GREMLIN Database
Q9HNJ3 - Probable acetyltransferase
UniProt: Q9HNJ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (164)
Sequences: 20195 (15578)
Seq/√Len: 1216.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_A141_W2.8801.00
107_T143_R2.7881.00
33_A98_E2.4181.00
15_C21_D2.4031.00
149_E169_G2.3791.00
11_R108_E2.3081.00
90_A123_R2.2661.00
130_V138_M2.2211.00
80_V117_A2.2161.00
148_R151_T2.1951.00
148_R166_H2.1141.00
9_G112_L2.0991.00
130_V141_W2.0481.00
9_G108_E2.0301.00
139_R142_E2.0271.00
138_M142_E1.9781.00
8_S69_A1.9711.00
115_T119_D1.8951.00
92_L110_G1.8371.00
31_D98_E1.8191.00
124_H154_D1.7691.00
114_T146_F1.7541.00
23_D46_E1.7301.00
114_T126_V1.7261.00
24_F74_P1.7201.00
67_V74_P1.6741.00
151_T166_H1.6701.00
22_V50_R1.6271.00
46_E50_R1.6191.00
110_G144_L1.6121.00
78_L109_A1.6061.00
138_M148_R1.6051.00
138_M166_H1.5941.00
17_V67_V1.5611.00
112_L115_T1.5271.00
132_E164_D1.5151.00
157_F162_Y1.5111.00
45_T48_E1.4951.00
96_L106_G1.4811.00
97_A100_H1.4681.00
19_E54_E1.4661.00
142_E148_R1.4471.00
135_Q138_M1.4411.00
52_W56_Q1.4121.00
94_V141_W1.3911.00
13_D69_A1.3891.00
7_I112_L1.3801.00
124_H162_Y1.3801.00
107_T140_V1.3601.00
8_S13_D1.3411.00
125_R169_G1.3411.00
75_I100_H1.3291.00
138_M168_Y1.3141.00
116_Y120_Q1.2701.00
78_L113_A1.2691.00
132_E151_T1.2641.00
155_A165_V1.2551.00
28_T97_A1.2521.00
24_F73_A1.2411.00
68_V96_L1.2401.00
117_A126_V1.2281.00
94_V137_S1.2051.00
133_D163_L1.1911.00
152_H167_C1.1871.00
106_G140_V1.1471.00
77_S95_F1.1441.00
26_H46_E1.1431.00
68_V109_A1.1361.00
22_V53_Y1.1221.00
73_A100_H1.1201.00
28_T95_F1.1161.00
50_R54_E1.0981.00
9_G12_V1.0871.00
125_R149_E1.0851.00
91_E129_R1.0831.00
117_A121_H1.0821.00
7_I116_Y1.0821.00
151_T164_D1.0771.00
130_V168_Y1.0761.00
101_W136_A1.0761.00
73_A99_D1.0671.00
98_E101_W1.0661.00
34_V101_W1.0651.00
22_V46_E1.0601.00
116_Y121_H1.0511.00
137_S141_W1.0371.00
7_I14_L1.0361.00
154_D164_D1.0301.00
128_A146_F1.0301.00
19_E50_R1.0271.00
33_A36_P1.0261.00
89_S127_F1.0151.00
148_R168_Y1.0061.00
51_E55_E0.9951.00
114_T170_V0.9831.00
107_T111_R0.9831.00
84_D87_N0.9811.00
153_R164_D0.9791.00
24_F27_D0.9761.00
44_V48_E0.9711.00
153_R169_G0.9671.00
131_F163_L0.9631.00
140_V144_L0.9551.00
66_F113_A0.9491.00
114_T144_L0.9401.00
141_W146_F0.9351.00
135_Q139_R0.9171.00
12_V105_Y0.9121.00
132_E166_H0.9081.00
80_V113_A0.9071.00
33_A101_W0.9041.00
111_R115_T0.9041.00
17_V77_S0.8991.00
146_F170_V0.8991.00
117_A123_R0.8941.00
107_T144_L0.8831.00
12_V109_A0.8811.00
13_D72_G0.8771.00
43_P49_E0.8761.00
94_V106_G0.8621.00
89_S125_R0.8601.00
66_F116_Y0.8591.00
19_E57_A0.8581.00
102_G136_A0.8561.00
19_E22_V0.8521.00
111_R144_L0.8521.00
23_D27_D0.8291.00
96_L105_Y0.8231.00
88_G162_Y0.8141.00
152_H155_A0.8131.00
149_E153_R0.8101.00
89_S155_A0.8091.00
26_H30_N0.8041.00
47_R50_R0.7951.00
15_C67_V0.7901.00
91_E127_F0.7881.00
22_V26_H0.7871.00
88_G157_F0.7821.00
51_E54_E0.7811.00
108_E112_L0.7741.00
27_D97_A0.7681.00
135_Q142_E0.7671.00
55_E59_A0.7621.00
29_I95_F0.7601.00
26_H49_E0.7581.00
142_E168_Y0.7551.00
154_D162_Y0.7531.00
130_V137_S0.7491.00
27_D73_A0.7451.00
35_W38_V0.7351.00
37_P131_F0.7331.00
102_G107_T0.7301.00
110_G140_V0.7271.00
10_E108_E0.7231.00
54_E58_S0.7211.00
100_H103_E0.7191.00
9_G14_L0.7171.00
157_F161_E0.7151.00
59_A62_G0.7131.00
48_E51_E0.7111.00
94_V110_G0.7101.00
130_V166_H0.6931.00
106_G110_G0.6891.00
129_R152_H0.6881.00
24_F97_A0.6881.00
139_R143_R0.6871.00
47_R51_E0.6811.00
129_R165_V0.6801.00
28_T74_P0.6781.00
105_Y108_E0.6751.00
31_D97_A0.6701.00
27_D99_D0.6701.00
107_T136_A0.6691.00
128_A137_S0.6671.00
96_L101_W0.6631.00
59_A63_T0.6621.00
37_P133_D0.6621.00
94_V140_V0.6581.00
11_R104_G0.6571.00
133_D161_E0.6511.00
55_E58_S0.6501.00
68_V105_Y0.6481.00
75_I105_Y0.6431.00
102_G139_R0.6431.00
136_A139_R0.6421.00
158_L161_E0.6381.00
70_V105_Y0.6301.00
15_C18_S0.6251.00
73_A97_A0.6231.00
132_E138_M0.6221.00
56_Q65_N0.6171.00
90_A117_A0.6171.00
78_L110_G0.6051.00
74_P77_S0.6021.00
144_L170_V0.6021.00
44_V49_E0.6011.00
102_G140_V0.5961.00
96_L100_H0.5931.00
156_M165_V0.5901.00
32_P36_P0.5891.00
65_N79_G0.5881.00
118_F170_V0.5871.00
80_V90_A0.5861.00
12_V108_E0.5861.00
31_D101_W0.5861.00
18_S21_D0.5851.00
141_W168_Y0.5851.00
69_A72_G0.5821.00
128_A168_Y0.5781.00
88_G124_H0.5761.00
70_V75_I0.5761.00
129_R167_C0.5711.00
35_W40_A0.5691.00
114_T118_F0.5681.00
46_E49_E0.5671.00
110_G146_F0.5631.00
16_P57_A0.5511.00
127_F152_H0.5501.00
158_L163_L0.5491.00
147_E153_R0.5471.00
96_L109_A0.5461.00
125_R155_A0.5421.00
81_H91_E0.5391.00
38_V95_F0.5381.00
68_V76_G0.5381.00
62_G66_F0.5331.00
79_G93_G0.5311.00
17_V25_L0.5311.00
157_F160_G0.5281.00
29_I77_S0.5251.00
83_V90_A0.5221.00
24_F28_T0.5211.00
49_E52_W0.5191.00
82_G90_A0.5181.00
92_L126_V0.5181.00
127_F155_A0.5171.00
90_A126_V0.5171.00
34_V95_F0.5161.00
150_G153_R0.5131.00
25_L29_I0.5121.00
115_T120_Q0.5031.00
131_F158_L0.5031.00
53_Y56_Q0.5031.00
61_N64_V0.5011.00
126_V146_F0.5011.00
63_T66_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vzyA 3 0.8989 100 0.3 Contact Map
3pzjA 2 0.9831 100 0.304 Contact Map
1yreA 2 0.9551 100 0.32 Contact Map
2z10A 2 0.9888 100 0.324 Contact Map
2fckA 2 0.9494 100 0.332 Contact Map
3r9fA 1 0.9494 100 0.335 Contact Map
1nslA 3 0.9719 100 0.336 Contact Map
3tcvA 2 0.9944 100 0.347 Contact Map
4r9mA 5 0.9438 100 0.355 Contact Map
3tthA 5 0.9157 100 0.36 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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