GREMLIN Database
SYS - Serine--tRNA ligase
UniProt: Q9HNJ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 460 (420)
Sequences: 4328 (2348)
Seq/√Len: 114.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
421_N427_T4.4151.00
250_Y264_H3.9441.00
187_V319_V3.7351.00
124_E127_R3.6431.00
324_D430_E3.2511.00
301_R304_D3.2291.00
36_E90_R3.1541.00
67_E71_Q3.1541.00
50_D76_R3.1261.00
306_A376_K3.0681.00
43_R83_E2.9221.00
427_T433_Q2.8161.00
141_V149_E2.7931.00
433_Q440_T2.7221.00
183_F322_R2.7011.00
168_F249_M2.6601.00
304_D307_E2.6071.00
342_A376_K2.5741.00
389_P396_E2.5241.00
146_L426_V2.5181.00
131_D134_R2.5091.00
151_D170_K2.4921.00
103_L208_E2.4811.00
318_A322_R2.3821.00
115_V334_T2.3721.00
137_P422_D2.3561.00
20_A115_V2.3411.00
187_V322_R2.3301.00
126_R317_E2.3191.00
15_R28_D2.3131.00
29_R97_E2.3041.00
263_K311_G2.2951.00
126_R329_V2.2901.00
430_E433_Q2.2801.00
62_K74_I2.1681.00
416_L426_V2.1441.00
10_H13_K2.1261.00
61_L66_D2.1131.00
186_D435_Y2.0861.00
308_R311_G2.0571.00
93_D97_E2.0451.00
317_E321_R2.0431.00
157_R253_E2.0131.00
110_D306_A1.9901.00
421_N425_T1.9561.00
161_V168_F1.9421.00
191_Q318_A1.9261.00
388_R395_A1.9131.00
325_L349_V1.8671.00
16_D20_A1.8661.00
201_P223_I1.8581.00
298_N308_R1.8571.00
204_A237_W1.8351.00
206_S251_R1.8221.00
190_E322_R1.8171.00
326_P418_Y1.8041.00
152_I173_G1.7941.00
128_E321_R1.7921.00
332_M344_K1.7811.00
240_P244_V1.7671.00
196_V249_M1.7611.00
112_D343_K1.7351.00
57_K60_E1.7221.00
49_H53_E1.7111.00
331_E343_K1.6911.00
110_D376_K1.6821.00
200_M271_F1.6751.00
16_D19_D1.6721.00
96_A100_R1.6631.00
147_G153_L1.6621.00
32_E36_E1.6531.00
8_R34_D1.6421.00
256_L259_D1.6331.00
17_A111_E1.6311.00
71_Q75_E1.6191.00
79_A83_E1.6161.00
109_P337_M1.6051.00
95_E99_E1.6041.00
438_G442_I1.5841.00
341_Q344_K1.5831.00
198_P245_P1.5831.00
29_R32_E1.5821.00
160_K253_E1.5621.00
224_G233_D1.5561.00
318_A321_R1.5521.00
53_E57_K1.5441.00
305_S399_H1.5411.00
339_F378_F1.5191.00
257_D301_R1.5151.00
6_F10_H1.5091.00
109_P334_T1.5081.00
41_K45_D1.4971.00
263_K298_N1.4871.00
17_A20_A1.4851.00
201_P236_L1.4741.00
47_L80_L1.4681.00
39_E43_R1.4601.00
83_E86_D1.4531.00
117_D121_E1.4511.00
130_F135_D1.4481.00
205_R251_R1.4471.00
167_Y288_V1.4441.00
35_E39_E1.4401.00
142_P145_D1.4331.00
234_D273_R1.4291.00
406_V411_V1.4241.00
301_R387_Y1.4241.00
177_E292_N1.4201.00
157_R249_M1.4011.00
40_L91_A1.4011.00
48_R88_E1.3981.00
204_A235_D1.3851.00
50_D53_E1.3751.00
43_R46_E1.3661.00
148_E156_E1.3561.00
263_K308_R1.3541.00
158_G167_Y1.3531.00
204_A217_V1.3511.00
246_V266_A1.3501.00
170_K194_E1.3351.00
299_F398_L1.3321.00
20_A334_T1.3321.00
71_Q74_I1.3291.00
11_P31_L1.3211.00
6_F13_K1.3161.00
54_V77_S1.3151.00
121_E333_C1.3061.00
89_A93_D1.3051.00
300_V308_R1.3041.00
40_L94_L1.2991.00
257_D390_E1.2961.00
217_V237_W1.2860.99
305_S374_N1.2860.99
162_S236_L1.2840.99
62_K67_E1.2750.99
36_E39_E1.2730.99
250_Y299_F1.2700.99
310_H345_Y1.2690.99
70_A74_I1.2670.99
75_E79_A1.2570.99
324_D419_Y1.2540.99
82_D86_D1.2470.99
118_S121_E1.2460.99
37_W41_K1.2430.99
126_R313_L1.2400.99
34_D38_R1.2390.99
60_E64_A1.2360.99
314_D321_R1.2220.99
187_V190_E1.2200.99
354_D367_L1.2170.99
46_E50_D1.2160.99
187_V318_A1.2090.99
306_A342_A1.2070.99
12_E16_D1.2030.99
86_D90_R1.1980.99
81_K85_A1.1930.99
142_P353_G1.1910.99
419_Y428_V1.1900.99
131_D326_P1.1810.99
89_A92_D1.1770.99
17_A109_P1.1700.99
127_R131_D1.1680.99
286_V413_V1.1600.99
6_F14_V1.1600.99
76_R79_A1.1590.99
203_S206_S1.1550.99
329_V347_I1.1510.99
181_V267_Y1.1450.99
321_R329_V1.1390.99
302_P387_Y1.1380.99
321_R327_Y1.1340.99
439_Q442_I1.1330.99
126_R321_R1.1320.99
298_N311_G1.1300.99
246_V375_F1.1300.99
372_V403_G1.1270.99
312_L372_V1.1260.99
172_A439_Q1.1210.99
100_R104_T1.1190.99
90_R93_D1.1190.99
112_D306_A1.1100.98
78_Q81_K1.1090.98
187_V191_Q1.1000.98
312_L375_F1.0970.98
40_L87_V1.0910.98
385_I398_L1.0890.98
72_E76_R1.0810.98
85_A88_E1.0810.98
57_K61_L1.0740.98
183_F431_A1.0680.98
341_Q375_F1.0670.98
421_N441_R1.0660.98
259_D262_V1.0550.98
196_V246_V1.0550.98
425_T441_R1.0540.98
209_G383_A1.0540.98
145_D148_E1.0520.98
60_E63_Q1.0510.98
184_M319_V1.0490.98
254_I386_Q1.0460.98
389_P393_E1.0460.98
61_L73_A1.0440.98
8_R38_R1.0420.98
331_E337_M1.0410.98
428_V433_Q1.0310.97
29_R101_L1.0260.97
110_D113_A1.0130.97
306_A310_H1.0090.97
222_R237_W1.0070.97
313_L329_V1.0040.97
380_A400_T1.0010.97
92_D96_A1.0010.97
72_E75_E0.9990.97
384_D397_H0.9970.97
351_A367_L0.9970.97
387_Y396_E0.9960.97
310_H313_L0.9960.97
33_V94_L0.9950.97
30_I101_L0.9930.97
298_N315_E0.9910.97
207_M220_A0.9910.97
427_T441_R0.9900.97
2_L7_V0.9860.97
136_L140_V0.9850.97
5_Q9_E0.9810.97
175_R186_D0.9810.97
351_A413_V0.9780.97
85_A89_A0.9780.97
252_D384_D0.9750.96
390_E393_E0.9740.96
313_L347_I0.9720.96
42_A46_E0.9710.96
13_K17_A0.9700.96
79_A82_D0.9700.96
307_E311_G0.9630.96
322_R431_A0.9600.96
13_K16_D0.9590.96
94_L98_L0.9590.96
141_V145_D0.9550.96
54_V57_K0.9550.96
17_A108_V0.9530.96
213_F220_A0.9490.96
158_G162_S0.9490.96
197_F292_N0.9470.96
32_E35_E0.9440.96
55_S77_S0.9430.96
7_V10_H0.9420.96
36_E97_E0.9390.96
222_R235_D0.9390.96
247_T297_V0.9340.95
324_D427_T0.9320.95
7_V30_I0.9250.95
438_G441_R0.9200.95
44_G84_L0.9200.95
118_S335_G0.9170.95
415_I419_Y0.9170.95
200_M269_P0.9100.95
254_I395_A0.9080.95
134_R427_T0.9020.95
215_K219_D0.9020.95
47_L83_E0.8980.94
191_Q315_E0.8980.94
36_E94_L0.8970.94
138_E422_D0.8970.94
56_S59_G0.8950.94
26_D29_R0.8930.94
97_E100_R0.8910.94
263_K315_E0.8860.94
51_R81_K0.8810.94
314_D317_E0.8810.94
30_I105_L0.8750.94
185_L189_R0.8750.94
172_A438_G0.8740.94
428_V436_M0.8690.93
257_D260_L0.8670.93
162_S203_S0.8630.93
2_L14_V0.8600.93
113_A331_E0.8570.93
250_Y262_V0.8560.93
204_A208_E0.8520.93
88_E92_D0.8510.93
354_D365_R0.8500.93
223_I236_L0.8470.92
44_G88_E0.8470.92
188_H405_G0.8460.92
324_D431_A0.8410.92
40_L90_R0.8410.92
257_D389_P0.8400.92
427_T440_T0.8330.92
2_L6_F0.8300.92
45_D48_R0.8300.92
186_D434_P0.8280.92
172_A436_M0.8280.92
254_I388_R0.8280.92
314_D318_A0.8260.92
77_S80_L0.8260.92
193_Y298_N0.8250.91
301_R389_P0.8230.91
246_V264_H0.8210.91
124_E328_R0.8190.91
33_V97_E0.8180.91
181_V408_V0.8150.91
22_G117_D0.8150.91
317_E327_Y0.8110.91
101_L104_T0.8090.91
200_M292_N0.8080.91
21_K338_G0.8070.91
436_M439_Q0.8070.91
256_L388_R0.8060.91
309_F345_Y0.8050.90
134_R137_P0.8040.90
428_V441_R0.8030.90
175_R189_R0.7970.90
162_S206_S0.7940.90
436_M442_I0.7920.90
55_S59_G0.7900.90
353_G413_V0.7900.90
269_P292_N0.7890.90
250_Y255_L0.7880.90
134_R326_P0.7830.89
190_E318_A0.7830.89
65_G70_A0.7820.89
99_E103_L0.7800.89
200_M290_Q0.7780.89
353_G365_R0.7750.89
177_E197_F0.7740.89
45_D91_A0.7740.89
211_G340_T0.7710.88
77_S81_K0.7650.88
94_L97_E0.7620.88
45_D49_H0.7610.88
125_R331_E0.7570.88
206_S248_N0.7560.88
44_G48_R0.7560.88
374_N399_H0.7550.87
319_V406_V0.7550.87
59_G74_I0.7500.87
15_R27_L0.7480.87
117_D333_C0.7460.87
43_R87_V0.7440.87
122_N333_C0.7420.87
123_V331_E0.7410.86
193_Y315_E0.7390.86
221_Y273_R0.7380.86
433_Q439_Q0.7370.86
249_M264_H0.7340.86
142_P413_V0.7340.86
40_L43_R0.7320.86
157_R168_F0.7290.86
286_V367_L0.7290.86
30_I98_L0.7280.85
56_S60_E0.7270.85
419_Y431_A0.7250.85
44_G91_A0.7240.85
70_A73_A0.7220.85
153_L167_Y0.7220.85
217_V224_G0.7220.85
200_M239_L0.7210.85
146_L420_Q0.7210.85
169_S412_L0.7200.85
4_R102_L0.7200.85
54_V73_A0.7190.85
125_R345_Y0.7190.85
306_A374_N0.7150.84
163_G236_L0.7110.84
41_K95_E0.7100.84
152_I170_K0.7100.84
179_A436_M0.7080.84
29_R33_V0.7070.84
35_E38_R0.7060.84
175_R437_N0.7060.84
170_K196_V0.7040.84
188_H265_Q0.7030.83
96_A99_E0.7030.83
158_G168_F0.7000.83
224_G234_D0.6990.83
54_V76_R0.6970.83
212_Q248_N0.6960.83
150_L426_V0.6930.83
332_M341_Q0.6930.83
91_A94_L0.6910.82
165_G369_V0.6910.82
296_L312_L0.6900.82
213_F217_V0.6900.82
242_A245_P0.6880.82
48_R84_L0.6870.82
217_V222_R0.6870.82
61_L64_A0.6850.82
165_G281_E0.6850.82
74_I78_Q0.6850.82
113_A337_M0.6830.82
172_A442_I0.6820.82
19_D24_D0.6810.81
119_E330_L0.6810.81
7_V14_V0.6800.81
12_E15_R0.6800.81
255_L259_D0.6770.81
13_K111_E0.6770.81
28_D32_E0.6760.81
310_H343_K0.6750.81
152_I172_A0.6750.81
169_S292_N0.6740.81
78_Q82_D0.6740.81
59_G78_Q0.6730.81
97_E101_L0.6720.81
427_T430_E0.6720.81
302_P396_E0.6700.80
254_I384_D0.6690.80
151_D171_G0.6680.80
247_T375_F0.6670.80
242_A265_Q0.6650.80
140_V353_G0.6630.80
83_E87_V0.6610.80
334_T337_M0.6600.79
313_L372_V0.6580.79
152_I416_L0.6580.79
162_S223_I0.6570.79
222_R233_D0.6550.79
137_P140_V0.6550.79
62_K70_A0.6550.79
162_S202_V0.6550.79
171_G194_E0.6530.79
87_V90_R0.6530.79
202_V245_P0.6510.78
33_V98_L0.6490.78
250_Y385_I0.6490.78
37_W98_L0.6480.78
57_K73_A0.6470.78
262_V265_Q0.6470.78
50_D54_V0.6460.78
147_G150_L0.6450.78
182_Q267_Y0.6440.78
188_H296_L0.6430.78
147_G416_L0.6430.78
44_G87_V0.6430.78
419_Y430_E0.6410.77
62_K65_G0.6390.77
299_F385_I0.6390.77
257_D393_E0.6390.77
125_R313_L0.6370.77
36_E40_L0.6360.77
178_H195_D0.6350.77
185_L265_Q0.6320.76
337_M344_K0.6320.76
255_L398_L0.6310.76
303_E389_P0.6290.76
75_E78_Q0.6260.76
67_E74_I0.6260.76
135_D138_E0.6250.76
161_V206_S0.6240.76
220_A244_V0.6220.75
220_A240_P0.6220.75
90_R94_L0.6200.75
193_Y296_L0.6190.75
253_E259_D0.6190.75
389_P394_S0.6190.75
134_R138_E0.6180.75
37_W95_E0.6170.75
51_R84_L0.6160.75
7_V31_L0.6150.74
76_R83_E0.6150.74
267_Y292_N0.6150.74
82_D85_A0.6150.74
15_R19_D0.6140.74
183_F187_V0.6130.74
162_S201_P0.6130.74
210_T297_V0.6120.74
37_W94_L0.6120.74
63_Q67_E0.6120.74
144_Y283_R0.6110.74
150_L173_G0.6090.74
196_V264_H0.6080.74
92_D95_E0.6070.74
349_V414_A0.6070.74
415_I428_V0.6060.73
153_L169_S0.6060.73
197_F269_P0.6040.73
297_V375_F0.6010.73
210_T247_T0.6000.73
73_A76_R0.5980.72
202_V239_L0.5970.72
51_R80_L0.5960.72
221_Y236_L0.5960.72
139_S145_D0.5950.72
223_I234_D0.5950.72
366_W411_V0.5940.72
306_A309_F0.5940.72
377_D399_H0.5930.72
281_E367_L0.5930.72
197_F200_M0.5920.72
369_V411_V0.5920.72
6_F11_P0.5920.72
285_I413_V0.5900.71
415_I431_A0.5890.71
155_F285_I0.5890.71
146_L149_E0.5890.71
309_F372_V0.5880.71
201_P238_L0.5880.71
288_V412_L0.5870.71
117_D120_A0.5860.71
223_I273_R0.5850.71
165_G367_L0.5850.71
99_E208_E0.5840.71
316_A370_S0.5840.71
141_V146_L0.5830.71
154_D157_R0.5820.70
161_V249_M0.5800.70
340_T344_K0.5780.70
387_Y398_L0.5780.70
167_Y285_I0.5770.70
91_A95_E0.5770.70
172_A175_R0.5750.69
21_K109_P0.5740.69
86_D89_A0.5730.69
62_K66_D0.5720.69
41_K44_G0.5710.69
316_A347_I0.5710.69
309_F313_L0.5700.69
319_V322_R0.5690.69
34_D102_L0.5690.69
116_G335_G0.5690.69
391_R395_A0.5670.68
428_V439_Q0.5670.68
177_E408_V0.5660.68
203_S236_L0.5660.68
84_L88_E0.5660.68
319_V405_G0.5650.68
47_L84_L0.5650.68
20_A109_P0.5650.68
110_D342_A0.5650.68
430_E440_T0.5620.68
217_V220_A0.5610.68
28_D31_L0.5610.68
51_R55_S0.5580.67
6_F9_E0.5580.67
61_L72_E0.5570.67
353_G367_L0.5560.67
134_R140_V0.5540.67
182_Q186_D0.5540.67
93_D96_A0.5540.67
312_L401_L0.5530.67
134_R421_N0.5520.66
242_A266_A0.5520.66
340_T375_F0.5520.66
66_D70_A0.5510.66
14_V108_V0.5510.66
273_R277_E0.5490.66
53_E56_S0.5490.66
188_H191_Q0.5480.66
426_V442_I0.5480.66
160_K252_D0.5480.66
408_V411_V0.5470.66
144_Y155_F0.5470.66
39_E42_A0.5470.66
250_Y253_E0.5470.66
255_L262_V0.5460.66
43_R47_L0.5460.66
159_A163_G0.5440.65
58_I77_S0.5440.65
140_V420_Q0.5440.65
168_F198_P0.5430.65
367_L409_P0.5430.65
220_A237_W0.5420.65
370_S403_G0.5420.65
298_N312_L0.5400.65
172_A189_R0.5400.65
247_T400_T0.5400.65
67_E72_E0.5380.64
147_G152_I0.5380.64
262_V299_F0.5380.64
258_D390_E0.5380.64
434_P437_N0.5380.64
351_A365_R0.5370.64
177_E409_P0.5360.64
246_V265_Q0.5350.64
19_D25_A0.5350.64
280_T330_L0.5340.64
21_K334_T0.5330.64
113_A334_T0.5320.64
128_E327_Y0.5320.64
343_K374_N0.5310.63
218_E273_R0.5310.63
311_G315_E0.5310.63
250_Y398_L0.5300.63
185_L195_D0.5290.63
189_R265_Q0.5290.63
387_Y390_E0.5280.63
420_Q424_G0.5280.63
288_V413_V0.5280.63
202_V207_M0.5280.63
112_D331_E0.5270.63
63_Q66_D0.5250.63
169_S197_F0.5240.62
37_W91_A0.5240.62
331_E347_I0.5240.62
351_A369_V0.5230.62
59_G62_K0.5220.62
302_P398_L0.5210.62
210_T244_V0.5210.62
118_S333_C0.5210.62
138_E420_Q0.5210.62
239_L245_P0.5210.62
40_L44_G0.5200.62
136_L139_S0.5190.62
411_V415_I0.5190.62
46_E49_H0.5190.62
110_D374_N0.5180.62
278_H282_T0.5160.61
233_D273_R0.5150.61
58_I70_A0.5150.61
184_M404_S0.5140.61
248_N251_R0.5140.61
3_S381_R0.5140.61
43_R90_R0.5130.61
11_P15_R0.5130.61
377_D381_R0.5120.61
7_V11_P0.5120.61
277_E280_T0.5100.60
326_P366_W0.5090.60
220_A268_S0.5080.60
112_D310_H0.5070.60
286_V354_D0.5050.60
240_P404_S0.5050.60
377_D397_H0.5050.60
47_L51_R0.5050.60
134_R324_D0.5040.59
177_E267_Y0.5030.59
27_L30_I0.5020.59
6_F108_V0.5020.59
67_E70_A0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dq0A 2 0.9217 100 0.27 Contact Map
1sesA 2 0.9109 100 0.275 Contact Map
3lssA 2 0.9283 100 0.277 Contact Map
1wleA 2 0.9457 100 0.282 Contact Map
2dq3A 2 0.9196 100 0.287 Contact Map
3vbbA 2 0.9348 100 0.288 Contact Map
3qneA 2 0.9239 100 0.309 Contact Map
3errA 2 0.913 100 0.399 Contact Map
2cjaA 2 0.8783 100 0.554 Contact Map
3w3sA 2 0.8609 100 0.618 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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