_R	38_R	1.042	0.98
331_E	337_M	1.041	0.98
428_V	433_Q	1.031	0.97
29_R	101_L	1.026	0.97
110_D	113_A	1.013	0.97
306_A	310_H	1.009	0.97
222_R	237_W	1.007	0.97
313_L	329_V	1.004	0.97
380_A	400_T	1.001	0.97
92_D	96_A	1.001	0.97
72_E	75_E	0.999	0.97
384_D	397_H	0.997	0.97
351_A	367_L	0.997	0.97
387_Y	396_E	0.996	0.97
310_H	313_L	0.996	0.97
33_V	94_L	0.995	0.97
30_I	101_L	0.993	0.97
298_N	315_E	0.991	0.97
207_M	220_A	0.991	0.97
427_T	441_R	0.990	0.97
2_L	7_V	0.986	0.97
136_L	140_V	0.985	0.97
5_Q	9_E	0.981	0.97
175_R	186_D	0.981	0.97
351_A	413_V	0.978	0.97
85_A	89_A	0.978	0.97
252_D	384_D	0.975	0.96
390_E	393_E	0.974	0.96
313_L	347_I	0.972	0.96
42_A	46_E	0.971	0.96
13_K	17_A	0.970	0.96
79_A	82_D	0.970	0.96
307_E	311_G	0.963	0.96
322_R	431_A	0.960	0.96
13_K	16_D	0.959	0.96
94_L	98_L	0.959	0.96
141_V	145_D	0.955	0.96
54_V	57_K	0.955	0.96
17_A	108_V	0.953	0.96
213_F	220_A	0.949	0.96
158_G	162_S	0.949	0.96
197_F	292_N	0.947	0.96
32_E	35_E	0.944	0.96
55_S	77_S	0.943	0.96
7_V	10_H	0.942	0.96
36_E	97_E	0.939	0.96
222_R	235_D	0.939	0.96
247_T	297_V	0.934	0.95
324_D	427_T	0.932	0.95
7_V	30_I	0.925	0.95
438_G	441_R	0.920	0.95
44_G	84_L	0.920	0.95
118_S	335_G	0.917	0.95
415_I	419_Y	0.917	0.95
200_M	269_P	0.910	0.95
254_I	395_A	0.908	0.95
134_R	427_T	0.902	0.95
215_K	219_D	0.902	0.95
47_L	83_E	0.898	0.94
191_Q	315_E	0.898	0.94
36_E	94_L	0.897	0.94
138_E	422_D	0.897	0.94
56_S	59_G	0.895	0.94
26_D	29_R	0.893	0.94
97_E	100_R	0.891	0.94
263_K	315_E	0.886	0.94
51_R	81_K	0.881	0.94
314_D	317_E	0.881	0.94
30_I	105_L	0.875	0.94
185_L	189_R	0.875	0.94
172_A	438_G	0.874	0.94
428_V	436_M	0.869	0.93
257_D	260_L	0.867	0.93
162_S	203_S	0.863	0.93
2_L	14_V	0.860	0.93
113_A	331_E	0.857	0.93
250_Y	262_V	0.856	0.93
204_A	208_E	0.852	0.93
88_E	92_D	0.851	0.93
354_D	365_R	0.850	0.93
223_I	236_L	0.847	0.92
44_G	88_E	0.847	0.92
188_H	405_G	0.846	0.92
324_D	431_A	0.841	0.92
40_L	90_R	0.841	0.92
257_D	389_P	0.840	0.92
427_T	440_T	0.833	0.92
2_L	6_F	0.830	0.92
45_D	48_R	0.830	0.92
186_D	434_P	0.828	0.92
172_A	436_M	0.828	0.92
254_I	388_R	0.828	0.92
314_D	318_A	0.826	0.92
77_S	80_L	0.826	0.92
193_Y	298_N	0.825	0.91
301_R	389_P	0.823	0.91
246_V	264_H	0.821	0.91
124_E	328_R	0.819	0.91
33_V	97_E	0.818	0.91
181_V	408_V	0.815	0.91
22_G	117_D	0.815	0.91
317_E	327_Y	0.811	0.91
101_L	104_T	0.809	0.91
200_M	292_N	0.808	0.91
21_K	338_G	0.807	0.91
436_M	439_Q	0.807	0.91
256_L	388_R	0.806	0.91
309_F	345_Y	0.805	0.90
134_R	137_P	0.804	0.90
428_V	441_R	0.803	0.90
175_R	189_R	0.797	0.90
162_S	206_S	0.794	0.90
436_M	442_I	0.792	0.90
55_S	59_G	0.790	0.90
353_G	413_V	0.790	0.90
269_P	292_N	0.789	0.90
250_Y	255_L	0.788	0.90
134_R	326_P	0.783	0.89
190_E	318_A	0.783	0.89
65_G	70_A	0.782	0.89
99_E	103_L	0.780	0.89
200_M	290_Q	0.778	0.89
353_G	365_R	0.775	0.89
177_E	197_F	0.774	0.89
45_D	91_A	0.774	0.89
211_G	340_T	0.771	0.88
77_S	81_K	0.765	0.88
94_L	97_E	0.762	0.88
45_D	49_H	0.761	0.88
125_R	331_E	0.757	0.88
206_S	248_N	0.756	0.88
44_G	48_R	0.756	0.88
374_N	399_H	0.755	0.87
319_V	406_V	0.755	0.87
59_G	74_I	0.750	0.87
15_R	27_L	0.748	0.87
117_D	333_C	0.746	0.87
43_R	87_V	0.744	0.87
122_N	333_C	0.742	0.87
123_V	331_E	0.741	0.86
193_Y	315_E	0.739	0.86
221_Y	273_R	0.738	0.86
433_Q	439_Q	0.737	0.86
249_M	264_H	0.734	0.86
142_P	413_V	0.734	0.86
40_L	43_R	0.732	0.86
157_R	168_F	0.729	0.86
286_V	367_L	0.729	0.86
30_I	98_L	0.728	0.85
56_S	60_E	0.727	0.85
419_Y	431_A	0.725	0.85
44_G	91_A	0.724	0.85
70_A	73_A	0.722	0.85
153_L	167_Y	0.722	0.85
217_V	224_G	0.722	0.85
200_M	239_L	0.721	0.85
146_L	420_Q	0.721	0.85
169_S	412_L	0.720	0.85
4_R	102_L	0.720	0.85
54_V	73_A	0.719	0.85
125_R	345_Y	0.719	0.85
306_A	374_N	0.715	0.84
163_G	236_L	0.711	0.84
41_K	95_E	0.710	0.84
152_I	170_K	0.710	0.84
179_A	436_M	0.708	0.84
29_R	33_V	0.707	0.84
35_E	38_R	0.706	0.84
175_R	437_N	0.706	0.84
170_K	196_V	0.704	0.84
188_H	265_Q	0.703	0.83
96_A	99_E	0.703	0.83
158_G	168_F	0.700	0.83
224_G	234_D	0.699	0.83
54_V	76_R	0.697	0.83
212_Q	248_N	0.696	0.83
150_L	426_V	0.693	0.83
332_M	341_Q	0.693	0.83
91_A	94_L	0.691	0.82
165_G	369_V	0.691	0.82
296_L	312_L	0.690	0.82
213_F	217_V	0.690	0.82
242_A	245_P	0.688	0.82
48_R	84_L	0.687	0.82
217_V	222_R	0.687	0.82
61_L	64_A	0.685	0.82
165_G	281_E	0.685	0.82
74_I	78_Q	0.685	0.82
113_A	337_M	0.683	0.82
172_A	442_I	0.682	0.82
19_D	24_D	0.681	0.81
119_E	330_L	0.681	0.81
7_V	14_V	0.680	0.81
12_E	15_R	0.680	0.81
255_L	259_D	0.677	0.81
13_K	111_E	0.677	0.81
28_D	32_E	0.676	0.81
310_H	343_K	0.675	0.81
152_I	172_A	0.675	0.81
169_S	292_N	0.674	0.81
78_Q	82_D	0.674	0.81
59_G	78_Q	0.673	0.81
97_E	101_L	0.672	0.81
427_T	430_E	0.672	0.81
302_P	396_E	0.670	0.80
254_I	384_D	0.669	0.80
151_D	171_G	0.668	0.80
247_T	375_F	0.667	0.80
242_A	265_Q	0.665	0.80
140_V	353_G	0.663	0.80
83_E	87_V	0.661	0.80
334_T	337_M	0.660	0.79
313_L	372_V	0.658	0.79
152_I	416_L	0.658	0.79
162_S	223_I	0.657	0.79
222_R	233_D	0.655	0.79
137_P	140_V	0.655	0.79
62_K	70_A	0.655	0.79
162_S	202_V	0.655	0.79
171_G	194_E	0.653	0.79
87_V	90_R	0.653	0.79
202_V	245_P	0.651	0.78
33_V	98_L	0.649	0.78
250_Y	385_I	0.649	0.78
37_W	98_L	0.648	0.78
57_K	73_A	0.647	0.78
262_V	265_Q	0.647	0.78
50_D	54_V	0.646	0.78
147_G	150_L	0.645	0.78
182_Q	267_Y	0.644	0.78
188_H	296_L	0.643	0.78
147_G	416_L	0.643	0.78
44_G	87_V	0.643	0.78
419_Y	430_E	0.641	0.77
62_K	65_G	0.639	0.77
299_F	385_I	0.639	0.77
257_D	393_E	0.639	0.77
125_R	313_L	0.637	0.77
36_E	40_L	0.636	0.77
178_H	195_D	0.635	0.77
185_L	265_Q	0.632	0.76
337_M	344_K	0.632	0.76
255_L	398_L	0.631	0.76
303_E	389_P	0.629	0.76
75_E	78_Q	0.626	0.76
67_E	74_I	0.626	0.76
135_D	138_E	0.625	0.76
161_V	206_S	0.624	0.76
220_A	244_V	0.622	0.75
220_A	240_P	0.622	0.75
90_R	94_L	0.620	0.75
193_Y	296_L	0.619	0.75
253_E	259_D	0.619	0.75
389_P	394_S	0.619	0.75
134_R	138_E	0.618	0.75
37_W	95_E	0.617	0.75
51_R	84_L	0.616	0.75
7_V	31_L	0.615	0.74
76_R	83_E	0.615	0.74
267_Y	292_N	0.615	0.74
82_D	85_A	0.615	0.74
15_R	19_D	0.614	0.74
183_F	187_V	0.613	0.74
162_S	201_P	0.613	0.74
210_T	297_V	0.612	0.74
37_W	94_L	0.612	0.74
63_Q	67_E	0.612	0.74
144_Y	283_R	0.611	0.74
150_L	173_G	0.609	0.74
196_V	264_H	0.608	0.74
92_D	95_E	0.607	0.74
349_V	414_A	0.607	0.74
415_I	428_V	0.606	0.73
153_L	169_S	0.606	0.73
197_F	269_P	0.604	0.73
297_V	375_F	0.601	0.73
210_T	247_T	0.600	0.73
73_A	76_R	0.598	0.72
202_V	239_L	0.597	0.72
51_R	80_L	0.596	0.72
221_Y	236_L	0.596	0.72
139_S	145_D	0.595	0.72
223_I	234_D	0.595	0.72
366_W	411_V	0.594	0.72
306_A	309_F	0.594	0.72
377_D	399_H	0.593	0.72
281_E	367_L	0.593	0.72
197_F	200_M	0.592	0.72
369_V	411_V	0.592	0.72
6_F	11_P	0.592	0.72
285_I	413_V	0.590	0.71
415_I	431_A	0.589	0.71
155_F	285_I	0.589	0.71
146_L	149_E	0.589	0.71
309_F	372_V	0.588	0.71
201_P	238_L	0.588	0.71
288_V	412_L	0.587	0.71
117_D	120_A	0.586	0.71
223_I	273_R	0.585	0.71
165_G	367_L	0.585	0.71
99_E	208_E	0.584	0.71
316_A	370_S	0.584	0.71
141_V	146_L	0.583	0.71
154_D	157_R	0.582	0.70
161_V	249_M	0.580	0.70
340_T	344_K	0.578	0.70
387_Y	398_L	0.578	0.70
167_Y	285_I	0.577	0.70
91_A	95_E	0.577	0.70
172_A	175_R	0.575	0.69
21_K	109_P	0.574	0.69
86_D	89_A	0.573	0.69
62_K	66_D	0.572	0.69
41_K	44_G	0.571	0.69
316_A	347_I	0.571	0.69
309_F	313_L	0.570	0.69
319_V	322_R	0.569	0.69
34_D	102_L	0.569	0.69
116_G	335_G	0.569	0.69
391_R	395_A	0.567	0.68
428_V	439_Q	0.567	0.68
177_E	408_V	0.566	0.68
203_S	236_L	0.566	0.68
84_L	88_E	0.566	0.68
319_V	405_G	0.565	0.68
47_L	84_L	0.565	0.68
20_A	109_P	0.565	0.68
110_D	342_A	0.565	0.68
430_E	440_T	0.562	0.68
217_V	220_A	0.561	0.68
28_D	31_L	0.561	0.68
51_R	55_S	0.558	0.67
6_F	9_E	0.558	0.67
61_L	72_E	0.557	0.67
353_G	367_L	0.556	0.67
134_R	140_V	0.554	0.67
182_Q	186_D	0.554	0.67
93_D	96_A	0.554	0.67
312_L	401_L	0.553	0.67
134_R	421_N	0.552	0.66
242_A	266_A	0.552	0.66
340_T	375_F	0.552	0.66
66_D	70_A	0.551	0.66
14_V	108_V	0.551	0.66
273_R	277_E	0.549	0.66
53_E	56_S	0.549	0.66
188_H	191_Q	0.548	0.66
426_V	442_I	0.548	0.66
160_K	252_D	0.548	0.66
408_V	411_V	0.547	0.66
144_Y	155_F	0.547	0.66
39_E	42_A	0.547	0.66
250_Y	253_E	0.547	0.66
255_L	262_V	0.546	0.66
43_R	47_L	0.546	0.66
159_A	163_G	0.544	0.65
58_I	77_S	0.544	0.65
140_V	420_Q	0.544	0.65
168_F	198_P	0.543	0.65
367_L	409_P	0.543	0.65
220_A	237_W	0.542	0.65
370_S	403_G	0.542	0.65
298_N	312_L	0.540	0.65
172_A	189_R	0.540	0.65
247_T	400_T	0.540	0.65
67_E	72_E	0.538	0.64
147_G	152_I	0.538	0.64
262_V	299_F	0.538	0.64
258_D	390_E	0.538	0.64
434_P	437_N	0.538	0.64
351_A	365_R	0.537	0.64
177_E	409_P	0.536	0.64
246_V	265_Q	0.535	0.64
19_D	25_A	0.535	0.64
280_T	330_L	0.534	0.64
21_K	334_T	0.533	0.64
113_A	334_T	0.532	0.64
128_E	327_Y	0.532	0.64
343_K	374_N	0.531	0.63
218_E	273_R	0.531	0.63
311_G	315_E	0.531	0.63
250_Y	398_L	0.530	0.63
185_L	195_D	0.529	0.63
189_R	265_Q	0.529	0.63
387_Y	390_E	0.528	0.63
420_Q	424_G	0.528	0.63
288_V	413_V	0.528	0.63
202_V	207_M	0.528	0.63
112_D	331_E	0.527	0.63
63_Q	66_D	0.525	0.63
169_S	197_F	0.524	0.62
37_W	91_A	0.524	0.62
331_E	347_I	0.524	0.62
351_A	369_V	0.523	0.62
59_G	62_K	0.522	0.62
302_P	398_L	0.521	0.62
210_T	244_V	0.521	0.62
118_S	333_C	0.521	0.62
138_E	420_Q	0.521	0.62
239_L	245_P	0.521	0.62
40_L	44_G	0.520	0.62
136_L	139_S	0.519	0.62
411_V	415_I	0.519	0.62
46_E	49_H	0.519	0.62
110_D	374_N	0.518	0.62
278_H	282_T	0.516	0.61
233_D	273_R	0.515	0.61
58_I	70_A	0.515	0.61
184_M	404_S	0.514	0.61
248_N	251_R	0.514	0.61
3_S	381_R	0.514	0.61
43_R	90_R	0.513	0.61
11_P	15_R	0.513	0.61
377_D	381_R	0.512	0.61
7_V	11_P	0.512	0.61
277_E	280_T	0.510	0.60
326_P	366_W	0.509	0.60
220_A	268_S	0.508	0.60
112_D	310_H	0.507	0.60
286_V	354_D	0.505	0.60
240_P	404_S	0.505	0.60
377_D	397_H	0.505	0.60
47_L	51_R	0.505	0.60
134_R	324_D	0.504	0.59
177_E	267_Y	0.503	0.59
27_L	30_I	0.502	0.59
6_F	108_V	0.502	0.59
67_E	70_A	0.500	0.59

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2dq0A	2	0.9217	100	0.27	Contact Map
1sesA	2	0.9109	100	0.275	Contact Map
3lssA	2	0.9283	100	0.277	Contact Map
1wleA	2	0.9457	100	0.282	Contact Map
2dq3A	2	0.9196	100	0.287	Contact Map
3vbbA	2	0.9348	100	0.288	Contact Map
3qneA	2	0.9239	100	0.309	Contact Map
3errA	2	0.913	100	0.399	Contact Map
2cjaA	2	0.8783	100	0.554	Contact Map
3w3sA	2	0.8609	100	0.618	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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